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  1. Article: A cellular and spatial atlas of

    Zhao, William / Kepecs, Benjamin / Mahadevan, Navin R / Segerstolpe, Asa / Weirather, Jason L / Besson, Naomi R / Giotti, Bruno / Soong, Brian Y / Li, Chendi / Vigneau, Sebastien / Slyper, Michal / Wakiro, Isaac / Jane-Valbuena, Judit / Ashenberg, Orr / Rotem, Asaf / Bueno, Raphael / Rozenblatt-Rosen, Orit / Pfaff, Kathleen / Rodig, Scott /
    Hata, Aaron N / Regev, Aviv / Johnson, Bruce E / Tsankov, Alexander M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... ...

    Abstract TP53
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.28.546977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors.

    Hoffman, Samantha E / Dowrey, Todd W / Villacorta Martin, Carlos / Bi, Kevin / Titchen, Breanna / Johri, Shreya / DelloStritto, Laura / Patel, Miraj / Mackichan, Colin / Inga, Stephanie / Chen, Judy / Grimaldi, Grace / Napolitano, Sara / Wakiro, Isaac / Wu, Jingyi / Yeung, Jason / Rotem, Asaf / Sicinska, Ewa / Shannon, Erin /
    Clancy, Thomas / Wang, Jiping / Denning, Sarah / Brais, Lauren / Besson, Naomi R / Pfaff, Kathleen L / Huang, Ying / Kao, Katrina Z / Rodig, Scott / Hornick, Jason L / Vigneau, Sebastien / Park, Jihye / Kulke, Matthew H / Chan, Jennifer / Van Allen, Eliezer M / Murphy, George J

    Science advances

    2023  Volume 9, Issue 39, Page(s) eadd9668

    Abstract: Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)-NET growth remain incompletely elucidated; however, the heterogeneous clinical ...

    Abstract Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP)-NET growth remain incompletely elucidated; however, the heterogeneous clinical behavior of GEP-NETs suggests that both cellular lineage dynamics and tumor microenvironment influence tumor pathophysiology. Here, we investigated the single-cell transcriptomes of tumor and immune cells from patients with gastroenteropancreatic NETs. Malignant GEP-NET cells expressed genes and regulons associated with normal, gastrointestinal endocrine cell differentiation, and fate determination stages. Tumor and lymphoid compartments sparsely expressed immunosuppressive targets commonly investigated in clinical trials, such as the programmed cell death protein-1/programmed death ligand-1 axis. However, infiltrating myeloid cell types within both primary and metastatic GEP-NETs were enriched for genes encoding other immune checkpoints, including
    MeSH term(s) Humans ; Neuroendocrine Tumors/genetics ; Intestinal Neoplasms/genetics ; Stomach Neoplasms/genetics ; Pancreatic Neoplasms/genetics ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.add9668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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