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Article ; Online: Giant Pseudoangiomatous Stromal Hyperplasia of the Adolescent Breast

Betul Duran / Burcin Agridag Ucpinar

Haseki Tıp Bülteni, Vol 60, Iss 2, Pp 183-

A Case Report with Emphasis on Image Findings and Literature Review

2022 Volume 185

Abstract: Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign mesenchymal proliferation of the breast with unclear etiology. It is diagnosed in a wide spectrum from incidental microscopic findings to palpable breast mass. Diagnosis is generally made in ... ...

Abstract	Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign mesenchymal proliferation of the breast with unclear etiology. It is diagnosed in a wide spectrum from incidental microscopic findings to palpable breast mass. Diagnosis is generally made in the premenopausal age group. PASH cases seen in adolescents reported in the literature are very rare and none of them has mentioned the radiologic features in detail. In this case report, we present a 12-year-old patient with giant (150x100x127 mm in size) PASH in her right breast, giving emphasis to the findings of the ultrasonography and magnetic resonance imaging, including contrast-enhanced dynamic and diffusion-weighted imaging sequences. To the best of our knowledge, the present case is the second biggest giant PASH seen in the adolescent age.
Keywords	pseudoangiomatous stromal hyperplasia ; breast neoplasms ; adolescent ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diagnostic Value of Diffusion Magnetic Resonance Imaging in Detecting Malignant Axillary Lymph Nodes in Breast Cancer Patients

Betul Duran / Burcin Agridag Ucpinar

Haseki Tıp Bülteni, Vol 59, Iss 5, Pp 381-

2021 Volume 387

Abstract: Aim:The prognostic value of apparent diffusion coefficient (ADC) measurement to detect axillary malignant lymph nodes in breast cancer is not clear. We aimed to investigate the prognostic importance of diffusion weighted imaging (DWI) in the ... ...

Abstract	Aim:The prognostic value of apparent diffusion coefficient (ADC) measurement to detect axillary malignant lymph nodes in breast cancer is not clear. We aimed to investigate the prognostic importance of diffusion weighted imaging (DWI) in the differentiation of metastatic and non-metastatic lymph nodes.Methods:Magnetic resonance imagings (MRIs) of 102 breast cancer patients were reviewed from the hospital PACS and automation systems between July 2018 and March 2021. Cortical thickness, short, long-axis diameters, long/short axis ratios and ADC measurements were done for ipsilateral and contralateral axillary lymph nodes. Univariate and multivariate regression analyses were performed.Results:Pathology revealed that 64 patients had ipsilateral metastatic lymph nodes while 38 patients did not. When grouped into metastatic and non-metastatic groups, breast tumor size, mean diameter of the short axis, long axis and cortical thickness were significantly higher in the metastatic group. Ipsilateral metastatic lymph nodes’ mean ADC values were significantly lower than non-metastatic ones with a calculated value of 0.972x10-3. The ipsilateral ADC value of the lymph node and loss of fatty hilum were the two significant factors to predict metastatic lymph nodes in multivariate analysis.Conclusion:DWI is a valuable noninvasive tool in the diagnosis of metastatic axillary lymph nodes.
Keywords	breast neoplasm ; axilla ; lymph nodes ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disseminated Juvenile Pilomyxoid Astrocytoma of the Hypothalamic-Chiasmatic Region

Ahmet Mesrur Halefoglu / Betul Duran Ozel

Acta Medica Iranica, Vol 57, Iss

2020 Volume 9

Abstract: Pilomyxoid astrocytoma (PMA) is a recently described histological type of pilocytic astrocytoma (PA), but the tumors show histological differences. PMA has more aggressive malignant behavior than PA. Magnetic Resonance Imaging (MRI) may play a crucial ... ...

Abstract	Pilomyxoid astrocytoma (PMA) is a recently described histological type of pilocytic astrocytoma (PA), but the tumors show histological differences. PMA has more aggressive malignant behavior than PA. Magnetic Resonance Imaging (MRI) may play a crucial role in the preoperative setting and also help to establish an appropriate therapeutic regimen. In this case report, we illustrated MRI findings of a hypothalamic-chiasmatic PMA in a 15-year-old female patient presenting with extensive leptomeningeal seeding. The patient was operated for total tumor resection, but could not survive the second post-operative day. We have comprehensively discussed the clinical, imaging, and histopathological features of these relatively rare tumors and also reviewed the recent literature.
Keywords	Pilocytic astrocytoma ; Pilomyxoid astrocytoma ; Leptomeningeal ; Dissemination ; Medicine (General) ; R5-920
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
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Article: Evaluation of diagnostic value of conventional and color Doppler ultrasound with elastography strain ratios in differentiation between benign and malignant lymph nodes.

Özel, Deniz / Özel, Betül Duran

Polish journal of radiology

2018 Volume 83, Page(s) e32–e36

Abstract: Introduction: The aim of this study was to evaluate the diagnostic value of conventional ultrasonography (USG) and color Doppler ultrasonography (CDU) with elastography strain ratios (ESR) in discrimination between benign and malignant lymphatic nodes.!# ...

Abstract	Introduction: The aim of this study was to evaluate the diagnostic value of conventional ultrasonography (USG) and color Doppler ultrasonography (CDU) with elastography strain ratios (ESR) in discrimination between benign and malignant lymphatic nodes. Material and methods: Two hundred and forty-seven patients (252 lymph nodes) were included in this study. USG and CDU with ESR were performed. Materials were obtained by using fine-needle or vacuum-assisted aspiration methods depending on the site and condition of lymph nodes. The χ Results: Ninety-two of 252 (36.5%) lymph nodes were malignant, and 160 (63.5%) were benign. Short axis, S/L ratio, presence or absence of the fatty hilum and extra-hilar vascularity were valuable, statistically significant indicators of malignancy. In contrast, long axis and ESR were not significant indicators of malignancy. The short axis cut-off value was calculated to be 12 mm and the S/L ratio cut-off value was calculated to be 1. Conclusions: Long axis of lymph nodes and strain ratios cannot be used as malignancy criteria, and their use is controversial despite the fact that some studies have found them valuable. On the other hand, our results support common knowledge that the short axis, S/L ratio, absence of the fatty hilum, and extrahilar vascularity are significant indicators.
Language	English
Publishing date	2018-02-04
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2675143-4
ISSN	1899-0967 ; 1733-134X
ISSN (online)	1899-0967
ISSN	1733-134X
DOI	10.5114/pjr.2018.73293
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluating the role of strain ratio elastography in determining malignancy potential and calculating objective BIRADS US scores using ultrasonography and elastography features.

Özel, Deniz / Özel, Betül Duran

Polish journal of radiology

2018 Volume 83, Page(s) e268–e274

Abstract: Purpose: The aims of this study were, firstly, to evaluate solid breast masses based on their malignancy potential and to determine whether the strain elastography ratio (SER) can contribute to classical grey-scale ultrasonography findings, and secondly, ...

Abstract	Purpose: The aims of this study were, firstly, to evaluate solid breast masses based on their malignancy potential and to determine whether the strain elastography ratio (SER) can contribute to classical grey-scale ultrasonography findings, and secondly, to define objective BIRADS US scores using ultrasound (US) and SER findings. Material and methods: A total of 280 patients and 297 solid breast masses were evaluated using sonographic and elastographic data. The SER was measured for each lesion. Results: The positive predictive values (PPV) for each criterion was calculated to be between 35% and 83.3%. The lowest PPV was obtained from hypoechogenicity (35%) and the highest PPV was obtained for anti-parallel features (83.3%). The difference between the mean SER of benign and malignant lesions was statistically significant. After ROC analysis, the SER cut-off value was calculated to be 3.1 for determining if the mass was benign or malignant. Mass scores were calculated for each solid breast mass based on positive predictive values, and BIRADS US score was defined as the sum of mass scores. Conclusions: SER findings can be used as malignancy criteria in evaluating solid breast masses. BIRADS US score can be objectively determined based on US and elastography features instead of doing subjective scoring. As an additional result, all solid breast masses have the possibility to be malignant, even though US and elastography findings indicate the opposite.
Language	English
Publishing date	2018-06-08
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2675143-4
ISSN	1899-0967 ; 1733-134X
ISSN (online)	1899-0967
ISSN	1733-134X
DOI	10.5114/pjr.2018.76790
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Article ; Online: A novel measurement to evaluate supraspinatus tendinopathies with strain elastography.

Özel, Deniz / Demir, Yüksel / Özel, Betül Duran / Adaş, Müjdat

Acta radiologica (Stockholm, Sweden : 1987)

2020 Volume 62, Issue 10, Page(s) 1365–1373

Abstract: Background: In addition to the traditional strain ratio (STR), a novel measurement termed hard percent of the whole tendon, provided by the device's software and resembling shear-wave elastography, was included in the study.: Purpose: To evaluate the ...

Abstract	Background: In addition to the traditional strain ratio (STR), a novel measurement termed hard percent of the whole tendon, provided by the device's software and resembling shear-wave elastography, was included in the study. Purpose: To evaluate the correlation between magnetic resonance imaging (MRI) and strain elastography findings in cases with rotator cuff tendinopathy, including tears. Material and methods: As a prospective study, cases suggestive of rotator cuff tendinopathy were included. After MRI evaluation by two observers, grading of the elastography examination was performed by a third radiologist. For the first measurement, the region of interest (ROI) was chosen from the gray-scale evaluation corresponding to the area showing a MRI pathological signal. Stiffness was assessed with the STR. For the second measurement, the whole visible tendon was measured as the ROI. The hard percent (unaffected areas as a percent) was measured. Correlation coefficients between MRI grade and the two strain value measurements were calculated. Results: There were 93 cases (31 men, 62 women) with 112 involved tendons. The correlation coefficient between MRI grade and age was calculated as 0.56, between MRI grade and STR it was -0.51, and with the novel measurement the correlation coefficient was -0.53. Conclusion: This study showed a good association of findings of tendon stiffness with those of tendinopathy on MRI. Using the hard ratio as a novel measurement, its correlation with MRI grade was as reliable as the STR. We also experienced that the benefit of elastography is a challenging issue for defining small ruptures.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Elasticity Imaging Techniques/methods ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Rotator Cuff/diagnostic imaging ; Rotator Cuff Injuries/diagnostic imaging ; Tendinopathy/diagnostic imaging ; Young Adult
Language	English
Publishing date	2020-10-29
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185120968567
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Article: Evaluating Qualitative and Quantitative Computerized Tomography Indicators of Chronic Obstructive Pulmonary Disease and Their Correlation with Pulmonary Function Tests.

Kaya, Lerzan / Özel, Deniz / Özel, Betül Duran

Polish journal of radiology

2017 Volume 82, Page(s) 511–515

Abstract: Background: With increasingly aging populations, chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death today. Emphysematous changes, an important component of the disease, must be determined on HRCT, either qualitatively or ... ...

Abstract	Background: With increasingly aging populations, chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death today. Emphysematous changes, an important component of the disease, must be determined on HRCT, either qualitatively or quantitatively. The purpose of this study was to evaluate features that help determine emphysematous changes and correlate them with respiratory function tests (RFTs). Material/methods: A total of thirty COPD patients and a control group of the same size, matched for age, were included in the study. The mean lung parenchyma density values on inspiration and expiration, visual HRCT scores, and pulmonary function tests were obtained. IBM SPSS statistical software (version 22) was used to perform correlation analysis (Pearson's coefficient) and the Mann-Whitney U test. Results: The most valuable RFTs for determining emphysematous changes were DLCO, FEV Conclusions: As regards the comparison between objective and subjective density values, the HRCT-based visual density values are satisfactory. On the other hand, the best assessment can be performed with the use of mean density values on expiration. DLCO, FEV
Language	English
Publishing date	2017-09-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2675143-4
ISSN	1899-0967 ; 1733-134X
ISSN (online)	1899-0967
ISSN	1733-134X
DOI	10.12659/PJR.901968
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Article ; Online: Obtaining accurate measurement of carotid intima-media thickness in children with classic congenital adrenal hyperplasia.

Ozkan, Fuat / Ozel, Deniz / Ozel, Betul Duran

European journal of pediatrics

2016 Volume 175, Issue 3, Page(s) 413–414

MeSH term(s)	Adrenal Hyperplasia, Congenital ; Carotid Arteries/diagnostic imaging ; Carotid Intima-Media Thickness ; Child ; Humans ; Risk Factors ; Tunica Intima/diagnostic imaging ; Tunica Media/diagnostic imaging
Language	English
Publishing date	2016-03
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-015-2677-3
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Article ; Online: Potential causes for obtaining non-diagnostic results from fine needle aspiration biopsy of thyroid nodules.

Özel, Deniz / Özel, Betül Duran / Özkan, Fuat

La Radiologia medica

2016 Volume 121, Issue 6, Page(s) 510–514

Abstract: Purpose: The aim of this prospective study was to evaluate factors that could affect the diagnostic result success ratio of fine needle aspiration biopsy of thyroid nodules.: Materials and methods: 664 patients and 696 nodules were included in this ... ...

Abstract	Purpose: The aim of this prospective study was to evaluate factors that could affect the diagnostic result success ratio of fine needle aspiration biopsy of thyroid nodules. Materials and methods: 664 patients and 696 nodules were included in this study. Demographic features of age and gender and nodule features of macrocalcification (MC) and internal content (cystic or solid predominance) were evaluated. All biopsies were performed from 1 cm or larger nodules. Three different size needles were used for comparison (22, 23 and 25 G). The patients in each group had a similar number of nodules with MC, and cystic predominance to obtain comparable results. All procedures were performed by the same radiologist, who had 4 years of experience. Histologically adequate material criteria were identified. All pathological specimens were evaluated as diagnostic or non-diagnostic by the same pathology technician. Chi-square, student's t test and univariate analysis were used for statistical analysis. Results: There were no statistically significant differences in demographic features and nodule properties from diagnostic results of fine needle aspiration biopsy of thyroid nodules. On the other hand, 23 G needles offered a better potential for obtaining adequate samples with a statistically significant difference. Conclusion: Obtaining adequate material in fine needle aspiration biopsy from thyroid nodules is a challenging issue and the results are controversial. Since we obtained the best ratio with 23 G needles, we recommend interventional radiologists to use 23 G needles as far as possible and not to consider needles thicker needles than 22 G or thinner than 25 G. Nodule features and demographic features did not have an effect on obtaining adequate cytological material.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Thyroid Nodule/pathology
Language	English
Publishing date	2016-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-016-0624-7
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Article ; Online: Diffuse cavernous hemangioma of the rectum

Ahmet Mesrur Halefoglu / Emel Kaya / Betul Duran Ozel

Şişli Etfal Hastanesi Tip Bülteni, Vol 48, Iss

magnetic resonance imaging features: a case report

2014 Volume 2

Abstract: Diffuse cavernous hemangioma of the rectum (DCHR) is a rare benign vascular lesion usually seen in young adults. The presenting symptom is painless recurrent rectal bleeding. Herein, we report a 5 year-old male patient with a history of DCHR. He had been ...

Abstract	Diffuse cavernous hemangioma of the rectum (DCHR) is a rare benign vascular lesion usually seen in young adults. The presenting symptom is painless recurrent rectal bleeding. Herein, we report a 5 year-old male patient with a history of DCHR. He had been diagnosed with DCHR at his birth. The definite diagnosis was made on the basis of biopsy wich was performed during colonoscopic examination. The patient underwent magnetic resonance imaging (MRI) examination which revealed characteristic signal intensity features of the tumor and also determined the exact location and extent of the lesion. The tumor had only minimally progressed in size compared to the last MRI examination. Currently, the patient is on medical treatment and being followed up by MRI. DCHRs are rarely encountered and often misdiagnosed because they can mimic internal hemorrhoids, inflammatory bowel disease, carcinoma and various other pathological conditions. In conclusion, we can emphasize that despite its rarity, DCHR should be considered in the differential diagnosis of young patients presenting with painless recurrent rectal bleeding.
Keywords	Diffuse cavernous hemangioma ; diagnosis ; rectal bleeding ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	Turkish
Publishing date	2014-01-01T00:00:00Z
Publisher	Yerkure Tanitim ve Yayincilik
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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