Article ; Online: Radiation Sensitivity: The Rise of Predictive Patient-Derived Cancer Models.
Seminars in radiation oncology
2023 Volume 33, Issue 3, Page(s) 279–286
Abstract: Patient-derived cancer models have been used for decades to improve our understanding of cancer and test anticancer treatments. Advances in radiation delivery have made these models more attractive for studying radiation sensitizers and understanding an ... ...
| Abstract | Patient-derived cancer models have been used for decades to improve our understanding of cancer and test anticancer treatments. Advances in radiation delivery have made these models more attractive for studying radiation sensitizers and understanding an individual patient's radiation sensitivity. Advances in the use of patient-derived cancer models lead to a more clinically relevant outcome, although many questions remain regarding the optimal use of patient-derived xenografts and patient-derived spheroid cultures. The use of patient-derived cancer models as personalized predictive avatars through mouse and zebrafish models is discussed, and the advantages and disadvantages of patient-derived spheroids are reviewed. In addition, the use of large repositories of patient-derived models to develop predictive algorithms to guide treatment selection is discussed. Finally, we review methods for establishing patient-derived models and identify key factors that influence their use as both avatars and models of cancer biology. |
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| MeSH term(s) | Humans ; Mice ; Animals ; Zebrafish ; Neoplasms/radiotherapy ; Disease Models, Animal ; Radiation Tolerance | |||||
| Language | English | |||||
| Publishing date | 2023-06-19 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1146999-7 | |||||
| ISSN | 1532-9461 ; 1053-4296 | |||||
| ISSN (online) | 1532-9461 | |||||
| ISSN | 1053-4296 | |||||
| DOI | 10.1016/j.semradonc.2023.03.005 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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