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  1. Article ; Online: A Multicenter Double-Blind, Placebo-Controlled Trial of Escitalopram in Children and Adolescents with Generalized Anxiety Disorder.

    Strawn, Jeffrey R / Moldauer, Leslie / Hahn, Rebekah D / Wise, Alexandria / Bertzos, Kristina / Eisenberg, Beth / Greenberg, Edward / Liu, Chengcheng / Gopalkrishnan, Mallika / McVoy, Molly / Knutson, James A

    Journal of child and adolescent psychopharmacology

    2023  Volume 33, Issue 3, Page(s) 91–100

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Adolescent ; Child ; Escitalopram ; Citalopram/adverse effects ; Anxiety Disorders/drug therapy ; Anxiety Disorders/diagnosis ; Double-Blind Method ; Nucleotidyltransferases/therapeutic use ; Treatment Outcome
    Chemical Substances Escitalopram (4O4S742ANY) ; Citalopram (0DHU5B8D6V) ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2023.0004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Optimizing ADAS-Cog Worksheets: A Survey of Clinical Trial Rater s' Perceptions.

    Meyer, Stephen M / Bertzos, Kristina A / Perez, Magdalena / Connor, Donald J / Schafer, Kimberly / Walter, Sarah

    Current Alzheimer research

    2017  Volume 14, Issue 9, Page(s) 1008–1016

    Abstract: Background: The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADASCog) remains the most widely used test of longitudinal cognitive functioning in Alzheimer's disease (AD) clinical trials. Unlike most neuropsychological tests, the ADAS-Cog ... ...

    Abstract Background: The Alzheimer's Disease Assessment Scale-Cognitive subscale (ADASCog) remains the most widely used test of longitudinal cognitive functioning in Alzheimer's disease (AD) clinical trials. Unlike most neuropsychological tests, the ADAS-Cog source documentation worksheets are not uniform across clinical trials, and vary by document layout, inclusion of administration and/or scoring instructions, and documentation of subtest scoring (e.g., recording correct versus incorrect scores), among other differences. Many ADAS-Cog test administrators (raters) participate in multiple AD trials and switching between different ADAS-Cog worksheets may increase the likelihood of administration and/or scoring mistakes that lessen the reliability of the instrument. An anonymous online survey sought raters' experiences with ADAS-Cog worksheets and their opinions on the design and content of the worksheets.
    Results: Results of the survey indicated preference for structure and standardization of the ADASCog worksheets, which has been considered in the development of a standard ADAS-Cog source document by the Alzheimer's Disease Cooperative Study (ADCS) Working Group.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Cognition ; Educational Status ; Humans ; Neuropsychological Tests/standards ; Reproducibility of Results ; Research Personnel/psychology ; Specialization ; Surveys and Questionnaires
    Language English
    Publishing date 2017-05-09
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2205170-3
    ISSN 1875-5828 ; 1567-2050
    ISSN (online) 1875-5828
    ISSN 1567-2050
    DOI 10.2174/1567205014666170417122744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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