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  1. Article: Management of acute aortic dissection in critical care.

    Flower, Luke / Arrowsmith, Joseph E / Bewley, Jeremy / Cook, Samantha / Cooper, Graham / Flower, Jake / Greco, Renata / Sadeque, Syed / Madhivathanan, Pradeep R

    Journal of the Intensive Care Society

    2023  Volume 24, Issue 4, Page(s) 409–418

    Abstract: Aortic dissections are associated with significant mortality and morbidity, with rapid treatment paramount. They are caused by a tear in the intimal lining of the aorta that extends into the media of the wall. Blood flow through this tear leads to the ... ...

    Abstract Aortic dissections are associated with significant mortality and morbidity, with rapid treatment paramount. They are caused by a tear in the intimal lining of the aorta that extends into the media of the wall. Blood flow through this tear leads to the formation of a false passage bordered by the inner and outer layers of the media. Their diagnosis is challenging, with most deaths caused by aortic dissection diagnosed at post-mortem. Aortic dissections are classified by location and chronicity, with management strategies depending on the nature of the dissection. The Stanford method splits aortic dissections into type A and B, with type A dissections involving the ascending aorta. De Bakey classifies dissections into I, II or III depending on their origin and involvement and degree of extension. The key to diagnosis is early suspicion, appropriate imaging and rapid initiation of treatment. Treatment focuses on initial resuscitation, transfer (if possible and required) to a suitable specialist centre, strict blood pressure and heart rate control and potentially surgical intervention depending on the type and complexity of the dissection. Effective post-operative care is extremely important, with awareness of potential post-operative complications and a multi-disciplinary rehabilitation approach required. In this review article we will discuss the aetiology and classifications of aortic dissection, their diagnosis and treatment principles relevant to critical care. Critical care clinicians play a key part in all these steps, from diagnosis through to post-operative care, and thus a thorough understanding is vital.
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2701626-2
    ISSN 1751-1437 ; 1751-1437
    ISSN (online) 1751-1437
    ISSN 1751-1437
    DOI 10.1177/17511437231162219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mechanical insufflation-exsufflation to promote extubation success in critically ill adults on intensive care: protocol for a randomised controlled feasibility trial.

    Swingwood, Ema / Voss, Sarah / Tume, Lyvonne N / Bewley, Jeremy / Turner, Nicholas / Ntoumenopoulos, George / Rose, Louise / Cramp, Fiona

    Pilot and feasibility studies

    2023  Volume 9, Issue 1, Page(s) 129

    Abstract: Background: Extubation failure, defined as reintubation within 48 h, is associated with increased intensive care unit (ICU) length of stay and higher mortality risk. One cause of extubation failure is secretion retention, resulting from an inability to ... ...

    Abstract Background: Extubation failure, defined as reintubation within 48 h, is associated with increased intensive care unit (ICU) length of stay and higher mortality risk. One cause of extubation failure is secretion retention, resulting from an inability to cough effectively. Mechanical insufflation-exsufflation (MI-E) simulates a cough aiding secretion clearance. However, MI-E is not routinely used in the ICU for invasively ventilated patients. This study aims to determine feasibility and acceptability of a randomised controlled trial (RCT) examining MI-E use to promote extubation success in intubated, ventilated adults.
    Methods: It is a single-centre, feasibility RCT with semi-structured interviews, economic scoping, and exploratory physiology study. The feasibility RCT (n = 50) will compare standard care to a MI-E protocol including a minimum of two MI-E sessions via the endotracheal tube prior to extubation. Post-extubation, MI-E will be delivered via facemask or mouthpiece up to two times/day for 48 h. MI-E settings will be individualised. All patients will receive standard care (no MI-E) in relation to mechanical ventilation, weaning, rehabilitation, physiotherapy techniques such as positioning, manual airway clearance techniques, manual/ventilator hyperinflation, endotracheal suctioning, and nebulisation. Clinical data collection will occur before, on completion, and 5-min post-physiotherapy sessions (intervention/control arms). Resource use will be calculated for each 24-h period. Analyses will be descriptive and address feasibility outcomes including participant recruitment and attrition, proportion of MI-E treatment sessions completed, dataset completeness, and frequency of adverse events and acceptability. Semi-structured online interviews informed by the Theoretical Framework of Acceptability (TFA) with patients, clinicians, and family members will explore the acceptability of the MI-E intervention and study processes. Interview data will be analysed using reflexive thematic analysis based on TFA domains through first-level coding. The embedded physiology study will use electrical impedance tomography and lung ultrasound to explore lung recruitment and de-recruitment during MI-E in a subset of 5-10 patients.
    Discussion: This study will examine feasibility and acceptability of a RCT protocol of MI-E to promote extubation success. Study findings will inform design modification and conduct of a future adequately powered trial. Furthermore, the study will contribute and advance the understanding of MI-E use in critically ill intubated adults.
    Trial registration: ISRCTN 24603037; IRAS 303674.
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809935-7
    ISSN 2055-5784
    ISSN 2055-5784
    DOI 10.1186/s40814-023-01362-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Acute renal failure: beware development of abdominal compartment syndrome.

    Bewley, Jeremy S

    BMJ (Clinical research ed.)

    2006  Volume 333, Issue 7574, Page(s) 917–918

    MeSH term(s) Abdomen ; Acute Kidney Injury/complications ; Compartment Syndromes/etiology ; Humans
    Language English
    Publishing date 2006-10-28
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.333.7574.917-c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults.

    Swingwood, Ema L / Stilma, Willemke / Tume, Lyvonne N / Cramp, Fiona / Voss, Sarah / Bewley, Jeremy / Ntoumenopoulos, George / Schultz, Marcus J / Scholte Op Reimer, Wilma / Paulus, Frederique / Rose, Louise

    Respiratory care

    2022  Volume 67, Issue 8, Page(s) 1043–1057

    Abstract: Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated ...

    Abstract Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated critically ill adults. Two authors independently searched electronic databases MEDLINE, Embase, and CINAHL via the Ovid platform; PROSPERO; Cochrane Library; ISI Web of Science; and International Clinical Trials Registry Platform between January 1990-April 2021. Inclusion criteria were (1) adult critically ill invasively ventilated subjects, (2) use of MI-E, (3) study design with original data, and (4) published from 1990 onward. Data were extracted by 2 authors independently using a bespoke extraction form. We used Mixed Methods Appraisal Tool to appraise risk of bias. Theoretical Domains Framework was used to interpret qualitative data. Of 3,090 citations identified, 28 citations were taken forward for data extraction. Main indications for MI-E use during invasive ventilation were presence of secretions and mucus plugging (13/28, 46%). Perceived contraindications related to use of high levels of positive pressure (18/28, 68%). Protocolized MI-E settings with a pressure of ±40 cm H
    MeSH term(s) Adult ; Critical Illness/therapy ; Humans ; Insufflation/methods ; Lung ; Respiration, Artificial/adverse effects
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.09704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Death from paracetamol overdose despite appropriate treatment with N-acetylcysteine.

    Bourdeaux, Chris / Bewley, Jeremy

    Emergency medicine journal : EMJ

    2007  Volume 24, Issue 5, Page(s) e31

    Abstract: A case of death from severe paracetamol poisoning which presented early and received appropriate treatment according to evidence-based guidelines is presented here. It is very rare for patients to die from paracetamol poisoning when they receive N- ... ...

    Abstract A case of death from severe paracetamol poisoning which presented early and received appropriate treatment according to evidence-based guidelines is presented here. It is very rare for patients to die from paracetamol poisoning when they receive N-acetylcysteine (NAC) within 8 h of ingestion. The patient had a marked lactic acidosis on presentation to hospital. This case demonstrates that a patient can die from paracetamol poisoning despite early and appropriate treatment, and raises the question whether lactic acidosis in a patient following paracetamol overdose should prompt the initiation of NAC treatment while awaiting paracetamol levels.
    MeSH term(s) Acetaminophen/poisoning ; Acetylcysteine/therapeutic use ; Analgesics, Non-Narcotic/poisoning ; Drug Overdose/complications ; Drug Overdose/drug therapy ; Fatal Outcome ; Free Radical Scavengers/therapeutic use ; Humans ; Male ; Middle Aged ; Multiple Organ Failure/chemically induced
    Chemical Substances Analgesics, Non-Narcotic ; Free Radical Scavengers ; Acetaminophen (362O9ITL9D) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2007-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2040124-3
    ISSN 1472-0213 ; 1472-0205
    ISSN (online) 1472-0213
    ISSN 1472-0205
    DOI 10.1136/emj.2006.043216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Using 'nudge' principles for order set design: a before and after evaluation of an electronic prescribing template in critical care.

    Bourdeaux, Christopher P / Davies, Keith J / Thomas, Matthew J C / Bewley, Jeremy S / Gould, Timothy H

    BMJ quality & safety

    2014  Volume 23, Issue 5, Page(s) 382–388

    Abstract: Objective: Computerised order sets have the potential to reduce clinical variation and improve patient safety but the effect is variable. We sought to evaluate the impact of changes to the design of an order set on the delivery of chlorhexidine ... ...

    Abstract Objective: Computerised order sets have the potential to reduce clinical variation and improve patient safety but the effect is variable. We sought to evaluate the impact of changes to the design of an order set on the delivery of chlorhexidine mouthwash and hydroxyethyl starch (HES) to patients in the intensive care unit.
    Methods: The study was conducted at University Hospitals Bristol NHS Foundation Trust, UK. Our intensive care unit uses a clinical information system (CIS). All drugs and fluids are prescribed with the CIS and drug and fluid charts are stored within a database. Chlorhexidine mouthwash was added as a default prescription to the prescribing template in January 2010. HES was removed from the prescribing template in April 2009. Both interventions were available to prescribe manually throughout the study period. We conducted a database review of all patients eligible for each intervention before and after changes to the configuration of choices within the prescribing system.
    Results: 2231 ventilated patients were identified as appropriate for treatment with chlorhexidine, 591 before the intervention and 1640 after. 55.3% were prescribed chlorhexidine before the change and 90.4% after (p<0.001). 6199 patients were considered in the HES intervention, 2177 before the intervention and 4022 after. The mean volume of HES infused per patient fell from 630 mL to 20 mL after the change (p<0.001) and the percentage of patients receiving HES fell from 54.1% to 3.1% (p<0.001). These results were well sustained with time.
    Conclusions: The presentation of choices within an electronic prescribing system influenced the delivery of evidence-based interventions in a predictable way and the effect was well sustained. This approach has the potential to enhance the effectiveness of computerised order sets.
    MeSH term(s) Chlorhexidine/therapeutic use ; Controlled Before-After Studies ; Critical Care/methods ; Critical Care/organization & administration ; Critical Care/standards ; Electronic Prescribing/standards ; Humans ; Hydroxyethyl Starch Derivatives/therapeutic use ; Mouthwashes/therapeutic use ; Patient Safety ; Respiration, Artificial
    Chemical Substances Hydroxyethyl Starch Derivatives ; Mouthwashes ; Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 2592912-4
    ISSN 2044-5423 ; 2044-5415
    ISSN (online) 2044-5423
    ISSN 2044-5415
    DOI 10.1136/bmjqs-2013-002395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.

    Eastwood, Glenn / Nichol, Alistair D / Hodgson, Carol / Parke, Rachael L / McGuinness, Shay / Nielsen, Niklas / Bernard, Stephen / Skrifvars, Markus B / Stub, Dion / Taccone, Fabio S / Archer, John / Kutsogiannis, Demetrios / Dankiewicz, Josef / Lilja, Gisela / Cronberg, Tobias / Kirkegaard, Hans / Capellier, Gilles / Landoni, Giovanni / Horn, Janneke /
    Olasveengen, Theresa / Arabi, Yaseen / Chia, Yew Woon / Markota, Andrej / Hænggi, Matthias / Wise, Matt P / Grejs, Anders M / Christensen, Steffen / Munk-Andersen, Heidi / Granfeldt, Asger / Andersen, Geir Ø / Qvigstad, Eirik / Flaa, Arnljot / Thomas, Matthew / Sweet, Katie / Bewley, Jeremy / Bäcklund, Minna / Tiainen, Marjaana / Iten, Manuela / Levis, Anja / Peck, Leah / Walsham, James / Deane, Adam / Ghosh, Angajendra / Annoni, Filippo / Chen, Yan / Knight, David / Lesona, Eden / Tlayjeh, Haytham / Svenšek, Franc / McGuigan, Peter J / Cole, Jade / Pogson, David / Hilty, Matthias P / Düring, Joachim P / Bailey, Michael J / Paul, Eldho / Ady, Bridget / Ainscough, Kate / Hunt, Anna / Monahan, Sinéad / Trapani, Tony / Fahey, Ciara / Bellomo, Rinaldo

    The New England journal of medicine

    2023  Volume 389, Issue 1, Page(s) 45–57

    Abstract: Background: Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes.: Methods: We randomly assigned ... ...

    Abstract Background: Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes.
    Methods: We randomly assigned adults with coma who had been resuscitated after out-of-hospital cardiac arrest of presumed cardiac or unknown cause and admitted to the intensive care unit (ICU) in a 1:1 ratio to either 24 hours of mild hypercapnia (target partial pressure of arterial carbon dioxide [Paco
    Results: A total of 1700 patients from 63 ICUs in 17 countries were recruited, with 847 patients assigned to targeted mild hypercapnia and 853 to targeted normocapnia. A favorable neurologic outcome at 6 months occurred in 332 of 764 patients (43.5%) in the mild hypercapnia group and in 350 of 784 (44.6%) in the normocapnia group (relative risk, 0.98; 95% confidence interval [CI], 0.87 to 1.11; P = 0.76). Death within 6 months after randomization occurred in 393 of 816 patients (48.2%) in the mild hypercapnia group and in 382 of 832 (45.9%) in the normocapnia group (relative risk, 1.05; 95% CI, 0.94 to 1.16). The incidence of adverse events did not differ significantly between groups.
    Conclusions: In patients with coma who were resuscitated after out-of-hospital cardiac arrest, targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months than targeted normocapnia. (Funded by the National Health and Medical Research Council of Australia and others; TAME ClinicalTrials.gov number, NCT03114033.).
    MeSH term(s) Adult ; Humans ; Carbon Dioxide/blood ; Coma/blood ; Coma/etiology ; Hospitalization ; Hypercapnia/blood ; Hypercapnia/etiology ; Out-of-Hospital Cardiac Arrest/blood ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/therapy ; Cardiopulmonary Resuscitation ; Critical Care
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2214552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest.

    Dankiewicz, Josef / Cronberg, Tobias / Lilja, Gisela / Jakobsen, Janus C / Levin, Helena / Ullén, Susann / Rylander, Christian / Wise, Matt P / Oddo, Mauro / Cariou, Alain / Bělohlávek, Jan / Hovdenes, Jan / Saxena, Manoj / Kirkegaard, Hans / Young, Paul J / Pelosi, Paolo / Storm, Christian / Taccone, Fabio S / Joannidis, Michael /
    Callaway, Clifton / Eastwood, Glenn M / Morgan, Matt P G / Nordberg, Per / Erlinge, David / Nichol, Alistair D / Chew, Michelle S / Hollenberg, Jacob / Thomas, Matthew / Bewley, Jeremy / Sweet, Katie / Grejs, Anders M / Christensen, Steffen / Haenggi, Matthias / Levis, Anja / Lundin, Andreas / Düring, Joachim / Schmidbauer, Simon / Keeble, Thomas R / Karamasis, Grigoris V / Schrag, Claudia / Faessler, Edith / Smid, Ondrej / Otáhal, Michal / Maggiorini, Marco / Wendel Garcia, Pedro D / Jaubert, Paul / Cole, Jade M / Solar, Miroslav / Borgquist, Ola / Leithner, Christoph / Abed-Maillard, Samia / Navarra, Leanlove / Annborn, Martin / Undén, Johan / Brunetti, Iole / Awad, Akil / McGuigan, Peter / Bjørkholt Olsen, Roy / Cassina, Tiziano / Vignon, Philippe / Langeland, Halvor / Lange, Theis / Friberg, Hans / Nielsen, Niklas

    The New England journal of medicine

    2021  Volume 384, Issue 24, Page(s) 2283–2294

    Abstract: Background: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty.: Methods: In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with ...

    Abstract Background: Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty.
    Methods: In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, or targeted normothermia with early treatment of fever (body temperature, ≥37.8°C). The primary outcome was death from any cause at 6 months. Secondary outcomes included functional outcome at 6 months as assessed with the modified Rankin scale. Prespecified subgroups were defined according to sex, age, initial cardiac rhythm, time to return of spontaneous circulation, and presence or absence of shock on admission. Prespecified adverse events were pneumonia, sepsis, bleeding, arrhythmia resulting in hemodynamic compromise, and skin complications related to the temperature management device.
    Results: A total of 1850 patients were evaluated for the primary outcome. At 6 months, 465 of 925 patients (50%) in the hypothermia group had died, as compared with 446 of 925 (48%) in the normothermia group (relative risk with hypothermia, 1.04; 95% confidence interval [CI], 0.94 to 1.14; P = 0.37). Of the 1747 patients in whom the functional outcome was assessed, 488 of 881 (55%) in the hypothermia group had moderately severe disability or worse (modified Rankin scale score ≥4), as compared with 479 of 866 (55%) in the normothermia group (relative risk with hypothermia, 1.00; 95% CI, 0.92 to 1.09). Outcomes were consistent in the prespecified subgroups. Arrhythmia resulting in hemodynamic compromise was more common in the hypothermia group than in the normothermia group (24% vs. 17%, P<0.001). The incidence of other adverse events did not differ significantly between the two groups.
    Conclusions: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not lead to a lower incidence of death by 6 months than targeted normothermia. (Funded by the Swedish Research Council and others; TTM2 ClinicalTrials.gov number, NCT02908308.).
    MeSH term(s) Aged ; Body Temperature ; Cardiopulmonary Resuscitation/methods ; Coma/etiology ; Coma/therapy ; Female ; Fever/etiology ; Fever/therapy ; Humans ; Hypothermia, Induced/adverse effects ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Out-of-Hospital Cardiac Arrest/complications ; Out-of-Hospital Cardiac Arrest/mortality ; Out-of-Hospital Cardiac Arrest/therapy ; Single-Blind Method ; Treatment Outcome
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Comparative Study ; Equivalence Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2100591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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