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  1. Article ; Online: Polymeric Micelles as Drug Delivery System: Recent Advances, Approaches, Applications and Patents.

    Jain, Anushka / Bhardwaj, Kamini / Bansal, Mukesh

    Current drug safety

    2024  Volume 19, Issue 2, Page(s) 163–171

    Abstract: Administering therapeutics through the oral route is a pervasive and widely approved medication administration approach. However, it has been found that many drugs show low systemic absorption when delivered through this route. Such limitations of oral ... ...

    Abstract Administering therapeutics through the oral route is a pervasive and widely approved medication administration approach. However, it has been found that many drugs show low systemic absorption when delivered through this route. Such limitations of oral drug delivery can be overcome by polymeric micelles acting as vehicles. As a result, they improve drug absorption by protecting loaded drug substances from the gastrointestinal system's hostile conditions, allowing controlled drug release at a specific site, extending the time spent in the gut through mucoadhesion, and inhibiting the efflux pump from reducing therapeutic agent accumulation. To promote good oral absorption of a weakly water-soluble medicinal drug, the loaded medicine should be protected from the hostile atmosphere of the GI tract. Polymeric micelles can be stacked with a broad assortment of ineffectively dissolvable medications, improving bioavailability. This review discusses the major mechanism, various types, advantages, and limitations for developing the polymeric micelle system and certain micellar drug delivery system applications. The primary goal of this review is to illustrate how polymeric micelles can be used to deliver poorly water-soluble medications.
    MeSH term(s) Humans ; Micelles ; Drug Delivery Systems ; Polymers ; Biological Availability ; Water
    Chemical Substances Micelles ; Polymers ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-01
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2250840-5
    ISSN 2212-3911 ; 1574-8863
    ISSN (online) 2212-3911
    ISSN 1574-8863
    DOI 10.2174/1574886318666230605120433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanogels as Drug Delivery Carrier: A Narrative Review on Formulation Techniques, Characterization, Applications, and Patents.

    Kumari, Alpana / Bhardwaj, Kamini / Mishra, Supriya / Singh, Lubhan / Pottoo, Faheem Hyder / Yasir, Mohd

    Current pharmaceutical biotechnology

    2024  

    Abstract: Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement ... ...

    Abstract Under the umbrella of targeted drug delivery systems, several techniques are unleashed in the market that allow a drug or other pharmacologically active material to be delivered to the target cell to treat a condition or health problem. The improvement of the pharmaceutical delivery systems' effectiveness, safety, and stability is accomplished through the Formulation of the nano-gel-based delivery system. Nanogels are aqueous dispersions of submicronsized, three-dimensional, strongly cross-linked networks of hydrophilic polymers that are inflated by water. Through a variety of delivery routes, such as oral, pulmonary, nasal, parenteral, and intraocular, an active pharmaceutical agent or therapeutic agent with a high or low molecular weight can be easily encapsulated into nanogels. Nanogels have been researched as drug delivery systems due to their beneficial qualities, such as biocompatibility, high stability, flexible particle size, drug loading capacity, and potential surface modification for active targeting by attaching ligands that recognize cognate receptors on target cells or tissues. By responding to internal or external stimuli, including pH, temperature, light, and redox, nano gels can be made to be stimulus-responsive, allowing for regulated drug release. Thus, in the fact of said characteristics' of nano gels, this review manuscript aims to provide an overview of characterization, evaluation, formulation technique, recent applications, and patents of nano gels.
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010281504240403053144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Artificial Intelligence in Pharmacovigilance and COVID-19.

    Bhardwaj, Kamini / Alam, Rabnoor / Pandeya, Ajay / Sharma, Pankaj Kumar

    Current drug safety

    2022  Volume 18, Issue 1, Page(s) 5–14

    Abstract: The history of pharmacovigilance started back 169 years ago with the death of a 15- year-old girl, Hannah greener. However, the Thalidomide incident of 1961 brought a sharp change in the pharmacovigilance process, with adverse drug reaction reporting ... ...

    Abstract The history of pharmacovigilance started back 169 years ago with the death of a 15- year-old girl, Hannah greener. However, the Thalidomide incident of 1961 brought a sharp change in the pharmacovigilance process, with adverse drug reaction reporting being systematic, spontaneous, and regulated timely. Therefore, continuous monitoring of marketed drugs was essential to ensure the safety of public health. Any observed adverse drug reaction detected by signals was to be reported by the health profession. Moreover, signal detection became the primary goal of pharmacovigilance based on reported cases. Among various methods used for signal detection, the Spontaneous Reporting System was most widely preferred; although, it had the limitation of "under- reporting". Gradually, the World Health Organization collaborating centre and "Uppsala Monitoring Centre" were established in 1978 for international monitoring of drugs. The centre was responsible for operating various databases like vigiflow, vigibase, vigilyze, and vigiaccess. Recently, huge data could be generated through spontaneous reporting linked with computational methods, such as Bayesian Framework, E-Synthesis. Furthermore, drug safety surveillance at an early stage prior to the official alerts or regulatory changes was made possible through social media. In addition, India created a National Pharmacovigilance Program, and Schedule Y of the Drug and Cosmetic Act 1945 was reviewed and amended in 2005. The collaboration of Information Technology and Pharmaceutical Company can further enhance the awareness regarding artificial intelligence in pharmacovigilance, which was in its infancy until 2017. Artificial intelligence helps improve the quality and accuracy of information much quickly.
    MeSH term(s) Female ; Humans ; Adolescent ; Pharmacovigilance ; Adverse Drug Reaction Reporting Systems ; Artificial Intelligence ; Bayes Theorem ; COVID-19 ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/epidemiology
    Language English
    Publishing date 2022-04-18
    Publishing country United Arab Emirates
    Document type Case Reports ; Journal Article
    ZDB-ID 2250840-5
    ISSN 2212-3911 ; 1574-8863
    ISSN (online) 2212-3911
    ISSN 1574-8863
    DOI 10.2174/1574886317666220405115548
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6400: Show issues Location:
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