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  1. AU="Bezler, Valerie"
  2. AU="Kevin Rostásy"
  3. AU=van Helden Mary J.
  4. AU="Grzegorz Adamczyk"
  5. AU="Longo, M"
  6. AU="Debarnot, Cecilé"
  7. AU="Thomas, Sophie"
  8. AU=Steyer Terence E AU=Steyer Terence E
  9. AU="Retrouvey, Jean-Marc"
  10. AU="Crecchio, Carmine"
  11. AU=Moll Philip J. W.
  12. AU="Coombs, Catherine C"
  13. AU="Safaei, Naser"
  14. AU="Bachouche, Imene"
  15. AU="Roignant, Jean-Yves"
  16. AU="Thabet, Nagwa"
  17. AU="Asor, Eyal"
  18. AU="Rahaman, Md Hasibur"
  19. AU="Angela Di Capua"
  20. AU=De Vitis R
  21. AU="Young, Kaelin C"

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  1. Artikel ; Online: IRF4 downregulation improves sensitivity and endurance of CAR T cell functional capacities.

    Harrer, Dennis Christoph / Bezler, Valerie / Hartley, Jordan / Herr, Wolfgang / Abken, Hinrich

    Frontiers in immunology

    2023  Band 14, Seite(n) 1185618

    Abstract: Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors. Crucial ... ...

    Abstract Chimeric antigen receptor (CAR) modified T cells can induce complete remissions in patients with advanced hematological malignancies. Nevertheless, the efficacy is mostly transient and remains so far poor in the treatment of solid tumors. Crucial barriers to long-term CAR T cell success encompass loss of functional capacities known as "exhaustion", among others. To extend CAR T cell functionality, we reduced interferon regulatory factor 4 (IRF4) levels in CAR T cells using a one-vector system encoding a specific short-hairpin (sh) RNA along with constitutive CAR expression. At baseline, CAR T cells with downregulated IRF4 showed equal cytotoxicity and cytokine release compared to conventional CAR T cells. However, under conditions of repetitive antigen encounter, IRF4
    Mesh-Begriff(e) Humans ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes ; Down-Regulation ; Immunotherapy, Adoptive/methods ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism
    Chemische Substanzen Receptors, Chimeric Antigen ; Interferon Regulatory Factors
    Sprache Englisch
    Erscheinungsdatum 2023-05-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1185618
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Magnetic CAR T cell purification using an anti-G4S linker antibody.

    Harrer, Dennis Christoph / Li, Sin-Syue / Kaljanac, Marcell / Bezler, Valerie / Barden, Markus / Pan, Hong / Herr, Wolfgang / Abken, Hinrich

    Journal of immunological methods

    2024  Band 528, Seite(n) 113667

    Abstract: Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often compromised by low transduction rates making refinement of the CAR T cell products necessary. Here, ... ...

    Abstract Chimeric antigen receptor (CAR) redirected T cells are successfully employed in the combat against several hematological malignancies, however, are often compromised by low transduction rates making refinement of the CAR T cell products necessary. Here, we report a broadly applicable enrichment protocol relying on marking CAR T cells with an anti-glycine
    Mesh-Begriff(e) T-Lymphocytes ; Cytotoxicity, Immunologic ; Receptors, Chimeric Antigen ; Cell Separation ; Magnetic Phenomena ; Immunotherapy, Adoptive/methods
    Chemische Substanzen Receptors, Chimeric Antigen
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
    DOI 10.1016/j.jim.2024.113667
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 795: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Artikel ; Online: CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop.

    Harrer, Dennis Christoph / Schenkel, Charlotte / Bezler, Valerie / Kaljanac, Marcell / Hartley, Jordan / Barden, Markus / Pan, Hong / Holzinger, Astrid / Herr, Wolfgang / Abken, Hinrich

    Cells

    2022  Band 11, Heft 23

    Abstract: The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs), ... ...

    Abstract The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs), commonly referred to as "fourth generation" CAR T-cells, are designed to release engineered payloads upon CAR-induced T-cell activation. Building on the TRUCK technology, we aimed to generate CAR T-cells with a CAR-inducible artificial, self-limiting autocrine loop. To this end, we engineered CAR T-cells with CAR triggered secretion of type-1 interferons (IFNs). At baseline, IFNα and IFNβ CAR T-cells showed similar capacities in cytotoxicity and cytokine secretion compared to conventional CAR T-cells. However, under "stress" conditions of repetitive rounds of antigen stimulation using BxPC-3 pancreas carcinoma cells as targets, anti-tumor activity faded in later rounds while being fully active in destructing carcinoma cells during first rounds of stimulation. Mechanistically, the decline in activity was primarily based on type-1 IFN augmented CAR T-cell apoptosis, which was far less the case for CAR T-cells without IFN release. Such autocrine self-limiting loops can be used for applications where transient CAR T-cell activity and persistence upon target recognition is desired to avoid lasting toxicities.
    Sprache Englisch
    Erscheinungsdatum 2022-11-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11233839
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4

    Patasic, Lea / Seifried, Janna / Bezler, Valerie / Kaljanac, Marcell / Schneider, Irene C / Schmitz, Heike / Tondera, Christiane / Hartmann, Jessica / Hombach, Andreas / Buchholz, Christian J / Abken, Hinrich / König, Renate / Cichutek, Klaus

    Medical microbiology and immunology

    2020  Band 209, Heft 6, Seite(n) 681–691

    Abstract: Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR ... ...

    Abstract Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4
    Mesh-Begriff(e) Ankyrin Repeat ; CD4-Positive T-Lymphocytes/drug effects ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Dose-Response Relationship, Immunologic ; Drug Evaluation, Preclinical ; Gammaretrovirus/genetics ; Genetic Vectors/genetics ; HEK293 Cells ; HIV/isolation & purification ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immunotherapy, Adoptive ; Lymphocyte Activation ; Lymphocyte Depletion/methods ; Peptides/chemistry ; Peptides/pharmacology ; Single-Chain Antibodies/immunology ; Transduction, Genetic
    Chemische Substanzen Peptides ; Single-Chain Antibodies
    Sprache Englisch
    Erscheinungsdatum 2020-09-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 120933-4
    ISSN 1432-1831 ; 0300-8584
    ISSN (online) 1432-1831
    ISSN 0300-8584
    DOI 10.1007/s00430-020-00692-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Un I Zs.170: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir

    Patasic, Lea / Seifried, Janna / Bezler, Valerie / Kaljanac, Marcell / Schneider, Irene C. / Schmitz, Heike / Tondera, Christiane / Hartmann, Jessica / Hombach, Andreas / Buchholz, Christian J. / Abken, Hinrich / König, Renate / Cichutek, Klaus

    2020  

    Abstract: Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR ... ...

    Abstract Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.

    Peer Reviewed
    Schlagwörter DARPin ; CAR T Cells ; HIV reservoir ; T cell therapy ; 610 Medizin und Gesundheit ; ddc:610
    Sprache Englisch
    Erscheinungsdatum 2020-09-12
    Verlag Robert Koch-Institut
    Erscheinungsland de
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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