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Article ; Online: Effects of sodium intake and cardiorespiratory fitness on body composition and genetic susceptibility to obesity: results from the Quebec Family Study.

Tremblay, Angelo / Pérusse, Louis / Bertrand, Catherine / Jacob, Raphaëlle / Couture, Christian / Drapeau, Vicky

2022 Volume 129, Issue 1, Page(s) 77–86

Abstract: The main aim of this study was to evaluate the effects of Na intake and cardiorespiratory fitness (CRF) on body composition. The study was also intended to assess whether Na intake and/or CRF mediate the genetic susceptibility to obesity. Analyses were ... ...

Abstract	The main aim of this study was to evaluate the effects of Na intake and cardiorespiratory fitness (CRF) on body composition. The study was also intended to assess whether Na intake and/or CRF mediate the genetic susceptibility to obesity. Analyses were performed on a sample of 526 adult participants from the Quebec Family Study for whom a complete data set was available for nutrient and energy intake, CRF and body composition variables. The effects of Na, CRF and their interaction were analysed by comparing sex-specific tertiles using general linear mixed models. In both males and females, we observed a significant effect of Na intake and CRF on all body composition variables. However, in females only, we found that the effect of Na intake on body composition variables varies according to CRF level such that high Na intake was associated with increased body fatness, but only in females with low CRF. This interaction effect remained significant after statistical adjustment for total sugar, fat and energy intake. Using mediation analysis, we also found Na intake and CRF to be significant mediators of the relationship between a polygenic risk score of obesity based on > 500 000 genetic variants and BMI or waist circumference. In conclusion, the current study shows that Na intake influences body composition via mechanisms that interact with aerobic fitness, especially in females. Furthermore, both Na intake and CRF seem to be involved in the expression of the genetic susceptibility to obesity.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Cardiorespiratory Fitness ; Genetic Predisposition to Disease ; Quebec ; Body Mass Index ; Obesity/genetics ; Body Composition ; Sodium, Dietary ; Physical Fitness
Chemical Substances	Sodium, Dietary
Language	English
Publishing date	2022-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114522000666
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Article ; Online: SAMU and residential care homes (EHPAD) COVID cell crisis

Bertrand, Catherine / Laurent, Marie / Lecarpentier, Eric

Médecine de Catastrophe - Urgences Collectives

Abstract: The Covid-19 health crisis forced the French emergency call centers (SAMU), to quickly adapt and reorganize on a daily basis. Call centers had to come up with specific responses to all types of calls and was to be the gatekeeper of the surge in referrals ...

Abstract	The Covid-19 health crisis forced the French emergency call centers (SAMU), to quickly adapt and reorganize on a daily basis. Call centers had to come up with specific responses to all types of calls and was to be the gatekeeper of the surge in referrals of elderly patients to in-hospital emergency departments. SAMU 94 and the Health faculty of the University of Créteil, France, jointly set up an online unit dedicated to nursing homes. Feedback shows that this geriatric unit is a valuable concept and that we should not wait for a second-wave crisis to consolidate its foundations.
Keywords	covid19
Publisher	Elsevier; PMC
Document type	Article ; Online
DOI	10.1016/j.pxur.2020.07.004
Database	COVID19

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Article ; Online: Georges Boussignac (1944–2020)

Ronchi, Luc / Bertrand, Catherine / Julien, Henri

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1016/j.pxur.2020.06.003
Database	COVID19

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Article ; Online: Dietary Mediators of the Genetic Susceptibility to Obesity-Results from the Quebec Family Study.

Jacob, Raphaëlle / Bertrand, Catherine / Llewellyn, Clare / Couture, Christian / Labonté, Marie-Ève / Tremblay, Angelo / Bouchard, Claude / Drapeau, Vicky / Pérusse, Louis

The Journal of nutrition

2021 Volume 152, Issue 1, Page(s) 49–58

Abstract: Background: Recent studies showed that eating behaviors such as disinhibition, emotional and external eating, and snacking mediate genetic susceptibility to obesity. It remains unknown if diet quality and intake of specific food groups also mediate the ... ...

Abstract	Background: Recent studies showed that eating behaviors such as disinhibition, emotional and external eating, and snacking mediate genetic susceptibility to obesity. It remains unknown if diet quality and intake of specific food groups also mediate the genetic susceptibility to obesity. Objective: This study aimed to assess if diet quality and intakes of specific food groups mediate the association between a polygenic risk score (PRS) for BMI and BMI and waist circumference (WC). We hypothesized that poor diet quality, high intakes of energy-dense food groups, and low intakes of nutrient-dense food groups mediate the genetic susceptibility to obesity. Methods: This cross-sectional study included 750 participants (56.3% women, aged 41.5 ± 14.9 y, BMI 27.8 ± 7.5 kg/m2) from the Quebec Family Study. A PRSBMI based on >500,000 genetic variants was calculated using LDpred2. Dietary intakes were assessed with a 3-d food record from which a diet quality score (i.e. Nutrient Rich Food Index 6.3) and food groups were derived. Mediation analyses were conducted using a regression-based and bootstrapping approach. Results: The PRSBMI explained 25.7% and 19.8% of the variance in BMI and WC, respectively. The association between PRSBMI and BMI was partly mediated by poor diet quality (β = 0.33 ± 0.12; 95% CI: 0.13, 0.60), high intakes of fat and high-fat foods (β = 0.46 ± 0.16; 95% CI: 0.19, 0.79) and sugar-sweetened beverages (β = 0.25 ± 0.14; 95% CI: 0.05, 0.60), and low intakes of vegetables (β = 0.15 ± 0.08; 95% CI: 0.03, 0.32), fruits (β = 0.37 ± 0.12; 95% CI: 0.17, 0.64), and dairy products (β = 0.17 ± 0.09; 95% CI: 0.02, 0.37). The same trends were observed for WC. Conclusions: The genetic susceptibility to obesity was partly mediated by poor diet quality and intakes of specific food groups. These results suggest that improvement in diet quality may reduce obesity risk among individuals with high genetic susceptibility and emphasize the need to intervene on diet quality among these individuals.
MeSH term(s)	Adult ; Body Mass Index ; Cross-Sectional Studies ; Diet ; Energy Intake ; Feeding Behavior ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Obesity/genetics ; Quebec ; Snacks
Language	English
Publishing date	2021-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1093/jn/nxab356
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Article ; Online: Sécurisation des parcours des patients sous traitement anti-tumoraux oraux : recommandations pour une meilleure organisation des services et gestion des appels entrants.

Fléchon, Aude / Villeminey, Clémentine / Despiau, Frédéric / Bertrand, Catherine / Lecarpentier, Eric / Joly, Florence

Bulletin du cancer

2019 Volume 106, Issue 6, Page(s) 514–526

Abstract: The emergence of oral cancer treatment in oncology has shifted patient follow-up from the hospital to the home. This trend has resulted in an increase in phone and e-mail interactions initiated by patients, but also by pharmacists, by liberal nurses, by ... ...

Title translation	Securing patients pathways treated by oral antitumoral: Guidelines for better organization of departments and management of incoming calls.
Abstract	The emergence of oral cancer treatment in oncology has shifted patient follow-up from the hospital to the home. This trend has resulted in an increase in phone and e-mail interactions initiated by patients, but also by pharmacists, by liberal nurses, by general practitioners, and an increase in calls to the emergency response services (SAMU) both for real or perceived emergencies. This increased volume of patient and pharmacist communication has caused significant disruption in the daily activity of affected oncology departments and in particular of the secretariats. The procedures for formulating and securing appropriate responses within a short time frame are generally not established, and as a result, there is a risk that decisions made could be inappropriate for the patient's situation, especially in the case of complications.. Tracking responses to phone calls is necessary and answers should be noted in the medical file, including side effects, in particular the serious AEs for a good quality of care. This guideline describes best practices for oncologists who manage "incoming" calls from patients or professionals involved in the care pathway.
MeSH term(s)	Administration, Oral ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Continuity of Patient Care ; Electronic Mail ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/statistics & numerical data ; Home Nursing ; Hospital Communication Systems/organization & administration ; Humans ; Interdisciplinary Communication ; Neoplasms/drug therapy ; Oncology Service, Hospital/organization & administration ; Oncology Service, Hospital/statistics & numerical data ; Patient Acceptance of Health Care ; Patient Care Team ; Practice Guidelines as Topic ; Telephone
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2019-05-21
Publishing country	France
Document type	Journal Article ; Practice Guideline
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2019.03.015
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Book ; Online: Landslides as geological hotspots of CO2 emission

Nevers, Pierre / Bouchez, Julien / Gaillardet, Jérôme / Thomazo, Christophe / Charpentier, Delphine / Faure, Laëticia / Bertrand, Catherine

eISSN: 2196-632X

clues from the instrumented Séchilienne landslide, western European Alps

2021

Abstract: This study makes use of a highly instrumented active landslide observatory (9 years of data) in the French Alps, the Séchilienne slope. Here, we use a combination of major element chemistry and isotopes ratios ( 87 Sr

Abstract	This study makes use of a highly instrumented active landslide observatory (9 years of data) in the French Alps, the Séchilienne slope. Here, we use a combination of major element chemistry and isotopes ratios ( 87 Sr <math xmlns="http://www.w3.org/1998/Math/MathML" id="M4" display="inline" overflow="scroll" dspmath="mathml"><mo>/</mo></math> <svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="8pt" height="14pt" class="svg-formula" dspmath="mathimg" md5hash="57ee8123d9c9aefcf23d9c7f6463c158"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="esurf-9-487-2021-ie00001.svg" width="8pt" height="14pt" src="esurf-9-487-2021-ie00001.png"/></svg:svg> 86 Sr, δ 34 S) measured in different water types of the stable and unstable part of the Séchilienne instability to assess the contribution of the different lithologies of the slope and the chemical weathering mechanisms. Chemical and isotopic ratios are used to characterize weathering processes and the origin of waters and their flow paths through the massif. A mixing model allows us to allocate the different major elements to different sources, to identify secondary carbonate formation as a major process affecting solutes in the subsurface waters of the instability, and to quantify the involvement of sulfuric and carbonic acids as a source of protons. We show that the instability creates favorable and sustained conditions for the production of sulfuric acid by pyrite oxidation, by opening new fractures and supplying fresh reactive surfaces. We clearly identify the contribution of the dissolution of each mineral phase to the chemistry of the waters, with a clear role of remote gypsum dissolution to the sulfate budget in the sampled waters. We are also able to refine the preexisting hydrogeological views on the local water circulation and water flow paths in the instability by showing the hydrological connectivity of the different zones. Overall, our results show that the Séchilienne landslide, despite its role in accelerating rock chemical and physical weathering, acts as a geological source of CO 2 to the atmosphere. If generalizable to other large instabilities in mountain ranges, this study illustrates the complex coupling between physical and chemical erosion and their impact on the carbon cycle and global climate. The study also highlights the importance of distinguishing between sulfite oxidation and gypsum dissolution as a source of sulfate ions to rivers, particularly in mountain ranges.
Subject code	333
Language	English
Publishing date	2021-06-09
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Risques chimiques

Bertrand, Catherine

accidents, attentats

(Collection Médecine des risques,)

2006

Author's details	Catherine Bertrand, Christine Ammirati, Claude Renaudeau
Series title	Collection Médecine des risques,
MeSH term(s)	Disasters ; Noxae ; Emergency Medical Services
Language	French
Size	xviii, 186 p. :, ill.
Publisher	Elsevier
Publishing place	Paris
Document type	Book
ISBN	2842995791 ; 9782842995799
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Crise COVID-19

Botero, Alexandra / Berges, Maïté / Clervoy, Lucie / Laurent, Marie / Bertrand, Catherine / Lecarpentier, Éric

Médecine de Catastrophe - Urgences Collectives

soins médico-psychologiques et EHPAD

2020 Volume 4, Issue 3, Page(s) 213–215

Keywords	General Nursing ; Emergency Medicine ; covid19
Language	French
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1439096-6
ISSN	1279-8479
ISSN	1279-8479
DOI	10.1016/j.pxur.2020.08.001
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Crise COVID-19 : Soins médico-psychologiques et EHPAD

Botero, Alexandra / Berges, Maïté Clervoy Lucie / Laurent, Marie / Bertrand, Catherine / Lecarpentier, Eric

Médecine de Catastrophe - Urgences Collectives

Abstract: Résumé En mars 2020, le SAMU met en place une organisation spécifique pour répondre aux flux d’appels générés par la crise sanitaire Une cellule de crise COVID-19 dédiée aux EHPAD est créée afin d’apporter une aide aux EHPAD, en grande difficulté Un ... ...

Abstract	Résumé En mars 2020, le SAMU met en place une organisation spécifique pour répondre aux flux d’appels générés par la crise sanitaire Une cellule de crise COVID-19 dédiée aux EHPAD est créée afin d’apporter une aide aux EHPAD, en grande difficulté Un numéro spécifique distinct du numéro 15 est attribué H24 Pendant trois mois, la cellule d’urgence médico psychologique (CUMP) du SAMU apporte des soins d’abord par téléphone puis en se rendant dans les EHPAD, révélant l’impact de la crise sur les personnels et les résidents Summary In March 2020, the SAMU set up a specific organisation to respond to the flow of calls generated by the health crisis A COVID-19 crisis unit dedicated to the EHPADs is created in order to provide assistance to the EHPADs, which are in great difficulty A specific number distinct from the number 15 is assigned H24 For three months, the emergency medical-psychological unit (CUMP) of the SAMU provides care first by telephone and then by visiting the EHPADs, revealing the impact of the crisis on staff and residents
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #695355
Database	COVID19

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Article: Conceptual hydrogeological model of flow and transport of dissolved organic carbon in a small Jura karst system

Charlier, Jean-Baptiste / Bertrand, Catherine / Mudry, Jacques

Journal of hydrology. 2012 Aug. 16, v. 460-461

2012

Abstract: This paper aims at characterizing infiltration and solute transport processes in a karst system during flood events in order to build a conceptual model of hydrogeological functioning. The study site is the small karst system of Fertans in the French ... ...

Abstract	This paper aims at characterizing infiltration and solute transport processes in a karst system during flood events in order to build a conceptual model of hydrogeological functioning. The study site is the small karst system of Fertans in the French Jura. Soil cover, rock matrix, and a small spring were monitored to measure hydrological and hydrochemical parameters, and particularly a continuous dissolved organic carbon (DOC) signal, which is a relevant environmental tracer of fast infiltration. We used two combined approaches. First, from hydrodynamic and hydrochemical data, we identified the system structure (consistent with a dual porosity scheme) and characterized the main processes occurring during flood events. Second, on the basis of this scheme, we built a new conceptual hydrogeological model coupled with DOC transport to numerically validate the hydrological functioning. This modelling approach is based on a rainfall–discharge model to simulate spring flow. Solute transport is modelled using mixing equations, including an empirical retardation factor, as well as a first order solute decay. The model was calibrated and validated on a set of nineteen flood events, showing its performances in simulating spring hydrographs and delayed DOC signals during flood events with various rainfall intensities. We showed that the recharge area of the karst system varied largely with low and high groundwater periods, which was attributed to the state of hydraulic connectivity in the unsaturated zone. The soil cover appeared to play an important role of mixing and transfer for the recharge water. The model simulated the contributions of pre-event and event waters during flood events and allowed a better quantification of the available resource. It showed, in particular, that total discharge of some flood events during low water periods is mainly composed of pre-event water via piston flow-type processes. Finally, this study shows that the mixing model can simulate solute transport correctly, taking into account degradation and retardation processes. It highlights the need for a quantitative approach on hydrochemical studies of karst systems in order to understand them better.
Keywords	dissolved organic carbon ; equations ; floods ; groundwater ; hydrologic models ; karsts ; labeling techniques ; monitoring ; pistons ; porosity ; rain intensity ; rocks ; simulation models ; soil ; solutes ; spring
Language	English
Dates of publication	2012-0816
Size	p. 52-64.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	0022-1694
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2012.06.043
Database	NAL-Catalogue (AGRICOLA)

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