LIVIVO - Search results -

Search results

Result 1 - 10 of total 20

Search options

Article ; Online: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy.

Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

2020 Volume 144, Page(s) 109984

Abstract: In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and ... ...

Abstract	In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen.
MeSH term(s)	Aminoglycosides/pharmacology ; Aminoglycosides/therapeutic use ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/immunology ; Codon, Nonsense/drug effects ; Defensins/biosynthesis ; Defensins/genetics ; Defensins/physiology ; Drug Repositioning ; Humans ; Immunity, Innate/drug effects ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Macrolides/therapeutic use ; Models, Genetic ; Pandemics ; SARS-CoV-2/physiology ; Transcription, Genetic/drug effects ; Virus Internalization
Chemical Substances	Aminoglycosides ; Antiviral Agents ; Codon, Nonsense ; Defensins ; Immunologic Factors ; Macrolides ; theta-defensin
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109984
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1132: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Acute and Subchronic Toxicity Study of Flavonoid Rich Extract of

Bhide, Ranjit M / Bethapudi, Bharathi / Chalichem, Nehru Sai Suresh / Nithyanantham, Muruganantham / Murugan, Sasi Kumar / Mundkinajeddu, Deepak

Journal of toxicology

2022 Volume 2022, Page(s) 8517603

Abstract: Glycyrrhiza ... ...

Abstract	Glycyrrhiza glabra
Language	English
Publishing date	2022-03-31
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2495098-1
ISSN	1687-8205 ; 1687-8191
ISSN (online)	1687-8205
ISSN	1687-8191
DOI	10.1155/2022/8517603
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress.

C M, Mohan Gowda / Murugan, Sasi Kumar / Bethapudi, Bharathi / Purusothaman, Divya / Mundkinajeddu, Deepak / D'Souza, Prashanth

PloS one

2023 Volume 18, Issue 5, Page(s) e0285012

Abstract: Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The ... ...

Abstract	Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The present study investigated the effects of HolixerTM (a clinically studied standardized Ocimum tenuiflorum extract) on modulating stress using two in vivo models, namely the swim endurance study in mice and forced swim test in rats. In addition, we explored the mechanism of action of HolixerTM on the HPA axis using two in vitro cell-based assays to check for its inhibitory effect on cortisol release and CRF1 receptor antagonistic activity. Ocimum tenuiflorum extract enhanced the swimming time in mice, reduced the stress-induced increase in immobility time, and prevented the increase in corticosterone in rats subjected to the forced swim test. Further, Ocimum tenuiflorum extract inhibited cortisol release and exhibited a significant CRF1 receptor antagonist activity. Thus, Ocimum tenuiflorum extract was found effective in managing stress, and the effect could be due to the inhibition of cortisol release and the antagonistic effect on the CRF1 receptors.
MeSH term(s)	Rats ; Mice ; Animals ; Hypothalamo-Hypophyseal System ; Ocimum sanctum ; Hydrocortisone/pharmacology ; Pituitary-Adrenal System ; Plant Extracts/pharmacology ; Corticosterone/pharmacology
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Plant Extracts ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285012
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Toxicological safety assessment of AP-Bio®, a standardized extract of Andrographis paniculata in Sprague Dawley rats.

Murugan, Sasi Kumar / Bethapudi, Bharathi / Rao, Amara Nageswara / Allan, Joseph Joshua / Mundkinajeddu, Deepak / D'Souza, Prashanth

Journal of applied toxicology : JAT

2023 Volume 43, Issue 11, Page(s) 1630–1644

Abstract: Andrographis paniculata, commonly known as green chiretta, is a traditionally used plant in India, China, and Southeast Asian countries for its varied health benefits including immune health. The objective of the present study was to assess the safety of ...

Abstract	Andrographis paniculata, commonly known as green chiretta, is a traditionally used plant in India, China, and Southeast Asian countries for its varied health benefits including immune health. The objective of the present study was to assess the safety of AP-Bio®, a standardized A. paniculata extract in Sprague Dawley rats by following the Organisation for Economic Cooperation and Development (OECD) test guidelines of acute and 90-day repeated dose sub-chronic toxicity studies. AP-Bio® did not show any treatment-related clinical signs of toxicity or mortality during the 14-day observation period in animals tested in the single-dose acute oral toxicity study up to a dose of 5000 mg/kg body weight. In the 90-day repeated dose sub-chronic oral toxicity study, no treatment-related adverse clinical signs were observed in any of the treated groups (300, 600, and 900 mg/kg). All treated animals showed usual weight gain and comparable feed intake. The ophthalmoscope examination did not reveal any abnormalities. Also, no toxicologically significant changes were observed in urinalysis, hematology, and blood chemistry parameters. Absolute organ weights and relative organ weights of vital organs did not differ significantly compared to control. Gross and histopathological findings did not show any remarkable and treatment-related changes. Results of the safety evaluation showed the median lethal dose (LD
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	604625-3
ISSN	1099-1263 ; 0260-437X
ISSN (online)	1099-1263
ISSN	0260-437X
DOI	10.1002/jat.4501
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1661: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression

Murugan, Sasi Kumar / Bethapudi, Bharathi / Raghunandhakumar, Subramanian / Purusothaman, Divya / Nithyanantham, Muruganantham / Mundkinajeddu, Deepak / Talkad, Muralidhar Srinivasaih

BMC Complement Med Ther. 2022 Dec., v. 22, no. 1 p.38-38

2022

Abstract: BACKGROUND: Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory, ... ...

Abstract	BACKGROUND: Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory, antioxidant, and antiulcer properties. AIM: To investigate the effect of FREG (GutGard®) on restoring intestinal barrier function in tumor necrosis factor-alpha (TNF-α) stimulated human colonic adenocarcinoma cell monolayer (Caco-2) and 2,4,6-Trinitrobenzenesulfonic acid (TNBS) induced ulcerative colitis in rats. METHODS: In in vitro, human intestinal Caco-2 cell monolayers were treated with TNF-α in the presence or absence of FREG and the paracellular permeability to FITC-conjugated 4-kD dextran (FD4) was measured to evaluate protection against the barrier dysfunction. In in vivo, intestinal barrier dysfunction was induced in male albino Wistar rats via intrarectal instillation of TNBS. Subsequently, the rats were treated orally with either FREG at 6.25, 12.5, and 25 mg/kg body weight, or Mesacol (250 mg/kg) for 5 days. On day 5, intestinal epithelial permeability was assessed with FD4 leakage into the serum. Also, colonic inflammation, colon morphology, histology and macroscopic score, weight to length ratio were evaluated. The activity of myeloperoxidase (MPO), TNF- α, secretory IgA levels and tight junction proteins expression were evaluated in rat’s colon. RESULTS: FREG protected the intestinal epithelial barrier integrity in human intestinal Caco-2 cells in vitro. FREG administration significantly improved the intestinal epithelial barrier function as evident from significant reduction in FD4 leakage. The colon morphology, histology score, macroscopic score, colon weight to length ratio also indicates beneficial effects of FREG on barrier function. In addition, FREG regulated the tight junction proteins, and markedly decreased TNF-α, MPO levels and significantly increased the secretory IgA levels in TNBS induced colitis rats. CONCLUSION: The study findings support the protective action of FREG on intestinal epithelial barrier integrity indicating its potential in protecting from implications of leaky gut.
Keywords	Glycyrrhiza glabra ; albino ; antioxidants ; blood serum ; body weight ; colon ; complement ; dextran ; epithelium ; flavonoids ; histology ; human cell lines ; humans ; inflammation ; males ; myeloperoxidase ; neoplasm cells ; permeability ; rats ; tight junctions ; tumor necrosis factor-alpha ; ulcerative colitis
Language	English
Dates of publication	2022-12
Size	p. 38.
Publishing place	BioMed Central
Document type	Article ; Online
ISSN	2662-7671
DOI	10.1186/s12906-021-03500-1
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Safety Evaluation of Standardized Extract of

Murugan, Sasikumar / Solanki, Himanshu / Purusothaman, Divya / Bethapudi, Bharathi / Ravalji, Mital / Mundkinajeddu, Deepak

BioMed research international

2021 Volume 2021, Page(s) 6671853

Abstract: NR-INF-02 is a standardized extract containing turmerosaccharides ... ...

Abstract	NR-INF-02 is a standardized extract containing turmerosaccharides from
MeSH term(s)	Administration, Oral ; Animals ; Body Weight/drug effects ; Chromatography, High Pressure Liquid ; Curcuma/adverse effects ; Curcuma/chemistry ; Curcuma/toxicity ; Dose-Response Relationship, Drug ; Feeding Behavior/drug effects ; Female ; Hormones/metabolism ; Male ; Organ Size/drug effects ; Plant Extracts/adverse effects ; Plant Extracts/toxicity ; Rats, Wistar ; Toxicity Tests, Subchronic ; Urinalysis ; Rats
Chemical Substances	Hormones ; Plant Extracts ; turmeric extract (856YO1Z64F)
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/6671853
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action.

Velusami, Chandrasekaran Chinampudur / Richard, Edwin Jothie / Bethapudi, Bharathi

Inflammopharmacology

2018 Volume 26, Issue 5, Page(s) 1233–1243

Abstract: Background: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells ...

Abstract	Background: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action. Methods: Dysregulation of cartilage homeostasis was induced by IL-1β and H Results: NR-INF-02 significantly attenuated IL-1β-induced chondrocyte cytotoxicity, apoptosis and release of chondrocyte degradation markers such as IL-6, IL-8, COX-2, PGE Conclusions: NR-INF-02 protects cartilage homeostasis by maintaining the balance between synthesis and degradation of cartilage matrix.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cartilage/drug effects ; Cartilage/metabolism ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/physiology ; Collagen Type II/biosynthesis ; Curcuma ; Homeostasis/drug effects ; Humans ; Interleukin-1beta/pharmacology ; Mice ; Osteoarthritis/drug therapy ; Plant Extracts/pharmacology ; Protective Agents/pharmacology ; RAW 264.7 Cells
Chemical Substances	Collagen Type II ; Interleukin-1beta ; Plant Extracts ; Protective Agents ; turmeric extract (856YO1Z64F)
Language	English
Publishing date	2018-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-017-0433-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3274: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression.

Murugan, Sasi Kumar / Bethapudi, Bharathi / Raghunandhakumar, Subramanian / Purusothaman, Divya / Nithyanantham, Muruganantham / Mundkinajeddu, Deepak / Talkad, Muralidhar Srinivasaih

BMC complementary medicine and therapies

2022 Volume 22, Issue 1, Page(s) 38

Abstract: Background: Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory, ... ...

Abstract	Background: Intestinal epithelial barrier dysfunction predisposes to many gastrointestinal, metabolic, and psychological disorders. A flavonoid rich extract of Glycyrrhiza glabra (FREG) has previously been reported to possess anti-inflammatory, antioxidant, and antiulcer properties. Aim: To investigate the effect of FREG (GutGard Methods: In in vitro, human intestinal Caco-2 cell monolayers were treated with TNF-α in the presence or absence of FREG and the paracellular permeability to FITC-conjugated 4-kD dextran (FD4) was measured to evaluate protection against the barrier dysfunction. In in vivo, intestinal barrier dysfunction was induced in male albino Wistar rats via intrarectal instillation of TNBS. Subsequently, the rats were treated orally with either FREG at 6.25, 12.5, and 25 mg/kg body weight, or Mesacol (250 mg/kg) for 5 days. On day 5, intestinal epithelial permeability was assessed with FD4 leakage into the serum. Also, colonic inflammation, colon morphology, histology and macroscopic score, weight to length ratio were evaluated. The activity of myeloperoxidase (MPO), TNF- α, secretory IgA levels and tight junction proteins expression were evaluated in rat's colon. Results: FREG protected the intestinal epithelial barrier integrity in human intestinal Caco-2 cells in vitro. FREG administration significantly improved the intestinal epithelial barrier function as evident from significant reduction in FD4 leakage. The colon morphology, histology score, macroscopic score, colon weight to length ratio also indicates beneficial effects of FREG on barrier function. In addition, FREG regulated the tight junction proteins, and markedly decreased TNF-α, MPO levels and significantly increased the secretory IgA levels in TNBS induced colitis rats. Conclusion: The study findings support the protective action of FREG on intestinal epithelial barrier integrity indicating its potential in protecting from implications of leaky gut.
MeSH term(s)	Animals ; Caco-2 Cells ; Flavonoids/pharmacology ; Glycyrrhiza ; Humans ; Intestinal Mucosa ; Male ; Plant Extracts/pharmacology ; Rats ; Tight Junction Proteins
Chemical Substances	Flavonoids ; Plant Extracts ; Tight Junction Proteins
Language	English
Publishing date	2022-02-07
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-021-03500-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy

Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

Med Hypotheses

Abstract	In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #592505
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Aminoglycosides can be a better choice over macrolides in COVID-19 regimen

Chalichem, Nehru Sai Suresh / Bethapudi, Bharathi / Mundkinajeddu, Deepak

Medical Hypotheses

Plausible mechanism for repurposing strategy

2020 Volume 144, Page(s) 109984

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109984
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 1132: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito