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  1. Book: The impact of HIV drug resistance on the selection of 1st and 2nd line ART in resource limited settings

    Bertagnolio, Silvia

    (The journal of infectious diseases ; 207, Suppl. 2)

    2013  

    Title variant The impact of HIV drug resistance on the selection of 1st- and 2nd-line ART in resource-limited settings
    Author's details ed.: Silvia Bertagnolio
    Series title The journal of infectious diseases ; 207, Suppl. 2
    Collection
    Language English
    Size S. S45 - S106
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT017703095
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Need assessment for HIV drug resistance testing and landscape of current and future technologies in low- and middle-income countries.

    Parkin, Neil / Harrigan, P Richard / Inzaule, Seth / Bertagnolio, Silvia

    PLOS global public health

    2023  Volume 3, Issue 10, Page(s) e0001948

    Abstract: Resistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and ... ...

    Abstract Resistance to antiretroviral drugs used to treat HIV is an important and evolving concern, particularly in low- and middle-income countries (LMICs) which have been impacted to the greatest extent by the HIV pandemic. Efforts to monitor the emergence and transmission of resistance over the past decade have shown that drug resistance-especially to the nucleoside analogue and non-nucleoside reverse transcriptase inhibitors-can (and have) increased to levels that can jeopardize the efficacy of available treatment options at the population level. The global shift to integrase-based regimens as the preferred first-line therapy as well as technological advancements in the methods for detecting resistance have had an impact in broadening and diversifying the landscape of and use case for HIV drug resistance testing. This review estimates the potential demand for HIV drug resistance tests, and surveys current testing methodologies, with a focus on their application in LMICs.
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0001948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antimicrobial resistance: Strengthening surveillance for public health action.

    Bertagnolio, Silvia / Suthar, Amitabh Bipin / Tosas, Olga / Van Weezenbeek, Kitty

    PLoS medicine

    2023  Volume 20, Issue 7, Page(s) e1004265

    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Public Health ; Drug Resistance, Bacterial ; World Health Organization ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1004265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Developing a priority global research agenda for antimicrobial resistance in the human health sector: protocol for a scoping review.

    Hamers, Raph L / Cassini, Alessandro / Asadinia, Koe Stella / Bertagnolio, Silvia

    BMJ open

    2022  Volume 12, Issue 6, Page(s) e060553

    Abstract: Introduction: To accelerate the response to the public health threat by antimicrobial resistance (AMR), the WHO is developing a Global Research Agenda for AMR in the human health sector that aims to provide a global and transparent assessment of ... ...

    Abstract Introduction: To accelerate the response to the public health threat by antimicrobial resistance (AMR), the WHO is developing a Global Research Agenda for AMR in the human health sector that aims to provide a global and transparent assessment of priority knowledge gaps related to critical bacteria-including
    Methods and analysis: This literature scoping review will follow the Arksey and O'Malley (2005) methodology and will include: (1) a hand search to identify relevant WHO guidelines and documents suggested by the WHO Steering Group for the AMR Global Research Agenda; (2) a grey literature search through a stakeholder mapping process and google searches of organisational websites; (3) a systematic search of relevant systematic reviews through bibliographic databases (PubMed, Embase and Web of Science); (4) screening of the reference lists of included studies. We will include relevant publications from the last 10 years (January 2012 to December 2021). Two researchers separately will review the yielded citations to determine eligibility based on predefined criteria. Relevant research questions with attributes will be extracted using a tool developed through an iterative process by the research team. Each identified research question will be classified and aggregated according to a conceptual framework (ie, 'knowledge matrix'), composed of three themes (ie, Prevention, Diagnosis and Care & Treatment) and four cross-cutting domains (ie, Descriptive, Discovery, Development, Delivery). We will present numerical and thematic summaries of the knowledge matrix. A qualitative content analysis is out of the scope of this protocol.
    Ethics and dissemination: The scoping review process will only involve identification, selection and analysis of documents available for use in the public domain, and will not include any personal information on individuals, therefore ethical approval is not required. The findings will be disseminated through a peer-reviewed publication and stakeholder meetings.
    MeSH term(s) Anti-Bacterial Agents ; Databases, Bibliographic ; Drug Resistance, Bacterial ; Humans ; Research Design ; Review Literature as Topic
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-060553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epidemiology of HIV drug resistance in low- and middle-income countries and WHO global strategy to monitor its emergence.

    Bertagnolio, Silvia / Jordan, Michael R / Giron, Amalia / Inzaule, Seth

    Current opinion in HIV and AIDS

    2022  Volume 17, Issue 4, Page(s) 229–239

    Abstract: Purpose of review: This review summarises the latest information of the epidemiology of HIV drug resistance (HIVDR) in low- and middle-income countries and the updated WHO global strategy for HIVDR surveillance and monitoring.: Recent findings: ... ...

    Abstract Purpose of review: This review summarises the latest information of the epidemiology of HIV drug resistance (HIVDR) in low- and middle-income countries and the updated WHO global strategy for HIVDR surveillance and monitoring.
    Recent findings: Finding from recent national-representative surveys show a rise in pretreatment drug resistance (PDR) to reverse transcriptase inhibitors and especially to the class of nonnucleoside reverse transcriptase inhibitors. Levels of PDR are especially high in infants <18 months and adults reporting prior exposure to antiretrovirals. Although viral suppression rates are generally high and increasing among adults on antiretroviral therapy, those with unsuppressed viremia have high levels of acquired drug resistance (ADR). Programmatic data on HIVDR to integrase-transfer-inhibitor resistance is scarce, highlighting the need to increase integrase-inhibitors resistance surveillance. As the landscape of HIV prevention, treatment and monitoring evolves, WHO has also adapted its strategy to effectively support countries in preventing and monitoring the emergence of HIVDR. This includes new survey methods for monitoring resistance emerging from patients diagnosed with HIV while on preexposure prophylaxis, and a laboratory-based ADR survey leveraging on remnant viral load specimens which are expected to strengthen dolutegravir-resistance surveillance.
    Summary: Monitoring HIVDR remains pivotal to ensure countries attain and sustain the global goals for ending HIV as a public health threat by 2030.
    MeSH term(s) Adult ; Anti-HIV Agents/therapeutic use ; Developing Countries ; Drug Resistance, Viral ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Reverse Transcriptase Inhibitors/therapeutic use ; Viral Load ; World Health Organization
    Chemical Substances Anti-HIV Agents ; Reverse Transcriptase Inhibitors
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improving systems to monitor transmitted HIV drug resistance.

    Bertagnolio, Silvia

    BMJ (Clinical research ed.)

    2012  Volume 345, Page(s) e6315

    MeSH term(s) Anti-Retroviral Agents ; Drug Resistance, Viral/genetics ; Female ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Male
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2012-09-20
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.e6315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Is increasing pretreatment HIV drug resistance a real menace or minor detail?

    Inzaule, Seth C / Hamers, Raph L / Bertagnolio, Silvia

    The lancet. HIV

    2020  Volume 7, Issue 5, Page(s) e316–e317

    MeSH term(s) Drug Resistance, Viral ; HIV Infections ; HIV-1 ; Humans ; Oligonucleotides
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2020-01-02
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30048-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: Real-life implications of prevalence meta-analyses? Doi plots and prediction intervals are the answer - Authors' reply.

    Soucy, Jean-Paul R / Langford, Bradley J / So, Miranda / Raybardhan, Sumit / MacFadden, Derek / Daneman, Nick / Bertagnolio, Silvia

    The Lancet. Microbe

    2023  Volume 4, Issue 7, Page(s) e491

    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00098-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: HIV Drug Resistance.

    Bertagnolio, Silvia / Jordan, Michael R / Doherty, Meg

    The New England journal of medicine

    2018  Volume 378, Issue 9, Page(s) 874

    MeSH term(s) Anti-HIV Agents ; Drug Resistance, Viral/drug effects ; HIV Infections ; Humans
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2018-03-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1716089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The First 110,593 COVID-19 Patients Hospitalised in Lombardy: A Regionwide Analysis of Case Characteristics, Risk Factors and Clinical Outcomes.

    Mauer, Nicole / Chiecca, Greta / Carioli, Greta / Gianfredi, Vincenza / Iacoviello, Licia / Bertagnolio, Silvia / Guerra, Ranieri / Odone, Anna / Signorelli, Carlo

    International journal of public health

    2022  Volume 67, Page(s) 1604427

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) COVID-19/epidemiology ; Comorbidity ; Hospitalization ; Humans ; Pandemics ; Risk Factors
    Language English
    Publishing date 2022-05-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.3389/ijph.2022.1604427
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