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  1. Book ; Conference proceedings ; Thesis: Metastasierungs- und Rezidivverhalten von plattenepithelialen Unterlippenkarzinomen

    Schieren, Ingmar Bernd Richard / Betz, Christian Stephan / Li, Lei

    eine retrospektive klinische Studie anhand eines Patientenkollektivs

    2020  

    Institution Universität Hamburg
    Event/congress Universität Hamburg (MedizinischeFakultät)
    Author's details vorgelegt von: Ingmar Bernd Richard Schieren ; Prüfungsausschuss, der Vorsitzende: Prof. Dr. Christian Betz, Prüfungsausschuss, zweiter Gutachter: PD Dr. Dr. Lei Li
    Subject code 610
    Language German
    Size 138 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Conference proceedings ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2021
    HBZ-ID HT021060513
    Database Catalogue ZB MED Medicine, Health

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    2021 E 1187 order for loan Magazin

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  2. Book ; Thesis: Erarbeitung eines perkutanen Injektionsweges in den Musculus constrictor pharyngis medius zur Therapie des Globus Pharyngis

    Schönholz, Sebastian / Betz, Christian Stephan / Hess, Markus M.

    2021  

    Institution Universität Hamburg
    Universität Hamburg / Medizinische Fakultät
    Author's details vorgelegt von: Sebastian Schönholz ; Prüfungsausschuss, der Vorsitzende: Prof. Dr. Christian Betz, Prüfungsausschuss, 2. Gutachter: Prof. Dr. Markus Hess
    Language German
    Size 94 Blätter, Illustrationen, 30 cm
    Publishing place Hamburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Hamburg, 2021
    HBZ-ID HT021379323
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Hereditary head and neck paraganglioma: from basics to practical consequences.

    Trache, Mihnea Cristian / Böttcher, Arne / Betz, Christian Stephan

    Current opinion in otolaryngology & head and neck surgery

    2022  Volume 31, Issue 2, Page(s) 111–117

    Abstract: Purpose of review: This review summarizes practical recommendations for screening, work-up, and management of hereditary head and neck paragangliomas based on the growing molecular and empirical understanding of this disease.: Recent findings: The ... ...

    Abstract Purpose of review: This review summarizes practical recommendations for screening, work-up, and management of hereditary head and neck paragangliomas based on the growing molecular and empirical understanding of this disease.
    Recent findings: The proportion of hereditary cases among head and neck paragangliomas is significant (∼33 to 50%), and specific genetic alterations may increase the risk of malignancy. Genotyping should be performed for each case, and patients carrying a pathological mutation should be regularly screened for new tumors. Computed tomography (CT), magnetic resonance imaging (MRI), digital subtraction angiography (DSA), and functional positron emission tomography (PET) can provide a reliable preoperative diagnosis in the absence of histology. Comparative data on therapeutic outcome and morbidity now render radiation, stereotactic radiosurgery, and active surveillance preferable over surgery in highly advanced cases of jugulotympanic and vagal paragangliomas, whereas surgery remains the first choice for most carotid body paragangliomas.
    Summary: Complete paraganglioma removal continues to be the primary therapeutic goal; however, this is sometimes impossible to accomplish with acceptable morbidity. In these cases, therapy selection should focus on preserving cranial nerve function and minimizing both tumor-associated and therapy-associated complications, particularly in genetically predisposed patients. An interdisciplinary approach to the management of hereditary head and neck paragangliomas is strongly recommended.
    MeSH term(s) Humans ; Head and Neck Neoplasms ; Paraganglioma, Extra-Adrenal/diagnosis ; Paraganglioma, Extra-Adrenal/genetics ; Paraganglioma, Extra-Adrenal/surgery ; Paraganglioma/diagnosis ; Paraganglioma/pathology ; Paraganglioma/surgery ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Conference proceedings: Psychische Folgen der Corona-Pandemie für HNO-ärzt:innen in Deutschland

    Schmitz, Lisa / Zech, Henrike / Betz, ChristianStephan

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766542
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  5. Article ; Online: Nasoseptal Flap for Skull Base Reconstruction in a Three-Year-Old Child With Nasofrontal Meningoencephalocele.

    Eden, Jördis Kristin / Böttcher, Arne / Betz, Christian Stephan

    Ear, nose, & throat journal

    2021  Volume 102, Issue 4, Page(s) NP149–NP153

    Abstract: Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. Traditionally, skull base defects have been repaired via a bifrontal craniotomy. With the ... ...

    Abstract Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. Traditionally, skull base defects have been repaired via a bifrontal craniotomy. With the introduction of pediatric endoscopic instrumentation, more of these lesions are accessible via an intranasal endoscopic approach, even in the infant population. However, due to the rarity of pediatric meningoencephaloceles, there is a lack of data demonstrating the successful adaptation of endoscopic skull base techniques to the pediatric population. In this report, we present a case of a pediatric frontonasal meningoencephalocele with an anterior skull base defect in a 3-year-old child that was successfully addressed transnasally following 4 failed transcranial approaches. The case highlights the importance of a thorough preoperative evaluation of the surgical approach as well as interdisciplinary management of these patients at a young age. Congenital anterior skull base defects with meningoencephaloceles and CSF leaks are rare clinical entities. Hence, an interdisciplinary approach is vital including experienced pediatricians, otolaryngologists, and neurosurgeons to evaluate the ideal surgical method on an individual basis. The transnasal endoscopic technique has been shown to be minimally invasive, efficient, and safe to apply even to the infant population which could positively be demonstrated in this case.
    MeSH term(s) Infant ; Humans ; Child ; Child, Preschool ; Plastic Surgery Procedures ; Surgical Flaps ; Skull Base/surgery ; Cerebrospinal Fluid Leak/etiology ; Cerebrospinal Fluid Leak/surgery ; Cerebrospinal Fluid Rhinorrhea/surgery ; Encephalocele/complications ; Encephalocele/surgery ; Meningocele/complications ; Meningocele/surgery ; Endoscopy/methods ; Retrospective Studies
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/0145561321995017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Conference proceedings: Der Verzicht auf eine adjuvante Radiatio des kontralateralen pathologisch negativen Halses scheint bei Oropharynxkarzinomen sicher zu sein

    Jansen, Florian / Betz, ChristianStephan / Möckelmann, Nikolaus / Böttcher, Arne

    Laryngo-Rhino-Otologie

    2023  Volume 102, Issue S 02

    Event/congress 94. Jahresversammlung Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn, Congress Center Leipzig, 2023-05-17
    Language German
    Publishing date 2023-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0043-1766613
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  7. Book: Autofluoreszenzdiagnostik von Karzinomen des oberen Luft-Speiseweges

    Betz, Christian Stephan / Arens, Christoph / Leunig, Andreas

    Grundlagen, praktische Durchführung und Ergebnisse

    2006  

    Author's details Christian Stephan Betz ; Christoph Arens ; Andreas Leunig
    Keywords Mundhöhlenkrebs ; Frühdiagnostik ; Fluoreszenz ; Fluorophore ; Endoskopie ; Videotechnik
    Subject Medizinische Endoskopie ; Endoskopische Untersuchung ; Diagnostische Endoskopie ; Spiegelung ; Früherkennung ; Frühdiagnose ; Mundhöhle ; Mundhöhlenkarzinom ; Mundhöhlencarcinom ; Orales Karzinom ; Orales Carcinom
    Language German
    Size 38 S., zahlr. Ill., graph. Darst., 28 cm, 158 gr.
    Publisher Verl. Endo-Press
    Publishing place Tuttlingen
    Publishing country Germany
    Document type Book
    HBZ-ID HT015794330
    ISBN 978-3-89756-130-4 ; 3-89756-130-1
    Database Catalogue ZB MED Medicine, Health

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  8. Article: A Four-Generational Report on Hereditary Head and Neck Paraganglioma.

    Trache, Mihnea Cristian / Bewarder, Julian / Betz, Christian Stephan / Möckelmann, Nikolaus / Böttcher, Arne

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24143

    Abstract: Background This article investigates the inheritance, penetrance, clinical presentation, and therapeutic outcomes of hereditary head and neck paragangliomas (HNPGLs) by offering a four-generational report of an 18-member family affected by this rare ... ...

    Abstract Background This article investigates the inheritance, penetrance, clinical presentation, and therapeutic outcomes of hereditary head and neck paragangliomas (HNPGLs) by offering a four-generational report of an 18-member family affected by this rare condition. Methodology Information was compiled by examination of patients and a review of medical records and correspondence (retrospective case series). Results Six members of the 18-member family were diagnosed with HNPGL between 2002 and 2018. A known pathogenic point mutation in subunit D of the succinyl dehydrogenase complex (SDHD, c.317G>T, p.Gly106Val) was responsible for the tumor phenotype. The mutation could be revealed in seven family members, three diseased adults, one healthy adult, and three healthy children, out of the nine who consented to gene testing. The median age at diagnosis was 33.5 years (range: 22-50 years). Five of the eight primary tumors were glomus caroticum, two were glomus jugulare, and one was a glomus vagale tumor. The therapeutic approaches were multimodal and included embolization therapy, surgery, radiation, and watchful waiting. Follow-up was reported for five of the six patients (mean follow-up of 34.8 months after primary therapy); three showed no disease progression or recurrence. Conclusions This study exemplifies the autosomal dominant, parent-of-origin-dependent inheritance and the high disease penetrance in hereditary paraganglioma-pheochromocytoma syndromes. Six out of a total of eight adult descendants (75%) of the original SDHD mutation carrier developed tumors, and the morbidity associated with the disease as well as its therapy was especially high in late-diagnosed, advanced cases. This substantiates the necessity for early radiologic surveillance and genetic testing.
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Evaluation of a short instrument for measuring health-related quality of life in oncological patients in routine care (HELP-6): an observational study.

    Schrage, Theresa / Görlach, Mirja / Betz, Christian Stephan / Bokemeyer, Carsten / Kröger, Nicolaus / Mueller, Volkmar / Krüll, Andreas / Schulz, Holger / Bleich, Christiane

    Frontiers in psychology

    2023  Volume 14, Page(s) 1158449

    Abstract: Purpose: Patient-reported outcomes have not been sufficiently implemented into the routine care of cancer patients because the existing instruments are often too long and complex or not cancer-specific. The aim of this study is the determination of ... ...

    Abstract Purpose: Patient-reported outcomes have not been sufficiently implemented into the routine care of cancer patients because the existing instruments are often too long and complex or not cancer-specific. The aim of this study is the determination of psychometric properties and item reduction of a newly developed health-related quality of life (HrQoL) questionnaire for use in oncological clinical routines.
    Methods: This observational study with a repeated measurements design included oncological inpatients and outpatients. A total of 630 patients participated at the first point of measurement and 404 at the second point of measurement. To evaluate the instrument, we conducted hierarchical confirmative factor analyses and for further validation correlated the resulting factors with standardized and validated HrQoL measurements. Test-retest reliability and responsiveness to change were tested.
    Results: The developed questionnaire "HELP-6" ("Hamburg Inventory for Measuring Quality of Life in Oncological Patients") has a six-factor structure and has moderate-to-good convergent validity (
    Conclusion: With the HELP-6 instrument for measuring HrQoL in cancer patients, we provide a short and practical patient-reported outcome instrument. Though responsiveness to change could not be confirmed for all dimensions in this study, the HELP-6 includes time-efficient completion and evaluation and is informative in relevant HrQoL dimensions of cancer patients. Therefore, the HELP-6 poses an important addition to inpatient and outpatient routine cancer care.
    Trial registration: This study was registered at Open Science Framework (https://osf.io/y7xce/), on 9 June 2018.
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1158449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characteristics of smell and taste disorders depending on etiology: a retrospective study.

    Trache, Mihnea Cristian / Schipp, Josef Maria Heinrich / Haack, Mareike / Adderson-Kisser, Christine / Högerle, Catalina / Becker, Sven / Betz, Christian Stephan

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 9, Page(s) 4111–4119

    Abstract: Purpose: This study investigates the impact of etiology on the epidemiologic profile, disease severity, type of treatment and therapy outcome in smell and taste disorders.: Methods: This is a retrospective analysis of 270 patients that presented with ...

    Abstract Purpose: This study investigates the impact of etiology on the epidemiologic profile, disease severity, type of treatment and therapy outcome in smell and taste disorders.
    Methods: This is a retrospective analysis of 270 patients that presented with a smell or taste disorder in a specialized, tertiary care center. An established questionnaire was used to collect data from patients and physicians. Olfactometry was performed with the Sniffin' Sticks test kit, while gustometry was performed by taste strips.
    Results: Post-traumatic etiology was associated with young age (median 46 years) and male sex, and showed the most severe degrees of smell loss compared to other etiologies (64.3% anosmia). Postinfectious causes occurred more frequently in females (77.3%) and correlated with a history of pharyngeal surgery, suggesting a vulnerability for virally mediated sensory dysfunction following adenoid/tonsil removal. Parosmia also correlated with both postinfectious etiology (62.5%) and female sex. In sinunasal etiology, the presence of nasal polyps worsened the overall olfactory test score by approximately 50%. In particular, smell threshold and discrimination were reduced, while smell identification was not significantly impacted by nasal polyp obstruction. Sinunasal dysfunction was the only etiology to show significant improvement after therapy (73.9% improved). Finally, we could establish good correlations between the subjective impairment and objective dysfunction for each sensory modality.
    Conclusion: Each etiology of chemosensory dysfunction shows particular distributions of variables like sex, age, comorbidities and operations, disease severity, sensory threshold, discrimination and identification. This paper offers a detailed account of the correlations between the cause and the characteristics of smell and taste loss.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Smell ; Retrospective Studies ; Taste Disorders/diagnosis ; Taste Disorders/epidemiology ; Taste Disorders/etiology ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Nasal Polyps/complications ; Anosmia ; Taste
    Language English
    Publishing date 2023-05-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-07967-1
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