Article ; Online: Real-Time and High-Resolution Monitoring of Neuronal Electrical Activity and pH Variations Based on the Co-Integration of Nanoelectrodes and Chem-FinFETs.
Small (Weinheim an der Bergstrasse, Germany)
2024 , Page(s) e2309055
Abstract: Developing new approaches amenable to the measurement of neuronal physiology in real-time is a very active field of investigation, as it will offer improved methods to assess the impact of diverse insults on neuronal homeostasis. Here, the development of ...
| Abstract | Developing new approaches amenable to the measurement of neuronal physiology in real-time is a very active field of investigation, as it will offer improved methods to assess the impact of diverse insults on neuronal homeostasis. Here, the development of an in vitro bio platform is reported which can record the electrical activity of cultured primary rat cortical neurons with extreme sensitivity, while simultaneously tracking the localized changes in the pH of the culture medium. This bio platform features passive vertical nanoprobes with ultra-high signal resolution (several mV amplitude ranges) and Chem-FinFETs (pH sensitivity of sub-0.1 pH units), covering an area as little as a neuronal soma. These multi-sensing units are arranged in an array to probe both chemically and electrically an equivalent surface of ≈ 0.5 mm |
|---|---|
| Language | English |
| Publishing date | 2024-03-29 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2168935-0 |
| ISSN | 1613-6829 ; 1613-6810 |
| ISSN (online) | 1613-6829 |
| ISSN | 1613-6810 |
| DOI | 10.1002/smll.202309055 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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