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Article ; Online: Designing a New Class of Mechanophoric Polymer Based on Epoxy-Functionalized Rhodamine Derivative.

Chakraborty, Swadhin / Bhattacharya, Koushik / Choudhury, Soumyadip / Singha, Nikhil K

2024 , Page(s) e2400065

Abstract: Mechanophoric polymers are an interesting class of smart polymers which contains a special force-sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the ... ...

Abstract	Mechanophoric polymers are an interesting class of smart polymers which contains a special force-sensitive molecular motif that can lead to a chemical change within the polymer network in response to mechanical force. This investigation reports the design of a mechanophoric polymer based on epoxy-functionalized rhodamine via a monomeric approach. In this case, rhodamine (Rh) is modified with glycidyl methacrylate (GMA) through an epoxy-amine reaction to design a vinyl-functionalized multi-armed macromonomer (Rh-GMA), which is reacted with butyl acrylate (BA) to prepare the crosslinked polymeric film. The crosslinked polymeric film demonstrates mechanophoric properties under UV and stretching conditions.
Language	English
Publishing date	2024-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1475027-2
ISSN	1521-3927 ; 1022-1336
ISSN (online)	1521-3927
ISSN	1022-1336
DOI	10.1002/marc.202400065
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Article ; Online: β-Amyloid peptide modulates peripheral immune responses and neuroinflammation in rats.

Adhikary, Krishnendu / Mohanty, Satyajit / Bandyopadhyay, Bidyut / Maiti, Rajkumar / Bhattacharya, Koushik / Karak, Prithviraj

Biomolecular concepts

2024 Volume 15, Issue 1

Abstract: Alzheimer's disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of β-amyloid (Aβ) peptide in the rat brain ... ...

Abstract	Alzheimer's disease (AD) is characterized by immune system dysregulation, impacting both central and peripheral immune responses. The study aimed to investigate the mechanism behind the neurotoxic effects of β-amyloid (Aβ) peptide in the rat brain including the study of neuroinflammation, neurodegeneration, and alterations in peripheral immune responses (PIR). The neuroinflammation brought on by Aβ
MeSH term(s)	Rats ; Animals ; Neuroinflammatory Diseases ; Amyloid beta-Peptides ; Alzheimer Disease ; Cytokines ; Immunity ; Disease Models, Animal
Chemical Substances	Amyloid beta-Peptides ; Cytokines
Language	English
Publishing date	2024-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2557908-3
ISSN	1868-503X ; 1868-5021
ISSN (online)	1868-503X
ISSN	1868-5021
DOI	10.1515/bmc-2022-0042
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Zs.A 7056: Show issues

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Article ; Online: Impact of a lifestyle intervention program on cardio-metabolic parameters among obese adults: A comparative population-based study in West Bengal, India.

Bose, Chaitali / Kinge, Amol Dilip / Sultana, Julekha / Biswas, Ajoy Kumar / Bhattacharya, Koushik / Syamal, Alak Kumar

Journal of medicine and life

2023 Volume 16, Issue 4, Page(s) 559–570

Abstract: The obesity epidemic is not only limited to high-income or urbanized societies, but has also become prevalent among rural communities, even in India. Approaches to modifiable behaviors, like unhealthy dietary habits or a sedentary lifestyle, could bring ... ...

Abstract	The obesity epidemic is not only limited to high-income or urbanized societies, but has also become prevalent among rural communities, even in India. Approaches to modifiable behaviors, like unhealthy dietary habits or a sedentary lifestyle, could bring positive results among obese populations. This research aimed to assess the effectiveness of lifestyle intervention programs to prevent obesity and cardio-metabolic risks among Bengali obese adults (Body Mass Index of 25-30kg/m
MeSH term(s)	Adult ; Female ; Humans ; Male ; Anthropometry ; Blood Glucose ; India/epidemiology ; Insulin Resistance ; Obesity/epidemiology ; Obesity/prevention & control ; Young Adult ; Middle Aged ; Program Evaluation ; Cardiometabolic Risk Factors ; Healthy Lifestyle ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data ; Triglycerides/blood
Chemical Substances	Blood Glucose ; Triglycerides
Language	English
Publishing date	2023-06-06
Publishing country	Romania
Document type	Comparative Study ; Journal Article
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3117 ; 1844-3109
ISSN (online)	1844-3117
ISSN	1844-3117 ; 1844-3109
DOI	10.25122/jml-2022-0006
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Article ; Online: Optimization of estrogen dosage for uterine receptivity for implantation in post-coital bilaterally ovariectomized mice.

Bhattacharya, Koushik / Sengupta, Pallav / Dutta, Sulagna / Syamal, Alak Kumar

Molecular and cellular biochemistry

2022 Volume 478, Issue 2, Page(s) 285–289

Abstract: Estrogens and progesterone, in unison and/or separately, synchronize the distinct events of blastocyst development, uterine priming and receptivity induction for implantation. In contrast to high implantation failure rates, the mechanistic concepts ... ...

Abstract	Estrogens and progesterone, in unison and/or separately, synchronize the distinct events of blastocyst development, uterine priming and receptivity induction for implantation. In contrast to high implantation failure rates, the mechanistic concepts regarding the uterine receptivity for implantation still remain elusive. The present study aims to define the minimum estradiol (E
MeSH term(s)	Mice ; Female ; Male ; Animals ; Progesterone/pharmacology ; Semen ; Estrogens/pharmacology ; Embryo Implantation ; Estradiol/pharmacology ; Uterus
Chemical Substances	Progesterone (4G7DS2Q64Y) ; Estrogens ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2022-07-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04505-1
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Zs.A 892: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Beyond traditional therapy: Mucoadhesive polymers as a new frontier in oral cancer management.

Das, Subhayan / Bhattacharya, Koushik / Blaker, Jonny J / Singha, Nikhil K / Mandal, Mahitosh

Biopolymers

2023 Volume 114, Issue 9, Page(s) e23556

Abstract: In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains ... ...

Abstract	In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.
MeSH term(s)	Humans ; Polymers ; Drug Delivery Systems/methods ; Pharmaceutical Preparations ; Mouth Mucosa ; Mouth Neoplasms/drug therapy
Chemical Substances	Polymers ; Pharmaceutical Preparations
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1123-x
ISSN	1097-0282 ; 0006-3525
ISSN (online)	1097-0282
ISSN	0006-3525
DOI	10.1002/bip.23556
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Zs.A 77: Show issues

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Article: Ovulation and rate of implantation following unilateral ovariectomy in mice.

Bhattacharya, Koushik

Journal of human reproductive sciences

2013 Volume 6, Issue 1, Page(s) 45–48

Abstract: Objectives: Removal of an ovary of any side of the body is called the unilateral ovariectomy (ULO). ULO models are used to analyze the existence of functional and physiological asymmetries between the ovaries, including the ovum implantation.: ... ...

Abstract	Objectives: Removal of an ovary of any side of the body is called the unilateral ovariectomy (ULO). ULO models are used to analyze the existence of functional and physiological asymmetries between the ovaries, including the ovum implantation. Materials and methods: ULO was done in mice without any specification on their stages of the estrous cycle. The animals were mated between 3(rd) and 15(th) day after ULO to observe the consequence of ULO on ovulation and ovum implantation. Results: Ovulation and number of implantation were decreased in proportion to single contralateral ovary if the animals were mated within 36 hrs of ULO. It resulted in increased weight of contralateral ovary due to hypertrophy, and also in compensatory ovulation, formation of corpus luteum (CL) that reached a peak after 14(th) and 15(th) day of ULO (sacrificed on 5(th) day of pregnancy i.e., 19(th) and 20(th) day of ULO) compared to animals undergone sham-surgery. Numbers of implantations were also increased progressively on the contralateral ovarian side and get to a peak after similar days of compensation. Discussion and conclusion: Following ULO, the remaining ovary started to compensate within 5(th) to 6(th) day of ULO even during pregnancy. Ovarian histology also showed increased formation of CL which is a marker of rate of ovulation.
Language	English
Publishing date	2013-07-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2418984-4
ISSN	1998-4766 ; 0974-1208
ISSN (online)	1998-4766
ISSN	0974-1208
DOI	10.4103/0974-1208.112381
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Article ; Online: The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review.

Adhikary, Krishnendu / Sarkar, Riya / Maity, Sriparna / Banerjee, Ipsita / Chatterjee, Prity / Bhattacharya, Koushik / Ahuja, Deepika / Sinha, Nirmalya Kumar / Maiti, Rajkumar

Journal of basic and clinical physiology and pharmacology

2024

Abstract: Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which is often triggered by an entire or relative inadequacy of insulin production or insulin resistance. As a result of resistance to insulin (IR) ... ...

Abstract	Type 2 diabetes mellitus is a long-lasting endocrine disorder characterized by persistent hyperglycaemia, which is often triggered by an entire or relative inadequacy of insulin production or insulin resistance. As a result of resistance to insulin (IR) and an overall lack of insulin in the body, type 2 diabetes mellitus (T2DM) is a metabolic illness that is characterized by hyperglycaemia. Notably, the occurrence of vascular complications of diabetes and the advancement of IR in T2DM are accompanied by dysbiosis of the gut microbiota. Due to the difficulties in managing the disease and the dangers of multiple accompanying complications, diabetes is a chronic, progressive immune-mediated condition that plays a significant clinical and health burden on patients. The frequency and incidence of diabetes among young people have been rising worldwide. The relationship between the gut microbiota composition and the physio-pathological characteristics of T2DM proposes a novel way to monitor the condition and enhance the effectiveness of therapies. Our knowledge of the microbiota of the gut and how it affects health and illness has changed over the last 20 years. Species of the genus Eubacterium, which make up a significant portion of the core animal gut microbiome, are some of the recently discovered 'generation' of possibly helpful bacteria. In this article, we have focused on pathogenesis and therapeutic approaches towards T2DM, with a special reference to gut bacteria from ancient times to the present day.
Language	English
Publishing date	2024-05-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1071737-7
ISSN	2191-0286 ; 0792-6855 ; 0334-1534
ISSN (online)	2191-0286
ISSN	0792-6855 ; 0334-1534
DOI	10.1515/jbcpp-2024-0043
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Zs.A 3207: Show issues

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Article ; Online: Graphene Quantum Dots-Ornamented Waterborne Epoxy-Based Fluorescent Adhesive via Reversible Addition-Fragmentation Chain Transfer-Mediated Miniemulsion Polymerization: A Potential Material for Art Conservation.

Samanta, Sarthik / Banerjee, Sovan Lal / Bhattacharya, Koushik / Singha, Nikhil K

ACS applied materials & interfaces

2021 Volume 13, Issue 30, Page(s) 36307–36319

Abstract: Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the ... ...

Abstract	Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the transparent nature of epoxy-based adhesives. Hence, the making of fluorescent adhesives has become an exciting topic for art conservators. Here, we have synthesized a new kind of waterborne epoxy-based fluorescent adhesive decorated with graphene quantum dots (GQDs) via reversible addition-fragmentation chain transfer (RAFT)-mediated surfactant-free miniemulsion polymerization. In this case, a new block copolymer (BCP), poly(1-vinyl-2-pyrrolidone)-
Language	English
Publishing date	2021-07-23
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c08812
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Article: A Randomized Controlled Trial Comparing Remission Induction with Modified Multitarget Therapy with Intravenous Cyclophosphamide in Proliferative Lupus Nephritis.

Pal, Atanu / Chaudhury, Arpita Ray / Bhunia, Abhirup / Bhattacharya, Koushik / Chatterjee, Suparna / Divyaveer, Smita Subhash / Sircar, Dipankar / Sen, Debabrata

Indian journal of nephrology

2023 Volume 33, Issue 5, Page(s) 340–347

Abstract: Introduction: Therapy of proliferative lupus nephritis (PLN) is yet to be optimized. Standard of care for induction consists of intravenous (IV) cyclophosphamide (CYC) and steroids, which shows an improved outcome, but end-stage renal disease (ESRD) ... ...

Abstract	Introduction: Therapy of proliferative lupus nephritis (PLN) is yet to be optimized. Standard of care for induction consists of intravenous (IV) cyclophosphamide (CYC) and steroids, which shows an improved outcome, but end-stage renal disease (ESRD) progression, increased mortality, and therapy-related adverse effects remain a major concern. The other treatment reported to induce early remission was the multitarget therapy comprising tacrolimus, mycophenolate, and steroid, but infections were high in the multitarget therapy. Considering azathioprine as a potentially safer and effective alternative anti-B-cell therapy, modified multitarget therapy (MMTT) was planned replacing mycophenolate with azathioprine. Material and methods: A single-center, 24-week, open-label, randomized controlled trial comprising adults of age 18-65 years with biopsy-proven PLN was carried out. The intervention groups were 1) MMTT: tacrolimus 0.075 mg/kg/day and azathioprine 2 mg/kg/day and 2) IV CYC group with a starting dose of 0.75 (adjusted to 0.5-1.0) g/m Results: Among 100 randomized patients, 48 were in MMTT arm and 52 were in IV CYC arm. At the end of 24 weeks, overall remission (complete and partial) was comparable in both the arms: MMTT (86.36%) and IV CYC (87.75%). There was comparable proteinuria reduction and systemic lupus erythematosus disease activity index (SLEDAI) score improvement with recovery of complement level C3 in both groups. Major adverse events were numerically more in the IV CYC group, including one death from pneumonia. Conclusion: The MMTT arm is as effective as IV CYC in improving short-term outcome in PLN, with a comparable safety profile.
Language	English
Publishing date	2023-07-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2134388-3
ISSN	1998-3662 ; 0971-4065
ISSN (online)	1998-3662
ISSN	0971-4065
DOI	10.4103/ijn.ijn_355_21
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Article: Graphene Quantum Dots-Ornamented Waterborne Epoxy-Based Fluorescent Adhesive via Reversible Addition–Fragmentation Chain Transfer-Mediated Miniemulsion Polymerization: A Potential Material for Art Conservation

Samanta, Sarthik / Banerjee, Sovan Lal / Bhattacharya, Koushik / Singha, Nikhil K

ACS applied materials & interfaces. 2021 July 23, v. 13, no. 30

2021

Abstract	Epoxy-based adhesives have gotten significant attention in the conservation of antiquities and repair or reconstruction of artifacts due to their excellent adhesion strength. However, it has become hard to detect repaired work in artifacts due to the transparent nature of epoxy-based adhesives. Hence, the making of fluorescent adhesives has become an exciting topic for art conservators. Here, we have synthesized a new kind of waterborne epoxy-based fluorescent adhesive decorated with graphene quantum dots (GQDs) via reversible addition–fragmentation chain transfer (RAFT)-mediated surfactant-free miniemulsion polymerization. In this case, a new block copolymer (BCP), poly(1-vinyl-2-pyrrolidone)-block-poly(glycidyl methacrylate), has been synthesized via surfactant-free RAFT-mediated miniemulsion polymerization using a polymerization-induced self-assembly technique. The GQDs were prepared from citric acid by a hydrothermal process, and this was used for making a fluorescence-active BCP/GQD nanocomposite emulsion. The obtained BCP/GQD nanocomposite adhesive was transparent and showed blue fluorescence under ultraviolet–visible light, indicating the easy detection of its mark on the artifacts. The BCP and BCP/GQD emulsions were applied to adhere ceramic and glass substrates, and their adhesion strength was evaluated by lap shear tests. The BCP/GQDs showed better adhesion strength than the BCP only, indicating better adhesive performance. Additionally, the synthesis process was carried out in aqueous media, indicating the sustainability and environment-friendliness of the process. We believe that this kind of new waterborne epoxy-based fluorescent adhesive will provide a new contrivance among art conservators to repair or reconstruct artifacts.
Keywords	adhesion ; ceramics ; citric acid ; composite polymers ; fluorescence ; glass ; graphene ; nanocomposites ; nanoemulsions ; polymerization
Language	English
Dates of publication	2021-0723
Size	p. 36307-36319.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c08812
Database	NAL-Catalogue (AGRICOLA)

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