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Article ; Online: Spezielle Tumorentitäten im Kopf-Hals-Bereich: Nasopharynxkarzinom, Speicheldrüsenkarzinom und Schilddrüsenkarzinom.

Zech, Henrike B / Betz, Christian S

2023 Volume 71, Issue 7, Page(s) 453–461

Abstract: Background: At the meetings of the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) in 2022, studies were presented which suggest changes in the clinical routine of nasopharyngeal, salivary gland, and ... ...

Title translation	Special tumor entities in the head and neck region: nasopharyngeal, salivary gland, and thyroid cancer.
Abstract	Background: At the meetings of the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO) in 2022, studies were presented which suggest changes in the clinical routine of nasopharyngeal, salivary gland, and thyroid cancer. Objective: Therapeutic innovations for special otorhinolaryngological tumor entities with potential clinical relevance were assessed after reviewing the studies presented at the ASCO 2022/ESMO 2022 meetings. Materials and methods: The presented clinical phase II and phase III studies were analyzed. Results were classified according to their potential clinical importance, taking into account current treatment standards. Results: Three studies were presented that dealt with the topic of risk-adapted treatment stratification in advanced nasopharyngeal cancer. Dose-reduced radiotherapy (60 Gy) in low-risk patients resulted in a favorable toxicity profile with promising oncological results in a single-arm phase II study. In a phase III study, intensity-modulated radiotherapy alone showed comparable survival to combined radiochemotherapy with cisplatin in selected low-risk patients. In high-risk patients, addition of the EGFR antibody nimotuzumab to definitive radiochemotherapy showed an increased 5‑year survival rate compared to placebo (phase III study). Although an immediate change in clinical practice in Europe based on these studies is questionable, the concept of risk-adapted therapy taking into account biological characteristics (Epstein-Barr virus [EBV] DNA level) is future orientated. Similar to previous years, the contributions on recurrent/metastatic salivary gland and thyroid cancer emphasized the importance of targeted therapies based on vulnerable molecular target lesions.
MeSH term(s)	Humans ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharyngeal Neoplasms/therapy ; Nasopharyngeal Neoplasms/pathology ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; Chemoradiotherapy ; Salivary Glands/pathology ; Clinical Trials, Phase II as Topic
Language	German
Publishing date	2023-06-09
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-023-01312-y
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Article ; Online: Endonasal-endoskopische anteriore Schädelbasischirurgie : Darstellung eines monozentrischen Entitätenprofils.

Schmitz, Lisa / Betz, Christian S / Stölzel, Katharina

HNO

2024 Volume 72, Issue 4, Page(s) 265–271

Abstract: Background: Extended endoscopic endonasal surgery (EEES) is an essential part of treatment of various pathologies of the anterior skull base. In addition to significant improvements in the quality of life of affected patients and a lower complication ... ...

Title translation	Endoscopic endonasal anterior skull base surgery : Presentation of a monocentric entity profile.
Abstract	Background: Extended endoscopic endonasal surgery (EEES) is an essential part of treatment of various pathologies of the anterior skull base. In addition to significant improvements in the quality of life of affected patients and a lower complication profile compared to open skull base surgery, the therapeutic results are comparable if the indications are correct. Materials and methods: Data of all endoscopic endonasal skull base procedures performed at the University Skull Base Center Hamburg under the direction of the Department of Otorhinolaryngology between June 2018 and November 2022 were retrospectively collected. Results: A total of 50 cases were identified. Of these, 56% (28/50) were malignant tumors, 24% (12/50) were benign pathologies with direct skull base involvement, and 20% (10/50) were anterior skull base defects with rhinoliquorrhea. In 96% (48/50) of cases, the preoperatively set goal of surgery (representative biopsy, complete resection, closure of the skull base defect) could be achieved. Complications grade III or higher according to Clavien-Dindo occurred in 4/50 cases. During the observation period, n = 5 olfactory neuroblastomas were diagnosed, all of which were exclusively and successfully operated on endoscopically. Conclusion: In recent years, the spectrum of endoscopically resectable pathologies of the anterior skull base has steadily expanded. In particular, midline-related tumors such as olfactory neuroblastoma or iatrogenic/idiopathic skull base defects with cerebrospinal fluid rhinorrhea are treated completely endoscopically with very good results. Nevertheless, there are also limitations to this technique. Due to high variance in the scope of frontobasal surgery, the extent, and the complex anatomy, as well as the overlapping responsibilities of the specialist disciplines, establishment of certified skull base centers and bundling of frontobasal surgery at these centers is highly relevant for quality assurance.
MeSH term(s)	Humans ; Retrospective Studies ; Quality of Life ; Skull Base/surgery ; Skull Base/pathology ; Endoscopy/methods ; Cerebrospinal Fluid Rhinorrhea/etiology ; Cerebrospinal Fluid Rhinorrhea/pathology ; Cerebrospinal Fluid Rhinorrhea/surgery
Language	German
Publishing date	2024-02-23
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-024-01438-7
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Article ; Online: Spezielle Tumorentitäten im Kopf-Hals-Bereich : Nasopharynxkarzinom, Speicheldrüsenkarzinom und Schilddrüsenkarzinom.

Zech, Henrike B / Betz, Christian S

HNO

2022 Volume 70, Issue 4, Page(s) 278–286

Abstract: Background: In recent years the number of studies on special tumor entities in the head and neck region has increased. During the 2021 meetings of the American Society of Clinical Oncology (ASMO) and the European Society for Medical Oncology (ESMO), ... ...

Title translation	Special tumor entities in the head and neck region : Nasopharyngeal carcinoma, salivary gland, and thyroid cancer.
Abstract	Background: In recent years the number of studies on special tumor entities in the head and neck region has increased. During the 2021 meetings of the American Society of Clinical Oncology (ASMO) and the European Society for Medical Oncology (ESMO), several studies were presented which predict changes in clinical treatment algorithms for nasopharyngeal carcinoma, salivary gland, and thyroid cancer. Objective: Future treatment alterations in specific head and neck tumor entities were evaluated after screening clinical studies presented at the 2021 ASCO and ESMO meetings. Materials and methods: A systematic analysis of the phase II and III clinical trials for nasopharyngeal carcinoma, salivary gland, and thyroid cancer treatment presented at ASCO and ESMO 2021 was performed. Taking into account current treatment standards, the results are structured in terms of their potential clinical significance. Results and conclusion: In curative treatment of advanced nasopharyngeal carcinoma, adjuvant therapy with capecitabine after primary chemoradiation should be discussed as a new standard. In the palliative treatment of nasopharyngeal carcinoma, an increasing role of immunotherapy can be predicted. Recurrent or metastatic salivary gland cancer can often be treated very effectively with targeted substances if molecular target lesions are present. Immunotherapies currently play a subordinate role; they only seem to be effective in a few patients with salivary gland cancer, who cannot currently be reliably identified using predictive markers. Patients with radioiodine-refractory differentiated thyroid cancer benefit from treatment with the multi-tyrosine kinase inhibitor cabozantinib after failure of vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) therapy.
MeSH term(s)	Humans ; Iodine Radioisotopes/therapeutic use ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/therapy ; Salivary Glands/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/therapy ; Vascular Endothelial Growth Factor A/therapeutic use
Chemical Substances	Iodine Radioisotopes ; Vascular Endothelial Growth Factor A
Language	German
Publishing date	2022-03-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-022-01157-x
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Article ; Online: Entscheidungsfindung bei der Behandlung der chronischen Rhinosinusitis mit Nasenpolypen in der Ära der Biologika.

Hoffmann, Anna S / Betz, Christian S / Böscke, Robert / Weber, Rainer K

HNO

2024 Volume 72, Issue 4, Page(s) 225–230

Abstract: Chronic rhinosinusitis is one of the most common chronic diseases in the population. Chronic rhinosinusitis with nasal polyps (CRSwNP) in adults is predominantly characterized by a type 2 inflammatory endotype. If sufficient control cannot be achieved ... ...

Title translation	Decision-making in the treatment of chronic rhinosinusitis with nasal polyps in the era of biologics.
Abstract	Chronic rhinosinusitis is one of the most common chronic diseases in the population. Chronic rhinosinusitis with nasal polyps (CRSwNP) in adults is predominantly characterized by a type 2 inflammatory endotype. If sufficient control cannot be achieved through primary drug therapy, surgical intervention is usually recommended as the next stage of treatment. Nowadays, various biologics are available that have been or will be approved for use in these patients. This review summarizes the presentations from the 29th Congress of the European Rhinologic Society in Sofia 2023 and the latest findings on decision-making in the treatment of CRSwNP. Standard therapy with medication and sinus surgery fails in some patients with CRSwNP. Biologics that act on the type 2 inflammatory pathway led to a reduction in the nasal polyp score (NPS), an improvement in nasal obstruction, and an improvement in quality of life without significant side effects. Biomarkers such as total IgE, serum eosinophils, and Osteoprotegerin (OPG) can provide indications of the success of the treatment. In summary, it can be said that for many patients with recurrent CRSwNP, a combination of paranasal sinus surgery and treatment with a biologic that is precisely tailored to the patient's endotype is the best option. However, the question of which surgical approach and which biologic at which time and for which patient is still ongoing and requires further studies.
MeSH term(s)	Adult ; Humans ; Nasal Polyps/complications ; Nasal Polyps/therapy ; Quality of Life ; Rhinosinusitis ; Rhinitis/complications ; Rhinitis/diagnosis ; Rhinitis/drug therapy ; Sinusitis/complications ; Sinusitis/diagnosis ; Sinusitis/drug therapy ; Biological Products/therapeutic use ; Chronic Disease
Chemical Substances	Biological Products
Language	German
Publishing date	2024-02-20
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-024-01430-1
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Article: The "fascia taco" for nasal septum perforation closure-A retrospective Cohort study on success rates and patient reported outcomes.

Bier, Johannes / Klingner, Alexandra / Stadlhofer, Rupert / Betz, Christian S / Böttcher, Arne

Laryngoscope investigative otolaryngology

2024 Volume 9, Issue 2, Page(s) e1248

Abstract: Objective: Nasal septum perforation (NSP) is a common condition affecting ~1.2% of the general population and is still considered challenging to treat. Therapeutic strategies range from conservative local treatments and septal button closures to over 40 ...

Abstract	Objective: Nasal septum perforation (NSP) is a common condition affecting ~1.2% of the general population and is still considered challenging to treat. Therapeutic strategies range from conservative local treatments and septal button closures to over 40 different surgical approaches. This study aimed to present a novel secure approach. Methods: We describe our novel and unique NSP closure approach using a "fascia taco," in which conchal cartilage is enveloped by temporalis fascia like a taco and splints are left in place for 6-8 weeks. A review of patient charts was conducted and questionnaires including the German-SNOT-22 and D-NOSE were sent by mail to all eligible patients who received a fascia taco between 2016 and 2021. Results: Thirty-three patients were identified. The questionnaire response rate was 54.5%. The mean operative time (cut to sew) for all patients who only underwent NSP closure was 90.4 min. The overall success rate in terms of postoperative NSP closure was 81.8%. We found an apparent but nonsignificant association between closure failure and smoking (failure rate 66.6% in smokers vs. 15.4% in nonsmokers; Conclusion: The fascia taco technique is an easy-to-apply, safe procedure for NSP closure that is short in duration and associated with a low morbidity, resulting in excellent patient satisfaction. Level of evidence: 4.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.1248
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Article ; Online: Wieviel Digitalisierung braucht die HNO-Lehre? : Chancen und Grenzen aus Sicht von Studierenden und Lehrenden.

Schmitz, Lisa / Betz, Christian S / Böttcher, Arne / Häußler, Sophia M / Praetorius, Mark

HNO

2024 Volume 72, Issue 5, Page(s) 325–333

Abstract: Background: Digitalization has long been an integral part of students' everyday lives and increasingly also of their medical training. It seems to be an unwritten law that "digital natives" want as much digitalization as possible. This study aims to ... ...

Title translation	How much digitization do ENT curricula need? : Opportunities and limits from the perspective of students and teachers.
Abstract	Background: Digitalization has long been an integral part of students' everyday lives and increasingly also of their medical training. It seems to be an unwritten law that "digital natives" want as much digitalization as possible. This study aims to shed more light on how students in the clinical phase of medical studies perceive the increasing digitalization of teaching and what they need for good education. Materials and methods: This study analyzed two surveys that were conducted using an online questionnaire. On the one hand, students in the 5th-9th semesters of the medical faculty at the University of Hamburg (n = 282) were surveyed (survey 1). Another survey addressed all employees of ENT clinics in Germany (n = 175; survey 2). Results: A total of 76 students took part in survey 1 and 123 lecturers in survey 2. The results show that both students and lecturers do not want face-to-face teaching to be completely replaced by digital formats. A total of 72.7% of students reject the possibility of teaching practical skills through digital formats. The majority of students surveyed stated that offline formats improve their concentration (61.1%), participation probability (63.9%), and motivation to learn (76.6%). In contrast, 40.2% of lecturers see digitalization as a way to reduce the workload without any relevant loss in teaching quality. Conclusion: Digital teaching formats have a negative impact on the medical education of the students surveyed. Interaction and physical presence are needed to increase the motivation to learn. This leads to the first conclusion that students are critical of the increasing digitalization of medical studies.
MeSH term(s)	Germany ; Students, Medical/statistics & numerical data ; Curriculum ; Male ; Female ; Humans ; Otolaryngology/education ; Attitude of Health Personnel ; Adult ; Computer-Assisted Instruction/methods ; Computer-Assisted Instruction/statistics & numerical data ; Young Adult ; Needs Assessment ; Attitude to Computers ; Faculty, Medical ; Surveys and Questionnaires
Language	German
Publishing date	2024-02-19
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-024-01437-8
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Article ; Online: Hereditary head and neck paraganglioma: from basics to practical consequences.

Trache, Mihnea Cristian / Böttcher, Arne / Betz, Christian Stephan

Current opinion in otolaryngology & head and neck surgery

2022 Volume 31, Issue 2, Page(s) 111–117

Abstract: Purpose of review: This review summarizes practical recommendations for screening, work-up, and management of hereditary head and neck paragangliomas based on the growing molecular and empirical understanding of this disease.: Recent findings: The ... ...

Abstract	Purpose of review: This review summarizes practical recommendations for screening, work-up, and management of hereditary head and neck paragangliomas based on the growing molecular and empirical understanding of this disease. Recent findings: The proportion of hereditary cases among head and neck paragangliomas is significant (∼33 to 50%), and specific genetic alterations may increase the risk of malignancy. Genotyping should be performed for each case, and patients carrying a pathological mutation should be regularly screened for new tumors. Computed tomography (CT), magnetic resonance imaging (MRI), digital subtraction angiography (DSA), and functional positron emission tomography (PET) can provide a reliable preoperative diagnosis in the absence of histology. Comparative data on therapeutic outcome and morbidity now render radiation, stereotactic radiosurgery, and active surveillance preferable over surgery in highly advanced cases of jugulotympanic and vagal paragangliomas, whereas surgery remains the first choice for most carotid body paragangliomas. Summary: Complete paraganglioma removal continues to be the primary therapeutic goal; however, this is sometimes impossible to accomplish with acceptable morbidity. In these cases, therapy selection should focus on preserving cranial nerve function and minimizing both tumor-associated and therapy-associated complications, particularly in genetically predisposed patients. An interdisciplinary approach to the management of hereditary head and neck paragangliomas is strongly recommended.
MeSH term(s)	Humans ; Head and Neck Neoplasms ; Paraganglioma, Extra-Adrenal/diagnosis ; Paraganglioma, Extra-Adrenal/genetics ; Paraganglioma, Extra-Adrenal/surgery ; Paraganglioma/diagnosis ; Paraganglioma/pathology ; Paraganglioma/surgery ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1232518-1
ISSN	1531-6998 ; 1068-9508
ISSN (online)	1531-6998
ISSN	1068-9508
DOI	10.1097/MOO.0000000000000867
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Article ; Online: Optische Diagnoseverfahren zur Verbesserung der Tumorfrühdiagnostik im oberen Luft-Speise-Weg.

Betz, C S

HNO

2016 Volume 64, Issue 1, Page(s) 2–3

Title translation	Optical diagnostic methods for improving early tumor diagnosis in the upper aerodigestive tract.
MeSH term(s)	Early Detection of Cancer/methods ; Endoscopy/methods ; Gastrointestinal Neoplasms/pathology ; Humans ; Microscopy/methods ; Respiratory Tract Neoplasms/pathology ; Tomography, Optical/methods ; Tomography, Optical Coherence/methods
Language	German
Publishing date	2016-01
Publishing country	Germany
Document type	Introductory Journal Article
ZDB-ID	200040-4
ISSN	1433-0458 ; 0017-6192
ISSN (online)	1433-0458
ISSN	0017-6192
DOI	10.1007/s00106-015-0103-9
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Article ; Online: Nasoseptal Flap for Skull Base Reconstruction in a Three-Year-Old Child With Nasofrontal Meningoencephalocele.

Eden, Jördis Kristin / Böttcher, Arne / Betz, Christian Stephan

Ear, nose, & throat journal

2021 Volume 102, Issue 4, Page(s) NP149–NP153

Abstract: Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. Traditionally, skull base defects have been repaired via a bifrontal craniotomy. With the ... ...

Abstract	Congenital anterior skull base defects with meningoencephaloceles causing nasal obstruction and cerebrospinal fluid (CSF) rhinorrhea are rare clinical entities. Traditionally, skull base defects have been repaired via a bifrontal craniotomy. With the introduction of pediatric endoscopic instrumentation, more of these lesions are accessible via an intranasal endoscopic approach, even in the infant population. However, due to the rarity of pediatric meningoencephaloceles, there is a lack of data demonstrating the successful adaptation of endoscopic skull base techniques to the pediatric population. In this report, we present a case of a pediatric frontonasal meningoencephalocele with an anterior skull base defect in a 3-year-old child that was successfully addressed transnasally following 4 failed transcranial approaches. The case highlights the importance of a thorough preoperative evaluation of the surgical approach as well as interdisciplinary management of these patients at a young age. Congenital anterior skull base defects with meningoencephaloceles and CSF leaks are rare clinical entities. Hence, an interdisciplinary approach is vital including experienced pediatricians, otolaryngologists, and neurosurgeons to evaluate the ideal surgical method on an individual basis. The transnasal endoscopic technique has been shown to be minimally invasive, efficient, and safe to apply even to the infant population which could positively be demonstrated in this case.
MeSH term(s)	Infant ; Humans ; Child ; Child, Preschool ; Plastic Surgery Procedures ; Surgical Flaps ; Skull Base/surgery ; Cerebrospinal Fluid Leak/etiology ; Cerebrospinal Fluid Leak/surgery ; Cerebrospinal Fluid Rhinorrhea/surgery ; Encephalocele/complications ; Encephalocele/surgery ; Meningocele/complications ; Meningocele/surgery ; Endoscopy/methods ; Retrospective Studies
Language	English
Publishing date	2021-02-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/0145561321995017
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Article ; Conference proceedings: Endoskopische Schädelbasischirurgie – eine monozentrische Fallserie

Betz, Christian S. / Jansen, Florian / Stölzel, Katharina

Laryngo-Rhino-Otologie

(Abstract- und Posterband)

2022 Volume 101, Issue S 02

Event/congress	Abstract- und Posterband - 93. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn Interface - Fokus Mensch im Zeitalter der technisierten Medizin, Deutsche Messe Hannover, 2022-05-25
Series title	Abstract- und Posterband
Language	German
Publishing date	2022-05-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0042-1747555
Database	Thieme publisher's database

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