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  1. AU="Bhat, Aishwarya"
  2. AU="Hossain, Md Zakir"
  3. AU=Jiang Xianhan
  4. AU="Mousavi, Seyyed Meysam"
  5. AU=Paulson J C
  6. AU="Saif, Tahir"
  7. AU=Alam Sabiha AU=Alam Sabiha
  8. AU="Braniff, Julia"
  9. AU="Kasim, Sazzli"
  10. AU=Brown Samuel M
  11. AU="Daubenberger, Claudia A."
  12. AU="Esteban, L"
  13. AU=Tyrka Audrey R.
  14. AU="Álvarez-Valenzuela, Francisco D"
  15. AU="Akrofi, M.M."
  16. AU="Torres, Daiana Rodrigues"
  17. AU="Bercovici, Nicholas"
  18. AU="Di Maio, Ginevra"
  19. AU="Indelicarto, Matthew"
  20. AU="Ma, Yan"
  21. AU="Ngan, CDR Kelly"
  22. AU="Arzamendi, Dabit"
  23. AU="Rezende, Carlos Eduardo Borges"
  24. AU="Brunvand, E."
  25. AU="Gateno, Jaime"

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  1. Artikel ; Online: Ultrasound-guided bilateral bi-level erector spinae plane block for perioperative analgesia in an adult patient with neuromuscular scoliosis undergoing spine surgery.

    Mistry, Tuhin / Bhat, Aishwarya Madhav / Balavenkatasubramanian, Jagannathan / Chandramohan, Madhanmohan / Sonawane, Kartik

    Journal of clinical anesthesia

    2021  Band 73, Seite(n) 110383

    Mesh-Begriff(e) Adult ; Analgesia ; Anesthesia, Conduction ; Humans ; Nerve Block ; Pain, Postoperative/etiology ; Pain, Postoperative/prevention & control ; Scoliosis/complications ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Ultrasonography, Interventional
    Sprache Englisch
    Erscheinungsdatum 2021-06-08
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2021.110383
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

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  2. Artikel ; Online: Proteo-Genomic Analysis of SARS-CoV-2: A Clinical Landscape of Single-Nucleotide Polymorphisms, COVID-19 Proteome, and Host Responses.

    Tushir, Sheetal / Kamanna, Sathisha / Nath, Sujith S / Bhat, Aishwarya / Rose, Steffimol / Aithal, Advait R / Tatu, Utpal

    Journal of proteome research

    2021  Band 20, Heft 3, Seite(n) 1591–1601

    Abstract: A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and continues to be a global health challenge. To understand viral disease biology, we have carried out proteo-genomic ... ...

    Abstract A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) and continues to be a global health challenge. To understand viral disease biology, we have carried out proteo-genomic analysis using next-generation sequencing (NGS) and mass spectrometry on nasopharyngeal swabs of COVID-19 patients to examine the clinical genome and proteome. Our study confirms the mutability of SARS-CoV-2 showing multiple single-nucleotide polymorphisms. NGS analysis detected 27 mutations, of which 14 are synonymous, 11 are missense, and 2 are extragenic in nature. Phylogenetic analysis of SARS-CoV-2 isolates indicated their close relation to a Bangladesh isolate and multiple origins of isolates within the country. Our proteomic analysis, for the first time, identified 13 different SARS-CoV-2 proteins from the clinical swabs. Of the total 41 peptides captured by high-resolution mass spectrometry, 8 matched to nucleocapsid protein, 2 to ORF9b, and 1 to spike glycoprotein and ORF3a, with remaining peptides mapping to ORF1ab polyprotein. Additionally, host proteome analysis revealed several key host proteins to be uniquely expressed in COVID-19 patients. Pathway analysis of these proteins points toward modulation in immune response, especially involving neutrophil and IL-12-mediated signaling. Besides revealing the aspects of host-virus pathogenesis, our study opens new avenues to develop better diagnostic markers and therapeutic approaches.
    Mesh-Begriff(e) COVID-19/virology ; Coronavirus Nucleocapsid Proteins/genetics ; Genome, Viral ; Genomics ; High-Throughput Nucleotide Sequencing ; Host Microbial Interactions/genetics ; Host Microbial Interactions/physiology ; Humans ; Mutation ; Pandemics ; Phosphoproteins/genetics ; Phylogeny ; Polymorphism, Single Nucleotide ; Polyproteins/genetics ; Proteome ; Proteomics ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/genetics ; Viral Proteins/genetics ; Viroporin Proteins/genetics
    Chemische Substanzen Coronavirus Nucleocapsid Proteins ; ORF1ab polyprotein, SARS-CoV-2 ; ORF3a protein, SARS-CoV-2 ; Phosphoproteins ; Polyproteins ; Proteome ; Spike Glycoprotein, Coronavirus ; Viral Proteins ; Viroporin Proteins ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-02-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078618-9
    ISSN 1535-3907 ; 1535-3893
    ISSN (online) 1535-3907
    ISSN 1535-3893
    DOI 10.1021/acs.jproteome.0c00808
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6189: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Proteo-genomic analysis of SARS-CoV-2: A clinical landscape of SNPs, COVID-19 proteome and host responses

    Tushir, Sheetal / Kamanna, Sathisha / Nath, Sujith S / Bhat, Aishwarya / Rose, Steffimol / Aithal, Advait R / Tatu, Utpal

    medRxiv

    Abstract: A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 and continues to be a global health challenge. To understand viral disease biology, we have carried out proteo-genomic analysis using next generation ... ...

    Abstract A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 and continues to be a global health challenge. To understand viral disease biology, we have carried out proteo-genomic analysis using next generation sequencing (NGS) and mass-spectrometry on nasopharyngeal swabs of COVID-19 patients to examine clinical genome and proteome. Our study confirms the hyper mutability of SARS-CoV-2 showing multiple SNPs. NGS analysis detected 27 mutations of which 14 are synonymous, 11 are missense and 2 are extragenic in nature. Phylogenetic analysis of SARS-CoV-2 isolates indicated their close relation to Bangladesh isolate and multiple origins of isolates within a country. Our proteomic analysis, for the first time identified 13 different SARS-CoV-2 proteins from the clinical swabs. Of the total 41 peptides captured by HRMS, 8 matched to nucleocapsid protein, 2 to ORF9b, 1 to spike glycoprotein and ORF3a, with remaining mapping to ORF1ab polyprotein. Additionally, host proteome analysis revealed several key host proteins to be uniquely expressed in COVID-19 patients. Pathway analysis of these proteins points towards modulation in immune response, especially involving neutrophil and IL-12 mediated signaling. Besides revealing the aspects of host-virus pathogenesis, our study opens new avenues to develop better diagnostic markers and therapeutics.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-11-30
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.11.27.20237032
    Datenquelle COVID19

    Volltext online

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  4. Artikel: Iatrogenic Damage to the Periodontium Caused by Endodontic Treatment Procedures: An Overview.

    Bhat, Aishwarya / Sirajuddin, Syed / Prabhu, Sandeep S / Chungkham, Sachidananda / Bilichodmath, Chandrasekhar

    The open dentistry journal

    2015  Band 9, Seite(n) 214–216

    Abstract: The tooth, the pulp tissue within it and its supporting structures should be viewed as one biologic unit. The interrelationship of these structures influences each other during health, function and disease. The interrelationship between periodontal and ... ...

    Abstract The tooth, the pulp tissue within it and its supporting structures should be viewed as one biologic unit. The interrelationship of these structures influences each other during health, function and disease. The interrelationship between periodontal and endodontic diseases has aroused much speculation, confusion and controversy. The endodontium and periodontiumare closely related and disease or damage of one tissue may lead to the involvement of the other.
    Sprache Englisch
    Erscheinungsdatum 2015-06-26
    Erscheinungsland United Arab Emirates
    Dokumenttyp Journal Article
    ZDB-ID 2396267-7
    ISSN 1874-2106
    ISSN 1874-2106
    DOI 10.2174/1874210601509010214
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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