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  1. Article: Neuroscience Engagement and Outreach on Neurodevelopmental Disorders: A Report from India.

    Bhatia, Divya

    Annals of neurosciences

    2023  Volume 30, Issue 2, Page(s) 119–123

    Abstract: The current project was funded by the Global Engagement Seed Grant from the International Brain Research Organisation (IBRO) as part of the IBRO-led Global Engagement Initiative. The project was focused on public awareness about neurodevelopmental ... ...

    Abstract The current project was funded by the Global Engagement Seed Grant from the International Brain Research Organisation (IBRO) as part of the IBRO-led Global Engagement Initiative. The project was focused on public awareness about neurodevelopmental disorders (NDDs) as well as neuroscience engagement. Thus, the project had two specific aims: (a) public awareness about epidemiology, diagnosis, risk factors, prevention of NDDs and relevant government guidelines and available policies (b) public engagement in neuroscience. Therefore, the current project report with an emphasis on the requirement of neuroscience engagement and outreach at the societal level, highlights several activities such as population-based workshops and webinars, carried out as part of the project in both rural and urban areas to enhance the public engagement in neuroscience and awareness on several NDDs.
    Key message: India is an extremely diverse country with significant variations in cultural, educational, financial, socioeconomic status and linguistic aspects. With about 27% of its population living below the poverty line, India accounts for about 23 million children suffering from a disability, most of whom do not seek medical help. These data highlight the gravity of the situation which calls for urgent actions from governments, healthcare professionals, researchers and policymakers to design adequate public awareness programs regarding several prevalent NDDs. Therefore, the current project was an effort to bring public awareness about brain health and the epidemiology, diagnosis and prevention of NDDs and relevant government guidelines and available policies.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2576191-2
    ISSN 0976-3260 ; 0972-7531
    ISSN (online) 0976-3260
    ISSN 0972-7531
    DOI 10.1177/09727531231176122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Editorial: Diabetic kidney disease: routes to drug development, pharmacology and underlying molecular mechanisms.

    Bhatia, Divya / Srivastava, Swayam Prakash

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1252315

    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1252315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Autophagy and mitophagy: physiological implications in kidney inflammation and diseases.

    Bhatia, Divya / Choi, Mary E

    American journal of physiology. Renal physiology

    2023  Volume 325, Issue 1, Page(s) F1–F21

    Abstract: Autophagy is a ubiquitous intracellular cytoprotective quality control program that maintains cellular homeostasis by recycling superfluous cytoplasmic components (lipid droplets, protein, or glycogen aggregates) and invading pathogens. Mitophagy is a ... ...

    Abstract Autophagy is a ubiquitous intracellular cytoprotective quality control program that maintains cellular homeostasis by recycling superfluous cytoplasmic components (lipid droplets, protein, or glycogen aggregates) and invading pathogens. Mitophagy is a selective form of autophagy that by recycling damaged mitochondrial material, which can extracellularly act as damage-associated molecular patterns, prevents their release. Autophagy and mitophagy are indispensable for the maintenance of kidney homeostasis and exert crucial functions during both physiological and disease conditions. Impaired autophagy and mitophagy can negatively impact the pathophysiological state and promote its progression. Autophagy helps in maintaining structural integrity of the kidney. Mitophagy-mediated mitochondrial quality control is explicitly critical for regulating cellular homeostasis in the kidney. Both autophagy and mitophagy attenuate inflammatory responses in the kidney. An accumulating body of evidence highlights that persistent kidney injury-induced oxidative stress can contribute to dysregulated autophagic and mitophagic responses and cell death. Autophagy and mitophagy also communicate with programmed cell death pathways (apoptosis and necroptosis) and play important roles in cell survival by preventing nutrient deprivation and regulating oxidative stress. Autophagy and mitophagy are activated in the kidney after acute injury. However, their aberrant hyperactivation can be deleterious and cause tissue damage. The findings on the functions of autophagy and mitophagy in various models of chronic kidney disease are heterogeneous and cell type- and context-specific dependent. In this review, we discuss the roles of autophagy and mitophagy in the kidney in regulating inflammatory responses and during various pathological manifestations.
    MeSH term(s) Humans ; Mitophagy ; Autophagy/physiology ; Nephritis ; Kidney ; Inflammation
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00012.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acral keratosis with eosinophilic dermal deposits: a rare subtype of colloid milium.

    Narayanan, Arunachalam / Bhatia, Divya / Chopra, Shikha / Budania, Anil / Khera, Sudeep

    International journal of dermatology

    2024  

    Language English
    Publishing date 2024-05-17
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Automated Shoulder Implant Manufacturer Detection using Encoder Decoder based Classifier from X-ray Images.

    Kanakatte, Aparna / Bhatia, Divya / Ghose, Avik

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2023  Volume 2023, Page(s) 1–4

    Abstract: Total shoulder arthroplasty is the process of replacing the damaged ball and socket joint in the shoulder with a prosthesis made with polyethylene and metal components. The prosthesis helps to restore the normal range of motion and reduce pain, enabling ... ...

    Abstract Total shoulder arthroplasty is the process of replacing the damaged ball and socket joint in the shoulder with a prosthesis made with polyethylene and metal components. The prosthesis helps to restore the normal range of motion and reduce pain, enabling the patient to return to their daily activities. These implants may need to be replaced over the years due to damage or wear and tear. It is a tedious and time-consuming process to identify the type of implant if medical records are not properly maintained. Artificial intelligence systems can speed up the treatment process by classifying the manufacturer and model of the prosthesis. We have proposed an encoder-decoder based classifier along with the supervised contrastive loss function that can identify the implant manufacturer effectively with increased accuracy of 92% from X-ray images overcoming the class imbalance problem.
    MeSH term(s) Humans ; Shoulder/diagnostic imaging ; Shoulder Joint/diagnostic imaging ; Shoulder Joint/surgery ; Joint Prosthesis ; Artificial Intelligence ; X-Rays ; Prosthesis Design ; Arthroplasty, Replacement/methods ; Polyethylene
    Chemical Substances Polyethylene (9002-88-4)
    Language English
    Publishing date 2023-12-11
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC40787.2023.10340429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cardiac Anomaly Detection from Cine MRI Images using Physiological Features and Random Forest Classifier.

    Bhatia, Divya / Kanakatte, Aparna / Ghose, Avik

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2022  Volume 2022, Page(s) 3801–3804

    Abstract: Computer-aided diagnosis (CAD) with cine MRI is a foremost research topic to enable improved, faster, and more accurate diagnosis of cardiovascular diseases (CVD). However, current approaches that use manual visualization or conventional clinical indices ...

    Abstract Computer-aided diagnosis (CAD) with cine MRI is a foremost research topic to enable improved, faster, and more accurate diagnosis of cardiovascular diseases (CVD). However, current approaches that use manual visualization or conventional clinical indices can lack accuracy for borderline cases. Also, manual visualization of 3D/4D MR data is time-consuming and expert-dependent. We try to simplify this process by creating an end-to-end automated CAD system that segments the critical substructures of the heart. The new domain-related physiological features are then calculated from the segmented regions. These features are fed to a random forest classifier that identifies the anomaly. We have obtained a very high accuracy when testing this end-to-end approach on the Automated Cardiac Diagnosis challenge (ACDC) dataset (4 pathologies, 1 normal). To prove the generalizability of the method we have blind-tested this approach on M&Ms-2 dataset which is a multi-center, multi-vendor, and multi-disease dataset with better than 90% accuracy.
    MeSH term(s) Cardiovascular Diseases ; Diagnosis, Computer-Assisted ; Heart/diagnostic imaging ; Heart Defects, Congenital ; Humans ; Magnetic Resonance Imaging, Cine
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC48229.2022.9871368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 3D Cardiac Substructures Segmentation from CMRI using Generative Adversarial Network (GAN).

    Kanakatte, Aparna / Bhatia, Divya / Ghose, Avik

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2022  Volume 2022, Page(s) 1698–1701

    Abstract: Cardiac magnetic resonance imaging (CMRI) improves the diagnosis of cardiovascular diseases by providing images at high spatio-temporal resolution helping physicians in providing correct treatment plans. Segmentation and identification of various ... ...

    Abstract Cardiac magnetic resonance imaging (CMRI) improves the diagnosis of cardiovascular diseases by providing images at high spatio-temporal resolution helping physicians in providing correct treatment plans. Segmentation and identification of various substructures of the heart at different cardiac phases of end-systole and end-diastole helps in the extraction of ventricular function information such as stroke volume, ejection fraction, myocardium thickness, etc. Manual delineation of the substructures is tedious, time-consuming, and error-prone. We have implemented a 3D GAN that includes 3D contextual information capable of segmenting and identifying the substructures at different cardiac phases with improved accuracy. Our method is evaluated on the ACDC dataset (4 pathologies, 1 healthy group) to show that the proposed out-performs other methods in literature with less amount of data. Also, the proposed provided a better Dice score in segmentation surpassing other methods on a blind-tested M&Ms dataset.
    MeSH term(s) Cardiovascular Diseases ; Heart/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Stroke Volume ; Ventricular Function
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC48229.2022.9871950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Emerging Role of Mitophagy in Kidney Diseases.

    Bhatia, Divya / Choi, Mary E

    Journal of life sciences (Westlake Village, Calif.)

    2020  Volume 1, Issue 3, Page(s) 13–22

    Abstract: Mitochondria fulfill the high metabolic energy demands of the kidney and are regularly exposed to oxidative stress causing mitochondrial damage. The selective removal of damaged and dysfunctional mitochondria through a process known as mitophagy is ... ...

    Abstract Mitochondria fulfill the high metabolic energy demands of the kidney and are regularly exposed to oxidative stress causing mitochondrial damage. The selective removal of damaged and dysfunctional mitochondria through a process known as mitophagy is essential in maintaining cellular homeostasis and physiological function. Mitochondrial quality control by mitophagy is particularly crucial for an organ such as the kidney, which is rich in mitochondria. The role of mitophagy in the pathogenesis of kidney diseases has lately gained significant attention. In this review, we summarize the current understanding of the implications of mitophagy during pathological conditions of the kidney, including acute and chronic kidney diseases.
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2688-1020
    ISSN (online) 2688-1020
    DOI 10.36069/jols/20191203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Autophagy in kidney disease: Advances and therapeutic potential.

    Bhatia, Divya / Choi, Mary E

    Progress in molecular biology and translational science

    2020  Volume 172, Page(s) 107–133

    Abstract: Autophagy is a highly conserved intracellular catabolic process for the degradation of cytoplasmic components that has recently gained increasing attention for its importance in kidney diseases. It is indispensable for the maintenance of kidney ... ...

    Abstract Autophagy is a highly conserved intracellular catabolic process for the degradation of cytoplasmic components that has recently gained increasing attention for its importance in kidney diseases. It is indispensable for the maintenance of kidney homeostasis both in physiological and pathological conditions. Investigations utilizing various kidney cell-specific conditional autophagy-related gene knockouts have facilitated the advancement in understanding of the role of autophagy in the kidney. Recent findings are raising the possibility that defective autophagy exerts a critical role in different pathological conditions of the kidney. An emerging body of evidence reveals that autophagy exhibits cytoprotective functions in both glomerular and tubular compartments of the kidney, suggesting the upregulation of autophagy as an attractive therapeutic strategy. However, there is also accumulating evidence that autophagy could be deleterious, which presents a formidable challenge in developing therapeutic strategies targeting autophagy. Here, we review the recent advances in research on the role of autophagy during different pathological conditions, including acute kidney injury (AKI), focusing on sepsis, ischemia-reperfusion injury, cisplatin, and heavy metal-induced AKI. We also discuss the role of autophagy in chronic kidney disease (CKD) focusing on the pathogenesis of tubulointerstitial fibrosis, podocytopathies including focal segmental glomerulosclerosis, diabetic nephropathy, IgA nephropathy, membranous nephropathy, HIV-associated nephropathy, and polycystic kidney disease.
    MeSH term(s) Animals ; Autophagy/physiology ; Autophagy-Related Proteins/physiology ; Cisplatin/toxicity ; Clinical Trials as Topic ; Disease Models, Animal ; Homeostasis ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/drug therapy ; Kidney Diseases/physiopathology ; Kidney Glomerulus/physiology ; Kidney Tubules/physiology ; Lysosomes/physiology ; Metals, Heavy/toxicity ; Mice ; Mice, Knockout ; Nephrosis, Lipoid/pathology ; Podocytes/pathology ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/physiology
    Chemical Substances Autophagy-Related Proteins ; Metals, Heavy ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-02-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2020.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A prospective observational study correlating possible novel biomarkers with disease severity and antihistamine response in chronic spontaneous urticaria.

    Bhatia, Divya / Mehta, Hitaishi / Bishnoi, Anuradha / Srivastava, Niharika / Vinay, Keshavamurthy / Parsad, Davinder / Kumaran, Muthu Sendhil

    Asia Pacific allergy

    2024  Volume 14, Issue 1, Page(s) 5–11

    Abstract: Background: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive.: Objective: To identify the role ... ...

    Abstract Background: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive.
    Objective: To identify the role of C5a, IL-9, and apo A-IV as potential biomarkers in predicting disease severity and antihistamine response in CSU patients.
    Methods: This was a prospective observational study of 95 patients and 42 controls. Serum analysis of C5a, IL-9, and apo A-IV was done using enyzme linked immunosorbent assay kits. Also, serum IgE and anti-thyroid peroxidase (TPO) levels were assessed in all patients. All patients were started on oral levocetirizine 5 mg at baseline and dose was titrated upwards to maximum of 20 mg based on response. Patients were categorized into antihistamine responders or nonresponders as per their disease response. Serological markers, serum IgE, and anti-TPO were correlated with baseline disease severity and antihistamine response.
    Results: C5a levels were significantly higher in cases as compared to controls (
    Conclusions: IL-9 and apo A-IV might be potential novel biomarkers to predict urticaria severity. Higher IL-9 might be a predictor of antihistamine response. Elevated anti-TPO and serum IgE might predict poor antihistamine response.
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2614800-6
    ISSN 2233-8268 ; 2233-8276
    ISSN (online) 2233-8268
    ISSN 2233-8276
    DOI 10.5415/apallergy.0000000000000132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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