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  1. Article: Giant lung bulla as a late-onset complication of mild SARS-CoV-2 pneumonia.

    Petroncini, Matteo / Valentini, Leonardo / Solli, Piergiorgio / Bertoglio, Pietro

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2023  

    Abstract: A 49-year-old Caucasian man was admitted to the Emergency Department for shortness of breath and cough. CT imaging showed bilateral a mild COVID-19 related pneumonia. He was hospitalized in the low-intensity COVID-19 unit where he received O2 therapy and ...

    Abstract A 49-year-old Caucasian man was admitted to the Emergency Department for shortness of breath and cough. CT imaging showed bilateral a mild COVID-19 related pneumonia. He was hospitalized in the low-intensity COVID-19 unit where he received O2 therapy and oral corticosteroids (CS). Three weeks after discharge a high-resolution computed tomography (HRCT) find a giant bulla of the inferior lobe. The bulla was resected by video-assisted thoracoscopic surgery (VATS) and the patient recovered completely. In our patient, it is reasonable to suspect that the development of the bulla is a result of SARS-CoV-2 infection, since no bulla was observed in the first HRCT two months before. SARS-CoV-2 related pneumonia may be responsible for lung remodeling due to diffuse alveolar damage and later interstitial myofibroblastic proliferation. Corticosteroids might have played a role in increasing SARS-CoV-2 dystrophic action. COVID-19 leads to pulmonary damages, which are still partially unknown and might result in development of bullae. In fit patient surgical treatment can be carried out safely.
    Language English
    Publishing date 2023-09-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2023.2559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 65: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article: Lung cancer screening: are we performing it satisfactorily?

    Minervini, Fabrizio / Bertoglio, Pietro / Kestenholz, Peter B / Scarci, Marco

    Journal of thoracic disease

    2023  Volume 15, Issue 6, Page(s) 2899–2901

    Language English
    Publishing date 2023-05-31
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Surgery for octogenarians: the secret is in the selection.

    Bertoglio, Pietro / Valentini, Leonardo / Scarci, Marco / Kestenholz, Peter / Minervini, Fabrizio

    Journal of thoracic disease

    2023  Volume 15, Issue 8, Page(s) 4134–4136

    Language English
    Publishing date 2023-07-21
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of intrapulmonary lymph nodes in patients with NSCLC and visceral pleural invasion. The VPI 1314 multicenter registry study protocol.

    Minervini, Fabrizio / Kestenholz, Peter / Bertoglio, Pietro / Li, Allen / Nilius, Henning

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0285184

    Abstract: Background: In the lung cancer classification (TNM), the involvement of thoracic lymph nodes is relevant from a diagnostic and prognostic point of view. Even if imaging modality could help in selecting patients who should undergo surgery, a systematic ... ...

    Abstract Background: In the lung cancer classification (TNM), the involvement of thoracic lymph nodes is relevant from a diagnostic and prognostic point of view. Even if imaging modality could help in selecting patients who should undergo surgery, a systematic lymph node dissection during lung surgery is mandatory to identify the subgroup of patients who can benefit from an adjuvant treatment.
    Methods: Patients undergoing elective lobectomy/bilobectomy/segmentectomy) for non-small cell lung cancer and lymphadenectomy with lymph nodes station 10-11-12-13-14 sampling that meet the inclusion and exclusion criteria will be recorded in a multicenter prospective database. The overall incidence of N1 patients (subclassified in: Hilar Lymph nodes, Lobar Lymph nodes and Sublobar Lymph nodes) will be examined as well as the incidence of visceral pleural invasion.
    Discussion: The aim of this multicenter prospective study is to evaluate the incidence of intrapulmonary lymph nodes metastases and the possible relation with visceral pleural invasion. Identifying patients with lymph node station 13 and 14 metastases and/or a link between visceral pleural invasion and presence of micro/macro metastases in intrapulmonary lymph nodes may have an impact on decision-making process.
    Trial registration: ClinicalTrials.gov ID: NCT05596578.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Prospective Studies ; Neoplasm Staging ; Lymphatic Metastasis/pathology ; Lymph Nodes/pathology ; Lung/pathology ; Lymph Node Excision ; Prognosis ; Pneumonectomy ; Registries ; Retrospective Studies ; Multicenter Studies as Topic
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0285184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Benign tumors of the chest wall.

    Minervini, Fabrizio / Sergi, Consolato Maria / Scarci, Marco / Kestenholz, Peter B / Valentini, Leonardo / Boschetti, Laura / Bertoglio, Pietro

    Journal of thoracic disease

    2024  Volume 16, Issue 1, Page(s) 722–736

    Abstract: Benign tumors of the chest wall are rare tumors that might arise from all the tissues of the chest: vessels, nerves, bones, cartilage, and soft tissues. Despite benign features, these tumors can have several histological characteristics and different ... ...

    Abstract Benign tumors of the chest wall are rare tumors that might arise from all the tissues of the chest: vessels, nerves, bones, cartilage, and soft tissues. Despite benign features, these tumors can have several histological characteristics and different behaviors. Even if they do not influence life expectancy, rarely they may have a potential risk of malignant transformation. They can cause several, oft, unspecific symptoms but more than 20% of affected patients are asymptomatic and are being diagnosed incidentally on chest radiograph or computed tomography scan. Pain is the most common described symptom. Together with a detailed medical history, a rigorous and meticulous clinical and radiological assessment is mandatory. If radiological features are unclear or in case surgery could not be performed, a biopsy should be indicated to establish a diagnosis. Radical surgical resection can often be offered to resect and cure these neoplasms, but this is might not be true for all types of tumors and, in some cases, their dimension or position might contra-indicate surgery. Given the rarity of these tumors, there is a lack of treatment's guidelines and prospective trials that include a significant number of patients. This review discusses, according to the latest evidence, the histological features and the best treatment of several chest wall benign tumors.
    Language English
    Publishing date 2024-01-05
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Posttraumatic transmediastinal pulmonary hernia: An extremely rare clinical entity.

    Brandolini, Jury / Bertoglio, Pietro / Kawamukai, Kenji / Bonfanti, Barbara / Forti Parri, Sergio Nicola / Garelli, Elena / Solli, Piergiorgio

    JTCVS techniques

    2023  Volume 18, Page(s) 168–170

    Language English
    Publishing date 2023-01-21
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.01.014
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  7. Article: Surgery for Solitary Fibrous Tumors of the Pleura: A Review of the Available Evidence.

    Bertoglio, Pietro / Querzoli, Giulia / Kestenholz, Peter / Scarci, Marco / La Porta, Marilina / Solli, Piergiorgio / Minervini, Fabrizio

    Cancers

    2023  Volume 15, Issue 16

    Abstract: Solitary fibrous tumors of the pleura (pSFT) are a relatively rare neoplasms that can arise from either visceral or parietal pleura and may have different aggressive biological behaviors. Surgery is well known to be the cornerstone of the treatment for ... ...

    Abstract Solitary fibrous tumors of the pleura (pSFT) are a relatively rare neoplasms that can arise from either visceral or parietal pleura and may have different aggressive biological behaviors. Surgery is well known to be the cornerstone of the treatment for pSFT. We reviewed the existing literature, focusing on the role of surgery in the management and treatment of pSFT. All English-written literature has been reviewed, focusing on those reporting on the perioperative management and postoperative outcomes. Surgery for pSFT is feasible and safe in all experiences reported in the literature, but surgical approaches and techniques may vary according to the tumor dimensions, localization, and surgeons' skills. Long-term outcomes are good, with a 10-year overall survival rate of more than 70% in most of the reported experiences; on the other hand, recurrence may happen in up to 17% of cases, which occurs mainly in the first two years after surgery, but case reports suggest the need for a longer follow-up to assess the risk of late recurrence. Malignant histology and dimensions are the most recognized risk factors for recurrence. Recurrence might be operated on in select patients. Surgery is the treatment of choice in pSFT, but a radical resection and a careful postoperative follow-up should be carried out.
    Language English
    Publishing date 2023-08-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15164166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lung Transplant Recipients and COVID-19: Report of Two Cases.

    Antonacci, Filippo / Petroncini, Matteo / Salvaterra, Elena / Bertoglio, Pietro / Daddi, Niccolò / Lai, Giulia / Brandolini, Jury / Solli, Piergiorgio / Dolci, Giampiero

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Although the WHO has declared the end of the pandemic emergency, COVID-19 still poses a threat to immunocompromised patients. The COVID-19 pandemic has spread throughout the world over the last two years, causing a significant number of deaths. After ... ...

    Abstract Although the WHO has declared the end of the pandemic emergency, COVID-19 still poses a threat to immunocompromised patients. The COVID-19 pandemic has spread throughout the world over the last two years, causing a significant number of deaths. After three years, SARS-CoV-2 has lost its initial lethality but has shown a significantly worse prognosis for immunocompromised patients, especially those who have undergone lung transplantation, compared with the general population. This paper presents two compelling case studies that highlight the complex challenges of COVID-19 infection in lung transplant recipients. The first case involves a patient who received a bilateral lung transplant for pulmonary artery hypertension in 2009, followed by a kidney transplant in 2022. Surprisingly, despite an initially favorable clinical course after contracting COVID-19, the patient deteriorated rapidly and died within a few days due to extensive lung involvement. This case highlights the unpredictable nature of COVID-19 and its potentially devastating impact on lung transplant recipients. The second case involves a patient who underwent bilateral lung transplantation five years earlier for chronic obstructive pulmonary disease (COPD). This individual also contracted COVID-19 and had pre-existing complications, including chronic lung allograft rejection (CLAD) and diffuse bronchial stenosis. Following viral infection, the patient's clinical condition deteriorated rapidly, with worsening bronchial stenosis. This case highlights the ability of COVID-19 to exacerbate pre-existing pulmonary complications in transplant recipients. These cases highlight the urgent need for increased vigilance and tailored management strategies when dealing with COVID-19 in lung transplant recipients. The unpredictable and detrimental course of the disease observed in these patients highlights the importance of implementing stringent preventive measures, such as vaccination and strict adherence to infection control protocols, in this vulnerable population. Further research is essential to gain a full understanding of the unique dynamics of COVID-19 in lung transplant recipients and to develop targeted interventions to improve their outcomes.
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134287
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Are the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study.

    Nachira, Dania / Bertoglio, Pietro / Ismail, Mahmoud / Napolitano, Antonio Giulio / Calabrese, Giuseppe / Kuzmych, Khrystyna / Congedo, Maria Teresa / Sassorossi, Carolina / Meacci, Elisa / Petracca Ciavarella, Leonardo / Chiappetta, Marco / Lococo, Filippo / Solli, Piergiorgio / Margaritora, Stefano

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Objectives: The aim of this study is to evaluate if the efficacy and safety of chest tube placement are influenced by the level of intercostal space insertion (uniportal VATS vs. biportal VATS) or by the type of drain employed (standard vs. smart ... ...

    Abstract Objectives: The aim of this study is to evaluate if the efficacy and safety of chest tube placement are influenced by the level of intercostal space insertion (uniportal VATS vs. biportal VATS) or by the type of drain employed (standard vs. smart coaxial drain).
    Methods: Data on patients who underwent either uniportal or biportal VATS upper lobectomies with lymphadenectomy were prospectively collected in three European centers. The uniportal VATS group with a 28 Fr standard chest tube (U-VATS standard) was compared with the uniportal VATS group with a 28 Fr smart drain (U-VATS smart), and U-VATS smart was also compared with biportal VATS with a 28 Fr smart drain inserted in the VIII intercostal space (Bi-VATS smart).
    Results: When comparing the U-VATS standard group with the U-VATS smart, a higher fluid output was recorded in the U-VATS smart (
    Conclusions: Chest tube insertion through the same incision space in uniportal VATS seems to be safe and effective. Smart drains can improve the fluid output in uniportal VATS, as if the drainage were inserted in a lower space (i.e., biportal VATS), but with less discomfort.
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: It takes all sorts to make a world: geographical differences and the future perspective of molecular testing in non-small cell lung cancer.

    Bertoglio, Pietro / Costardi, Lorena / Viti, Andrea / Ruffini, Enrico / Guerrera, Francesco

    Journal of thoracic disease

    2020  Volume 12, Issue 9, Page(s) 5050–5052

    Language English
    Publishing date 2020-10-29
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-2020-49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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