Article: A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Cell. 2022 Mar. 03, v. 185, no. 5
2022
Abstract: Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated ... ...
Institution | COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium |
---|---|
Abstract | Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 severity in an integrated comparison with influenza and sepsis patients versus healthy volunteers. We identify immune signatures and correlates of host response. Hallmarks of disease severity involved cells, their inflammatory mediators and networks, including progenitor cells and specific myeloid and lymphocyte subsets, features of the immune repertoire, acute phase response, metabolism, and coagulation. Persisting immune activation involving AP-1/p38MAPK was a specific feature of COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive of severity and outcome. Systems-based integrative analyses including tensor and matrix decomposition of all modalities revealed feature groupings linked with severity and specificity compared to influenza and sepsis. Our approach and blood atlas will support future drug development, clinical trial design, and personalized medicine approaches for COVID-19. |
Keywords | COVID-19 infection ; biomarkers ; clinical trials ; coagulation ; disease severity ; drug development ; influenza ; metabolism ; patients ; precision medicine ; proteome |
Language | English |
Dates of publication | 2022-0303 |
Size | p. 916-938.e58. |
Publishing place | Elsevier Inc. |
Document type | Article |
ZDB-ID | 187009-9 |
ISSN | 1097-4172 ; 0092-8674 |
ISSN (online) | 1097-4172 |
ISSN | 0092-8674 |
DOI | 10.1016/j.cell.2022.01.012 |
Database | NAL-Catalogue (AGRICOLA) |
More links
Kategorien
In stock of ZB MED Bonn / Germany
Z 75/702: Show issues | ||||
Z 93: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.