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  1. Article ; Online: Commentary: Surgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2.

    Bhandarkar, Archis R / Spinner, Robert J

    Neurosurgery

    2022  Volume 92, Issue 2, Page(s) e15–e16

    MeSH term(s) Humans ; Neurofibromatosis 2/complications ; Neurofibromatosis 2/surgery ; Peripheral Nerves/pathology ; Neurilemmoma/surgery ; Patients ; Neurofibromatosis 1 ; Nerve Sheath Neoplasms/surgery
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002241
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  2. Article ; Online: Commentary: Natural History of Brachial Plexus, Peripheral Nerve, and Spinal Schwannomas.

    Bhandarkar, Archis R / Spinner, Robert J

    Neurosurgery

    2022  Volume 91, Issue 6, Page(s) e151–e152

    MeSH term(s) Humans ; Brachial Plexus ; Neurilemmoma/surgery ; Brachial Plexus Neuropathies/surgery ; Nerve Transfer
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002131
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  3. Article ; Online: Single incision endoscopic strip craniectomy for sagittal craniosynostosis.

    Ahn, Edward S / Bhandarkar, Archis R

    Neurosurgical focus: Video

    2021  Volume 4, Issue 2, Page(s) V10

    Abstract: The authors describe an endoscopic strip craniectomy through a single incision for the treatment of sagittal craniosynostosis in a young infant. The endoscopic strip craniectomy was first introduced with the use of two incisions on either end of the ... ...

    Abstract The authors describe an endoscopic strip craniectomy through a single incision for the treatment of sagittal craniosynostosis in a young infant. The endoscopic strip craniectomy was first introduced with the use of two incisions on either end of the fused suture. This single-incision technique offers several advantages. There is a cosmetic advantage and a reduced risk of wound complications. This technique also allows for early control of emissary veins and an inside-out identification of the lambdoid sutures. Endoscopic visualization is optimized to reduce the risk of blood loss, especially because circulating blood volume is very limited in these young infants. The video can be found here: https://vimeo.com/514366415.
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 2643-5217
    ISSN (online) 2643-5217
    DOI 10.3171/2021.1.FOCVID20120
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  4. Article ; Online: Precision oncology in neurofibromatosis type 1: quantification of differential sensitivity to selumetinib in plexiform neurofibromas using single-cell RNA sequencing.

    Bhandarkar, Archis R / Bhandarkar, Shaan / Babovic-Vuksanovic, Dusica / Raghunathan, Aditya / Schwartz, Jonathan / Spinner, Robert J

    Journal of neuro-oncology

    2024  

    Abstract: Purpose: Selumetinib is an FDA-approved targeted therapy for plexiform neurofibromas in neurofibromatosis type 1(NF1) with durable response rates seen in most, but not all patients. In this proof-of-concept study, we demonstrate single-cell RNA ... ...

    Abstract Purpose: Selumetinib is an FDA-approved targeted therapy for plexiform neurofibromas in neurofibromatosis type 1(NF1) with durable response rates seen in most, but not all patients. In this proof-of-concept study, we demonstrate single-cell RNA sequencing(scRNAseq) as a technique for quantifying drug response to selumetinib at the single cell level.
    Methods: scRNAseq data from neurofibroma biopsies was obtained from a public genomics repository. Schwann cell populations were identified through standard clustering techniques and single-cell selumetinib sensitivity was quantified on a scale of 0(resistant) to 1(sensitive) based on the expression pattern of a 500 gene selumetinib sensitivity signature from the BeyondCell sensitivity library.
    Results: A total of seven plexiform neurofibromas were included in our final analysis. The median absolute number of Schwann cells across samples was 658 cells (IQR: 1,029 cells, Q1-Q3: 135 cells to 1,163 cells). There was a statistically significant difference in selumetinib sensitivity profiles across samples (p < 0.001). The tumor with the highest median selumetinib sensitivity score had a median selumetinib sensitivity score of 0.64(IQR: 0.14, Q1-Q3: 0.59-0.70, n = 112 cells) and the tumor with the lowest median selumetinib sensitivity score had a median score of 0.37 (IQR: 0.21, Q1-Q3: 0.27-0.48, n = 1,034 cells).
    Conclusions: scRNAseq of plexiform neurofibroma biopsies reveals differential susceptibilities to selumetinib on a single cell level. These findings may explain the partial responses seen in clinical trials of selumetinib for NF1 and demonstrate the value of collecting scRNAseq data for future NF1 trials.
    Language English
    Publishing date 2024-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-024-04711-5
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  5. Article ; Online: Predictors of airway, respiratory, and pulmonary complications following elective anterior cervical discectomy and fusion.

    Hardman, Morgan / Bhandarkar, Archis R / Jarrah, Ryan M / Bydon, Mohamad

    Clinical neurology and neurosurgery

    2022  Volume 217, Page(s) 107245

    Abstract: Introduction: Anterior cervical discectomy and fusion (ACDF) is a commonly performed procedure on the cervical spine. While the procedure is generally well tolerated, respiratory and pulmonary complications (RPC) are an unlikely yet possible ... ...

    Abstract Introduction: Anterior cervical discectomy and fusion (ACDF) is a commonly performed procedure on the cervical spine. While the procedure is generally well tolerated, respiratory and pulmonary complications (RPC) are an unlikely yet possible complication following ACDF. Few previous studies have specifically identified risk factors associated with RPC following ACDF. As the incidence of an RPC is rare at a single institution, a large national database is required for meaningful analysis.
    Objective: The goal of this study is to characterize the predictors for RPC following an ACDF by utilizing a large national database.
    Methods: The National Inpatient Sample (NIS) was queried from 2016 to 2018 for all patients who had received elective ACDF for degenerative cervical spine disease. We categorized several complications as airway complications including various abscess, angioedema, laryngeal edema, vocal cord paralysis, dysphonia, various etiologies of pneumonia, and acute respiratory distress syndrome. A Firth's logistic regression model was used to identify predictors of RPC.
    Results: We identified a final cohort of 52,575 admissions in which an ACDF was performed of which 1454 admissions had an RPC. Older patients were 1.03 times more likely to have an RPC (OR = 1.03, 95%CI: 1.02-1.04). African American patients compared to Caucasian patients were 1.44 times more likely to have an RPC (OR = 1.44, 95%CI: 1.23-1.68). Obese patients were found to be 1.64 to have an RPC (OR = 1.64, 95%CI: 1.45-1.85). Diabetic patients are 2.07 times more likely to have an RPC (OR = 2.07, 95%CI: 1.76-2.44). Hypertensive patients are 1.91 times more likely to have an RPC (OR = 1.91, 95%CI: 1.59-2.27). Urban based hospitals were 1.11 and 1.46 times more likely to have an RPC (OR = 1.11, 95%CI: 0.79-1.59; OR = 1.46, 95%CI: 1.06-2.08; teaching and non-teaching respectively). Patients who underwent multilevel procedure were 1.32 times more likely to experience a follow-on RPC (OR = 1.32, 95%CI: 1.17-1.49) DISCUSSION: Our study identified modifiable predictors of RPC after elective ACDF (e.g. obesity, diabetes) which can be used to guide preoperative patient optimization.
    MeSH term(s) Cervical Vertebrae/surgery ; Diskectomy/adverse effects ; Diskectomy/methods ; Elective Surgical Procedures/adverse effects ; Humans ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Retrospective Studies ; Spinal Fusion/adverse effects ; Spinal Fusion/methods
    Language English
    Publishing date 2022-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2022.107245
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  6. Article ; Online: Characterizing T-cell dysfunction and exclusion signatures in malignant peripheral nerve sheath tumors reveals susceptibilities to immunotherapy.

    Bhandarkar, Archis R / Bhandarkar, Shaan / Babovic-Vuksanovic, Dusica / Parney, Ian F / Spinner, Robert J

    Journal of neuro-oncology

    2023  Volume 164, Issue 3, Page(s) 693–699

    Abstract: Purpose: Malignant peripheral nerve sheath tumors (MPNSTs) are malignant tumors that arise from peripheral nerves and are the leading cause of mortality in Neurofibromatosis Type 1 (NF1). In this study, we characterized whether transcriptomic signatures ...

    Abstract Purpose: Malignant peripheral nerve sheath tumors (MPNSTs) are malignant tumors that arise from peripheral nerves and are the leading cause of mortality in Neurofibromatosis Type 1 (NF1). In this study, we characterized whether transcriptomic signatures of T-cell dysfunction (TCD) and exclusion (TCE) that inversely correlate with response to immune checkpoint blockade (ICB) immunotherapy exist in MPNSTs.
    Methods: MPNST transcriptomes were pooled from Gene Expression Omnibus (GEO). For each sample, a tumor immune dysfunction and exclusion (TIDE) score, TCD and TCE subscores, and cytotoxic T-cell(CTL) level were calculated. In the TIDE predictive algorithm, tumors are predicted to have an ICB response if they are either immunologically hot (CTL-high) without TCD or immunologically cold (CTL-low) without TCE. TIDE scores greater than zero correspond with ICB nonresponse.
    Results: 73 MPNST samples met inclusion criteria, including 50 NF1-associated MPNSTs (68.5%). The average TIDE score was + 0.41 (SD = 1.16) with 22 (30.1%) predicted ICB responders. 11 samples were CTL-high (15.1%) with an average TCD score of + 0.99 (SD = 0.63). Among 62 CTL-low tumors, 21 were predicted to have ICB response with an average TCE score of + 0.31(SD = 1.20). Age(p = 0.18), sex(p = 0.41), NF1 diagnosis (p = 0.17), and PRC2 loss(p = 0.29) were not associated with ICB responder status.
    Conclusions: Transcriptomic analysis of TCD and TCE signatures in MPNST samples reveals that a select subset of patients with MPNSTs may benefit from ICB immunotherapy.
    MeSH term(s) Humans ; Neurofibrosarcoma ; Nerve Sheath Neoplasms/genetics ; Nerve Sheath Neoplasms/therapy ; Nerve Sheath Neoplasms/diagnosis ; Neurofibromatosis 1/genetics ; Neurofibromatosis 1/therapy ; Neurofibromatosis 1/complications ; Immunotherapy ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04467-4
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  7. Article ; Online: Placental-based allograft use for tissue regeneration and scar prevention for neurosurgical wounds.

    Fiani, Brian / Jarrah, Ryan / Nathani, Karim Rizwan / Bhandarkar, Archis R

    Regenerative medicine

    2022  Volume 17, Issue 8, Page(s) 517–519

    Abstract: Tweetable abstract Proper wound healing, including internal and surface tissue regeneration with the minimization of scar formation, is one of the most significant topics in surgical discussions and ... ...

    Abstract Tweetable abstract Proper wound healing, including internal and surface tissue regeneration with the minimization of scar formation, is one of the most significant topics in surgical discussions and EpiFix
    MeSH term(s) Allografts ; Amnion/transplantation ; Chorion ; Cicatrix/prevention & control ; Female ; Humans ; Placenta ; Pregnancy ; Wound Healing
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0074
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  8. Article ; Online: In Reply to the Letter to Editor Regarding "How United States Neurosurgery Training Programs Can Innovatively Assess Resident Applicants in a Post-Step 1 World".

    Bhandarkar, Archis R / Graffeo, Christopher S / Johnson, Jeremiah

    World neurosurgery

    2020  Volume 143, Page(s) 590

    MeSH term(s) Humans ; Internship and Residency ; Neurosurgery/education ; Neurosurgical Procedures ; United States
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.08.111
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  9. Article ; Online: Stepping Up: How U.S. Neurosurgery Training Programs Can Innovatively Assess Resident Applicants in a Post-Step 1 World.

    Bhandarkar, Archis R / Graffeo, Christopher S / Johnson, Jeremiah

    World neurosurgery

    2020  Volume 142, Page(s) 291–293

    MeSH term(s) Humans ; Internship and Residency/trends ; Job Application ; Neurosurgery/education ; Neurosurgery/trends ; Neurosurgical Procedures/education ; Neurosurgical Procedures/trends ; Organizational Innovation ; United States
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.07.078
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  10. Article ; Online: Letter to the Editor Regarding "Racial and Ethnic Disparities in the Inpatient Management of Primary Spinal Cord Tumors".

    Bhandarkar, Archis R / Alvi, Mohammed Ali / Albertie, Monica L / Bydon, Mohamad

    World neurosurgery

    2021  Volume 147, Page(s) 239

    MeSH term(s) Continental Population Groups ; Ethnic Groups ; Humans ; Inpatients ; Spinal Cord Neoplasms/therapy
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.11.067
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