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  1. Article ; Online: Pigmented demodicosis presenting as lentigo maligna diagnosed by reflectance confocal microscopy.

    Bertold, Clemence / Martel, Philippe / Passeron, Thierry / Bahadoran, Philippe

    The British journal of dermatology

    2022  Volume 188, Issue 1, Page(s) 149–150

    MeSH term(s) Humans ; Hutchinson's Melanotic Freckle ; Melanoma ; Skin Neoplasms ; Microscopy, Confocal ; Diagnosis, Differential
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac023
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  2. Article: [Vitiligo, no longer a fatality in 2023].

    Alvarez Martinez, David / Bertold, Clémence / Passeron, Thierry / Cortes, Begonia

    Revue medicale suisse

    2022  Volume 19, Issue 820, Page(s) 637–641

    Abstract: Vitiligo is an acquired auto-inflammatory disorder characterized by a depigmentation. It is a polygenic disease developed in a context of allelic variations. Its pathophysiology is complex, associating intrinsic skin defects, exposome triggering factors ... ...

    Abstract Vitiligo is an acquired auto-inflammatory disorder characterized by a depigmentation. It is a polygenic disease developed in a context of allelic variations. Its pathophysiology is complex, associating intrinsic skin defects, exposome triggering factors and innate then adaptive auto-immune activation leading to the loss of melanocytes. The diagnosis is clinical. Nevertheless, Wood's lamp is mandatory to assess the lesions and their activity, especially in fair-skinned patients. The management of vitiligo is long and aims to halt the depigmentation process and to repigment the affected areas. This requires a combination of immunosuppressive topical or systemic treatment with ultraviolet rays from phototherapy or sun exposure.
    MeSH term(s) Humans ; Vitiligo/therapy ; Vitiligo/diagnosis ; Vitiligo/pathology ; Skin ; Melanocytes/pathology ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Immunosuppressive Agents
    Language French
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    DOI 10.53738/REVMED.2023.19.820.637
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  3. Article ; Online: Laser-assisted depigmentation for vitiligo universalis: A retrospective monocentric study comparing nano- and picosecond lasers.

    Martinez, David Alvarez / Bertold, Clémence / Le Duff, Florence / Bahadoran, Philippe / Passeron, Thierry

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 37, Issue 6, Page(s) e708–e710

    MeSH term(s) Humans ; Vitiligo/radiotherapy ; Retrospective Studies ; Lasers ; Hypopigmentation ; Lasers, Solid-State
    Language English
    Publishing date 2022-12-30
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18822
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    Zs.A 3492: Show issues Location:
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  4. Article ; Online: Efficacy and safety of a novel triple combination cream compared to Kligman's trio for melasma: A 24-week double-blind prospective randomized controlled trial.

    Bertold, Clémence / Fontas, Eric / Singh, Tanya / Gastaut, Nadia / Ruitort, Sandra / Wehrlen Pugliese, Sylvia / Passeron, Thierry

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  Volume 37, Issue 12, Page(s) 2601–2607

    Abstract: Background: Kligman's trio (KT), combining hydroquinone, retinoic acid and corticosteroid, is considered as the gold standard treatment of melasma. Its efficacy has never been matched before, but it is tempered by frequent adverse effects.: Objective!# ...

    Abstract Background: Kligman's trio (KT), combining hydroquinone, retinoic acid and corticosteroid, is considered as the gold standard treatment of melasma. Its efficacy has never been matched before, but it is tempered by frequent adverse effects.
    Objective: To assess the efficacy and tolerance of a New Trio (NT) combination with isobutylamido-thiazolyl-resorcinol, retinoic acid and cortosteroid compared to KT.
    Methods: We conducted a 24-week monocentric trial, randomized, double-blind, controlled versus KT, with 40 melasma patients. NT and KT were applied for 12 weeks and associated with the same sunscreen applied for 24 weeks. The primary endpoint was the modified Melasma Area Severity Index (mMASI) at 12 weeks. Patient quality of life was investigated using MelasQoL.
    Results: After 12 weeks, KT and NT groups both demonstrated a significant improvement in mMASI, respectively -2.84 (SE 0.69, p < 0.0002) and -4.33 (SE 0.71, p < 0.0001). The mean difference between the two groups was -1.49 (IC 95% -3.52 to 0.54, p = 0.14). MelasQoL improvement was -6.66 (SE 3.29, p = 0.0515) with KT and -12.57 (SE 3.29, p = 0.0006) with NT.
    Conclusion: The NT combination appears to be an effective treatment option for treating melasma and could be considered as a well-tolerated alternative to KT.
    MeSH term(s) Humans ; Quality of Life ; Prospective Studies ; Tretinoin/adverse effects ; Treatment Outcome ; Emollients ; Melanosis/drug therapy ; Hydroquinones/adverse effects
    Chemical Substances Tretinoin (5688UTC01R) ; Emollients ; Hydroquinones
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19455
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  5. Article ; Online: Tocilizumab for Corticosteroid-Refractory Immune Checkpoint Inhibitor-Induced Generalized Morphea.

    Blaise, Manon / Cardot-Leccia, Nathalie / Seitz-Polski, Barbara / Picard-Gauci, Alexandra / Bertold, Clémence / Passeron, Thierry / Montaudié, Henri

    JAMA dermatology

    2023  Volume 159, Issue 1, Page(s) 112–114

    MeSH term(s) Humans ; Scleroderma, Localized/chemically induced ; Scleroderma, Localized/drug therapy ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized/adverse effects ; Nivolumab
    Chemical Substances tocilizumab (I031V2H011) ; Immune Checkpoint Inhibitors ; Antibodies, Monoclonal, Humanized ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2022.5146
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  6. Article ; Online: Reliability and agreement testing of a new automated measurement method to determine facial vitiligo extent using standardized ultraviolet images and a dedicated algorithm.

    Marin Dit Bertoud, Quentin / Bertold, Clémence / Ezzedine, Khaled / Pandya, Amit G / Cherel, Marie / Castillo Martinez, Alejandro / Seguy, Marie-Anne / Abdallah, Marwa / Bae, Jung Min / Böhm, Markus / Parsad, Davinder / Rosmarin, David / Wolkerstorfer, Albert / Bahadoran, Philippe / Blaise, Manon / Dugourd, Pierre-Michel / Philippo, Valérie / Delaval, Jean-Michel / Passeron, Thierry

    The British journal of dermatology

    2023  Volume 190, Issue 1, Page(s) 62–69

    Abstract: Background: Facial repigmentation is the primary outcome measure for most vitiligo trials. The Facial Vitiligo Area Scoring Index (F-VASI) score is often chosen as the primary outcome measure to assess the efficacy of treatments for facial vitiligo. ... ...

    Abstract Background: Facial repigmentation is the primary outcome measure for most vitiligo trials. The Facial Vitiligo Area Scoring Index (F-VASI) score is often chosen as the primary outcome measure to assess the efficacy of treatments for facial vitiligo. Although useful, this scoring system remains subjective and has several limitations.
    Objectives: To assess the agreement and reliability of an algorithmic method to measure the percentage depigmentation of vitiligo on the face.
    Methods: We developed a dedicated algorithm called Vitil-IA® to assess depigmentation on standardized facial ultraviolet (UV) pictures. We then conducted a cross-sectional study using the framework of the ERASE trial (NCT04843059) in 22 consecutive patients attending a tertiary care centre for vitiligo. Depigmentation was analysed before any treatment and, for 7 of them, after 3 and 6 months of narrowband UVB treatment combined with 16 mg methylprednisolone, both used twice weekly. Interoperator and interacquisition repeatability measures were assessed for the algorithm. The results of the algorithmic measurement were then compared with the F-VASI and the percentage of depigmented skin scores assessed by 13 raters, including 7 experts in the grading of vitiligo lesions.
    Results: Thirty-one sets of pictures were analysed with the algorithmic method. Internal validation showed excellent reproducibility, with a variation of < 3%. The percentage of depigmentation assessed by the system showed high agreement with the percentage of depigmentation assessed by raters [mean error (ME) -11.94 and mean absolute error (MAE) 12.71 for the nonexpert group; ME 0.43 and MAE 5.57 for the expert group]. The intraclass correlation coefficient (ICC) for F-VASI was 0.45 [95% confidence interval (CI) 0.29-0.62] and 0.52 (95% CI 0.37-0.68) for nonexperts and experts, respectively. When the results were analysed separately for homogeneous and heterogeneous depigmentation, the ICC for homogeneous depigmentation was 0.47 (95% CI 0.31-0.77) and 0.85 (95% CI 0.72-0.94) for nonexperts and experts, respectively. When grading heterogeneous depigmentation, the ICC was 0.19 (95% CI 0.05-0.43) and 0.38 (95% CI 0.20-0.62) for nonexperts and experts, respectively.
    Conclusions: We demonstrated that the Vitil-IA algorithm provides a reliable assessment of facial involvement in vitiligo. The study underlines the limitations of the F-VASI score when performed by nonexperts for homogeneous vitiligo depigmentation, and in all raters when depigmentation is heterogeneous.
    MeSH term(s) Humans ; Vitiligo/diagnosis ; Vitiligo/therapy ; Vitiligo/pathology ; Reproducibility of Results ; Cross-Sectional Studies ; Treatment Outcome ; Skin/pathology ; Ultraviolet Therapy
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad304
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    Ui VI Zs.23: Show issues Location:
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