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  1. Book ; Thesis: In-vitro-Differenzierung unreifer Thymozyten der Ratte

    Beyer, Marc

    Analyse der Signaltransduktionskaskaden

    2001  

    Author's details vorgelegt von Marc Beyer
    Language German
    Size 80 Bl., Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 2002
    HBZ-ID HT013457367
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 4234 order for loan Magazin

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  2. Book ; Thesis: Induktion einer tumorspezifischen autologen T-Zellantwort durch Kokultivierung oder Fusion dendritischer Zellen mit primären Tumorzellen

    Beyer, Marc Daniel

    2005  

    Author's details vorgelegt von Marc Daniel Beyer
    Language German
    Size 126 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 2005
    HBZ-ID HT014489052
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2004 D 1565 order for loan Magazin

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  3. Article ; Online: ATAC-ing human tissue Treg cells.

    Köhne, Maren / Beyer, Marc

    Immunity

    2021  Volume 54, Issue 4, Page(s) 605–607

    Abstract: What defines regulatory T (Treg) cells in healthy human tissues? In this issue of Immunity, Delacher et al. describe a human follicular helper T cell-like tissue-repair Treg cell signature governed by BATF based on chromatin accessibility data and link ... ...

    Abstract What defines regulatory T (Treg) cells in healthy human tissues? In this issue of Immunity, Delacher et al. describe a human follicular helper T cell-like tissue-repair Treg cell signature governed by BATF based on chromatin accessibility data and link this on a transcriptome and protein level to important functional features like CCR8 expression.
    MeSH term(s) Chromatin ; Humans ; T-Lymphocytes, Regulatory ; Transcriptome
    Chemical Substances Chromatin
    Language English
    Publishing date 2021-04-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.03.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 69: Show issues

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  4. Article ; Online: Epigenetic control of microglial immune responses.

    Scholz, Rebekka / Brösamle, Desirée / Yuan, Xidi / Beyer, Marc / Neher, Jonas J

    Immunological reviews

    2024  

    Abstract: Microglia, the major population of brain-resident macrophages, are now recognized as a heterogeneous population comprising several cell subtypes with different (so far mostly supposed) functions in health and disease. A number of studies have performed ... ...

    Abstract Microglia, the major population of brain-resident macrophages, are now recognized as a heterogeneous population comprising several cell subtypes with different (so far mostly supposed) functions in health and disease. A number of studies have performed molecular characterization of these different microglial activation states over the last years making use of "omics" technologies, that is transcriptomics, proteomics and, less frequently, epigenomics profiling. These approaches offer the possibility to identify disease mechanisms, discover novel diagnostic biomarkers, and develop new therapeutic strategies. Here, we focus on epigenetic profiling as a means to understand microglial immune responses beyond what other omics methods can offer, that is, revealing past and present molecular responses, gene regulatory networks and potential future response trajectories, and defining cell subtype-specific disease relevance through mapping non-coding genetic variants. We review the current knowledge in the field regarding epigenetic regulation of microglial identity and function, provide an exemplary analysis that demonstrates the advantages of performing joint transcriptomic and epigenomic profiling of single microglial cells and discuss how comprehensive epigenetic analyses may enhance our understanding of microglial pathophysiology.
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lung T cell response in COVID-19.

    Shakiba, Mehrnoush Hadaddzadeh / Gemünd, Ioanna / Beyer, Marc / Bonaguro, Lorenzo

    Frontiers in immunology

    2023  Volume 14, Page(s) 1108716

    Abstract: The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory ... ...

    Abstract The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory response in driving both the resolution of the disease and uncontrolled deleterious inflammatory status in severe cases. In this mini-review, we cover some important aspects of the role of T cells in COVID-19 with a special focus on the local response in the lung. We focus on the reported T cell phenotypes in mild, moderate, and severe COVID-19, focusing on lung inflammation and on both the protective and damaging roles of the T cell response, also highlighting the open questions in the field.
    MeSH term(s) Humans ; COVID-19/immunology ; Lung/immunology ; Pandemics ; SARS-CoV-2 ; T-Lymphocytes/immunology ; Inflammation/immunology
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1108716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Implications of regulatory T cells in non-lymphoid tissue physiology and pathophysiology.

    Malko, Darya / Elmzzahi, Tarek / Beyer, Marc

    Frontiers in immunology

    2022  Volume 13, Page(s) 954798

    Abstract: Treg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during ... ...

    Abstract Treg cells have been initially described as gatekeepers for the control of autoimmunity, as they can actively suppress the activity of other immune cells. However, their role goes beyond this as Treg cells further control immune responses during infections and tumor development. Furthermore, Treg cells can acquire additional properties for e.g., the control of tissue homeostasis. This is instructed by a specific differentiation program and the acquisition of effector properties unique to Treg cells in non-lymphoid tissues. These tissue Treg cells can further adapt to their tissue environment and acquire distinct functional properties through specific transcription factors activated by a combination of tissue derived factors, including tissue-specific antigens and cytokines. In this review, we will focus on recent findings extending our current understanding of the role and differentiation of these tissue Treg cells. As such we will highlight the importance of tissue Treg cells for tissue maintenance, regeneration, and repair in adipose tissue, muscle, CNS, liver, kidney, reproductive organs, and the lung.
    MeSH term(s) Antigens ; Autoimmunity ; Cell Differentiation ; Homeostasis ; T-Lymphocytes, Regulatory ; Transcription Factors
    Chemical Substances Antigens ; Transcription Factors
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.954798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Combined Analysis of mRNA Expression and Open Chromatin in Microglia.

    Scholz, Rebekka / Brösamle, Desirée / Yuan, Xidi / Neher, Jonas J / Beyer, Marc

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2713, Page(s) 543–571

    Abstract: The advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity of microglial cell states in the homeostatic and diseased brain. This includes rather complex proteomic, ... ...

    Abstract The advance of single-cell RNA-sequencing technologies in the past years has enabled unprecedented insights into the complexity and heterogeneity of microglial cell states in the homeostatic and diseased brain. This includes rather complex proteomic, metabolomic, morphological, transcriptomic, and epigenetic adaptations to external stimuli and challenges resulting in a novel concept of core microglia properties and functions. To uncover the regulatory programs facilitating the rapid transcriptomic adaptation in response to changes in the local microenvironment, the accessibility of gene bodies and gene regulatory elements can be assessed. Here, we describe the application of a previously published method for simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq) on microglia nuclei isolated from frozen mouse brain tissue.
    MeSH term(s) Animals ; Mice ; Chromatin/genetics ; Microglia ; Proteomics ; RNA, Messenger/genetics ; RNA
    Chemical Substances Chromatin ; RNA, Messenger ; RNA (63231-63-0)
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3437-0_35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cost-Efficient Transcriptomic-Based Drug Screening.

    Leidner, Jacqueline / Theis, Heidi / Kraut, Michael / Ragogna, Alice / Beyer, Marc / Schultze, Joachim / Schulte-Schrepping, Jonas / Carraro, Caterina / Bonaguro, Lorenzo

    Journal of visualized experiments : JoVE

    2024  , Issue 204

    Abstract: Transcriptomics allows to obtain comprehensive insights into cellular programs and their responses to perturbations. Despite a significant decrease in the costs of library production and sequencing in the last decade, applying these technologies at the ... ...

    Abstract Transcriptomics allows to obtain comprehensive insights into cellular programs and their responses to perturbations. Despite a significant decrease in the costs of library production and sequencing in the last decade, applying these technologies at the scale necessary for drug screening remains prohibitively expensive, obstructing the immense potential of these methods. Our study presents a cost-effective system for transcriptome-based drug screening, combining miniaturized perturbation cultures with mini-bulk transcriptomics. The optimized mini-bulk protocol provides informative biological signals at cost-effective sequencing depth, enabling extensive screening of known drugs and new molecules. Depending on the chosen treatment and incubation time, this protocol will result in sequencing libraries within approximately 2 days. Due to several stopping points within this protocol, the library preparation, as well as the sequencing, can be performed time-independently. Processing simultaneously a high number of samples is possible; measurement of up to 384 samples was tested without loss of data quality. There are also no known limitations to the number of conditions and/or drugs, despite considering variability in optimal drug incubation times.
    MeSH term(s) Transcriptome ; Drug Evaluation, Preclinical ; Gene Expression Profiling ; Gene Library ; Costs and Cost Analysis
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Interleukin-2 treatment of tumor patients can expand regulatory T cells.

    Beyer, Marc

    Oncoimmunology

    2012  Volume 1, Issue 7, Page(s) 1181–1182

    Abstract: Augmented numbers of regulatory T cells contribute to the overall immunosuppression in tumor patients. Interleukin-2 has been widely used in the clinics in anticancer therapy, yet evidence has accumulated that the major drawback, limiting clinical ... ...

    Abstract Augmented numbers of regulatory T cells contribute to the overall immunosuppression in tumor patients. Interleukin-2 has been widely used in the clinics in anticancer therapy, yet evidence has accumulated that the major drawback, limiting clinical efficacy, is the expansion of regulatory T cells, which aggravates immunosuppression.
    Language English
    Publishing date 2012-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.20639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A guide to systems-level immunomics.

    Bonaguro, Lorenzo / Schulte-Schrepping, Jonas / Ulas, Thomas / Aschenbrenner, Anna C / Beyer, Marc / Schultze, Joachim L

    Nature immunology

    2022  Volume 23, Issue 10, Page(s) 1412–1423

    Abstract: The immune system is highly complex and distributed throughout an organism, with hundreds to thousands of cell states existing in parallel with diverse molecular pathways interacting in a highly dynamic and coordinated fashion. Although the ... ...

    Abstract The immune system is highly complex and distributed throughout an organism, with hundreds to thousands of cell states existing in parallel with diverse molecular pathways interacting in a highly dynamic and coordinated fashion. Although the characterization of individual genes and molecules is of the utmost importance for understanding immune-system function, high-throughput, high-resolution omics technologies combined with sophisticated computational modeling and machine-learning approaches are creating opportunities to complement standard immunological methods with new insights into immune-system dynamics. Like systems immunology itself, immunology researchers must take advantage of these technologies and form their own diverse networks, connecting with researchers from other disciplines. This Review is an introduction and 'how-to guide' for immunologists with no particular experience in the field of omics but with the intention to learn about and apply these systems-level approaches, and for immunologists who want to make the most of interdisciplinary networks.
    MeSH term(s) Computer Simulation ; Immune System ; Machine Learning
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01309-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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