Article ; Online: Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial.
Indian journal of dermatology, venereology and leprology
2016 Volume 82, Issue 1, Page(s) 42–46
Abstract: Background: Warts are known to clear spontaneously with the development of cell-mediated immunity (CMI) to the virus. Purified protein derivative (PPD) of tuberculin bacilli has been used as a non-specific stimulant of CMI to achieve this outcome.: ... ...
Abstract | Background: Warts are known to clear spontaneously with the development of cell-mediated immunity (CMI) to the virus. Purified protein derivative (PPD) of tuberculin bacilli has been used as a non-specific stimulant of CMI to achieve this outcome. Aim: To study the effect of PPD in the treatment of warts. Methods: Patients with difficult-to-treat warts were selected for immunotherapy. Each patient received 2.5 TU of PPD intralesionally in a few warts. A total of four sessions were given at 2 weekly intervals and patients were followed up for 6 months after the last dose. Results: Sixty-one patients were recruited of which 55 completed 6 months follow up and were available for analysis. Of these, 25 had verruca vulgaris, 18 had verruca plana and 12 had plantar warts. Forty two (76%) patients showed complete clearance after four sessions while the remaining 13 (24%) patients were non-responders. One patient developed a recurrence after total clearance during the follow-up period. Adverse effects were erythema, edema and pain at the site of injections. Limitations: As this was an uncontrolled trial, there is no comparison with a non-intervention group. Also, a Mantoux test was not done due to practical difficulties. Conclusion: Immunotherapy with PPD is helpful in the treatment of cutaneous warts. |
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MeSH term(s) | Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Immunotherapy/methods ; Injections, Intralesional ; Male ; Middle Aged ; Prospective Studies ; Skin Neoplasms/pathology ; Skin Neoplasms/physiopathology ; Skin Neoplasms/therapy ; Treatment Outcome ; Tuberculin/administration & dosage ; Warts/pathology ; Warts/physiopathology ; Warts/therapy ; Young Adult |
Chemical Substances | Tuberculin |
Language | English |
Publishing date | 2016-01 |
Publishing country | India |
Document type | Clinical Trial ; Journal Article |
ZDB-ID | 416068-x |
ISSN | 0973-3922 ; 0019-5162 ; 0378-6323 |
ISSN (online) | 0973-3922 |
ISSN | 0019-5162 ; 0378-6323 |
DOI | 10.4103/0378-6323.171650 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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