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Book ; Online: Practical Clinical Andrology

Bettocchi, Carlo / Busetto, Gian Maria / Carrieri, Giuseppe / Cormio, Luigi

2023

Author's details	edited by Carlo Bettocchi, Gian Maria Busetto, Giuseppe Carrieri, Luigi Cormio
Keywords	Urology ; Reproductive health ; Endocrinology
Subject code	616.6
Language	English
Size	1 Online-Ressource (XIII, 340 p. 73 illus., 67 illus. in color)
Edition	1st ed. 2023
Publisher	Springer International Publishing ; Imprint: Springer
Publishing place	Cham
Document type	Book ; Online
HBZ-ID	HT021598239
ISBN	978-3-031-11701-5 ; 9783031117008 ; 9783031117022 ; 9783031117039 ; 3-031-11701-8 ; 303111700X ; 3031117026 ; 3031117034
DOI	10.1007/978-3-031-11701-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Practical Clinical Andrology

Bettocchi, Carlo / Busetto, Gian Maria / Carrieri, Giuseppe / Cormio, Luigi

2023

Keywords	Urology & urogenital medicine ; Reproductive medicine ; Endocrinology ; Andrology ; Sexual Medicine ; Infertility ; Sexual Dysfunctions ; Transgender Health ; Reproductive Medicine
Language	0\|e
Size	1 electronic resource (340 pages)
Publisher	Springer Nature
Publishing place	Cham
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021620905
ISBN	9783031117015 ; 3031117018
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Development and validation of 3-dimensional simulators for penile prosthesis surgery.

Reisman, Yacov / van Renterghem, Koen / Meijer, Boaz / Ricapito, Anna / Fode, Mikkel / Bettocchi, Carlo

The journal of sexual medicine

2024 Volume 21, Issue 5, Page(s) 494–499

Abstract: Background: The acquisition of skills in penile prosthesis surgery has many limitations mainly due to the absence of simulators and models for training. Three-dimensional (3D) printed models can be utilized for surgical simulations, as they provide an ... ...

Abstract	Background: The acquisition of skills in penile prosthesis surgery has many limitations mainly due to the absence of simulators and models for training. Three-dimensional (3D) printed models can be utilized for surgical simulations, as they provide an opportunity to practice before entering the operating room and provide better understanding of the surgical approach. Aim: This study aimed to evaluate and validate a 3D model of human male genitalia for penile prosthesis surgery. Methods: This study included 3 evaluation and validation stages. The first stage involved verification of the 3D prototype model for anatomic landmarks compared with a cadaveric pelvis. The second stage involved validation of the improved model for anatomic accuracy and teaching purposes with the Rochester evaluation score. The third stage comprised validation of the suitability of the 3D prototype model as a surgical simulator and for skill acquisition. The third stage was performed at 3 centers using a modified version of a pre-existing, validated questionnaire and correlated with the Rochester evaluation score. Outcome: We sought to determine the suitability of 3D model for training in penile prosthesis surgery in comparison with the available cadaveric model. Results: The evaluation revealed a high Pearson correlation coefficient (0.86) between questions of the Rochester evaluation score and modified validated questionnaire. The 3D model scored 4.33 ± 0.57 (on a Likert scale from 1 to 5) regarding replication of the relevant human anatomy for the penile prosthesis surgery procedure. The 3D model scored 4.33 ± 0.57 (on a Likert scale from 1 to 5) regarding its ability to improve technical skills, teach and practice the procedure, and assess a surgeon's ability. Furthermore, the experts stated that compared with the cadaver, the 3D model presented greater ethical suitability, reduced costs, and easier accessibility. Clinical implications: A validated 3D model is a suitable alternative for penile prosthesis surgery training. Strengths and limitations: This is the first validated 3D hydrogel model for penile prosthesis surgery teaching and training that experts consider suitable for skill acquisition. Because specific validated guidelines and questionnaires for the validation and verifications of 3D simulators for penile surgery are not available, a modified questionnaire was used. Conclusion: The current 3D model for penile prosthesis surgery shows promising results regarding anatomic properties and suitability to train surgeons to perform penile implant surgery. The possibility of having an ethical, easy-to-use model with lower costs and limited consequences for the environment is encouraging for further development of the models.
MeSH term(s)	Humans ; Male ; Penile Prosthesis ; Penile Implantation/methods ; Penile Implantation/education ; Models, Anatomic ; Cadaver ; Simulation Training/methods ; Printing, Three-Dimensional ; Clinical Competence/standards
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article ; Validation Study
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1093/jsxmed/qdae020
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Article ; Online: ZSI-375 artificial urinary sphincter: efficacy, safety, and long-term outcomes.

Bettocchi, Carlo / Ricapito, Anna / Falagario, Ugo / Selvaggio, Oscar / Annese, Pasquale / Mancini, Vito / Busetto, Gian Maria / Cormio, Luigi / Carrieri, Giuseppe

Minerva urology and nephrology

2024

Language	English
Publishing date	2024-01-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062840-4
ISSN	2724-6442
ISSN (online)	2724-6442
DOI	10.23736/S2724-6051.23.05693-8
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Article ; Online: GnRH in the Treatment of Hypogonadotropic Hypogonadism.

Bettocchi, Carlo / Rinaldi, Marco / Sebastiani, Francesco

Current pharmaceutical design

2020 Volume 27, Issue 24, Page(s) 2754–2756

Abstract: Gonadotropin-releasing hormone (GnRH) is the focus of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH that are mainly congenital and may or ... ...

Abstract	Gonadotropin-releasing hormone (GnRH) is the focus of the scientific debate for the treatment of hypogonadotropic hypogonadism. Sexual maturation and reproductive function depend on the pulsatile secretion of GnRH that are mainly congenital and may or may not be associated with other genetic anomalies or syndromes. Clinical manifestations include a wide range of metabolic, endocrine, and psychologic dysfunctions. The following manuscript focuses on the effects of GnRH therapy on fertility and cognitive abilities, aiming to investigate the current level of evidence for this treatment regimen. Current literature has been reviewed with the aim of highlighting the key findings on these two aspects.
MeSH term(s)	Fertility ; Gonadotropin-Releasing Hormone ; Humans ; Hypogonadism/drug therapy ; Syndrome
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2020-11-25
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666201125113319
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Article: European Society of Sexual Medicine consensus statement on the use of animal models for studying Peyronie's disease.

Castiglione, Fabio / Çakır, Onur Ö / Schifano, Nicolò / Corona, Giovanni / Reisman, Yacov / Bettocchi, Carlo / Cellek, Selim / Ilg, Marcus M

Sexual medicine

2023 Volume 11, Issue 4, Page(s) qfad046

Abstract: Introduction: Animal models are frequently used for translational research in Peyronie's disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting, and outcome measures.: Aim: This ... ...

Abstract	Introduction: Animal models are frequently used for translational research in Peyronie's disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting, and outcome measures. Aim: This European Society for Sexual Medicine consensus statement aims to provide guidance in utilization of animal models in PD research in a standardized and uniform fashion. Methods: PubMed was searched for studies using animal models for PD. The following search terms were used: ("Peyronie's disease" OR "penile fibrosis" OR "penile curvature" OR "induration penis plastica" OR "erectile dysfunction") AND ("rodent" OR "mouse" OR "mice" OR "rat" OR "rabbit"). Outcomes: This European Society for Sexual Medicine statement describes best practice guidelines for utilization of animals in PD research: power calculation, details of available models, surgical procedures, and measurement techniques, while highlighting possible pitfalls and translational limitations of the models. Results: In total, 2490 studies were retrieved and 2446 articles were excluded. A total of 44 studies were included, of which 40 studies used rats, 1 study used both rats and mice, 1 study used a genetic mouse model, and 2 studies used rabbits. A significant number of the studies (70.5%) used transforming growth factor β 1 for induction of fibrosis. Oxford 2011 Levels of Evidence criteria could not be applied due to the nature of the studies. Conclusion: Despite certain limitations of PD animal models presented, we aimed to provide guidance for their appropriate use in translational research, with the purpose of improving study quality and reproducibility as well as facilitating interpretation of reported results and conclusions.
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2734882-9
ISSN	2050-1161
ISSN	2050-1161
DOI	10.1093/sexmed/qfad046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Investigating the risk factors of penile arterial insufficiency and veno-occlusive dysfunction in patients with erectile dysfunction.

Habous, Mohamad / Khattak, Ahmed / Farag, Mohammed / Binsaleh, Saleh / Ralph, David / Aziz, Mohammed / Bettocchi, Carlo / Muir, Gordon

BJUI compass

2023 Volume 5, Issue 1, Page(s) 34–41

Abstract: Objective: To investigate the risk factors for penile arterial insufficiency (PAI), which is a known cause of erectile dysfunction (ED).: Methods: Patients who attended our urology clinic complaining of ED for more than 6 months were prospectively ... ...

Abstract	Objective: To investigate the risk factors for penile arterial insufficiency (PAI), which is a known cause of erectile dysfunction (ED). Methods: Patients who attended our urology clinic complaining of ED for more than 6 months were prospectively enrolled in this study over 1-year period. Patient consent was taken and ethical committee approval. Complete medical history and thorough general and local examination including body mass index (BMI), Peyronie's disease (PD) and penile size measurements (length and girth) were done for all of them. Laboratory tests included testosterone, lipid profile and glycated haemoglobin (HA1c). A penile duplex ultrasound study (PDU) was done for all patients after intracavernosal injection (ICI) with alprostadil. Peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured after 15 min. Statistical analysis was done using SPSS. Results: A total of 440 patients were enrolled in this analysis. The mean age was 48(23-81), and the mean BMI was 30 (18-51). Older patients had lower PSV ( Conclusions: Ageing, tobacco consumption, DM and hypertension seem to have a negative impact on penile haemodynamics, which was statistically significant. In our patients, there was no statistically significant effect on penile haemodynamics in patients with increased BMI, low testosterone or PD or according to the size of the penis.
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.275
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of low-intensity extracorporeal shockwave therapy on vascular parameters and sexual function in patients with arteriogenic erectile dysfunction.

Rubino, Matteo / Ricapito, Anna / Finati, Marco / Falagario, Ugo G / Annese, Pasquale / Mancini, Vito / Busetto, Gian Maria / Cormio, Luigi / Carrieri, Giuseppe / Bettocchi, Carlo

Asian journal of andrology

2024

Abstract: Abstract: Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy (Li-ESWT). However, the clinical significance of these findings remains unclear, and definitive ... ...

Abstract	Abstract: Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy (Li-ESWT). However, the clinical significance of these findings remains unclear, and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be established. This was an observational study of 113 patients with ED, evaluated between January 2019 and December 2021 in Andrology Unit at the Department of Urology and Renal Transplantation, University of Foggia (Foggia, Italy). Penile dynamic Doppler was performed to evaluate vascular parameters and 5-item version of the International Index of Erectile Dysfunction (IIEF-5) questionnaire was administered to assess the severity of ED. This was repeated 1 month after treatment. Patients with a peak systolic velocity (PSV) <30 cm s-1 were considered eligible for Li-ESWT. Our protocol consisted of 8 weekly sessions with 1500 strokes distributed in 5 different locations along the penis. After treatment, a significant mean (±standard deviation [s.d.]) PSV increase of 5.0 (±3.4) cm s-1 was recorded and 52/113 (46.0%) patients reached a PSV >30 cm s-1 at posttherapeutic penile dynamic Doppler. A clinically significant IIEF-5 score improvement was observed in 7 patients, 21 patients, and 2 patients with mild-to-moderate, moderate, and severe pretreatment ED, respectively. No different outcomes were assessed based on smoking habits, previous pelvic surgery, or use of oral phosphodiesterase-5 inhibitor (PDE5i). On the other side, only 1 (6.7%) in 15 patients with diabetes mellitus showed an IIEF-5 score improvement after Li-ESWT. Shockwave treatment determined a significant increase in PSV and correlated IIEF-5 improvement in ED patients. This advantage seemed particularly evident for moderate ED and was not affected by smoking habits, previous pelvic surgery, and use of PDE5i. Conversely, diabetic patients did not benefit from the treatment.
Language	English
Publishing date	2024-03-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202384
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Article: Place des implants péniens d’érection dans le traitement de la dysfonction érectile : le point en 2020.

Chevallier, Daniel / Faix, Antoine / Bettocchi, Carlo / Djinovic, Rados / Ralph, David

Revue medicale suisse

2020 Volume 16, Issue 686, Page(s) 525–530

Abstract: Penile erection implants are considered to be the « Gold Standard » for the treatment of erectile dysfunction with an organic component that escapes pharmacological and mechanical treatment. The place of preoperative information is fundamental. It is a ... ...

Title translation	Penile prosthesis in the treatment of erectile dysfunction: updates in 2020.
Abstract	Penile erection implants are considered to be the « Gold Standard » for the treatment of erectile dysfunction with an organic component that escapes pharmacological and mechanical treatment. The place of preoperative information is fundamental. It is a simple and minimally invasive surgery. Penile Erection Implants are becoming more and more a full-fledged treatment line, which can be offered at the same time as other Erectile Dysfunction treatments. In this article, we will discuss the presentation of the different implants available, the elements underlying their indication, the place of preoperative information, the mains steps of the surgical procedure, the outcomes and satisfaction rates.
MeSH term(s)	Erectile Dysfunction/surgery ; Humans ; Male ; Minimally Invasive Surgical Procedures ; Patient Satisfaction ; Penile Prosthesis ; Treatment Outcome
Language	French
Publishing date	2020-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Maladie de Lapeyronie : le point en 2020.

Faix, Antoine / Chevallier, Daniel / Bettocchi, Carlo / Djinovic, Rados / Ralph, David

Revue medicale suisse

2020 Volume 16, Issue 686, Page(s) 531–538

Abstract: Peyronie's disease (PD) is a relatively unknown cause of sexual dysfunction. Symptoms may include the appearance of an erectile deformity, pain in the penis and erectile dysfunction (ED). The etiology is most often unclear, and medical treatments are ... ...

Title translation	Peyronie's Disease: update in 2020.
Abstract	Peyronie's disease (PD) is a relatively unknown cause of sexual dysfunction. Symptoms may include the appearance of an erectile deformity, pain in the penis and erectile dysfunction (ED). The etiology is most often unclear, and medical treatments are limited, although improvement is always possible. However, surgical treatment remains the only option when the disease has stabilized and in the event of significant erectile and sexual disability.
MeSH term(s)	Erectile Dysfunction/complications ; Erectile Dysfunction/physiopathology ; Humans ; Male ; Penile Erection ; Penile Induration/complications ; Penile Induration/physiopathology ; Penis/physiopathology
Language	French
Publishing date	2020-03-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
Database	MEDical Literature Analysis and Retrieval System OnLINE

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