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  1. AU="Bertilacchi, Maria Sofia"
  2. AU="I.C.F.Wong, "
  3. AU="Pootrakul, Llana"
  4. AU="Heydari Beni, Nargess"
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  1. Article ; Online: Blood oxygenation state in COVID-19 patients: Unexplored role of 2,3-bisphosphoglycerate.

    Bertilacchi, Maria Sofia / Piccarducci, Rebecca / Celi, Alessandro / Germelli, Lorenzo / Romei, Chiara / Bartholmai, Brian / Barbieri, Greta / Giacomelli, Chiara / Martini, Claudia

    Biomedical journal

    2024  , Page(s) 100723

    Abstract: Background: COVID-19 reduces lung functionality causing a decrease of blood oxygen levels (hypoxemia) often related to a decreased cellular oxygenation (hypoxia). Besides lung injury, other factors are implicated in the regulation of oxygen availability ...

    Abstract Background: COVID-19 reduces lung functionality causing a decrease of blood oxygen levels (hypoxemia) often related to a decreased cellular oxygenation (hypoxia). Besides lung injury, other factors are implicated in the regulation of oxygen availability such as pH, partial arterial carbon dioxide tension (PaCO
    Material and methods: Sixty-eight COVID-19 patients were enrolled at hospital admission. The lung involvement was quantified using chest-Computer Tomography (CT) analysed with automatic software (CALIPER). Haemoglobin concentrations, glycemia, and routine analysis were evaluated in the whole blood, while partial arterial oxygen tension (PaO
    Results: A higher percentage of interstitial lung disease (ILD) and vascular pulmonary-related structure (VRS) volume on chest-CT quantified with CALIPER had been found in COVID-19 patients with a worse disease outcome (R = 0.4342; and R = 0.3641, respectively). Furthermore, patients with lower PaO
    Conclusions: Overall, the data reveal a different pattern of activation of blood oxygenation compensatory mechanisms reflecting a different course of the COVID-19 disease specifically focusing on 2,3-BPG modulation.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698541-X
    ISSN 2320-2890 ; 2320-2890
    ISSN (online) 2320-2890
    ISSN 2320-2890
    DOI 10.1016/j.bj.2024.100723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interaction of graphene and WS

    Convertino, Domenica / Nencioni, Martina / Russo, Lara / Mishra, Neeraj / Hiltunen, Vesa-Matti / Bertilacchi, Maria Sofia / Marchetti, Laura / Giacomelli, Chiara / Trincavelli, Maria Letizia / Coletti, Camilla

    Nanoscale

    2024  Volume 16, Issue 4, Page(s) 1792–1806

    Abstract: Graphene and bidimensional (2D) materials have been widely used in nerve conduits to boost peripheral nerve regeneration. Nevertheless, the experimental and commercial variability in graphene-based materials generates graphene forms with different ... ...

    Abstract Graphene and bidimensional (2D) materials have been widely used in nerve conduits to boost peripheral nerve regeneration. Nevertheless, the experimental and commercial variability in graphene-based materials generates graphene forms with different structures and properties that can trigger entirely diverse biological responses from all the players involved in nerve repair. Herein, we focus on the graphene and tungsten disulfide (WS
    MeSH term(s) Humans ; Graphite/chemistry ; Neutrophils ; Nerve Regeneration ; Mesenchymal Stem Cells
    Chemical Substances Graphite (7782-42-5)
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr04927b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.

    Piccarducci, Rebecca / Giacomelli, Chiara / Bertilacchi, Maria Sofia / Benito-Martinez, Andrea / Di Giorgi, Nicoletta / Daniele, Simona / Signore, Giovanni / Rocchiccioli, Silvia / Vilar, Marçal / Marchetti, Laura / Martini, Claudia

    Biochimica et biophysica acta. Molecular basis of disease

    2023  Volume 1869, Issue 7, Page(s) 166793

    Abstract: The Apolipoprotein E (ApoE) has been known to regulate cholesterol and β-amyloid (Aβ) production, redistribution, and elimination, in the central nervous system (CNS). The ApoE ε4 polymorphic variant leads to impaired brain cholesterol homeostasis and ... ...

    Abstract The Apolipoprotein E (ApoE) has been known to regulate cholesterol and β-amyloid (Aβ) production, redistribution, and elimination, in the central nervous system (CNS). The ApoE ε4 polymorphic variant leads to impaired brain cholesterol homeostasis and amyloidogenic pathway, thus representing the major risk factor for Alzheimer's Disease (AD). Currently, less is known about the molecular mechanisms connecting ApoE ε4-related cholesterol metabolism and cholinergic system degeneration, one of the main AD pathological features. Herein, in vitro cholinergic neuron models were developed in order to study ApoE neuronal expression and investigate the possible interplay between cholesterol metabolism and cholinergic pathway impairment prompted by ε4 isoform. Particularly, alterations specifically occurring in ApoE ε4-carrying neurons (i.e. increased intracellular ApoE, amyloid precursor protein (APP) and Aβ levels, elevated apoptosis, and reduced cell survival) were recapitulated. ApoE ε4 expression was found to increase intracellular cholesterol accumulation, by regulating the related gene expression, while reducing cholesterol precursor acetyl-CoA, which in turn fuels the acetylcholine (ACh) synthesis route. In parallel, although the ACh intracellular signalling was activated, as demonstrated by the boosted extracellular ACh as well as increased IP
    MeSH term(s) Humans ; Acetylcholine ; Alzheimer Disease/metabolism ; Apolipoprotein E4/genetics ; Apolipoproteins E/genetics ; Cholesterol ; Cholinergic Agents ; Neurons/metabolism ; Protein Kinase C-epsilon/metabolism
    Chemical Substances Acetylcholine (N9YNS0M02X) ; Apolipoprotein E4 ; Apolipoproteins E ; Cholesterol (97C5T2UQ7J) ; Cholinergic Agents ; ApoE protein, human ; Protein Kinase C-epsilon (EC 2.7.11.13)
    Language English
    Publishing date 2023-06-17
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 60-7
    ISSN 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2023.166793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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