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Article ; Online: Assessing Clinical Outcome Measures in Chiari I Malformation.

Mummareddy, Nishit / Bhamidipati, Akshay / Shannon, Chevis N

2022 Volume 34, Issue 1, Page(s) 167–174

Abstract: The purpose of this article was to consider, evaluate, and compare the clinical outcomes measurement tools that are used to assess patients with Chiari I malformation. This article highlights the variety of general and disease-specific outcome measures ... ...

Abstract	The purpose of this article was to consider, evaluate, and compare the clinical outcomes measurement tools that are used to assess patients with Chiari I malformation. This article highlights the variety of general and disease-specific outcome measures used in both the pediatric and adult Chiari I malformation patient populations. Although general measures can be associated with clinical outcomes and quality of life, that association is not often found to be statistically significant, and they do not often have the capabilities to assess and measure factors that directly impact the Chiari patient population. However, limitations exist when considering the disease-specific outcome measures, as these tools most often have not been rigorously evaluated externally from the initial validation or have been externally validated but results cannot be replicated. Identifying an outcomes measurement tool for both adults and patients will contribute to the clinical tools available to providers for decision-making and management.
MeSH term(s)	Adult ; Humans ; Child ; Quality of Life
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1196855-2
ISSN	1558-1349 ; 1042-3680
ISSN (online)	1558-1349
ISSN	1042-3680
DOI	10.1016/j.nec.2022.08.010
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Article ; Online: Predictors of acute post-thrombectomy intracranial hemorrhage expansion in anterior circulation infarcts.

Bhamidipati, Akshay / Mummareddy, Nishit / Ahn, Seoiyoung / Bendfeldt, Gabriel / Lyons, Alexander T / Gangavarapu, Surya / Chen, Jeffrey / Jo, Jacob / Kamal, Naveed / Roth, Steven G / Froehler, Michael T / Chitale, Rohan V / Fusco, Matthew R

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2024 , Page(s) 15910199241247884

Abstract: Background: Post-mechanical thrombectomy (MT) intracranial hemorrhage (ICH) is a major source of morbidity in treated acute ischemic stroke patients with large vessel occlusion. ICH expansion may further contribute to morbidity. We sought to identify ... ...

Abstract	Background: Post-mechanical thrombectomy (MT) intracranial hemorrhage (ICH) is a major source of morbidity in treated acute ischemic stroke patients with large vessel occlusion. ICH expansion may further contribute to morbidity. We sought to identify factors associated with ICH expansion on imaging evaluation post-MT. Methods: We performed a retrospective cohort study of patients undergoing MT at a single comprehensive stroke center. Per protocol, patients underwent dual-energy head CT (DEHCT) post-MT followed by a 24-h interval non-contrast enhanced MRI. ICH expansion was defined as any increase in blood volume between the two studies if identified on the DEHCT. Univariate and multivariable analyses were performed to identify risk factors for ICH expansion. Results: ICH was identified on DEHCT in 13% of patients ( Conclusion: Expansion of post-MT ICH on 24-h interval MRI relative to immediate post-thrombectomy DEHCT is significantly associated with baseline anticoagulant usage and petechial hemorrhage inside the infarct margins or presence of intraparenchymal hematoma (ECASS-II HI2/PH1/PH2).
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199241247884
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Article ; Online: OmicNavigator: open-source software for the exploration, visualization, and archival of omic studies.

Ernst, Terrence R / Blischak, John D / Nordlund, Paul / Dalen, Joe / Moore, Justin / Bhamidipati, Akshay / Dwivedi, Pankaj / LoGrasso, Joe / Curado, Marco Rocha / Engelmann, Brett Warren

BMC bioinformatics

2024 Volume 25, Issue 1, Page(s) 162

Abstract: Background: The results of high-throughput biology ('omic') experiments provide insight into biological mechanisms but can be challenging to explore, archive and share. The scale of these challenges continues to grow as omic research volume expands and ... ...

Abstract	Background: The results of high-throughput biology ('omic') experiments provide insight into biological mechanisms but can be challenging to explore, archive and share. The scale of these challenges continues to grow as omic research volume expands and multiple analytical technologies, bioinformatic pipelines, and visualization preferences have emerged. Multiple software applications exist that support omic study exploration and/or archival. However, an opportunity remains for open-source software that can archive and present the results of omic analyses with broad accommodation of study-specific analytical approaches and visualizations with useful exploration features. Results: We present OmicNavigator, an R package for the archival, visualization and interactive exploration of omic studies. OmicNavigator enables bioinformaticians to create web applications that interactively display their custom visualizations and analysis results linked with app-derived analytical tools, graphics, and tables. Studies created with OmicNavigator can be viewed within an interactive R session or hosted on a server for shared access. Conclusions: OmicNavigator can be found at https://github.com/abbvie-external/OmicNavigator.
MeSH term(s)	Software ; Computational Biology/methods ; User-Computer Interface ; Computer Graphics
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-024-05743-4
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Article: A Comprehensive Overview of Antibiotic Selection and the Factors Affecting It.

Patel, Karan / Bunachita, Sean / Agarwal, Ank A / Bhamidipati, Akshay / Patel, Urvish K

Cureus

2021 Volume 13, Issue 3, Page(s) e13925

Abstract: In order to prescribe an antibiotic, a physician must go through a series of decision-making processes that involve both the drug and the host. In this review article, we outline exactly what those decision-making processes are and some of their ... ...

Abstract	In order to prescribe an antibiotic, a physician must go through a series of decision-making processes that involve both the drug and the host. In this review article, we outline exactly what those decision-making processes are and some of their limitations. Before a medication can be prescribed, a physician has to determine if the antibiotic works against the host pathogen. To do this, basic science techniques are employed including phenotypic methods such as broth dilution methods, Kirby-Bauer susceptibility testing, Epsilometer test (E-test), and genotypic methods such as the new and upcoming automated tests. After determining if a drug has potential to work, the physician must consider the drug's mechanism of action in order to determine a dosing regimen. Some groups of drugs should be administered at high concentrations infrequently, others should be given more frequently in smaller doses, and others lie somewhere between this spectrum. Finally, external factors such as the patient's age, especially for pediatrics and geriatrics patients, need to be considered, as these groups have the highest health care burden but are among the most vulnerable when it comes to the side effects of drugs.
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13925
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Article: Cost of Vestibular Schwannoma Treatment: A Systematic Review and Meta-Analysis

Koester, Stefan W. / Dambrino IV, Robert J. / Bhamidipati, Akshay / Wong, Gunther / Liles, Campbell / Feldman, Michael / Chambless, Lola B.

Journal of Neurological Surgery Part B: Skull Base

2023

Abstract: Introduction: Research furthering treatment efficacy for microsurgical resection and stereotactic radiosurgery for vestibular schwannoma (VS) is ever-growing; however, there remains a paucity of research addressing treatment costs. Our aim is to define ... ...

Abstract	Introduction: Research furthering treatment efficacy for microsurgical resection and stereotactic radiosurgery for vestibular schwannoma (VS) is ever-growing; however, there remains a paucity of research addressing treatment costs. Our aim is to define the reported costs of different treatment modalities used for VS. Methods: A systematic review of the literature for VS treatment cost was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using PubMed and Web of Science databases. Literature that presented cost of VS treatment specific to the modality was included. Articles from 1990 to present day in English were considered. Cost was corrected for inflation to April 2022 dollars using the US Bureau of Labor Statistics Inflation Calculator. Results: A total of 407 articles were included in the analysis. After review, eight articles provided data on cost of treatment. In total, 687 patients were included across seven studies, with study dates ranging from 1997 to 2020. The average cost of resection was $54,321.99 (range = $10,243–95,590, n = 8), radiosurgery $27,837.92 (range = $6,281–51,676, n = 6), and observation $6,304.88 (range = $2,149–11,886, n = 3). Conclusion: Our findings describe the limited and significant variability of data on published costs for the treatment of VS. Given the relative clinical equipoise between treatment modalities in some scenarios, better understanding of this end-point will help physicians make more responsible recommendations in the resource-constrained environment of modern healthcare and this analysis should serve as a starting point for more robust analysis into cost-effectiveness of treatment for VS.
Keywords	vestibular schwannoma ; acoustic neuromas ; treatment cost ; literature review ; surgery vs stereotactic radiosurgery
Language	English
Publishing date	2023-08-29
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2654269-9
ISSN	2193-634X ; 2193-6331
ISSN (online)	2193-634X
ISSN	2193-6331
DOI	10.1055/a-2162-1134
Database	Thieme publisher's database

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Article ; Online: Flat-panel dual-energy head computed tomography in the angiography suite after thrombectomy for acute stroke: A clinical feasibility study.

DiNitto, Julie / Feldman, Michael / Grimaudo, Heather / Mummareddy, Nishit / Ahn, Seoiyoung / Bhamidipati, Akshay / Anderson, Drew / Ramirez-Giraldo, Juan Carlos / Fusco, Matthew / Chitale, Rohan / Froehler, Michael T

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2023 , Page(s) 15910199231157462

Abstract: Background: Management of large vessel occlusion (LVO) patients after thrombectomy is affected by the presence of intracranial hemorrhage (ICH) on post-procedure imaging. Differentiating contrast staining from hemorrhage on post-procedural imaging has ... ...

Abstract	Background: Management of large vessel occlusion (LVO) patients after thrombectomy is affected by the presence of intracranial hemorrhage (ICH) on post-procedure imaging. Differentiating contrast staining from hemorrhage on post-procedural imaging has been facilitated by dual-energy computed tomography (DECT), traditionally performed in dedicated computed tomography (CT) scanners with subsequent delays in treatment. We employed a novel method of DECT using the Siemens cone beam CT (DE-CBCT) in the angiography suite to evaluate for post-procedure ICH and contrast extravasation. Methods: After endovascular treatment for LVO was performed and before the patient was removed from the operating table, DE-CBCT was performed using the Siemens Q-biplane system, with two separate 20-second CBCT scans at two energy levels: 70 keV (standard) and 125 keV with tin filtration (nonstandard). Post-procedurally, patients also underwent a standard DECT using Siemens SOMATOM Force CT scanner. Two independent reviewers blindly evaluated the DE-CBCT and DECT for hemorrhage and contrast extravasation. Results: We successfully performed intra-procedural DE-CBCT in 10 subjects with no technical failure. The images were high-quality and subjectively useful to differentiate contrast from hemorrhage. The one hemorrhage seen on standard DECT was very small and clinically silent. The interrater reliability was 100% for both contrast and hemorrhage detection. Conclusion: We demonstrate that intra-procedural DE-CBCT after thrombectomy is feasible and provides clinically meaningful images. There was close agreement between findings on DE-CBCT and standard DECT. Our findings suggest that DE-CBCT could be used in the future to improve stroke thrombectomy patient workflow and to more efficiently guide the postoperative management of these patients.
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199231157462
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Article ; Online: The clinical utility of dual-energy CT in post-thrombectomy care: Part 2, the predictive value of contrast density and volume for delayed hemorrhagic transformation.

Ahn, Seoiyoung / Roth, Steven G / Mummareddy, Nishit / Ko, Yeji / Bhamidipati, Akshay / Jo, Jacob / DiNitto, Julie / Fusco, Matthew R / Chitale, Rohan V / Froehler, Michael T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2023 Volume 32, Issue 8, Page(s) 107216

Abstract: Objectives: Dual-energy CT allows differentiation between blood and iodinated contrast. This study aims to determine the predictive value of contrast density and volume on post-thrombectomy dual-energy CT for delayed hemorrhagic transformation and its ... ...

Abstract	Objectives: Dual-energy CT allows differentiation between blood and iodinated contrast. This study aims to determine the predictive value of contrast density and volume on post-thrombectomy dual-energy CT for delayed hemorrhagic transformation and its impact on 90-day outcomes. Materials and methods: A retrospective analysis was performed on patients who underwent thrombectomy for anterior circulation large-vessel occlusion at a comprehensive stroke center from 2018-2021. Per institutional protocol, all patients underwent dual-energy CT immediately post-thrombectomy and MRI or CT 24 hours afterward. The presence of hemorrhage and contrast staining was evaluated by dual-energy CT. Delayed hemorrhagic transformation was determined by 24-hour imaging and classified into petechial hemorrhage or parenchymal hematoma using ECASS III criteria. Univariable and multivariable analyses were performed to determine predictors and outcomes of delayed hemorrhagic transformation. Results: Of 97 patients with contrast staining and without hemorrhage on dual-energy CT, 30 and 18 patients developed delayed petechial hemorrhage and delayed parenchymal hematoma, respectively. On multivariable analysis, delayed petechial hemorrhage was predicted by anticoagulant use (OR,3.53;p=0.021;95%CI,1.19-10.48) and maximum contrast density (OR,1.21;p=0.004;95%CI,1.06-1.37;per 10 HU increase), while delayed parenchymal hematoma was predicted by contrast volume (OR,1.37;p=0.023;95%CI,1.04-1.82;per 10 mL increase) and low-density lipoprotein (OR,0.97;p=0.043;95%CI,0.94-1.00;per 1 mg/dL increase). After adjusting for potential confounders, delayed parenchymal hematoma was associated with worse functional outcomes (OR,0.07;p=0.013;95%CI,0.01-0.58) and mortality (OR,7.83;p=0.008;95%CI,1.66-37.07), while delayed petechial hemorrhage was associated with neither. Conclusion: Contrast volume predicted delayed parenchymal hematoma, which was associated with worse functional outcomes and mortality. Contrast volume can serve as a useful predictor of delayed parenchymal hematoma following thrombectomy and may have implications for patient management.
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2023.107216
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Article ; Online: The clinical utility of dual-energy CT in post-thrombectomy care: Part 1, predictors and outcomes of subarachnoid and intraparenchymal hemorrhage.

Ahn, Seoiyoung / Mummareddy, Nishit / Roth, Steven G / Jo, Jacob / Bhamidipati, Akshay / Ko, Yeji / DiNitto, Julie / Chitale, Rohan V / Fusco, Matthew R / Froehler, Michael T

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

2023 Volume 32, Issue 8, Page(s) 107217

Abstract: Objectives: Dual-energy CT allows differentiation between blood and iodinated contrast. We aimed to determine predictors of subarachnoid and intraparenchymal hemorrhage on dual-energy CT performed immediately post-thrombectomy and the impact of these ... ...

Abstract	Objectives: Dual-energy CT allows differentiation between blood and iodinated contrast. We aimed to determine predictors of subarachnoid and intraparenchymal hemorrhage on dual-energy CT performed immediately post-thrombectomy and the impact of these hemorrhages on 90-day outcomes. Materials and methods: A retrospective analysis was performed on patients who underwent thrombectomy for anterior circulation large-vessel occlusion and subsequent dual-energy CT at a comprehensive stroke center from 2018-2021. The presence of contrast, subarachnoid hemorrhage, or intraparenchymal hemorrhage immediately post-thrombectomy was assessed by dual-energy CT. Univariable and multivariable analyses were performed to identify predictors of post-thrombectomy hemorrhages and 90-day outcomes. Patients with unknown 90-day mRS were excluded. Results: Of 196 patients, subarachnoid hemorrhage was seen in 17, and intraparenchymal hemorrhage in 23 on dual-energy CT performed immediately post-thrombectomy. On multivariable analysis, subarachnoid hemorrhage was predicted by stent retriever use in the M2 segment of MCA (OR,4.64;p=0.017;95%CI,1.49-14.35) and the number of thrombectomy passes (OR,1.79;p=0.019;95%CI,1.09-2.94;per an additional pass), while intraparenchymal hemorrhage was predicted by preprocedural non-contrast CT-based ASPECTS (OR,8.66;p=0.049;95%CI,0.92-81.55;per 1 score decrease) and preprocedural systolic blood pressure (OR,5.10;p=0.037;95%CI,1.04-24.93;per 10 mmHg increase). After adjusting for potential confounders, intraparenchymal hemorrhage was associated with worse functional outcomes (OR,0.25;p=0.021;95%CI,0.07-0.82) and mortality (OR,4.30;p=0.023,95%CI,1.20-15.36), while subarachnoid hemorrhage was associated with neither. Conclusions: Intraparenchymal hemorrhage immediately post-thrombectomy was associated with worse functional outcomes and mortality and can be predicted by low ASPECTS and elevated preprocedural systolic blood pressure. Future studies focusing on management strategies for patients presenting with low ASPECTS or elevated blood pressure to prevent post-thrombectomy intraparenchymal hemorrhage are warranted.
MeSH term(s)	Humans ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery ; Retrospective Studies ; Stroke/diagnostic imaging ; Stroke/etiology ; Stroke/surgery ; Thrombectomy/adverse effects ; Tomography, X-Ray Computed ; Treatment Outcome ; Brain Ischemia/complications
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1131675-5
ISSN	1532-8511 ; 1052-3057
ISSN (online)	1532-8511
ISSN	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2023.107217
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Article ; Online: Neurological Examination Frequency and Time-to-Delirium After Traumatic Brain Injury.

Chotai, Silky / Chen, Jeffrey W / Turer, Robert / Smith, Candice / Kelly, Patrick D / Bhamidipati, Akshay / Davis, Philip / McCarthy, Jack T / Bendfeldt, Gabriel A / Peyton, Mary B / Dennis, Bradley M / Terry, Douglas P / Guillamondegui, Oscar / Yengo-Kahn, Aaron M

Neurosurgery

2023 Volume 93, Issue 6, Page(s) 1425–1431

Abstract: Background: Frequent neurological examinations in patients with traumatic brain injury (TBI) disrupt sleep-wake cycles and potentially contribute to the development of delirium.: Objective: To evaluate the risk of delirium among patients with TBI ... ...

Abstract	Background: Frequent neurological examinations in patients with traumatic brain injury (TBI) disrupt sleep-wake cycles and potentially contribute to the development of delirium. Objective: To evaluate the risk of delirium among patients with TBI with respect to their neuro-check frequencies. Methods: A retrospective study of patients presenting with TBI at a single level I trauma center between January 2018 and December 2019. The primary exposure was the frequency of neurological examinations (neuro-checks) assigned at the time of admission. Patients admitted with hourly (Q1) neuro-check frequencies were compared with those who received examinations every 2 (Q2) or 4 (Q4) hours. The primary outcomes were delirium and time-to-delirium. The onset of delirium was defined as the first documented positive Confusion Assessment Method for the Intensive Care Unit score. Results: Of 1552 patients with TBI, 458 (29.5%) patients experienced delirium during their hospital stay. The median time-to-delirium was 1.8 days (IQR: 1.1, 2.9). Kaplan-Meier analysis demonstrated that patients assigned Q1 neuro-checks had the greatest rate of delirium compared with the patients with Q2 and Q4 neuro-checks ( P < .001). Multivariable Cox regression modeling demonstrated that Q2 neuro-checks (hazard ratio: 0.439, 95% CI: 0.33-0.58) and Q4 neuro-checks (hazard ratio: 0.48, 95% CI: 0.34-0.68) were protective against the development of delirium compared with Q1. Other risk factors for developing delirium included pre-existing dementia, tobacco use, lower Glasgow Coma Scale score, higher injury severity score, and certain hemorrhage patterns. Conclusion: Patients with more frequent neuro-checks had a higher risk of developing delirium compared with those with less frequent neuro-checks.
MeSH term(s)	Humans ; Retrospective Studies ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Intensive Care Units ; Glasgow Coma Scale ; Delirium/diagnosis ; Delirium/epidemiology ; Delirium/etiology ; Neurologic Examination/methods
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/neu.0000000000002562
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Article ; Online: Genomic Characterization of Prostatic Basal Cell Carcinoma.

Low, Jin-Yih / Ko, Minjeong / Hanratty, Brian / Patel, Radhika A / Bhamidipati, Akshay / Heaphy, Christopher M / Sayar, Erolcan / Lee, John K / Li, Shan / De Marzo, Angelo M / Nelson, William G / Gupta, Anuj / Yegnasubramanian, Srinivasan / Ha, Gavin / Epstein, Jonathan I / Haffner, Michael C

The American journal of pathology

2022 Volume 193, Issue 1, Page(s) 4–10

Abstract: Basal cell carcinoma (BCC) of the prostate is a rare tumor. Compared with the more common acinar adenocarcinoma (AAC) of the prostate, BCCs show features of basal cell differentiation and are thought to be biologically distinct from AAC. The spectrum of ... ...

Abstract	Basal cell carcinoma (BCC) of the prostate is a rare tumor. Compared with the more common acinar adenocarcinoma (AAC) of the prostate, BCCs show features of basal cell differentiation and are thought to be biologically distinct from AAC. The spectrum of molecular alterations of BCC has not been comprehensively described, and genomic studies are lacking. Herein, whole genome sequencing was performed on archival formalin-fixed, paraffin-embedded specimens of two cases with BCC. Prostatic BCCs were characterized by an overall low copy number and mutational burden. Recurrent copy number loss of chromosome 16 was observed. In addition, putative driver gene alterations in KIT, DENND3, PTPRU, MGA, and CYLD were identified. Mechanistically, depletion of the CYLD protein resulted in increased proliferation of prostatic basal cells in vitro. Collectively, these studies show that prostatic BCC displays distinct genomic alterations from AAC and highlight a potential role for loss of chromosome 16 in the pathogenesis of this rare tumor type.
MeSH term(s)	Male ; Humans ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Prostate/pathology ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Skin Neoplasms/pathology ; Genomics ; Receptor-Like Protein Tyrosine Phosphatases, Class 2 ; Guanine Nucleotide Exchange Factors
Chemical Substances	PTPRU protein, human (EC 3.1.3.48) ; Receptor-Like Protein Tyrosine Phosphatases, Class 2 (EC 3.1.3.48) ; DENND3 protein, human ; Guanine Nucleotide Exchange Factors
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2022.09.010
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