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Article ; Online: Viability of Bacteriophages in the Complex Hydrogel Wound Dressings

Beschastnov, V V / Ryabkov, M G / Leontiev, A E / Tulupov, A A / Yudanova, T N / Shirokova, I Yu / Belyanina, N А / Kovalishena, O V

Sovremennye tekhnologii v meditsine

2021 Volume 13, Issue 2, Page(s) 32–38

Abstract: Using bacteriophages to overcome the increasing resistance of microorganisms to antibiotics is a novel research venue of clinical importance. Among other challenges, this technique is expected to create and maintain an adequate local concentration of ... ...

Abstract	Using bacteriophages to overcome the increasing resistance of microorganisms to antibiotics is a novel research venue of clinical importance. Among other challenges, this technique is expected to create and maintain an adequate local concentration of bacteriophages at the site of application. In addition, the possibility of combining the phage preparation with antioxidants and anesthetics may provide new options for stimulating the reparative process. Materials and methods: A technique for incorporating bacteriophages into the complex hydrogel wound dressing Results: In all samples containing bacteriophages, the presence of viable and lytically active phages was noted within 1 to 7 days, as evidenced by the "negative colonies" on the culture lawns. On days 1 to 3, no secondary growth was recorded in the phage-containing samples. In hydrogel samples containing phages, succinic acid, and lidocaine, secondary bacterial colonies were detected starting from day 4 indicating some reduction in the lytic activity. Conclusion: The results suggest that bacteriophages immobilized in the hydrogel maintain their viability and lytic activity, and this activity persists when the phages are combined with succinic acid and lidocaine.
MeSH term(s)	Bacteriophages ; Bandages ; Hydrogels ; Polyvinyl Alcohol ; Staphylococcus aureus
Chemical Substances	Hydrogels ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2021-04-30
Publishing country	Russia (Federation)
Document type	Journal Article
ISSN	2309-995X
ISSN (online)	2309-995X
DOI	10.17691/stm2021.13.2.03
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Article ; Online: Application of Phagotherapy in the Treatment of Burn Patients (Review).

Leontyev, А E / Pavlenko, I V / Kovalishena, О V / Saperkin, N V / Tulupov, А А / Beschastnov, V V

Sovremennye tekhnologii v meditsine

2020 Volume 12, Issue 3, Page(s) 95–103

Abstract: Treatment of patients with a burn injury is a complex process involving multicomponent multidirectional intensive therapy of the majority of organs and systems damaged by thermal effects on the skin, alternating with repeated surgical interventions aimed ...

Abstract	Treatment of patients with a burn injury is a complex process involving multicomponent multidirectional intensive therapy of the majority of organs and systems damaged by thermal effects on the skin, alternating with repeated surgical interventions aimed at removing nonviable tissues with subsequent plastic closure of wound defects. After the recovery from the burn shock, local infectious complications are considered to be the leading problem that decelerates the process of recovery and is the main cause of lethal outcomes. Since the skin integrity is broken, microorganisms penetrate readily into the internal environment of the human organism resulting in a septic state with multiple organ failure. A widespread and often uncontrollable use of antibacterial drugs in medical practice has led to the emergence of multiple drug resistance (MDR) in microorganisms. Introduction of drugs made on the basis of bacteriophages into practice is presently becoming increasingly important. This is confirmed by the growing interest in this field of pharmacology, the development of special programs aimed at studying the processes of phage and bacterial cell interaction. This review presents the main types of bacteria pertaining to MDR pathogens, principles of their classification, and the risk factors for infecting patients. The mechanisms of the selective action of phage particles on a bacterial cell and the possibility of using phage therapy in the treatment of burn injury (experimental and clinical data) based on the analysis of foreign literature are demonstrated as well as new positive properties of phages related to the changes in the macroorganism immune status caused by the interaction with bacteriophage particles.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria ; Bacteriophages ; Burns/therapy ; Humans ; Phage Therapy/methods
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-06-28
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ISSN	2309-995X
ISSN (online)	2309-995X
DOI	10.17691/stm2020.12.3.12
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Article ; Online: A Case of the Severe Gunshot Penetrating Multiple Wound of the Abdomen Complicated by a Local and Generalized Infectious Process

Beschastnov V.V. / Maramokhin V.N.

Sovremennye Tehnologii v Medicine, Vol 3, Iss 1, Pp 146-

2011 Volume 148

Abstract: A case of the abdomen gunshot penetrating multiple wound with the injury of the hollow and parenchymal (liver) organ complicated by a local and generalized infectious process is presented. ...

Abstract	A case of the abdomen gunshot penetrating multiple wound with the injury of the hollow and parenchymal (liver) organ complicated by a local and generalized infectious process is presented.
Keywords	gunshot wound ; dermotension ; wound of the liver. ; Medicine (General) ; R5-920 ; Medicine ; R
Language	Russian
Publishing date	2011-03-01T00:00:00Z
Publisher	Nizhny Novgorod State Medical Academy of the Ministry of Health and Social Development
Document type	Article ; Online
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Article ; Online: Results of the Purulent Wound Treatment Microbiological Monitoring in Conditions of Generally Surgical Hospital

Beschastnov V.V. / Pevnev A.A. / Malakhova N.I. / Moskovskaya N.I.

Sovremennye Tehnologii v Medicine, Vol 1, Iss 2, Pp 53-

2015 Volume 56

Abstract: Aim of investigation is a study of the wound infection agent quantitative and qualitative composition alterations in a process of the patient with the soft tissue purulent wound treatment by different methods in conditions of a generally surgical ... ...

Abstract	Aim of investigation is a study of the wound infection agent quantitative and qualitative composition alterations in a process of the patient with the soft tissue purulent wound treatment by different methods in conditions of a generally surgical hospital. Materials and Methods. 166 results of the initial and 286 dynamic bacteriological investigations in patients with purulent wounds at a local treatment by the open and closed methods are analyzed. Results. It is revealed, that a secondary infection of wound with a hospital flora, resistant to antibacterial therapy, is at the open method treatment at the 10—15 days in 37% of cases. The enterobacteria were the main part of the soft tissue purulent wound nosocomial infections in a general surgery department, which must be considered at the antimicrobic therapy tactics detection.
Keywords	purulent wound ; microbiology ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	616
Language	Russian
Publishing date	2015-09-01T00:00:00Z
Document type	Article ; Online
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Article: Vyzhivaemost' pri vypolnenii pervichnykh i vtorichnykh amputatsiĭ u bol'nykh s kriticheskoĭ ishemieĭ nizhnikh konechnosteĭ.

Kudykin, M N / Deriabin, R A / Vasiagin, A N / Beschastnov, V V / Riabkov, M G / Sheĭko, G E / Maklakhov, I V

Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery

2017 Volume 23, Issue 2, Page(s) 126–129

Abstract: The authors analysed therapeutic outcomes in a total of 171 patients presenting with critical lower limb ischaemia and subjected to amputation at various levels. In so doing, eighty-eight (Group One) patients sustained primary amputation and the ... ...

Title translation	Survival of patients with primary and secondary amputations for critical lower limb ischaemia.
Abstract	The authors analysed therapeutic outcomes in a total of 171 patients presenting with critical lower limb ischaemia and subjected to amputation at various levels. In so doing, eighty-eight (Group One) patients sustained primary amputation and the remaining eighty-three (Group Two) patients endured secondary amputation after an initially undertaken attempt at revascularization. It was determined that performing primary amputation statistically significantly shortened the lifespan in the postoperative period as compared with secondary amputation performed. There was no clear-cut interrelationship between the presence of accompanying pathology and the lifespan in the post-amputation period. 18 months after discharge from hospital the mortality rate in Group One patients amounted to 52% and in Group Two patients to 29% (p<0.05).
Language	Russian
Publishing date	2017
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	2186202-3
ISSN	1027-6661
ISSN	1027-6661
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Zs.A 6111: Show issues

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Article: Znachenie opticheskoĭ kogerentnoĭ tomografii i morfometrii dlia otsenki sostoianiia parapankreaticheskoĭ zhirovoĭ kletchatki pri infitsirovannom pankreonekroze.

Ryabkov, M G / Mokeev, O A / Kiseleva, E B / Shabanov, D V / Gelikonov, V M / Gelikonov, G V / Spiridonov, A A / Bederina, E L / Gladkova, N D / Beschastnov, V V

Arkhiv patologii

2018 Volume 80, Issue 3, Page(s) 46–52

Abstract: Objective: To investigate the morphometric and optical coherence tomography (OCT) characteristics of the microstructure of retroperitoneal peripancreatic adipose tissue during passive drainage and active perfusion-aspiration drainage for infected ... ...

Title translation	The value of optical coherence tomography and morphometry in evaluating the peripancreatic adipose tissue in infected pancreatic necrosis.
Abstract	Objective: To investigate the morphometric and optical coherence tomography (OCT) characteristics of the microstructure of retroperitoneal peripancreatic adipose tissue during passive drainage and active perfusion-aspiration drainage for infected pancreatic necrosis. Material and methods: The authors analyzed 74 samples of peripancreatic adipose tissue obtained from 37 patients with passive (Group 1) and active perfusion-aspiration drainage (Group 2) of a focus of peripancreatitis. The tissues were examined with OCT, then fixed in a formalin solution and underwent histological examination, including morphometric one. Results: The examined groups showed qualitative and quantitative differences in the tissue microstructure. In Group 1 samples, the proportion (median (upper quartile; lower quartile)) of interlobular connective tissue was 5.6 (3.9; 6.1)%; and that of adipocytes was 44.6 (41.2; 51.6)%. Necrotic tissue occupied 46.2 (35.6; 56.1)% of the area of specimens. The OCT images of necrotic tissue displayed a preponderance of unstructured regions with a high signal level while the parenchymal areas showed a cellular structured pattern. In Group 2 samples, the proportion of interlobular connective tissue was 16.2 (11.4; 19.7)%, and that of adipocytes was 68.5 (59.7; 71.2)%. At the same time, Group 2 exhibited necrosis - 14.4 (11.5; 19.2%) that was 3.2 times less than in Group 1. The OCT images of Group 2 samples showed a preponderance of cellular structured regions characteristic of the parenchyma, with pronounced stromal elements, which corresponded to the histological pattern. Conclusion: Active perfusion-aspiration drainage of peripancreatic adipose tissue versus passive drainage is associated with a smaller proportion of necrotic tissue (14.4% versus 46.2%; p≤0.05) and a larger proportion of a stromal vascular component (16.2% vs. 5.6%; p≤0.05). OCT could qualitatively distinguish viable fat tissue parenchyma from necrotic areas, without specially preparing the samples, which was confirmed by histomorphometric results.
MeSH term(s)	Adipose Tissue/diagnostic imaging ; Adipose Tissue/pathology ; Drainage ; Humans ; Necrosis/diagnostic imaging ; Pancreatic Neoplasms/diagnostic imaging ; Tomography, Optical Coherence
Language	Russian
Publishing date	2018-06-21
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol201880346-52
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Zs.A 82: Show issues

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Article: Primenenie adaptatsionno-repozitsionnykh apparatov dlia zakrytiia granuliruiushchikh ran miagkikh tkaneĭ.

Izmaĭlov, S G / Beschastnov, V V

Vestnik khirurgii imeni I. I. Grekova

2000 Volume 159, Issue 2, Page(s) 66–70

Abstract: The authors propose a new method of closing granulating wounds by attaching its edges with the help of an adaptation-reposition apparatus. This method was used in treatment of 53 patients with granulating wounds of different localization. Good results ... ...

Title translation	The use of adaptive-repositioning apparatus for the closing of granulating soft-tissue wounds.
Abstract	The authors propose a new method of closing granulating wounds by attaching its edges with the help of an adaptation-reposition apparatus. This method was used in treatment of 53 patients with granulating wounds of different localization. Good results were noted in 88.7% and satisfactory ones in 11.3%. The method was shown to be highly efficient as compared with the control group.
MeSH term(s)	Caprolactam ; Equipment Design ; Evaluation Studies as Topic ; Granulation Tissue/surgery ; Humans ; Soft Tissue Injuries/surgery ; Suture Techniques/instrumentation ; Sutures
Chemical Substances	Caprolactam (6879X594Z8) ; capron (9012-24-2)
Language	Russian
Publishing date	2000
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	603433-0
ISSN	0042-4625
ISSN	0042-4625
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Zs.B 747: Show issues

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Article ; Online: Antioxidant Activity of Pyrimidine Derivatives in Local Treatment of Septic Wounds of Soft Tissues (in an Experiment)

Beschastnov V.V. / Izmailov S.G. / Botyakov А.А. / Zharinov A.Y. / Panteleev D.A. / Melnikova N.B.

Sovremennye Tehnologii v Medicine, Vol 3, Iss 3, Pp 21-

2011 Volume 26

Abstract: The aim of the study is to assess antioxidant activity of Xymedon in ointments in reparative process of septic wounds of soft tissues in the experiment on dogs. Materials and Methods. To treat septic wounds, in I phase of wound process in the control ... ...

Abstract	The aim of the study is to assess antioxidant activity of Xymedon in ointments in reparative process of septic wounds of soft tissues in the experiment on dogs. Materials and Methods. To treat septic wounds, in I phase of wound process in the control group of animals Laevomecolum ointment was used, in the main group — Levoxycol, containing Laevomycetin — 0.75 g, Xymedon — 4 g, polyethylene oxides with molecular weight 1500 (ПЭО-1500) — 19.05 g, ПЭО-400 — 76.2 g. The effectiveness of treatment was assessed based on subjective (visual test of wound condition) and objective (microbiological, cytological investigations, biochemical test, planimetry) criteria. To assess oxidative process in paravulnar tissues, there were determined the activity of the enzymes of catalase and superoxide dismutase, lipid peroxidation activity (diene, triene conjugates and the number of olefinic links). Results. Oxidation-reduction processes in paravulnar tissues were characterized by maximum values of lipid peroxidation before the treatment, at the height of inflammation. In the course of treatment there was tendency for gradual results normalization and the return to their initial level, however, in the main group treated by Levoxycol the tendency was more expressed. Improved repair characteristics of ointments based on Xymedon can be explained mainly by the increase of antioxidant activity of superoxide dismutase and catalase that can be due to Xymedon as an activator of enzymes and endogenic antioxidant resulting from the process of it biotransformation.
Keywords	septic wound ; Xymedon ; enzymes ; antioxidant protection ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	630
Language	Russian
Publishing date	2011-09-01T00:00:00Z
Publisher	Nizhny Novgorod State Medical Academy of the Ministry of Health and Social Development
Document type	Article ; Online
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Article: Primenenie ranoadaptera dlia lecheniia gnoĭnykh ran.

Izmaĭlov, S G / Beschastnov, V V / Lediaev, D S

Khirurgiia

2004 , Issue 4, Page(s) 24–26

Abstract: The method of closure of soft tissues purulent wounds with wound-adapter of original construction has been developed and used in clinical practice. This method provides complete reposition and adaptation of wound margins without suture eruption. Good ... ...

Title translation	Wound-adapter in the treatment of purulent wounds.
Abstract	The method of closure of soft tissues purulent wounds with wound-adapter of original construction has been developed and used in clinical practice. This method provides complete reposition and adaptation of wound margins without suture eruption. Good results (primary closure) were achieved in 85.8% cases in the study group, and in 49.7% cases in the control group, satisfactory results (secondary closure partly) - in 14.2 and 50.3% cases, respectively. Hospital stay was reduced from 27.6 +/- 1.5 to 22.4 +/- 0.7 bed-days (p < 0,05).
MeSH term(s)	Equipment Design ; Female ; Humans ; Male ; Soft Tissue Infections/pathology ; Soft Tissue Infections/surgery ; Suppuration ; Suture Techniques/instrumentation ; Treatment Outcome ; Wounds and Injuries/pathology ; Wounds and Injuries/surgery
Language	Russian
Publishing date	2004
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
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Zs.B 740: Show issues

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Article: [Hardware controlled laparostomy in staged treatment of peritonitis with abdominal compression syndrome].

Izmaĭlov, S G / Riabkov, M G / Shchukin, A Iu / Beschastnov, V V / Martynov, V L

Khirurgiia

2008 , Issue 11, Page(s) 47–52

Abstract: Clinical results of treatment were analyzed in 97 with patients generalized peritonitis. Application of staging hardware controlled laparostomy (HCL) allowed to halve the frequency of wound complication in comparison with semienclosed treatment mode. ... ...

Abstract	Clinical results of treatment were analyzed in 97 with patients generalized peritonitis. Application of staging hardware controlled laparostomy (HCL) allowed to halve the frequency of wound complication in comparison with semienclosed treatment mode. High clinical efficacy of control and correction of biophysical parameters of abdominal cavity was revealed: lethality from generalized peritonitis decreases in 2.4 times (from 39.3% to 14.3%) as a result of HCL application with monitoring and correction of intra-abdominal pressure in comparison with uncontrolled traditional treatment modes. Construction of the apparatus used for controlled laparostomy allows to open and close abdominal cavity under control of intra-abdominal pressure and tighting force of paravulnar tissues.
MeSH term(s)	Abdomen ; Adolescent ; Adult ; Aged ; Animals ; Compartment Syndromes/complications ; Compartment Syndromes/surgery ; Decompression, Surgical/instrumentation ; Disease Models, Animal ; Dogs ; Equipment Design ; Female ; Follow-Up Studies ; Humans ; Laparotomy/instrumentation ; Male ; Middle Aged ; Peritonitis/complications ; Peritonitis/surgery ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	Russian
Publishing date	2008
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	419230-8
ISSN	2309-5628 ; 0023-1207
ISSN (online)	2309-5628
ISSN	0023-1207
Database	MEDical Literature Analysis and Retrieval System OnLINE

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