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  1. Article ; Online: Tapering belimumab in patients with systemic lupus erythematosus: a single-centre experience.

    Fredi, Micaela / Vojinovic, Tamara / Regola, Francesca / Babaglioni, Giorgia / Bettoni, Daria / Andreoli, Laura / Tincani, Angela / Franceschini, Franco

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 2, Page(s) e18–e20

    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Lupus Erythematosus, Systemic/drug therapy ; Immunosuppressive Agents/therapeutic use ; Treatment Outcome
    Chemical Substances belimumab (73B0K5S26A) ; Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents
    Language English
    Publishing date 2022-08-11
    Publishing country England
    Document type Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Understanding adverse drug reactions in older adults through drug-drug interactions.

    Marengoni, A / Pasina, L / Concoreggi, C / Martini, G / Brognoli, F / Nobili, A / Onder, G / Bettoni, D

    European journal of internal medicine

    2014  Volume 25, Issue 9, Page(s) 843–846

    Abstract: Aims: The aims of this study are to evaluate prevalence and characteristics of adverse drug reactions (ADRs) and to evaluate the potential contribution of specific medications, therapeutic categories and drug-drug interactions (DDIs) in older adults.: ...

    Abstract Aims: The aims of this study are to evaluate prevalence and characteristics of adverse drug reactions (ADRs) and to evaluate the potential contribution of specific medications, therapeutic categories and drug-drug interactions (DDIs) in older adults.
    Methods: All ADR reporting forms of persons aged 65+ years collected by the pharmacovigilance of one of the main hospitals in Italy during 2013 were evaluated. DDIs were analysed by a computerized prescription system (INTERCheck) and based on the interactions' database managed by the Istituto di Ricerche Farmacologiche Mario Negri. DDIs were classified according to their clinical relevance as contraindicated, major, and moderate.
    Results: Amongst all the ADR reporting forms (n=1014) collected during 2013, 343 affected older adults. The most frequent ADRs were: haemorrhages (n=122, 35.5%), allergic reactions (n=56, 16.3%), and elevated International Normalized Ratio (INR>6, n=54, 15.7%). The specific medications that contributed to ADRs were warfarin (42.5%), acenocumarol (9%), and allopurinol (8.5%); while the therapeutic categories were haematological agents (67%) and proton pump inhibitors (13%). A total of 912 DDIs were found; one third of them were contraindicated or major and 31.5% of them potentially contributed to ADRs; of these, the most frequent were: warfarin and heparin (contraindicated, n=5); warfarin and a statin (major, n=38); warfarin and a proton pump inhibitor (moderate, n=40). At least one DDI contributed to 66 haemorrhages out of 122 (54%) and to 41 elevated INR out of 54 (76%).
    Conclusion: DDIs significantly contribute to the onset of ADRs in older adults and intervention programmes, e.g., the employment of a computerized system, may reduce the burden of iatrogenic illnesses in the elderly.
    MeSH term(s) Acenocoumarol/adverse effects ; Age Factors ; Aged ; Allopurinol/adverse effects ; Drug Hypersensitivity/epidemiology ; Drug Hypersensitivity/etiology ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Female ; Hematologic Agents/adverse effects ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; International Normalized Ratio ; Italy/epidemiology ; Male ; Prevalence ; Proton Pump Inhibitors/adverse effects ; Warfarin/adverse effects
    Chemical Substances Hematologic Agents ; Proton Pump Inhibitors ; Warfarin (5Q7ZVV76EI) ; Allopurinol (63CZ7GJN5I) ; Acenocoumarol (I6WP63U32H)
    Language English
    Publishing date 2014-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2014.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Advances in CMV Management: A Single Center Real-Life Experience.

    Malagola, Michele / Pollara, Caterina / Polverelli, Nicola / Zollner, Tatiana / Bettoni, Daria / Gandolfi, Lisa / Gramegna, Doriana / Morello, Enrico / Turra, Alessandro / Corbellini, Silvia / Signorini, Liana / Moioli, Giovanni / Bernardi, Simona / Zanaglio, Camilla / Farina, Mirko / Testa, Tullio Elia / Caruso, Arnaldo / Russo, Domenico

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 534268

    Abstract: CMV infection is a major challenge in allogeneic stem cell transplantation (allo-SCT). The changing landscape in CMV management includes the introduction of letermovir in prophylaxis of high-risk patients and the source of CMV DNA monitoring (plasma-PL ... ...

    Abstract CMV infection is a major challenge in allogeneic stem cell transplantation (allo-SCT). The changing landscape in CMV management includes the introduction of letermovir in prophylaxis of high-risk patients and the source of CMV DNA monitoring (plasma-PL vs. whole blood-WB), for pre-emptive therapy (PET) initiation. We report here how our real-life experience in CMV management evolved, following letermovir registration. We focus on: (i) the effects of systematic use of letermovir for CMV prophylaxis in high-risk patients, (ii) the results of a longitudinal comparison of CMV DNAemia monitoring in PL and WB. From December 2018 to April 2020, 60 allo-SCTs have been performed in our center (LET
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.534268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Biomedical Research Programs at Present and Future High-Energy Particle Accelerators.

    Patera, Vincenzo / Prezado, Yolanda / Azaiez, Faical / Battistoni, Giuseppe / Bettoni, Diego / Brandenburg, Sytze / Bugay, Aleksandr / Cuttone, Giacomo / Dauvergne, Denis / de France, Gilles / Graeff, Christian / Haberer, Thomas / Inaniwa, Taku / Incerti, Sebastien / Nasonova, Elena / Navin, Alahari / Pullia, Marco / Rossi, Sandro / Vandevoorde, Charlot /
    Durante, Marco

    Frontiers in physics

    2020  Volume 8, Page(s) 380

    Abstract: Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these ... ...

    Abstract Biomedical applications at high-energy particle accelerators have always been an important section of the applied nuclear physics research. Several new facilities are now under constructions or undergoing major upgrades. While the main goal of these facilities is often basic research in nuclear physics, they acknowledge the importance of including biomedical research programs and of interacting with other medical accelerator facilities providing patient treatments. To harmonize the programs, avoid duplications, and foster collaboration and synergism, the International Biophysics Collaboration is providing a platform to several accelerator centers with interest in biomedical research. In this paper, we summarize the programs of various facilities in the running, upgrade, or construction phase.
    Language English
    Publishing date 2020-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721033-9
    ISSN 2296-424X
    ISSN 2296-424X
    DOI 10.3389/fphy.2020.00380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Economic and outcomes consequences of TachoSil®

    Colombo GL / Bettoni D / Di Matteo S / Grumi C / Molon C / Spinelli D / Mauro G / Tarozzo A / Bruno GM

    Vascular Health and Risk Management, Vol 2014, Iss default, Pp 569-

    a systematic review

    2014  Volume 576

    Abstract: Giorgio L Colombo,1,2 Daria Bettoni,3 Sergio Di Matteo,2 Camilla Grumi,3 Cinzia Molon,4 Daniela Spinelli,5 Gaetano Mauro,6 Alessia Tarozzo,4 Giacomo M Bruno2 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2Studi Analisi Valutazioni ... ...

    Abstract Giorgio L Colombo,1,2 Daria Bettoni,3 Sergio Di Matteo,2 Camilla Grumi,3 Cinzia Molon,4 Daniela Spinelli,5 Gaetano Mauro,6 Alessia Tarozzo,4 Giacomo M Bruno2 1Department of Drug Sciences, University of Pavia, Pavia, Italy; 2Studi Analisi Valutazioni Economiche (SAVE), Milan, Italy; 3Hospital Pharmacy, Spedali Civili Brescia, Brescia, Italy; 4Città della Salute e della Scienza di Torino, Presidio Molinette, Turin, Italy; 5Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; 6Scuola di Specializzazione in Farmacia Ospedaliera, Università La Sapienza, Roma, Italy Background: TachoSil® is a medicated sponge coated with human fibrinogen and human thrombin. It is indicated as a support treatment in adult surgery to improve hemostasis, promote tissue sealing, and support sutures when standard surgical techniques are insufficient. This review systematically analyses the international scientific literature relating to the use of TachoSil in hemostasis and as a surgical sealant, from the point of view of its economic impact. Methods: We carried out a systematic review of the PubMed literature up to November 2013. Based on the selection criteria, papers were grouped according to the following outcomes: reduction of time to hemostasis; decrease in length of hospital stay; and decrease in postoperative complications. Results: Twenty-four scientific papers were screened, 13 (54%) of which were randomized controlled trials and included a total of 2,116 patients, 1,055 of whom were treated with TachoSil. In the clinical studies carried out in patients undergoing hepatic, cardiac, or renal surgery, the time to hemostasis obtained with TachoSil was lower (1–4 minutes) than the time measured with other techniques and hemostatic drugs, with statistically significant differences. Moreover, in 13 of 15 studies, TachoSil showed a statistically significant reduction in postoperative complications in comparison with the standard surgical procedure. The range of the observed decrease in the length of hospital stay for TachoSil patients was 2.01–3.58 days versus standard techniques, with a statistically significant difference in favor of TachoSil in eight of 15 studies. Conclusion: This analysis shows that TachoSil has a role as a supportive treatment in surgery to improve hemostasis and promote tissue sealing when standard techniques are insufficient, with a consequent decrease in postoperative complications and hospital costs. Keywords: TachoSil®, systematic review, economic evaluation, cost analysis, outcomes research
    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2014-09-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Economic and outcomes consequences of TachoSil®: a systematic review.

    Colombo, Giorgio L / Bettoni, Daria / Di Matteo, Sergio / Grumi, Camilla / Molon, Cinzia / Spinelli, Daniela / Mauro, Gaetano / Tarozzo, Alessia / Bruno, Giacomo M

    Vascular health and risk management

    2014  Volume 10, Page(s) 569–575

    Abstract: Background: TachoSil(®) is a medicated sponge coated with human fibrinogen and human thrombin. It is indicated as a support treatment in adult surgery to improve hemostasis, promote tissue sealing, and support sutures when standard surgical techniques ... ...

    Abstract Background: TachoSil(®) is a medicated sponge coated with human fibrinogen and human thrombin. It is indicated as a support treatment in adult surgery to improve hemostasis, promote tissue sealing, and support sutures when standard surgical techniques are insufficient. This review systematically analyses the international scientific literature relating to the use of TachoSil in hemostasis and as a surgical sealant, from the point of view of its economic impact.
    Methods: We carried out a systematic review of the PubMed literature up to November 2013. Based on the selection criteria, papers were grouped according to the following outcomes: reduction of time to hemostasis; decrease in length of hospital stay; and decrease in postoperative complications.
    Results: Twenty-four scientific papers were screened, 13 (54%) of which were randomized controlled trials and included a total of 2,116 patients, 1,055 of whom were treated with TachoSil. In the clinical studies carried out in patients undergoing hepatic, cardiac, or renal surgery, the time to hemostasis obtained with TachoSil was lower (1-4 minutes) than the time measured with other techniques and hemostatic drugs, with statistically significant differences. Moreover, in 13 of 15 studies, TachoSil showed a statistically significant reduction in postoperative complications in comparison with the standard surgical procedure. The range of the observed decrease in the length of hospital stay for TachoSil patients was 2.01-3.58 days versus standard techniques, with a statistically significant difference in favor of TachoSil in eight of 15 studies.
    Conclusion: This analysis shows that TachoSil has a role as a supportive treatment in surgery to improve hemostasis and promote tissue sealing when standard techniques are insufficient, with a consequent decrease in postoperative complications and hospital costs.
    MeSH term(s) Blood Loss, Surgical/prevention & control ; Cost-Benefit Analysis ; Drug Combinations ; Drug Costs ; Fibrinogen/adverse effects ; Fibrinogen/economics ; Fibrinogen/therapeutic use ; Hemostatic Techniques/adverse effects ; Hemostatic Techniques/economics ; Hemostatics/economics ; Hemostatics/therapeutic use ; Hospital Costs ; Humans ; Length of Stay/economics ; Outcome and Process Assessment, Health Care/economics ; Postoperative Hemorrhage/economics ; Postoperative Hemorrhage/prevention & control ; Thrombin/adverse effects ; Thrombin/economics ; Thrombin/therapeutic use ; Time Factors ; Treatment Outcome
    Chemical Substances Drug Combinations ; Hemostatics ; TachoSil ; Fibrinogen (9001-32-5) ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2014-09-10
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2186568-1
    ISSN 1178-2048 ; 1176-6344
    ISSN (online) 1178-2048
    ISSN 1176-6344
    DOI 10.2147/VHRM.S63199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ram-pressure feeding of supermassive black holes.

    Poggianti, Bianca M / Jaffé, Yara L / Moretti, Alessia / Gullieuszik, Marco / Radovich, Mario / Tonnesen, Stephanie / Fritz, Jacopo / Bettoni, Daniela / Vulcani, Benedetta / Fasano, Giovanni / Bellhouse, Callum / Hau, George / Omizzolo, Alessandro

    Nature

    2017  Volume 548, Issue 7667, Page(s) 304–309

    Abstract: When a supermassive black hole at the centre of a galaxy accretes matter, it gives rise to a highly energetic phenomenon: an active galactic nucleus. Numerous physical processes have been proposed to account for the funnelling of gas towards the galactic ...

    Abstract When a supermassive black hole at the centre of a galaxy accretes matter, it gives rise to a highly energetic phenomenon: an active galactic nucleus. Numerous physical processes have been proposed to account for the funnelling of gas towards the galactic centre to feed the black hole. There are also several physical processes that can remove gas from a galaxy, one of which is ram-pressure stripping by the hot gas that fills the space between galaxies in galaxy clusters. Here we report that six out of a sample of seven 'jellyfish' galaxies-galaxies with long 'tentacles' of material that extend for dozens of kiloparsecs beyond the galactic disks-host an active nucleus, and two of them also have galactic-scale ionization cones. The high incidence of nuclear activity among heavily stripped jellyfish galaxies may be due to ram pressure causing gas to flow towards the centre and triggering the activity, or to an enhancement of the stripping caused by energy injection from the active nucleus, or both. Our analysis of the galactic position and velocity relative to the cluster strongly supports the first hypothesis, and puts forward ram pressure as another possible mechanism for feeding the central supermassive black hole with gas.
    Language English
    Publishing date 2017-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature23462
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  8. Book ; Online: Study of $e^+e^-\to\gamma\phi J/\psi$ from $\sqrt{s}=4.600$ to $4.951$ GeV

    BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Albrecht, M. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Ferroli, R. Baldini / Balossino, I. / Ban, Y. / Batozskaya, V. / Becker, D. / Begzsuren, K. / Berger, N. / Bertani, M. /
    Bettoni, D. / Bianchi, F. / Bianco, E. / Bloms, J. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Z. J. / Cheng, W. S.

    2022  

    Abstract: Using data samples with an integrated luminosity of $6.4$~fb$^{-1}$ collected by the BESIII detector operating at the BEPCII storage ring, the process of $e^+e^-\to\gamma\phi J/\psi$ is studied. The processes of $e^+e^-\to\phi\chi_{c1,c2}$, $\chi_{c1,c2}\ ...

    Abstract Using data samples with an integrated luminosity of $6.4$~fb$^{-1}$ collected by the BESIII detector operating at the BEPCII storage ring, the process of $e^+e^-\to\gamma\phi J/\psi$ is studied. The processes of $e^+e^-\to\phi\chi_{c1,c2}$, $\chi_{c1,c2}\to\gamma J/\psi$ are observed with a significance of more than $10\sigma$. The $\sqrt{s}$-dependent cross section of $e^+e^- \to \phi\chi_{c1,c2}$ is measured between 4.600 and 4.951~GeV, and evidence of a resonance structure is found for the first time in the $\phi\chi_{c2}$ process. We also search for the processes of $e^+e^-\to\gamma X(4140)$, $\gamma X(4274)$ and $\gamma X(4500)$ via the $\gamma\phi J/\psi$ final state, but no obvious structures are found. The upper limits on the production cross section times the branching fraction for these processes at the 90% confidence level are reported.

    Comment: 35 pages, 9 figures
    Keywords High Energy Physics - Experiment
    Subject code 612
    Publishing date 2022-10-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Book ; Online: First Direct Measurement of the Absolute Branching Fraction of $\Sigma^+ \to \Lambda e^+ \nu_{e}$

    BESIII Collaboration / Ablikim, M. / Achasov, M. N. / Adlarson, P. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, Y. / Bakina, O. / Ferroli, R. Baldini / Balossino, I. / Ban, Y. / Batozskaya, V. / Becker, D. / Begzsuren, K. / Berger, N. / Bertani, M. / Bettoni, D. /
    Bianchi, F. / Bianco, E. / Bloms, J. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, T. T. / Chang, W. L. / Che, G. R. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Y. Q. / Chen, Z. J.

    2022  

    Abstract: The first direct measurement of the absolute branching fraction of $\Sigma^+ \to \Lambda e^+ \nu_{e}$ is reported based on an $e^+e^-$ annihilation sample of $(10087\pm44) \times 10^6$ $J/\psi$ events collected with the BESIII detector at $\sqrt{s}=3.097$ ...

    Abstract The first direct measurement of the absolute branching fraction of $\Sigma^+ \to \Lambda e^+ \nu_{e}$ is reported based on an $e^+e^-$ annihilation sample of $(10087\pm44) \times 10^6$ $J/\psi$ events collected with the BESIII detector at $\sqrt{s}=3.097$ GeV. The branching fraction is determined to be ${\mathcal B}(\Sigma^+ \to \Lambda e^+ \nu_{e}) = [2.93\pm0.74(\rm stat) \pm 0.13(\rm syst)]\times 10^{-5}$, which is the most precise measurement obtained in a single experiment to date and also the first result obtained at a collider experiment. Combining this result with the world average of ${\mathcal B}(\Sigma^- \to \Lambda e^- \bar{\nu}_{e})$ and the lifetimes of $\Sigma^{\pm}$, the ratio, $\frac{\Gamma(\Sigma^- \to \Lambda e^- \bar{\nu}_{e})}{\Gamma(\Sigma^+ \to \Lambda e^+ \nu_{e})}$, is determined to be $1.06 \pm 0.28$, which is within 1.8 standard deviations of the value expected in the absence of second-class currents that are forbidden in the Standard Model.

    Comment: 8 pages, 3 figures
    Keywords High Energy Physics - Experiment ; High Energy Physics - Phenomenology
    Subject code 612
    Publishing date 2022-12-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Book ; Online: First Observation of the Semileptonic Decay $\Lambda_c^+\rightarrow pK^- e^+\nu_e$

    Ablikim, M. / Achasov, M. N. / Adlarson, P. / Albrecht, M. / Aliberti, R. / Amoroso, A. / An, M. R. / An, Q. / Bai, X. H. / Bai, Y. / Bakina, O. / Ferroli, R. Baldini / Balossino, I. / Ban, Y. / Batozskaya, V. / Becker, D. / Begzsuren, K. / Berger, N. / Bertani, M. /
    Bettoni, D. / Bianchi, F. / Bloms, J. / Bortone, A. / Boyko, I. / Briere, R. A. / Brueggemann, A. / Cai, H. / Cai, X. / Calcaterra, A. / Cao, G. F. / Cao, N. / Cetin, S. A. / Chang, J. F. / Chang, W. L. / Chelkov, G. / Chen, C. / Chen, Chao / Chen, G. / Chen, H. S. / Chen, M. L. / Chen, S. J. / Chen, S. M. / Chen, T. / Chen, X. R. / Chen, X. T. / Chen, Y. B. / Chen, Z. J. / Cheng, W. S. / Choi, S. K. / Chu, X.

    2022  

    Abstract: Using $4.5 \mathrm{fb}^{-1}$ of $e^+e^-$ annihilation data samples collected at the center-of-mass energies ranging from 4.600 GeV to 4.699 GeV with the BESIII detector at the BEPCII collider, a first study of $\Lambda_c^+$ decaying semileptonically into ...

    Abstract Using $4.5 \mathrm{fb}^{-1}$ of $e^+e^-$ annihilation data samples collected at the center-of-mass energies ranging from 4.600 GeV to 4.699 GeV with the BESIII detector at the BEPCII collider, a first study of $\Lambda_c^+$ decaying semileptonically into the inclusive $pK^-$ system $\Lambda_c^+\rightarrow pK^-e^+\nu_e$ is performed. The $\Lambda_c^+\rightarrow pK^-e^+\nu_e$ decay is observed with a significance of $8.2\sigma$ and the branching fraction is measured to be $\mathcal{B}(\Lambda_c^+\rightarrow pK^- e^+\nu_e)=(0.82\pm0.15_{\rm stat.}\pm0.06_{\rm syst.})\times 10^{-3}$. In addition, first evidence for the decay $\Lambda_c^+\rightarrow \Lambda(1520) e^+\nu_e$ is obtained with a significance of $3.3\sigma$ and the branching fraction is measured to be $\mathcal{B}(\Lambda_c^+\rightarrow \Lambda(1520) e^+\nu_e)=(1.36\pm0.56_{\rm stat.}\pm0.14_{\rm syst.})\times 10^{-3}$. We also measure the branching fraction for $\Lambda_c^+\rightarrow pK^-_{\rm non-\Lambda(1520)} e^+\nu_e$ to be $\mathcal{B}(\Lambda_c^+\rightarrow pK^-_{\rm non-\Lambda(1520)} e^+\nu_e)=(0.53\pm0.15_{\rm stat.}\pm0.06_{\rm syst.})\times 10^{-3}$. Using a measurement of the inclusive semileptonic $\Lambda_c^+$ branching fraction from BESIII, the relative branching fractions are determined to be $[\mathcal{B}(\Lambda_c^+\rightarrow pK^-e^+\nu_e)/\mathcal{B}(\Lambda_c^+\rightarrow X e^+\nu_e)]=(2.1\pm0.4_{\rm stat.}\pm0.1_{\rm syst.})\%$ and $[\mathcal{B}(\Lambda_c^+\rightarrow \Lambda^*(1520) e^+\nu_e)/\mathcal{B}(\Lambda_c^+\rightarrow X e^+\nu_e)]=(3.4\pm1.4_{\rm stat.}\pm0.4_{\rm syst.})\%$. These measurements provide a clear confirmation that semileptonic $\Lambda_c^+$ decays are not saturated by the $\Lambda \ell^+\nu_{\ell}$ final state.

    Comment: 13 pages, 9 figures and 2 tables
    Keywords High Energy Physics - Experiment
    Subject code 612
    Publishing date 2022-07-23
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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