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Article ; Online: The impact of sleeve gastrectomy on polycystic ovarian syndrome: a single-center 1-year cohort study.

Alamdari, Nasser Malekpour / Sadegh, Gholam Hossein Monavar / Farsi, Yeganeh / Besharat, Sara / Hajimirzaie, Seyed Hossein / Abbasi, Maryam

Irish journal of medical science

2023 Volume 193, Issue 2, Page(s) 721–724

Abstract: Background and aim: Obesity is one of the risk factors for polycystic ovarian syndrome (PCOS), and weight loss is the mainstay of treatment. This study investigates the effects of sleeve gastrectomy on clinical and paraclinical signs and symptoms of ... ...

Abstract	Background and aim: Obesity is one of the risk factors for polycystic ovarian syndrome (PCOS), and weight loss is the mainstay of treatment. This study investigates the effects of sleeve gastrectomy on clinical and paraclinical signs and symptoms of PCOS patients referred to a tertiary hospital. Methods: Female patients with a definite diagnosis of PCOS and body mass index (BMI) > 40 kg/m Results: Fifty patients enrolled in the study. The mean age of patients was 31.69 ± 9.54 years. The mean BMI before and after the surgery was 44.28 ± 3.03 and 29.37 ± 2.41 kg/m Conclusion: Weight loss and improvements in hyperandrogenism following sleeve gastrectomy result in clinical and paraclinical improvement of PCOS signs and symptoms, including oligomenorrhea and ovulation induction.
MeSH term(s)	Female ; Humans ; Young Adult ; Adult ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/surgery ; Cohort Studies ; Oligomenorrhea ; Luteinizing Hormone/therapeutic use ; Follicle Stimulating Hormone/therapeutic use ; Gastrectomy ; Weight Loss
Chemical Substances	Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2023-08-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-023-03488-2
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Article ; Online: Evaluation of the efficacy of platelet-rich plasma on healing of clean diabetic foot ulcers: A randomized clinical trial in Tehran, Iran.

Malekpour Alamdari, Nasser / Shafiee, Alireza / Mirmohseni, Atefeh / Besharat, Sara

Diabetes & metabolic syndrome

2021 Volume 15, Issue 2, Page(s) 621–626

Abstract: Background and aims: Diabetic foot ulcers (DFUs) are among challenging hurdles both for the patient and the physician. There is a recent trend toward finding novel and clinically efficient modalities to treat this potentially hazardous complication of ... ...

Abstract	Background and aims: Diabetic foot ulcers (DFUs) are among challenging hurdles both for the patient and the physician. There is a recent trend toward finding novel and clinically efficient modalities to treat this potentially hazardous complication of diabetes mellitus in a timely manner. Herein, we aim to appraise the efficacy of platelet-rich plasma (PRP) in healing of clean DFUs. Methods: 90 patients with clean DFUs consisting of 56 (62.2%) males and 34 (37.8%) females with mean age (±standard deviation) of 56.52 (±7.14) years were enrolled in this study between June 2017 and December 2018. They were randomly allocated into control group (47 patients who received conventional dressing along with silver sulfadiazine ointment twice daily), and case group (43 patients who received PRP gel twice weekly for 3 weeks). All the patients were followed up for 6 months. Results: Our study showed that PRP significantly increased the healing rate of DFUs regardless of the age (p-value: 0.0), gender (p-value: 0.0), or smoking (p-value: 0.0) and blood pressure (p-value: 0.0) status of patients, but it did not have a significant impact on the need for amputation (p-value: 0.11), level of amputation (p-value: 0.16), or the need for further treatments such as graft or angioplasty (p-value: 0.52). Conclusion: Regardless of the age, gender, or smoking and blood pressure status of patients, PRP can be efficiently used in diabetic patients to accelerate the healing rate of foot ulcers.
MeSH term(s)	Aged ; Bandages ; Blood Glucose/metabolism ; Diabetic Foot/blood ; Diabetic Foot/epidemiology ; Diabetic Foot/therapy ; Female ; Follow-Up Studies ; Humans ; Iran/epidemiology ; Male ; Middle Aged ; Platelet-Rich Plasma ; Silver Sulfadiazine/administration & dosage ; Treatment Outcome ; Wound Healing/physiology
Chemical Substances	Blood Glucose ; Silver Sulfadiazine (W46JY43EJR)
Language	English
Publishing date	2021-03-10
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2021.03.005
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Article ; Online: Risk Factors of Recurrent Anal Abscess in Patients with Type 2 Diabetes Mellitus; a 4-Year Retrospective study.

Malekpour Alamdari, Nasser / Afaghi, Siamak / Esmaeili Tarki, Farzad / Fathi, Mohammad / Besharat, Sara / Rahimi, Fatemehsadat

Archives of academic emergency medicine

2022 Volume 10, Issue 1, Page(s) e69

Abstract: Introduction: Anal abscess is considered as a relatively common compilation in type 2 diabetes mellitus (T2DM) patients. This study aimed to determine the risk factors of recurrent anal abscess in T2DM patients.: Methods: In this 4-year retrospective ...

Abstract	Introduction: Anal abscess is considered as a relatively common compilation in type 2 diabetes mellitus (T2DM) patients. This study aimed to determine the risk factors of recurrent anal abscess in T2DM patients. Methods: In this 4-year retrospective cross-sectional study, T2DM patients hospitalized due to anal abscess in Shahid Modarres Hospital, Tehran, Iran from December 2016 to December 2020 were studied. The independent risk factors of disease recurrence were determined among demographic factors, underlying diseases, diabetes-related factors, clinical factors, laboratory parameters, abscess type, and culture using multivariate stepwise logistic regression analysis. Results: 203 patients were enrolled in the study. 58 (28.6%) patients had at least one re-occurrence of anal abscess during four years. The recurrent episodes had occurred more frequently in the first year after the initial treatment (55.2%). The prevalence of comorbidities such as metabolic syndrome, coronary artery disease, chronic kidney disease, end stage renal disease, and peripheral vascular disease was significantly higher amongst patients with abscess recurrence. The patients with recurrent anal abscess had statically significant poor glycemic control (HbA1C > 7.5), decreased levels of Estimated Glomerular Filtration Rate (e-GFR), and higher C-reactive Protein (CRP) upon the first admission. Presence of metabolic syndrome, HbA1c > 7.5%, WBC > 11.0 ×10 Conclusion: Th recurrence rate of anal abscess in this series was 28.6 %. It seems that in T2DM patients with uncontrolled diabetes who have metabolic syndrome and increased CRP and WBC in their routine tests, the probability of anal abscess reoccurrence is high.
Language	English
Publishing date	2022-08-24
Publishing country	Iran
Document type	Journal Article
ISSN	2645-4904
ISSN (online)	2645-4904
DOI	10.22037/aaem.v10i1.1692
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Article ; Online: COVID 19 in a traumatic thoracic aortic injury patient

Besharat, Sara / Malekpour Alamdari, Nasser

Journal of Cellular & Molecular Anesthesia; Vol. 5 No.; 2476-5120 ; 2538-2462

2020 Volume 3, Issue : July 2020

Abstract: The number of traumatic thoracic aortic injuries being treated by endovascular procedures is on the rise. Coronavirus (COVID-19) has affected healthcare systems worldwide and was declared a global pandemic by the world health organization (WHO) in March ... ...

Abstract	The number of traumatic thoracic aortic injuries being treated by endovascular procedures is on the rise. Coronavirus (COVID-19) has affected healthcare systems worldwide and was declared a global pandemic by the world health organization (WHO) in March 2020. In this study, we discuss a 37-year-old man with thoracic aorta trauma caused by a motor–vehicle accident that underwent Thoracic endovascular aortic repair (TEVAR) and was incidentally diagnosed with concurrent COVID-19. During this pandemic period, physicians should be on the lookout for COVID-19 with low thresholds for testing, as a timely diagnosis will improve patient outcomes and reduce the risk of transmission. A delay in diagnosis puts the patients at risk of not receiving effective treatment and may result in the transmission of infection to hospital staff, environment (i.e. operating rooms and equipment), and other members of the community.
Keywords	COVID-19 ; TEVAR ; covid19
Language	English
Publishing date	2020-05-15
Publisher	Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences
Publishing country	ir
Document type	Article ; Online
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Article: Chronic constipation and acute small bowel obstruction due to small bowel encapsulation: A case report.

Hajimirzaei, Seyed Hossein / Abbasi, Maryam / Alamdari, Nasser Malekpour / Besharat, Sara / Farsi, Yeganeh / Gharib, Atoosa / Seyyedi, Mahdiyeh Sadat

Clinical case reports

2023 Volume 11, Issue 12, Page(s) e8144

Abstract: Key clinical message: Peritoneal encapsulation is most of the time asymptomatic and is found incidentally, but when symptomatic it usually presents with bowel obstruction. CT scan is a gold standard for the diagnosis of bowel encapsulation.: Abstract!# ...

Abstract	Key clinical message: Peritoneal encapsulation is most of the time asymptomatic and is found incidentally, but when symptomatic it usually presents with bowel obstruction. CT scan is a gold standard for the diagnosis of bowel encapsulation. Abstract: Congenital peritoneal encapsulation (CPE), abdominal cocoon syndrome (ACS), and sclerosing encapsulating peritonitis (SEP) are syndromes in which the small bowel is encapsulated. Small bowel encapsulation is usually asymptomatic and rarely presents with small bowel obstruction. In this article, we report a 65-year-old man who presented to our hospital with signs and symptoms of small bowel obstruction. He underwent an urgent operation, and small bowel encapsulation was diagnosed. One year after the surgery, all symptoms improved.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8144
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Article: Language Abnormalities in Alzheimer's Disease Arise from Reduced Informativeness: A Cross-Linguistic Study in English and Persian.

Bayat, Sabereh / Santai, Mahya / Panahi, Mehrdad Mohammad / Khodadadi, Amirhossein / Ghassimi, Mahdieh / Rezaei, Sahar / Besharat, Sara / Mahboubi, Zahra / Almasi, Mostafa / Sanei Taheri, Morteza / Dickerson, Bradford C / Rezaii, Neguine

medRxiv : the preprint server for health sciences

2024

Abstract: Introduction: This research investigates the psycholinguistic origins of language impairments in Alzheimer's Disease (AD), questioning if these impairments result from language-specific structural disruptions or from a universal deficit in generating ... ...

Abstract	Introduction: This research investigates the psycholinguistic origins of language impairments in Alzheimer's Disease (AD), questioning if these impairments result from language-specific structural disruptions or from a universal deficit in generating meaningful content. Methods: Cross-linguistic analysis was conducted on language samples from 184 English and 52 Persian speakers, comprising both AD patients and healthy controls, to extract various language features. Furthermore, we introduced a machine learning-based metric, Language Informativeness Index (LII), to quantify informativeness. Results: Indicators of AD in English were found to be highly predictive of AD in Persian, with a 92.3% classification accuracy. Additionally, we found robust correlations between the typical linguistic abnormalities of AD and language emptiness (low LII) across both languages. Discussion: Findings suggest AD linguistics impairments are attributed to a core universal difficulty in generating informative messages. Our approach underscores the importance of incorporating biocultural diversity into research, fostering the development of inclusive diagnostic tools.
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.19.24304407
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Article: Impaired language in Alzheimer's disease: A comparison between English and Persian implicates content-word frequency rather than the noun-verb distinction.

Sanati, Mahya / Bayat, Sabereh / Panahi, Mehrdad Mohammad / Khodadadi, Amirhossein / Rezaee, Sahar / Ghasimi, Mahdieh / Besharat, Sara / Fooladi, Zahra Mahboubi / Dooghaee, Mostafa Almasi / Taheri, Morteza Sanei / Dickerson, Bradford C / Goldberg, Adele / Rezaii, Neguine

medRxiv : the preprint server for health sciences

2024

Abstract: This study challenges the conventional psycholinguistic view that the distinction between nouns and verbs is pivotal in understanding language impairments in neurological disorders. Traditional views link frontal brain region damage with verb processing ... ...

Abstract	This study challenges the conventional psycholinguistic view that the distinction between nouns and verbs is pivotal in understanding language impairments in neurological disorders. Traditional views link frontal brain region damage with verb processing deficits and posterior temporoparietal damage with noun difficulties. However, this perspective is contested by findings from patients with Alzheimer's disease (pwAD), who show impairments in both word classes despite their typical temporoparietal atrophy. Notably, pwAD tend to use semantically lighter verbs in their speech than healthy individuals. By examining English-speaking pwAD and comparing them with Persian-speaking pwAD, this research aims to demonstrate that language impairments in Alzheimer's disease (AD) stem from the distributional properties of words within a language rather than distinct neural processing networks for nouns and verbs. We propose that the primary deficit in AD language production is an overreliance on high-frequency words. English has a set of particularly high-frequency verbs that surpass most nouns in usage frequency. Since pwAD tend to use high-frequency words, the byproduct of this word distribution in the English language would be an over-usage of high-frequency verbs. In contrast, Persian features complex verbs with an overall distribution lacking extremely high-frequency verbs like those found in English. As a result, we hypothesize that Persian-speaking pwAD would not have a bias toward the overuse of high-frequency verbs. We analyzed language samples from 95 English-speaking pwAD and 91 healthy controls, along with 27 Persian-speaking pwAD and 27 healthy controls. Employing uniform automated natural language processing methods, we measured the usage rates of nouns, verbs, and word frequencies across both cohorts. Our findings showed that English-speaking pwAD use higher-frequency verbs than healthy individuals, a pattern not mirrored by Persian-speaking pwAD. Crucially, we found a significant interaction between the frequencies of verbs used by English and Persian speakers with and without AD. Moreover, regression models that treated noun and verb frequencies as separate predictors did not outperform models that considered overall word frequency alone in classifying AD. In conclusion, this study suggests that language abnormalities among English-speaking pwAD reflect the unique distributional properties of words in English rather than a universal noun-verb class distinction. Beyond offering a new understanding of language abnormalities in AD, the study highlights the critical need for further investigation across diverse languages to deepen our insight into the mechanisms of language impairments in neurological disorders.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.09.24305534
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Article ; Online: The Historical Epidemiology of Human Monkeypox: A Review of Evidence from the 1970 Emergence to the 2022 Outbreak.

Rahimi, Fatemeh Sadat / Afaghi, Siamak / Tarki, Farzad Esmaeili / Moeinabadi-Bidgoli, Kasra / Golmohammadi, Maryam / Alamdari, Nasser Malekpour / Besharat, Sara

The Tohoku journal of experimental medicine

2022 Volume 258, Issue 4, Page(s) 243–255

Abstract: Human Monkeypox (HMPX) outbreak in the year 2022 occurs in many countries outside of the African regions, a common location of such outbreaks, with a considerable rate of human-to-human transmission, which was an uncommon route of infection before. The ... ...

Abstract	Human Monkeypox (HMPX) outbreak in the year 2022 occurs in many countries outside of the African regions, a common location of such outbreaks, with a considerable rate of human-to-human transmission, which was an uncommon route of infection before. The epidemiological reports also represent a sharping pace of infection spreading between communities rather than in previous outbreaks as the following pace of afflictions is unpredictable. Also, the cautions regarding the sexually transmitted infection of the such virus have been raised in this outbreak. Further, the main reservoirs of the recent outbreaks are yet to be revealed. As a consequence, the World Health Organization (WHO) has declared the 2022 HMPX outbreak as an "Atypical" phenomenon compared to its previous characteristics. To better recognize the properties of this outbreak, herein we systematically described and compared the historical evidence of monkeypox virus outbreaks in the aspects of epidemiological, clinical, and molecular evolutions since its emergence, as well as an explanation of the previous investigations and considerations of WHO and other international health societies over time. The history of human and monkeypox virus interaction during the past 64 years provides viewpoints on preventing strategies and assessing the present and potential future hazards of health implications.
MeSH term(s)	Humans ; Mpox (monkeypox)/epidemiology ; Monkeypox virus ; Disease Outbreaks
Language	English
Publishing date	2022-10-06
Publishing country	Japan
Document type	Review ; Journal Article
ZDB-ID	123477-8
ISSN	1349-3329 ; 0040-8727
ISSN (online)	1349-3329
ISSN	0040-8727
DOI	10.1620/tjem.2022.J081
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Article: N-acetylcysteine as adjuvant therapy for hospitalized Covid-19 patients: A single-center prospective cohort study.

Afaghi, Siamak / Moghimi, Negin / Malekpour Alamdari, Nasser / Rahimi, Fatemeh Sadat / Irilouzadian, Rana / Esmaeili Tarki, Farzad / Moghimi, Morvarid / Besharat, Sara / Salehi Omran, Hossein / Karimi, Anita

Caspian journal of internal medicine

2023 Volume 14, Issue 3, Page(s) 543–552

Abstract: Background: Whilst over two years have passed since the COVID-19 pandemic's emergence, the proper management of the disease remains challenging. N-acetylcysteine (NAC) as a potentially effective therapeutic option has been suggested by studies, while ... ...

Abstract	Background: Whilst over two years have passed since the COVID-19 pandemic's emergence, the proper management of the disease remains challenging. N-acetylcysteine (NAC) as a potentially effective therapeutic option has been suggested by studies, while the exact clinical role of this agent is yet to be evaluated. Methods: This prospective case-control study was conducted in a major referral respiratory center in Tehran, Iran. We enrolled 217 patients treated with an intravenous daily dose of 1500 mg NAC as a case group; and 245 control patients who did not receive NAC. Two groups were matched based on other treatments, socio-demographics, medical history, and comorbidities. Results: After ten days of adjuvant therapy with NAC, patients in the NAC group and control group had median room-air SpO2 of 91% and 88%, respectively (P=0.02). Also, the SpO2 to FiO2 ratio had a median of 463 and 421 in the case and control groups, respectively (P=0.01). Furthermore, the case group's hospitalization period was three days shorter (P=0.002). Further, cough, dyspnea, and decreased appetite were reported to have a significantly lower incidence in the case group (P=0.03, 0.001, 0.008). Conclusion: We showed that a daily intravenous dose of NAC in hospitalized COVID-19 patients could shorten the hospital stay and improve some clinical symptoms; however, it does not remarkably improve the risk of ICU admission and the 28 days in-hospital mortality rate.
Language	English
Publishing date	2023-07-13
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2971933-1
ISSN	2008-6172 ; 2008-6164
ISSN (online)	2008-6172
ISSN	2008-6164
DOI	10.22088/cjim.14.3.553
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Article ; Online: Successful Repair of Bilateral Ureteral Stricture 3 Years after En Bloc Kidney Transplant: A Case Report.

Asgari, Majid Ali / Besharat, Sara / Bakhtiyari, Mahmood / Alirezaei, Amirhesam

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2018 Volume 17, Issue 6, Page(s) 819–822

Abstract: En bloc kidney transplants of small pediatric kidneys into adult recipients have been shown to have outcomes similar to transplants from standard adult deceased donors. Here, we report a 27-year-old male patient with successful repair of bilateral ... ...

Abstract	En bloc kidney transplants of small pediatric kidneys into adult recipients have been shown to have outcomes similar to transplants from standard adult deceased donors. Here, we report a 27-year-old male patient with successful repair of bilateral ureteral stricture 3 years after en bloc kidney transplant at the Shahid Modarres Hospital (Tehran, Iran). The patient received an en bloc deceased kidney donation from a 9-month-old infant. An end-to-end anastomosis of the aorta to the internal iliac artery and an end-to-side external iliac vein anastomosis to vena cava were performed. At an outpatient visit about 2.5 years later, the patient showed increasing levels of creatinine from 1.1 to 1.8 mg/dL compared with measurements at his 2-month visit. A computed tomography scan performed without any contrast agent at that time confirmed the existence of hydronephrosis in both the medial and lateral kidneys. A nephrostography showed a ureteral stricture. Because endoscopic surgery for ureteral dilatation was not successful, the decision was made to perform ureteral repair by the open surgical technique. The short length of the ureters resulted in the lateral renal pelvis being anastomosed to the bladder by flap (Boari flap). The ureter of the patient's native kidney was transected in the middle portion, and the distal ureter was anastomosed to the medial renal pelvis using the end-to-end method. Here, we showed that, despite limited experiences with pediatric donors, en bloc kidney transplant can be performed under the guidance of experienced surgical techniques and precise postoperative follow-up.
MeSH term(s)	Adult ; Age Factors ; Anastomosis, Surgical ; Constriction, Pathologic ; Humans ; Infant ; Kidney Transplantation/adverse effects ; Male ; Tissue Donors/supply & distribution ; Treatment Outcome ; Ureteral Obstruction/diagnostic imaging ; Ureteral Obstruction/etiology ; Ureteral Obstruction/surgery ; Urologic Surgical Procedures
Language	English
Publishing date	2018-04-09
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2017.0228
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