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  1. Book ; Conference proceedings: Progress in primary aldosteronism

    Beuschlein, Felix

    [in July 2009, the International Symposium Progress in Primary Aldosteronism was held ... in Munich, Germany]

    (Hormone and metabolic research ; 42,6 = Special issue)

    2010  

    Event/congress International Symposium Progress in Primary Aldosteronism (2009, München)
    Author's details guest ed.: F. Beuschlein
    Series title Hormone and metabolic research ; 42,6 = Special issue
    Collection
    Language English
    Size S. 371 - 465 : Ill., graph. Darst.
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT016688747
    Database Catalogue ZB MED Medicine, Health

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    Zs A 681 -42- not available for loan Zeitschriften-Lesesaal

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  2. Book: Facharztprüfung innere Medizin

    Beuschlein, Felix / Endres, Stefan

    in Fällen, Fragen und Antworten ; [mit dem Plus im Web]

    2013  

    Title variant Innere Medizin
    Author's details hrsg. von Stefan Endres. Mit Beitr. von Felix Beuschlein
    Keywords Innere Krankheit
    Subject Innere Erkrankung
    Language German
    Size XV, 557 S. : zahlr. Ill., graph. Darst., 240 mm x 170 mm
    Edition 4., aktualisierte Aufl.
    Publisher Elsevier, Urban & Fischer
    Publishing place München
    Publishing country Germany
    Document type Book
    Accompanying material Zugang zu zusätzlichem Internetmaterial über Code
    HBZ-ID HT017593526
    ISBN 978-3-437-23334-0 ; 3-437-23334-3 ; 9783437168376 ; 3437168371
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2013 A 728 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtliche Gründen nicht verfügbar

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  3. Article ; Online: Connshing syndrome - myth or reality?

    Beuschlein, Felix

    Annales d'endocrinologie

    2018  Volume 79, Issue 3, Page(s) 123–124

    MeSH term(s) Cushing Syndrome/classification ; Cushing Syndrome/diagnosis ; Cushing Syndrome/etiology ; Humans ; Hydrocortisone/secretion ; Syndrome ; Terminology as Topic
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2018-04-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2018.03.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Secondary hypertension as a cause of treatment resistance.

    Sudano, Isabella / Suter, Paolo / Beuschlein, Felix

    Blood pressure

    2023  Volume 32, Issue 1, Page(s) 2224898

    Abstract: In secondary hypertension, elevated blood pressure is caused by a known and/or potentially treatable underlying disease.Although the prevalence of secondary hypertension depends on the patient population and the thoroughness of applied diagnostic ... ...

    Abstract In secondary hypertension, elevated blood pressure is caused by a known and/or potentially treatable underlying disease.Although the prevalence of secondary hypertension depends on the patient population and the thoroughness of applied diagnostic approaches, arterial hypertension is classified in 90 to 95% as primary in nature. In young patients, individuals without a family history of hypertension, late onset of hypertension or worsening of a previous well-controlled hypertension as well as in patients who have a difficult to treat hypertension, the prevalence of secondary hypertension is significantly higher.Because the identification and the specific therapy of secondary hypertension may result in normalisation or improvement of elevated blood pressure in many cases, a targeted diagnostics is of great importance.
    MeSH term(s) Humans ; Hyperaldosteronism/diagnosis ; Hypertension/epidemiology
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1170048-8
    ISSN 1651-1999 ; 1651-2480 ; 0803-7051 ; 0803-8023
    ISSN (online) 1651-1999 ; 1651-2480
    ISSN 0803-7051 ; 0803-8023
    DOI 10.1080/08037051.2023.2224898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Autonome Kortisolsekretion : Laborartefakt oder Krankheit?

    Riester, Anna / Beuschlein, Felix

    Der Internist

    2021  Volume 63, Issue 1, Page(s) 18–24

    Abstract: Background: Autonomous cortisol secretion was mentioned for the first time in 2016 in the European Guideline on the management of adrenal incidentalomas.: Objectives: Review of the state of knowledge on diagnosis, epidemiology, co-morbidities, ... ...

    Title translation Autonomous cortisol secretion : Laboratory artifact or disease?
    Abstract Background: Autonomous cortisol secretion was mentioned for the first time in 2016 in the European Guideline on the management of adrenal incidentalomas.
    Objectives: Review of the state of knowledge on diagnosis, epidemiology, co-morbidities, mortality and treatment of autonomous cortisol secretion in comparison to non-hormone producing adenomas. Recommendation for clinical practice based on the current European guideline.
    Materials und methods: Analysis of relevant clinical studies, discussion of basic literature and expert opinions.
    Results and conclusions: Autonomous cortisol secretion is a term used to describe abnormal cortisol secretion diagnosed by a pathological 1‑mg dexamethasone suppression test in patients with adrenal incidentaloma, but without clinical manifestation of overt Cushing's syndrome. It is associated with increased mortality and morbidity, especially hypertension, diabetes mellitus type II, dyslipidemia and obesity. Adrenalectomy, as the only specific therapy option, should be considered in an interdisciplinary tumour board.
    MeSH term(s) Adrenal Gland Neoplasms/diagnosis ; Artifacts ; Dexamethasone ; Humans ; Hydrocortisone ; Laboratories
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Hydrocortisone (WI4X0X7BPJ)
    Language German
    Publishing date 2021-10-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01188-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is there a role for the adrenal glands in long COVID?

    Kanczkowski, Waldemar / Beuschlein, Felix / Bornstein, Stefan R

    Nature reviews. Endocrinology

    2022  Volume 18, Issue 8, Page(s) 451–452

    MeSH term(s) Adrenal Glands ; COVID-19/complications ; Humans
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-022-00700-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 93: Show issues

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  7. Article ; Online: Hypokalemia and the Prevalence of Primary Aldosteronism.

    Gruber, Sven / Beuschlein, Felix

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2020  Volume 52, Issue 6, Page(s) 347–356

    Abstract: Hypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of ... ...

    Abstract Hypokalemia is closely linked with the pathophysiology of primary aldosteronism (PA). Although hypokalemic PA is less common than the normokalemic course of the disease, hypokalemia is of particular importance for the manifestation and development of comorbidities. Specifically, a growing body of evidence demonstrates that hypokalemia in PA patients is associated with a more severe disease course regarding cardiovascular and metabolic morbidity and mortality. It is also well appreciated that low potassium levels per se can promote or exacerbate hypertension. The spectrum of hypokalemia-related symptoms ranges from asymptomatic courses to life-threatening conditions. Hypokalemia is found in 9-37% of all cases of PA with a predominance in patients with aldosterone producing adenoma. Conversely, hypokalemia resolves in almost 100% of cases after both, specific medical or surgical treatment of the disease. However, to date, high-level evidence about the prevalence of primary aldosteronism in a hypokalemic population is missing. Epidemiological data are expected from the recently launched IPAHK+study ("Incidence of Primary Aldosteronism in Patients with Hypokalemia").
    MeSH term(s) Adrenal Cortex Neoplasms/complications ; Adrenal Cortex Neoplasms/epidemiology ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/pathology ; Adrenocortical Adenoma/complications ; Adrenocortical Adenoma/epidemiology ; Adrenocortical Adenoma/metabolism ; Adrenocortical Adenoma/pathology ; Aldosterone/metabolism ; Disease Progression ; Humans ; Hyperaldosteronism/epidemiology ; Hyperaldosteronism/etiology ; Hyperaldosteronism/pathology ; Hypertension/complications ; Hypertension/epidemiology ; Hypertension/pathology ; Hypokalemia/complications ; Hypokalemia/epidemiology ; Hypokalemia/pathology ; Prevalence ; Severity of Illness Index
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2020-04-06
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1134-4980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 681: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Book ; Thesis: Untersuchungen zur klonalen Zusammensetzung tumoröser und hyperplastischer Raumforderungen der Nebennierenrinde des Menschen

    Beuschlein, Felix

    1996  

    Author's details vorgelegt von Felix Beuschlein
    Language German
    Size 96 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1998
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT009507968
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1998 MB 2788 order for loan Magazin

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  9. Article ; Online: Adrenocortical carcinoma - towards genomics guided clinical care.

    Crona, Joakim / Beuschlein, Felix

    Nature reviews. Endocrinology

    2019  Volume 15, Issue 9, Page(s) 548–560

    Abstract: Adrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates in the cortex of the adrenal gland. The disease is associated with heterogeneous but mostly poor outcomes and lacks effective pharmaceutical treatment options. Multi-omics ... ...

    Abstract Adrenocortical carcinoma (ACC) is an aggressive and rare neoplasm that originates in the cortex of the adrenal gland. The disease is associated with heterogeneous but mostly poor outcomes and lacks effective pharmaceutical treatment options. Multi-omics studies have defined the landscape of molecular alterations in ACC. Specific molecular signatures can be detected in body fluids, potentially enabling improved diagnostic applications for patients with adrenal tumours. Importantly, pan-molecular data sets further reveal a spectrum within ACC, with three major subgroups that have different disease outcomes. These new subgroups have value as prognostic biomarkers. Research has revealed that the p53-RB and the WNT-β-catenin pathways are common disease drivers in ACC. However, these pathways remain difficult to target by therapeutic interventions. Instead, a unique characteristic of ACC is steroidogenic differentiation, which has emerged as a potential treatment target, with several agents undergoing preclinical or clinical investigations. Finally, a large proportion of ACC tumours have genetic profiles that are associated with promising therapeutic responsiveness in other cancers. All these opportunities now await translation from the laboratory into the clinical setting, thereby offering a real potential of improved survival outcomes and increased quality of life for patients with this serious condition.
    MeSH term(s) Adrenal Cortex Neoplasms/diagnosis ; Adrenal Cortex Neoplasms/genetics ; Adrenal Cortex Neoplasms/therapy ; Adrenocortical Carcinoma/diagnosis ; Adrenocortical Carcinoma/genetics ; Adrenocortical Carcinoma/therapy ; Antibodies, Monoclonal/therapeutic use ; Biomarkers, Tumor/genetics ; Clinical Trials as Topic/methods ; Genetic Therapy/methods ; Genomics/methods ; Humans
    Chemical Substances Antibodies, Monoclonal ; Biomarkers, Tumor
    Language English
    Publishing date 2019-05-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-019-0221-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Disease monitoring of patients with pheochromocytoma or paraganglioma by biomarkers and imaging studies.

    Schreiner, Florentine / Beuschlein, Felix

    Best practice & research. Clinical endocrinology & metabolism

    2019  Volume 34, Issue 2, Page(s) 101347

    Abstract: Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, a large proportion of which secrete catecholamines. PPGL are associated with a high cardiovascular morbidity and come with a risk of malignancy. The therapy of choice is surgical ... ...

    Abstract Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors, a large proportion of which secrete catecholamines. PPGL are associated with a high cardiovascular morbidity and come with a risk of malignancy. The therapy of choice is surgical resection. Nevertheless, PPGL are associated with a lifelong risk of tumor persistence or recurrence. Currently, there are no clinical, biochemical, histopathological or imaging characteristics, which can predict or exclude malignant behavior or tumor recurrence. Therefore, long-term follow-up is recommended even after apparent complete surgical removal. Early detection of recurrence is essential to reduce cardiovascular morbidity and mortality due to catecholamine secretion, to prevent morbidity by mass effects of paraganglioma (PGL) or by metastatic spread of disease. Due to the rarity of these tumors, no prospective data on long-term surveillance exist. In fact, current recommendations are based on retrospective analyses, expert opinions and case studies. The aim of this review is to provide an overview on the current state of knowledge with regard to known factors that increase the risk of recurrence and might impact disease monitoring as well as the available possibilities for biochemical and imaging follow-up. Based on this overview, we aim to propose a practical approach for a patient-oriented follow-up after surgical removal of a PPGL.
    MeSH term(s) Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/epidemiology ; Adrenal Gland Neoplasms/therapy ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/urine ; Diagnostic Imaging/methods ; Diagnostic Imaging/standards ; Humans ; Monitoring, Physiologic/methods ; Monitoring, Physiologic/standards ; Morbidity ; Paraganglioma/diagnosis ; Paraganglioma/epidemiology ; Paraganglioma/therapy ; Pheochromocytoma/diagnosis ; Pheochromocytoma/epidemiology ; Pheochromocytoma/therapy ; Retrospective Studies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-10-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2019.101347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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