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  1. Article: Diagnostic Challenges and Treatment Approach to Seronegative Autoimmune Encephalitis.

    Bhasin, Amman / Haftka-George, Alexis

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56844

    Abstract: Seronegative autoimmune encephalitis (AE) is a rare, immune-mediated inflammatory syndrome that presents with a wide spectrum of neuropsychiatric symptoms, such as cognitive impairment, seizures, psychosis, focal neurological defects, and altered ... ...

    Abstract Seronegative autoimmune encephalitis (AE) is a rare, immune-mediated inflammatory syndrome that presents with a wide spectrum of neuropsychiatric symptoms, such as cognitive impairment, seizures, psychosis, focal neurological defects, and altered consciousness. This disease process presents with no identifiable autoimmune antibodies, which leads to uncertain diagnosis, delayed treatment, and prolonged hospital admissions. Early diagnosis and prompt treatment of AE should not be delayed, as early recognition and treatment leads to improved outcomes and disease reversibility for these patients. In this study, we present a case report of a 77-year-old male who presented with acutely altered mental status. This patient underwent an extensive workup and demonstrated no signs of clinical improvement throughout a prolonged hospital admission. The diagnostic challenges and treatment obstacles encountered during our care of this patient are described in this case report, along with recommendations for early diagnosis and prompt treatment for patients with suspected seronegative AE.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Optic Disc Hemorrhages in Severe Anemia and Thrombocytopenia.

    Janetos, Timothy M / Bhasin, Ajay

    Journal of general internal medicine

    2022  Volume 38, Issue 1, Page(s) 234–235

    MeSH term(s) Humans ; Optic Disk ; Optic Nerve Diseases ; Retinal Hemorrhage/diagnostic imaging ; Retinal Hemorrhage/etiology ; Anemia/complications ; Anemia/diagnosis ; Thrombocytopenia/complications ; Thrombocytopenia/diagnosis
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07853-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2205: Show issues Location:
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  3. Article ; Online: Pathologic Ventricular Interdependence in Constrictive Pericarditis.

    Bhasin, Ajay / Hughes, Zachary H

    Journal of general internal medicine

    2022  Volume 38, Issue 7, Page(s) 1759–1760

    MeSH term(s) Humans ; Pericarditis, Constrictive/diagnosis ; Pericarditis, Constrictive/diagnostic imaging ; Echocardiography
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-022-07979-3
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  4. Article ; Online: The burden of RSV, hMPV, and PIV amongst hospitalized adults in the United States from 2016 to 2019.

    Bhasin, Ajay / Nguyen, David C / Briggs, Benjamin J / Nam, Hannah H

    Journal of hospital medicine

    2024  

    Abstract: Background: Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and parainfluenza virus (PIV) hospitalize many people yearly. Though severe lower respiratory tract disease has been described in children, the elderly, and the ... ...

    Abstract Background: Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and parainfluenza virus (PIV) hospitalize many people yearly. Though severe lower respiratory tract disease has been described in children, the elderly, and the immunocompromised, there is a gap in our understanding of RSV, hMPV, and PIV in hospitalized adults. We sought to evaluate the association of RSV, hMPV, and PIV with severe respiratory disease requiring noninvasive or mechanical ventilation and death in hospitalized adults in the United States.
    Methods: We conducted a retrospective, pooled, cross-sectional study of general medicine hospitalizations in the United States from 2016 to 2019 using the National Inpatient Sample published by the Agency for Healthcare Quality and Research. We used multivariable Poisson regression to estimate the likelihood of severe respiratory disease or death. We used linear regression to estimate the mean difference in length of stay for those hospitalized with and without a respiratory virus.
    Results: We found that RSV (incidence rate ratio [IRR]: 1.68, 95% confidence interval [CI]: 1.61-1.74, p < .001), hMPV (IRR: 1.82, 95% CI: 1.71-1.93, p < .001), and PIV (IRR: 1.81, 95% CI: 1.68-1.94, p < .001) were independently associated with severe respiratory disease, even after adjustment. Additionally, we found the presence of a respiratory virus prolonged hospitalizations by (0.79 ± 0.27 days, p < .003) for RSV, (0.88 ± 0.28 days, p < .002) for hMPV, and (1.43 ± 0.30 days, p < .001) for PIV.
    Conclusions: RSV, hMPV, and PIV have a significant burden on hospitalized adults, even without classic risk factors.
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13320
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  5. Article ; Online: Predictive and Prognostic Biomarkers and Tumor Antigens for Targeted Therapy in Urothelial Carcinoma.

    Eturi, Aditya / Bhasin, Amman / Zarrabi, Kevin K / Tester, William J

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 8

    Abstract: Urothelial carcinoma (UC) is the fourth most prevalent cancer amongst males worldwide. While patients with non-muscle-invasive disease have a favorable prognosis, 25% of UC patients present with locally advanced disease which is associated with a 10-15% ... ...

    Abstract Urothelial carcinoma (UC) is the fourth most prevalent cancer amongst males worldwide. While patients with non-muscle-invasive disease have a favorable prognosis, 25% of UC patients present with locally advanced disease which is associated with a 10-15% 5-year survival rate and poor overall prognosis. Muscle-invasive bladder cancer (MIBC) is associated with about 50% 5 year survival when treated by radical cystectomy or trimodality therapy; stage IV disease is associated with 10-15% 5 year survival. Current therapeutic modalities for MIBC include neoadjuvant chemotherapy, surgery and/or chemoradiation, although patients with relapsed or refractory disease have a poor prognosis. However, the rapid success of immuno-oncology in various hematologic and solid malignancies offers new targets with tremendous therapeutic potential in UC. Historically, there were no predictive biomarkers to guide the clinical management and treatment of UC, and biomarker development was an unmet need. However, recent and ongoing clinical trials have identified several promising tumor biomarkers that have the potential to serve as predictive or prognostic tools in UC. This review provides a comprehensive summary of emerging biomarkers and molecular tumor targets including programmed death ligand 1 (PD-L1), epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), fibroblast growth factor receptor (FGFR), DNA damage response and repair (DDR) mutations, poly (ADP-ribose) polymerase (PARP) expression and circulating tumor DNA (ctDNA), as well as their clinical utility in UC. We also evaluate recent advancements in precision oncology in UC, while illustrating limiting factors and challenges related to the clinical application of these biomarkers in clinical practice.
    MeSH term(s) Humans ; Biomarkers, Tumor ; Prognosis ; Molecular Targeted Therapy ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/drug therapy ; Antigens, Neoplasm/metabolism ; Urologic Neoplasms/therapy ; Carcinoma, Transitional Cell/therapy ; Carcinoma, Transitional Cell/metabolism ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology
    Chemical Substances Biomarkers, Tumor ; Antigens, Neoplasm
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29081896
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    Zs.MO 81: Show issues

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  6. Article ; Online: Virtual immediate feedback with POCUS in Belize.

    Mulye, Anita / Bhasin, Ajay / Borger, Bonita / Fant, Colleen

    Frontiers in digital health

    2023  Volume 5, Page(s) 1268905

    Abstract: Point of care ultrasound (POCUS) is a portable and accessible tool that has immense potential in low- and middle-income countries (LMIC) for diagnostic accuracy and medical education. We implemented a hybrid in-person and virtual training curriculum to ... ...

    Abstract Point of care ultrasound (POCUS) is a portable and accessible tool that has immense potential in low- and middle-income countries (LMIC) for diagnostic accuracy and medical education. We implemented a hybrid in-person and virtual training curriculum to teach providers in Belize the basic techniques of lung ultrasound in the diagnosis of pneumonia. Between August 2021 and June 2022, a total of eleven lung scans were performed at Hillside Clinic for patients presenting with respiratory complaints. Deidentified images were shared via the ButterflyIQ web platform to POCUS experts in the United States. We found that training was solidified through virtual, immediate feedback using the common interfaces Butterfly iQ + and WhatsApp to share images and guide diagnostic reasoning. The aim of this review study is to share our experience and challenges in the implementation of a POCUS training curriculum in an LMIC, provide an example of training methodology that can be effective, and discuss how this can be implemented and modified for clinicians in similar settings.
    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-253X
    ISSN (online) 2673-253X
    DOI 10.3389/fdgth.2023.1268905
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  7. Article ; Online: Papular Acneform Eruption With Mucositis.

    Zieman, Daniel P / Bhasin, Arveen / Sluzevich, Jason C

    Cutis

    2023  Volume 111, Issue 5, Page(s) E36–E38

    MeSH term(s) Humans ; Mucositis ; Skin Diseases ; Acneiform Eruptions/diagnosis ; Acneiform Eruptions/etiology ; Exanthema
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391840-3
    ISSN 2326-6929 ; 0011-4162 ; 0151-9522
    ISSN (online) 2326-6929
    ISSN 0011-4162 ; 0151-9522
    DOI 10.12788/cutis.0786
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    Zs.B 1315: Show issues Location:
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    Zs.MG 44: Show issues

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  8. Article ; Online: Many (un)happy returns: Challenges and opportunities for potentially avoidable ED visits after discharge to a skilled nursing facility.

    Bhasin, Ajay / Griffey, Richard T / Ruhnke, Gregory W

    Journal of hospital medicine

    2023  Volume 19, Issue 1, Page(s) 77–78

    MeSH term(s) Humans ; Patient Discharge ; Skilled Nursing Facilities ; Patient Readmission ; Retrospective Studies ; Emergency Service, Hospital
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13240
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  9. Article ; Online: Don't anchor on me!

    Tantoco, Ann-Marie / Bhasin, Ajay / Santos, Maria / Kastl, Art / Bracken, Adam

    Journal of hospital medicine

    2024  Volume 19, Issue 4, Page(s) 323–326

    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13298
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  10. Article ; Online: Evaluation of Cladophora and Chlamydomonas microalgae for environmental sustainability: A comparative study of antimicrobial and photocatalytic dye degradation.

    Guleria, Samriti / Simsek, Halis / Chawla, Prince / Relhan, Ankush / Bhasin, Aparajita

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 340, Issue Pt 1, Page(s) 122806

    Abstract: The present study emphasizes exploring the potential of bioactive compounds such as polysaccharides, protein, pigments, antioxidants, and vitamins extracted from two microalgae species, Cladophora and Chlamydomonas. The extraction process was optimized ... ...

    Abstract The present study emphasizes exploring the potential of bioactive compounds such as polysaccharides, protein, pigments, antioxidants, and vitamins extracted from two microalgae species, Cladophora and Chlamydomonas. The extraction process was optimized for different periods, and the extracted bioactive compounds were characterized. These bioactive compounds showed significant antibacterial activity against gram-positive and gram-negative bacteria. Notably, Cladophora species exhibited a higher zone of inhibition than Chlamydomonas species against both gram-positive and gram-negative bacterial strains. Moreover, the photocatalytic activity of these bioactive compounds was investigated for the degradation of methylene blue and crystal violet dyes under different light conditions. The results demonstrated that Cladophora species exhibited superior photocatalytic activity under natural sunlight, UV light, and visible light sources compared to Chlamydomonas species. Moreover, Cladophora species achieved the highest dye degradation efficiencies of 78% and 72% for methylene blue and crystal violet, respectively, within 150 min compared to UV light and visible light sources.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Coloring Agents ; Microalgae ; Chlamydomonas ; Methylene Blue/chemistry ; Gentian Violet ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Anti-Infective Agents ; Light ; Catalysis
    Chemical Substances Anti-Bacterial Agents ; Coloring Agents ; Methylene Blue (T42P99266K) ; Gentian Violet (J4Z741D6O5) ; Anti-Infective Agents
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2599: Show issues Location:
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