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  1. Article: Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements.

    Bertucci, Alexandre / Bertucci, François / Gonçalves, Anthony

    Cancers

    2023  Volume 15, Issue 5

    Abstract: The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most altered pathways in human cancers, and it plays a central role in cellular growth, survival, metabolism, and cellular mobility, making it a particularly interesting therapeutic target. ... ...

    Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is one of the most altered pathways in human cancers, and it plays a central role in cellular growth, survival, metabolism, and cellular mobility, making it a particularly interesting therapeutic target. Recently, pan-inhibitors and then selective p110α subunit inhibitors of PI3K were developed. Breast cancer is the most frequent cancer in women and, despite therapeutic progress in recent years, advanced breast cancers remain incurable and early breast cancers are at risk of relapse. Breast cancer is divided in three molecular subtypes, each with its own molecular biology. However, PI3K mutations are found in all breast cancer subtypes in three main "hotspots". In this review, we report the results of the most recent and main ongoing studies evaluating pan-PI3K inhibitors and selective PI3K inhibitors in each breast cancer subtype. In addition, we discuss the future of their development, the various potential mechanisms of resistance to these inhibitors and the ways to circumvent them.
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15051416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive power of tertiary lymphoid structure signature for neoadjuvant chemotherapy response and immunotherapy benefit in HER2-negative breast cancer.

    Bertucci, François / De Nonneville, Alexandre / Finetti, Pascal / Mamessier, Emilie

    Cancer communications (London, England)

    2023  Volume 43, Issue 8, Page(s) 943–946

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Neoadjuvant Therapy ; Tertiary Lymphoid Structures ; Treatment Outcome ; Receptor, ErbB-2
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: RE: HER2DX ERBB2 mRNA expression in advanced HER2-positive breast cancer treated with T-DM1.

    Bertucci, François / de Nonneville, Alexandre / Finetti, Pascal / Mamessier, Emilie

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 6, Page(s) 762–763

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Ado-Trastuzumab Emtansine ; Receptor, ErbB-2/metabolism ; RNA, Messenger/genetics ; Trastuzumab/therapeutic use ; Maytansine/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols
    Chemical Substances Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Receptor, ErbB-2 (EC 2.7.10.1) ; RNA, Messenger ; Trastuzumab (P188ANX8CK) ; Maytansine (14083FR882) ; ERBB2 protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.131: Show issues Location:
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  4. Article ; Online: The MonarchE trial: improving the clinical outcome in HR

    Bertucci, François / Finetti, Pascal / Mamessier, Emilie / De Nonneville, Alexandre

    Cancer communications (London, England)

    2023  Volume 43, Issue 8, Page(s) 938–942

    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Receptor, ErbB-2 ; Biomarkers, Tumor
    Chemical Substances Receptor, ErbB-2 (EC 2.7.10.1) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2523-3548
    ISSN (online) 2523-3548
    DOI 10.1002/cac2.12466
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  5. Article: Sacituzumab govitecan in triple-negative breast cancer.

    de Nonneville, Alexandre / Goncalves, Anthony / Mamessier, Emilie / Bertucci, François

    Annals of translational medicine

    2022  Volume 10, Issue 11, Page(s) 647

    Language English
    Publishing date 2022-06-07
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Macrophages reprogramming driven by cancer-associated fibroblasts under FOLFIRINOX treatment correlates with shorter survival in pancreatic cancer.

    Hussain, Zainab / Bertran, Thomas / Finetti, Pascal / Lohmann, Eugenie / Mamessier, Emilie / Bidaut, Ghislain / Bertucci, François / Rego, Moacyr / Tomasini, Richard

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 1

    Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) remains a clinically challenging cancer, mainly due to limited therapeutic options and the presence of a highly prominent tumor microenvironment (TME), facilitating tumor progression. The TME is ... ...

    Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) remains a clinically challenging cancer, mainly due to limited therapeutic options and the presence of a highly prominent tumor microenvironment (TME), facilitating tumor progression. The TME is predominated by heterogeneous populations of cancer-associated fibroblasts (CAFs) and tumor associated macrophages (TAMs), in constant communication with each other and with tumor cells, influencing many tumoral abilities such as therapeutic resistance. However how the crosstalk between CAFs and macrophages evolves following chemotherapeutic treatment remains poorly understood, limiting our capacity to halt therapeutic resistance.
    Methods: We combined biological characterization of macrophages indirectly cocultured with human PDAC CAFs, under FOLFIRINOX treatment, with mRNAseq analyses of such macrophages and evaluated the relevance of the specific gene expression signature in a large series of primary PDAC patients to search for correlation with overall survival (OS) after FOLFIRINOX chemotherapy.
    Results: Firstly, we demonstrated that CAFs polarize naïve and M1 macrophages towards an M2-like phenotype with a specific increase of CD200R and CD209 M2 markers. Then, we demonstrated that CAFs counteract the pro-inflammatory phenotype induced by the FOLFIRINOX on Macrophages. Indeed, we highlighted that, under FOLFIRINOX, CAFs limit the FOLFIRINOX-induced cell death of macrophages and further reinforce their M2 phenotype as well as their immunosuppressive impact through specific chemokines production. Finally, we revealed that under FOLFIRINOX CAFs drive a specific macrophage gene expression signature involving SELENOP and GOS2 that correlates with shortened OS in FOLFIRINOX-treated PDAC patients.
    Conclusion: Our study provides insight into the complex interactions between TME cells under FOLFIRINOX treatment. It suggests potential novel candidates that could be used as therapeutic targets in combination with FOLFIRINOX to prevent and alleviate TME influx on therapeutic resistance as well as biomarkers to predict FOLFIRINOX response in PDAC patients. Video Abstract.
    MeSH term(s) Humans ; Pancreatic Neoplasms/pathology ; Cancer-Associated Fibroblasts/metabolism ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Macrophages/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Tumor Microenvironment
    Chemical Substances folfirinox
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01388-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: RE: NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis.

    de Nonneville, Alexandre / Finetti, Pascal / Mamessier, Emilie / Bertucci, François

    Journal of the National Cancer Institute

    2022  Volume 114, Issue 7, Page(s) 1046–1047

    MeSH term(s) Brain Neoplasms ; Breast/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Cycle Proteins ; Female ; Humans
    Chemical Substances Cell Cycle Proteins
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djac031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: A machine learning-based algorithm to eliminate breast and axillary surgery in patients with breast cancer and pathological complete response after neoadjuvant chemotherapy.

    de Nonneville, Alexandre / Boudin, Laurys / Houvenaeghel, Gilles / Gonçalves, Anthony / Bertucci, François

    Annals of translational medicine

    2023  Volume 11, Issue 11, Page(s) 397

    Language English
    Publishing date 2023-03-06
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-23-689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Giant Paratesticular Liposarcoma: Case Report and Literature Review.

    Caviglia, Alberto / Beverini, Martina / Pacchetti, Andrea / Branger, Nicolas / Pignot, Geraldine / Bertucci, François / Walz, Jochen

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 162–166

    Abstract: Liposarcoma of the spermatic cord (LSC) is a very rare disease. In literature, are reported less than 350 cases. Genitourinary sarcomas account for <5% of all soft-tissue sarcomas and <2% of malignant urologic tumours. An inguinal mass is the clinical ... ...

    Abstract Liposarcoma of the spermatic cord (LSC) is a very rare disease. In literature, are reported less than 350 cases. Genitourinary sarcomas account for <5% of all soft-tissue sarcomas and <2% of malignant urologic tumours. An inguinal mass is the clinical presentation, which can mimic a hernia or hydrocele. Since it is such a rare disease, there are insufficient data on chemotherapy and radiotherapy, and in any case, the data come from low-level scientific evidence. Here, we report the case of a patient who came to the observation for a giant inguinal mass, in which a definitive diagnosis was obtained with the histological examination.
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000528221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficacy of Trastuzumab Deruxtecan in a Patient With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer With Acute Intracranial Hypertension Because of Brain Metastases.

    Dufour, Ondine / Bertucci, François / Boudin, Laurys / Sabatier, Renaud / Gonçalves, Anthony / de Nonneville, Alexandre

    JCO precision oncology

    2023  Volume 7, Page(s) e2200520

    MeSH term(s) Female ; Humans ; Brain Neoplasms/drug therapy ; Brain Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Trastuzumab/therapeutic use
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK) ; trastuzumab deruxtecan (5384HK7574)
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.22.00520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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