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  1. AU="Bertolucci, S."
  2. AU="de Barros, Rosires M B"
  3. AU="Carr, Crystal C"
  4. AU="Davies, Mark Lloyd"
  5. AU=St Gelais Corine
  6. AU=Engstrom Malitta
  7. AU="Hongo, Akane"
  8. AU="Krykorková, I"
  9. AU=Yan Bing
  10. AU="Nakos, Konstantinos"
  11. AU="Schreiner, Ryan"
  12. AU=Pltz T
  13. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  14. AU="Goretsky, Anton"
  15. AU="Cordoza, Makayla L"
  16. AU=Midoux Patrick AU=Midoux Patrick
  17. AU="Mundt, H M"
  18. AU=Tsivitse Susan

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  1. Artikel ; Online: Earthquake prediction: heed the signs and save lives.

    Bertolucci, Sergio / Mulargia, Francesco / Giardini, Domenico

    Nature

    2019  Band 577, Heft 7788, Seite(n) 29

    Sprache Englisch
    Erscheinungsdatum 2019-12-31
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-019-03941-2
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  2. Artikel ; Online: In vitro

    Leite, Paula Mendonça / Freitas, Aline / Amorim, Juliana / Figueiredo, Rita Carolina Duarte / Bertolucci, Suzan / Faraco, André / Martins, Maria / Carvalho, Maria G / Castilho, Rachel

    Journal of basic and clinical physiology and pharmacology

    2021  Band 33, Heft 4, Seite(n) 499–510

    Abstract: Objectives: Warfarin is the most widely used anticoagulant in the world, but it has several limitations including its narrow therapeutic range, need for dose adjustment and high potential for interactions. The simultaneous use of other drugs or even ... ...

    Abstract Objectives: Warfarin is the most widely used anticoagulant in the world, but it has several limitations including its narrow therapeutic range, need for dose adjustment and high potential for interactions. The simultaneous use of other drugs or even medicinal plants and certain foods could interfere with its therapeutic activity. In this context, this study aims to investigate the
    Methods: Ethanol extracts and essential oils were evaluated,
    Results: Thirteen of the 17 plants selected demonstrated a significant anticoagulant effect in at least one of the evaluated parameters.
    Conclusions: Thus, the results of this study could be a useful indicator for clinical practice towards the possibility of interaction between these plants and anticoagulants, although further clinical research is needed taking into consideration the limitations of
    Mesh-Begriff(e) Anticoagulants ; Cross-Sectional Studies ; Plants, Medicinal ; Prothrombin Time ; Warfarin
    Chemische Substanzen Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Sprache Englisch
    Erscheinungsdatum 2021-07-19
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2021-0079
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  3. Artikel ; Online: Inhibition of α-Glycosidase by Lippia dulcis Trevir. (Verbenaceae) Preparations, Quantification of Verbascoside, and Study of Its Molecular Docking.

    Ritter Ruas, Natalia / Carvalho Pereira, Aline / Lopes Silva Pereira, Luciana / Mesquita Germano, Carolina / Fontes Ferreira da Cunha, Elaine / Alves de Carvalho, Alexandre / Alves Lameira, Osmar / Eduardo Brasil Pereira Pinto, José / Kelly Vilela Bertolucci, Suzan

    Chemistry & biodiversity

    2023  Band 20, Heft 2, Seite(n) e202200760

    Abstract: This study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α-glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L. dulcis preparations. The substrate concentration and ... ...

    Abstract This study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α-glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L. dulcis preparations. The substrate concentration and presence of reduced glutathione were evaluated for their effect on the in vitro inhibition of the GL enzyme. Assays were also performed in the presence and absence of simulated gastric fluid. The antidiabetic fractions 2 and 3 were the most inhibited GL, but their activity were significantly decreased in the presence of gastric fluid. Chromatographic analyses confirmed the predominant presence of VEB in the samples. The samples had VEB concentrations between 49.9 and 243.5 mg/g. Simulation of the molecular docking of VEB were consistent with its GL-inhibitory activity. It can conclude that the crude ethanol extract and fractions show inhibitory activity against the GL enzyme.
    Mesh-Begriff(e) Molecular Docking Simulation ; Glycoside Hydrolase Inhibitors/chemistry ; Lippia ; Glycoside Hydrolases ; Verbenaceae ; Plant Extracts/chemistry ; Hyaluronoglucosaminidase ; Hypoglycemic Agents/chemistry ; alpha-Glucosidases/chemistry
    Chemische Substanzen Glycoside Hydrolase Inhibitors ; acteoside (3TGX09BD5B) ; Glycoside Hydrolases (EC 3.2.1.-) ; Plant Extracts ; Hyaluronoglucosaminidase (EC 3.2.1.35) ; Hypoglycemic Agents ; alpha-Glucosidases (EC 3.2.1.20)
    Sprache Englisch
    Erscheinungsdatum 2023-01-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202200760
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Konferenzbeitrag ; Online: Proceedings of the International School of Physics "Enrico Fermi"

    Bertolucci, S / Bottigli, U / Oliva, P

    course CLXXV

    (Proceedings of the International School of Physics "Enrico Fermi ; v. 175)

    2010  

    Abstract: High energy physics (HEP) has a crucial role in the context of fundamental physics. HEP experiments make use of a massive array of sophisticated detectors to analyze the particles produced in high-energy scattering events. This book contains the papers ... ...

    Titelvarianten Radiation and particle detectors, Rivelatori per radiazione e particelle
    Körperschaft International School of Physics "Enrico Fermi"
    Società italiana di fisica
    ebrary, Inc
    Veranstaltung/Kongress International School of Physics "Enrico Fermi (2009, VarennaItaly)
    Verfasserangabe edited by S. Bertolucci and U. Bottigli and P. Olivia : Varenna on Lake Como, Villa Monastero, 20-25 July 2009 : Radiation and Particle Detectors = Rendiconti della Scuola Internazionale di Fisica "Enrico Fermi" : CLXXV corso / a cura di S. Bertolucci e U. Bottigli e di P. Oliva : Varenna Sul Lago di Como, Villa Monastero, 20-25 Luglio 2009 : Rivelatori per radiazione e particelle
    Serientitel Proceedings of the International School of Physics "Enrico Fermi ; v. 175
    Abstract High energy physics (HEP) has a crucial role in the context of fundamental physics. HEP experiments make use of a massive array of sophisticated detectors to analyze the particles produced in high-energy scattering events. This book contains the papers from the workshop 'Radiation and Particle Detectors', organized by the International School of Physics, and held in Varenna in July 2009. Its subject is the use of detectors for research in fundamental physics, astro-particle physics and applied physics. Subjects covered include the measurement of: the position and length of ionization trails, t
    Schlagwörter Nuclear counters ; Particles (Nuclear physics) ; Radiation/Measurement
    Sprache Englisch
    Umfang Online-Ressource (xxiii, 171 p), ill. (some col.), port
    Verlag IOS Press
    Erscheinungsort Amsterdam
    Dokumenttyp Buch ; Konferenzbeitrag ; Online
    Anmerkung At head of title: Italian Physical Society = Soceità Italiana di Fisica ; Includes bibliographical references
    ISBN 9781607506300 ; 9788874380589 ; 1607506300 ; 8874380585
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  5. Artikel ; Online: Progesterone 5β-reductase genes of the Brassicaceae family as function-associated molecular markers.

    Munkert, J / Costa, C / Budeanu, O / Petersen, J / Bertolucci, S / Fischer, G / Müller-Uri, F / Kreis, W

    Plant biology (Stuttgart, Germany)

    2015  Band 17, Heft 6, Seite(n) 1113–1122

    Abstract: This study aimed to define progesterone 5β-reductases (P5βR, EC 1.3.99.6, enone 1,4-reductases) as function-associated molecular markers at the plant family level. Therefore cDNAs were isolated from 25 Brassicaceae species, including two species, ... ...

    Abstract This study aimed to define progesterone 5β-reductases (P5βR, EC 1.3.99.6, enone 1,4-reductases) as function-associated molecular markers at the plant family level. Therefore cDNAs were isolated from 25 Brassicaceae species, including two species, Erysimum crepidifolium and Draba aizoides, known to produce cardiac glycosides. The sequences were used in a molecular phylogeny study. The cladogram created is congruent to the existing molecular analyses. Recombinant His-tagged forms of the P5βR cDNAs from Aethionema grandiflorum, Draba aizoides, Nasturtium officinale, Raphanus sativus and Sisymbrium officinale were expressed in E. coli. Enone 1,4-reductase activity was demonstrated in vitro using progesterone and 2-cyclohexen-1-one as substrates. Evidence is provided that functional P5βRs are ubiquitous in the Brassicaceae. The recombinant P5βR enzymes showed different substrate preferences towards progesterone and 2-cyclohexen-1-one. Sequence comparison of the catalytic pocket of the P5βR enzymes and homology modelling using Digitalis lanata P5βR (PDB ID: 2V6G) as template highlighted the importance of the hydrophobicity of the binding pocket for substrate discrimination. It is concluded that P5βR genes or P5βR proteins can be used as valuable function-associated molecular markers to infer taxonomic relationship and evolutionary diversification from a metabolic/catalytic perspective.
    Mesh-Begriff(e) Amino Acid Sequence ; Brassicaceae/enzymology ; Brassicaceae/genetics ; Cyclohexanones/metabolism ; DNA, Complementary ; Digitalis ; Escherichia coli ; Gene Expression ; Genes, Plant ; Hydrophobic and Hydrophilic Interactions ; Models, Molecular ; Oxidoreductases/genetics ; Oxidoreductases/metabolism ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Progesterone/metabolism ; Progesterone Reductase/genetics ; Progesterone Reductase/metabolism ; Substrate Specificity
    Chemische Substanzen Cyclohexanones ; DNA, Complementary ; Plant Proteins ; 2-cyclohexen-1-one (445160R1U6) ; Progesterone (4G7DS2Q64Y) ; Oxidoreductases (EC 1.-) ; Progesterone Reductase (EC 1.1.1.145) ; progesterone 5 beta-reductase (EC 1.3.1.-)
    Sprache Englisch
    Erscheinungsdatum 2015-11
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464075-2
    ISSN 1438-8677 ; 1435-8603
    ISSN (online) 1438-8677
    ISSN 1435-8603
    DOI 10.1111/plb.12361
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Z 99/704: Hefte anzeigen

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  6. Artikel ; Online: Search for magnetic monopoles produced via the Schwinger mechanism.

    Acharya, B / Alexandre, J / Benes, P / Bergmann, B / Bertolucci, S / Bevan, A / Branzas, H / Burian, P / Campbell, M / Cho, Y M / de Montigny, M / De Roeck, A / Ellis, J R / Sawy, M El / Fairbairn, M / Felea, D / Frank, M / Gould, O / Hays, J /
    Hirt, A M / Ho, D L-J / Hung, P Q / Janecek, J / Kalliokoski, M / Korzenev, A / Lacarrère, D H / Leroy, C / Levi, G / Lionti, A / Maulik, A / Margiotta, A / Mauri, N / Mavromatos, N E / Mermod, P / Millward, L / Mitsou, V A / Ostrovskiy, I / Ouimet, P-P / Papavassiliou, J / Parker, B / Patrizii, L / Păvălaş, G E / Pinfold, J L / Popa, L A / Popa, V / Pozzato, M / Pospisil, S / Rajantie, A / de Austri, R Ruiz / Sahnoun, Z / Sakellariadou, M / Santra, A / Sarkar, S / Semenoff, G / Shaa, A / Sirri, G / Sliwa, K / Soluk, R / Spurio, M / Staelens, M / Suk, M / Tenti, M / Togo, V / Tuszyn'ski, J A / Upreti, A / Vento, V / Vives, O

    Nature

    2022  Band 602, Heft 7895, Seite(n) 63–67

    Abstract: Electrically charged particles can be created by the decay of strong enough electric fields, a phenomenon known as the Schwinger ... ...

    Abstract Electrically charged particles can be created by the decay of strong enough electric fields, a phenomenon known as the Schwinger mechanism
    Sprache Englisch
    Erscheinungsdatum 2022-02-02
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-021-04298-1
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  7. Artikel ; Online: VIP-2 -High-Sensitivity Tests on the Pauli Exclusion Principle for Electrons.

    Piscicchia, Kristian / Marton, Johann / Bartalucci, Sergio / Bazzi, Massimiliano / Bertolucci, Sergio / Bragadireanu, Mario / Cargnelli, Michael / Clozza, Alberto / Del Grande, Raffaele / De Paolis, Luca / Fiorini, Carlo / Guaraldo, Carlo / Iliescu, Mihail / Laubenstein, Matthias / Miliucci, Marco / Milotti, Edoardo / Napolitano, Fabrizio / Pichler, Andreas / Scordo, Alessandro /
    Shi, Hexi / Sirghi, Diana Laura / Sirghi, Florin / Sperandio, Laura / Doce, Oton Vazquez / Zmeskal, Johann / Curceanu, Catalina

    Entropy (Basel, Switzerland)

    2020  Band 22, Heft 11

    Abstract: The VIP collaboration is performing high sensitivity tests of the Pauli Exclusion Principle for electrons in the extremely low cosmic background environment of the underground Gran Sasso National Laboratory INFN (Italy). In particular, the VIP-2 Open ... ...

    Abstract The VIP collaboration is performing high sensitivity tests of the Pauli Exclusion Principle for electrons in the extremely low cosmic background environment of the underground Gran Sasso National Laboratory INFN (Italy). In particular, the VIP-2 Open Systems experiment was conceived to put strong constraints on those Pauli Exclusion Principle violation models which respect the so-called Messiah-Greenberg superselection rule. The experimental technique consists of introducing a direct current in a copper conductor, and searching for the X-rays emission coming from a forbidden atomic transition from the L shell to the K shell of copper when the K shell is already occupied by two electrons. The analysis of the first three months of collected data (in 2018) is presented. The obtained result represents the best bound on the Pauli Exclusion Principle violation probability which fulfills the Messiah-Greenberg rule.
    Sprache Englisch
    Erscheinungsdatum 2020-10-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e22111195
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Experimental search for the violation of Pauli exclusion principle: VIP-2 Collaboration.

    Shi, H / Milotti, E / Bartalucci, S / Bazzi, M / Bertolucci, S / Bragadireanu, A M / Cargnelli, M / Clozza, A / De Paolis, L / Di Matteo, S / Egger, J-P / Elnaggar, H / Guaraldo, C / Iliescu, M / Laubenstein, M / Marton, J / Miliucci, M / Pichler, A / Pietreanu, D /
    Piscicchia, K / Scordo, A / Sirghi, D L / Sirghi, F / Sperandio, L / Vazquez Doce, O / Widmann, E / Zmeskal, J / Curceanu, C

    The European physical journal. C, Particles and fields

    2018  Band 78, Heft 4, Seite(n) 319

    Abstract: The VIolation of Pauli exclusion principle -2 experiment, or VIP-2 experiment, at the Laboratori Nazionali del Gran Sasso searches for X-rays from copper atomic transitions that are prohibited by the Pauli exclusion principle. Candidate direct violation ... ...

    Abstract The VIolation of Pauli exclusion principle -2 experiment, or VIP-2 experiment, at the Laboratori Nazionali del Gran Sasso searches for X-rays from copper atomic transitions that are prohibited by the Pauli exclusion principle. Candidate direct violation events come from the transition of a 2
    Sprache Englisch
    Erscheinungsdatum 2018-04-20
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1459069-4
    ISSN 1434-6052 ; 1434-6044
    ISSN (online) 1434-6052
    ISSN 1434-6044
    DOI 10.1140/epjc/s10052-018-5802-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Konferenzbeitrag: Seasonal variation of kaurane-type diterpenes and cinnamic acid derivatives in leaves of Mikania laevigata and Mikania glomerata cultivated under different shading conditions

    Bertolucci, SK / Pinto, JB / Pereira, AD / Oliveira, AB / Braga, FC

    Planta Medica

    2011  

    Abstract: Mikania glomerata Spreng. and Mikania laevigata Sch.Bip. ex Baker are medicinal plants popularly named 'guaco', whose leaves are used to treat respiratory diseases, with coumarin (1) and kaurane-type diterpenes regarded as the bioactive constituents. ... ...

    Veranstaltung/Kongress 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Antalya, Turkey, 2011
    Abstract Mikania glomerata Spreng. and Mikania laevigata Sch.Bip. ex Baker are medicinal plants popularly named 'guaco', whose leaves are used to treat respiratory diseases, with coumarin (1) and kaurane-type diterpenes regarded as the bioactive constituents. The goal of the study was to undertake seasonal studies on the contents of chemical markers in leaves under different shading conditions. Species were cultivated under different levels of solar radiation and full sunlight. The leaves were collected in the middle of each season year.The contents of 1, o-coumaric (2), benzoylgrandifloric (3), cinnamoylgrandifloric (4) and kaurenoic (5) acids were quantified in dried leaves of both species by RP-HPLC [1].Significant differences were found in the contents of cinnamic acid derivatives (1 and 2) and kaurane-type diterpenes (3, 4 and 5) for the evaluated harvesting periods and cultivation environments. o-Coumaric acid was solely detected in M. laevigata in concentrations bellow the limit of quantification (<0,045%), in plants under 80% shading, collected in the autumn. Both 1 and 2 were not detected in the analyzed samples of M. glomerata.The average concentration of coumarin reached its maximum (0.94%) in the summer, in plants growing under 80% shading.In general, both species presented higher amounts of the kaurane-type diterpenes in plants cultivated under sunlight, except for 3 in M. glomerata. Altogether, the obtained results point out that the highest content of coumarin is reached in M. laevigata cultivated under 80% shading, preferentially harvested in the summer, but with reduced levels of kaurane-type diterpenes.On the other hand, M. glomerata shall be cultivated under full sunlight for maximum contents of the kaurane-type diterpenes.
    Acknowledgement: Acknowledgments: FAPEMIG, CAPES and CNPq, for the financial support.
    References: 1. Bertolucci SKV et al. (2009) Planta Med 75: 280–285.
    Sprache Englisch
    Erscheinungsdatum 2011-08-05
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0031-1282205
    Datenquelle Thieme Verlag

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  10. Artikel ; Konferenzbeitrag: HPLC-DAD analysis of chemical markers in leaves of Mikania laevigata and Mikania glomerata submitted to long-term storage

    Bertolucci, SK / Pinto, JB / Pereira, AD / Oliveira, AB / Braga, FC

    Planta Medica

    2011  

    Abstract: Mikania laevigata Sch. Bip. ex Baker and Mikania glomerata Spreng., known in Brazil as guaco, are medicinal species widely used to treat respiratory affections. Stability analyses of vegetal drugs are crucial to assure the quality of derived products. ... ...

    Veranstaltung/Kongress 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Antalya, Turkey, 2011
    Abstract Mikania laevigata Sch. Bip. ex Baker and Mikania glomerata Spreng., known in Brazil as guaco, are medicinal species widely used to treat respiratory affections. Stability analyses of vegetal drugs are crucial to assure the quality of derived products. The present study aimed at undertaking qualitative and quantitative analysis of cheminal markers [coumarin (CO), o-coumaric (OC), kaurenoic (KA), benzoylgrandifloric (BA) and cinnamoylgrandifloric (CA) acids] in dried leaves of M. laevigata and M. glomerata submitted to long-term storage. The plant materials were stored in a dark room with controlled temperature and humidity, and had their fingerprints analyzed three-monthly up to 18 months. Changes in chemical markers were evaluated by UV spectral purity of the peaks and by quantitative analysis of their contents (% w/w in dried leaves), employing an HPLC method previously reported by us [1]. The concentrations of the chemical markers did not vary significantly within the evaluated storage period (p>0.05) for both species. In contrast, changes in BA, CA and KA peaks were detected for three-months stored samples of both species and CO peak, found only in M. laevigata, was detected after six months of storage, suggesting compound degradation. The CO contents in M. laevigata samples ranged from 0.10±0.03% to 0.12±0.03% and therefore fulfill the Brazilian pharmacopoeical requirement established for the species (minimum of 0.1% w/w), except for the 12-month sample (0.09±0.03%) [2].Therefore, the quality control of Mikania species should be based both on the quantification of the selected compounds and fingerprint analysis.
    Acknowledgement: FAPEMIG, CAPES and CNPq, for the financial support.
    References: 1. Bertolucci SKV et al. (2009) Planta Med75:280–285. 2. Farmacopéia Brasileira IV (2005) Sexto fascículo:292.
    Sprache Englisch
    Erscheinungsdatum 2011-08-05
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0031-1282206
    Datenquelle Thieme Verlag

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