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  1. Book: Hypogonadism

    Bhasin, Shalender

    (Endocrinology and metabolism clinics of North America ; volume 51, number 1 (March 2022))

    2022  

    Author's details editors Shalender Bhasin, Channa N. Jayasena
    Series title Endocrinology and metabolism clinics of North America ; volume 51, number 1 (March 2022)
    Collection
    Language English
    Size xvi, 228 Seiten, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT021318356
    ISBN 978-0-323-89678-8 ; 0-323-89678-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 148 -51,1- not available for loan Lesesaal EG

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  2. Article ; Online: Time-Restricted Eating to Improve Health-A Promising Idea in Need of Stronger Clinical Trial Evidence.

    Bhasin, Shalender

    JAMA internal medicine

    2022  Volume 182, Issue 9, Page(s) 963–964

    MeSH term(s) Eating ; Health Promotion ; Humans
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2022.3038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Testosterone replacement in aging men: an evidence-based patient-centric perspective.

    Bhasin, Shalender

    The Journal of clinical investigation

    2021  Volume 131, Issue 4

    Language English
    Publishing date 2021-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI146607
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  4. Article ; Online: Rectal foreign body removal: increasing incidence and cost to the NHS.

    Bhasin, S / Williams, J G

    Annals of the Royal College of Surgeons of England

    2021  Volume 103, Issue 10, Page(s) 734–737

    Abstract: Introduction: Insertion of foreign objects into the rectum is a well-described phenomenon and not an uncommon referral to the general surgeon on call. Although usually not life-threatening, there can be consequences following migration of the object or ... ...

    Abstract Introduction: Insertion of foreign objects into the rectum is a well-described phenomenon and not an uncommon referral to the general surgeon on call. Although usually not life-threatening, there can be consequences following migration of the object or perforation of the large bowel. This study looks at the incidence of removal of foreign objects from the rectum over the last decade and the financial burden it presents to the NHS.
    Methods: Hospital Episode Statistics for 2010-2019 were used to calculate the number of rectal foreign bodies that required removal in hospital. Data for age groups and genders have been compared.
    Results: A total of 3,500 rectal foreign bodies were removed over the course of 9 years. Males accounted for 85.1% of rectal foreign bodies whilst 14.9% were females. This equates to 348 bed-days per annum. Admission peaks were observed in the second and fifth decades of life.
    Conclusion: This study shows that the incidence of rectal foreign bodies is higher in men and has been increasing over the period studied. Most foreign bodies can be removed trans-anally with the use of anaesthesia, with only a small proportion of patients requiring hospital stay over 24 hours (mean length of stay = 24 hours). Nearly 400 rectal foreign body removals are performed each year with an annual cost of £338,819, illustrating the effect this has on NHS resources.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Foreign Bodies/economics ; Foreign Bodies/epidemiology ; Foreign Bodies/surgery ; Foreign-Body Migration/economics ; Foreign-Body Migration/epidemiology ; Foreign-Body Migration/surgery ; Health Care Costs/statistics & numerical data ; Humans ; Infant ; Length of Stay/economics ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Rectum/surgery ; Sex Factors ; State Medicine/economics ; State Medicine/statistics & numerical data ; United Kingdom/epidemiology ; Young Adult
    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2020.7129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum to "Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy" [J Vet Cardiol 25 (2019 Oct) 41-51].

    Yang, V K / Rush, J E / Bhasin, S / Wagers, A J / Lee, R T

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2198278-8
    ISSN 1875-0834 ; 1760-2734
    ISSN (online) 1875-0834
    ISSN 1760-2734
    DOI 10.1016/j.jvc.2024.03.001
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  6. Article ; Online: Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics.

    Bhasin, Sidharth / Das, Asmita

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–17

    Abstract: SHP1 is a protein tyrosine phosphatase playing a central role in immunity, cell growth, development, and survival. The inhibition of SHP1 can help in better prognosis in various disorders like breast and ovarian cancer, melanoma, atherosclerosis, hypoxia, ...

    Abstract SHP1 is a protein tyrosine phosphatase playing a central role in immunity, cell growth, development, and survival. The inhibition of SHP1 can help in better prognosis in various disorders like breast and ovarian cancer, melanoma, atherosclerosis, hypoxia, hypoactive immune response, and familial dysautonomia. The currently available inhibitors of SHP1 have the side effect of inhibiting the activity of SHP2, which shares >60% sequence similarity with SHP1 but has distinct biological functions. Thus, there is a need to search for novel specific inhibitors of SHP1. The current study uses a combination of virtual screening and molecular dynamic simulations, followed by PCA and MM-GBSA analysis, to screen about 35000 compounds; to predict that two rigidin analogues can potentially selectively inhibit SHP1 but not SHP2. Our studies demonstrate that these rigidin analogues are more potent at inhibiting SHP1 than the commercially available inhibitor NSC-87877. Further, cross-binding studies with SHP2 exhibited poor binding efficiency and lower stability of the complex, thus indicating a specificity of the rigidin analogues for SHP1, which is crucial in preventing side effects due to the diverse physiological functions of SHP2 in cellular signaling, proliferation, and hematopoiesis. Additionally, SHP1 is essential in mediating the inhibitory signaling in antitumor immune cells like NK and T cells. Hence, the rigidin analogues that inhibit SHP1 will potentiate the anti-tumor immune response by the release of inhibitory function of NK cells, thus driving NK activating response, in addition to their intrinsic anti-tumor function. Thus, SHP1 inhibition is a novel double-blade approach towards anti-cancer immunotherapeutics.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2227708
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  7. Article: Selective Androgen Receptor Modulators as Function Promoting Therapies.

    Bhasin, S

    The Journal of frailty & aging

    2015  Volume 4, Issue 3, Page(s) 121–122

    Language English
    Publishing date 2015
    Publishing country France
    Document type Journal Article
    ISSN 2260-1341
    ISSN 2260-1341
    DOI 10.14283/jfa.2015.65
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hypogonadism.

    Bhasin, Shalender / Jayasena, Channa N

    Endocrinology and metabolism clinics of North America

    2022  Volume 51, Issue 1, Page(s) xv–xvi

    MeSH term(s) Humans ; Hypogonadism/diagnosis ; Hypogonadism/therapy ; Testosterone
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 92116-6
    ISSN 1558-4410 ; 0889-8529
    ISSN (online) 1558-4410
    ISSN 0889-8529
    DOI 10.1016/j.ecl.2021.11.015
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  9. Article ; Online: Functional exercise training plus promyogenic therapy: A winning formula for preventing and treating mobility-disability?

    Reid, Kieran F / Storer, Thomas W / Bhasin, Shalender

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 6, Page(s) 2017–2022

    MeSH term(s) Humans ; Exercise ; Exercise Therapy ; Disabled Persons
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18293
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  10. Article: Antibody-Drug Conjugates: A Review of Approved Drugs and Their Clinical Level of Evidence.

    Gogia, Pooja / Ashraf, Hamza / Bhasin, Sidharth / Xu, Yiqing

    Cancers

    2023  Volume 15, Issue 15

    Abstract: Antibody-drug conjugates (ADCs) are an innovative family of agents assembled through linking cytotoxic drugs (payloads) covalently to monoclonal antibodies (mAbs) to be delivered to tumor tissue that express their particular antigen, with the theoretical ...

    Abstract Antibody-drug conjugates (ADCs) are an innovative family of agents assembled through linking cytotoxic drugs (payloads) covalently to monoclonal antibodies (mAbs) to be delivered to tumor tissue that express their particular antigen, with the theoretical advantage of an augmented therapeutic ratio. As of June 2023, eleven ADCs have been approved by the Food and Drug Administration (FDA) and are on the market. These drugs have been added to the therapeutic armamentarium of acute myeloblastic and lymphoblastic leukemias, various types of lymphoma, breast, gastric or gastroesophageal junction, lung, urothelial, cervical, and ovarian cancers. They have proven to deliver more potent and effective anti-tumor activities than standard practice in a wide variety of indications. In addition to targeting antigen-expressing tumor cells, bystander effects have been engineered to extend cytotoxic killing to low-antigen-expressing or negative tumor cells in the heterogenous tumor milieu. Inevitably, myelosuppression is a common side effect with most of the ADCs due to the effects of the cytotoxic payload. Also, other unique side effects are specific to the tissue antigen that is targeted for, such as the cardiac toxicity with Her-2 targeting ADCs, and the hemorrhagic side effects with the tissue factor (TF) targeting Tisotumab vedotin. Further exciting developments are centered in the strategies to improve the tolerability and efficacy of the ADCs to improve the therapeutic window; as well as the development of novel payloads including (1) peptide-drug conjugates (PDCs), with the peptide replacing the monoclonal antibody, rendering greater tumor penetration; (2) immune-stimulating antibody conjugates (ISACs), which upon conjugation of the antigen, cause an influx of pro-inflammatory cytokines to activate dendritic cells and harness an anti-tumor T-cell response; and (3) the use of radioactive isotopes as a payload to enhance cytotoxic activity.
    Language English
    Publishing date 2023-07-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15153886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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