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  1. Article: The detrimental effects of progression of retinal degeneration in the visual cortex.

    Bhattacharyya, Anwesha

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 904175

    Abstract: The leading cause of blindness in inherited and age-related retinal degeneration (RD) is the death of retinal photoreceptors such as rods and cones. The most prevalent form of RD is age-related macular degeneration (AMD) which affects the macula ... ...

    Abstract The leading cause of blindness in inherited and age-related retinal degeneration (RD) is the death of retinal photoreceptors such as rods and cones. The most prevalent form of RD is age-related macular degeneration (AMD) which affects the macula resulting in an irreversible loss of vision. The other is a heterogenous group of inherited disorders known as Retinitis Pigmentosa (RP) caused by the progressive loss of photoreceptors. Several approaches have been developed in recent years to artificially stimulate the remaining retinal neurons using optogenetics, retinal prostheses, and chemical photoswitches. However, the outcome of these strategies has been limited. The success of these treatments relies on the morphology, physiology, and proper functioning of the remaining intact structures in the downstream visual pathway. It is not completely understood what all alterations occur in the visual cortex during RD. In this review, I will discuss the known information in the literature about morphological and functional changes that occur in the visual cortex in rodents and humans during RD. The aim is to highlight the changes in the visual cortex that will be helpful for developing tools and strategies directed toward the restoration of high-resolution vision in patients with visual impairment.
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.904175
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  2. Article ; Online: Ligand structure and diluent nature in defining improved Am

    Kanekar, A S / Bhattacharyya, A / Mohapatra, P K

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 13, Page(s) 5871–5880

    Abstract: Separation of ... ...

    Abstract Separation of Am
    Language English
    Publishing date 2024-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03261b
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  3. Article ; Online: Empirical causal analysis of flood risk factors on U.S. flood insurance payouts:Implications for solvency and risk reduction.

    Bhattacharyya, Arkaprabha / Hastak, Makarand

    Journal of environmental management

    2024  Volume 352, Page(s) 120075

    Abstract: This paper presents a regression model that quantifies the causal relationship between flood risk factors and the flood insurance payout in the U.S. The flood risk factors that have been considered in this research are flood exposure, infrastructure ... ...

    Abstract This paper presents a regression model that quantifies the causal relationship between flood risk factors and the flood insurance payout in the U.S. The flood risk factors that have been considered in this research are flood exposure, infrastructure vulnerability, social vulnerability, and the number of mobile homes. Historical data for the annual flood insurance payout, flood risk factors, and other control variables were collected for six years between 2016 and 2021 and used in a Mixed Effects Regression model to derive the empirical relationships. The regression model expressed the natural logarithm of the annual flood insurance payout in a county based on the flood risk factors and control variables. The paper presents the regression coefficients that quantify the causal influence. It has been found that all four flood risk factors have statistically significant positive influence on the flood insurance payout in a county. However, the extent of the influence is different for different flood risk factors. Among them, flood exposure has the highest influence on the flood insurance payout, which is followed by the number of mobile homes, infrastructure vulnerability, and social vulnerability. Since the federal flood insurance program in the U.S. has a large debt to the U.S. treasury, the government should plan for effective risk reduction that can reduce the flood insurance payout in future to keep the program solvent. The outcomes of this research are expected to facilitate that decision-making process by providing the empirical relationship between flood risk factors and flood insurance payout.
    MeSH term(s) Floods ; Risk Factors ; Insurance ; Forecasting ; Risk Reduction Behavior
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120075
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  4. Article ; Online: Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem Cells.

    Bhattacharyya, Anita

    American journal on intellectual and developmental disabilities

    2020  Volume 125, Issue 2, Page(s) 90–92

    Abstract: Our bodies are made up of over 250 specific cell types, and all initially arise from stem cells during embryonic development. Stem cells have two characteristics that make them unique: (1) they are pluripotent, meaning that they can differentiate into ... ...

    Abstract Our bodies are made up of over 250 specific cell types, and all initially arise from stem cells during embryonic development. Stem cells have two characteristics that make them unique: (1) they are pluripotent, meaning that they can differentiate into all cell types of the body, and (2) they are capable of self-renewal to generate more of themselves and are thus able to populate an organism. Human pluripotent stem cells were first isolated from human embryos twenty years ago ( Thomson et al., 1998 ) and more recently, technology to reprogram somatic cells, such as skin and blood, to induced pluripotent stem cells has emerged ( Park et al., 2008

    Takahashi et al., 2007

    Yu et al., 2007 ). Induced pluripotent stem cells, or iPSCs, are particularly valuable as disease specific iPSCs can be generated from individuals with specific genetic mutations diseases. Researchers have harnessed the power of stem cells to understand many aspects of developmental biology in model organisms (e.g. worms, mice) and more recently, in humans. Human stem cells in culture recapitulate development. For example, formation of the brain occurs prenatally and follows a specific pattern of timing and cell generation. Human stem cells in the culture dish follow a similar pattern when exposed to developmental cues and can thus be used to understand aspects of prenatal human brain development that are not accessible by other means. Disease-specific iPSCs are a valuable tool to model neural development in specific neurodevelopmental disorders like Down syndrome. Down syndrome is a classic developmental disorder; mistakes that are made during development of a particular organ system result in the characteristics of the disorder. In the brain, mistakes during prenatal brain development lead to intellectual disability. Trisomy 21 (Ts21) iPSCs generated from somatic cells of Down syndrome individuals may enable us to understand the mistakes made during Down syndrome brain development.
    MeSH term(s) Brain/embryology ; Brain/growth & development ; Down Syndrome ; Fetal Development/physiology ; Human Development/physiology ; Humans ; Induced Pluripotent Stem Cells
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2477909-X
    ISSN 1944-7558 ; 1944-7515
    ISSN (online) 1944-7558
    ISSN 1944-7515
    DOI 10.1352/1944-7558-125.2.90
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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.55: Show issues Location:
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  5. Article ; Online: Artificial intelligence paternalism.

    Diaz Milian, Ricardo / Bhattacharyya, Anirban

    Journal of medical ethics

    2023  Volume 49, Issue 3, Page(s) 183–184

    MeSH term(s) Humans ; Paternalism ; Artificial Intelligence ; Personal Autonomy ; Advance Directives
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/jme-2022-108768
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1163: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Current approaches to vision restoration using optogenetic therapy.

    Parnami, Kashish / Bhattacharyya, Anwesha

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1236826

    Abstract: Inherited progressive degeneration of photoreceptors such as retinitis pigmentosa (RP) is the most common cause of blindness leading to severe vision impairment affecting ~1 in 5,000 people worldwide. Although the function and morphology of the ... ...

    Abstract Inherited progressive degeneration of photoreceptors such as retinitis pigmentosa (RP) is the most common cause of blindness leading to severe vision impairment affecting ~1 in 5,000 people worldwide. Although the function and morphology of the photoreceptors get disrupted, there is evidence that the inner retinal neurons such as bipolar cells and the retinal ganglion cells are left intact until later stages. Among several innovative therapeutic options aiming to restore vision, optogenetic therapy can bestow light sensitivity to remaining retinal neurons by ectopic expression of light-sensitive proteins. Since the advent of this technique, a diverse class of opsins (microbial and mammalian opsins), chimeric proteins, ligand-gated ion channels, and switchable opsins have been used to study their potential in vision restoration. These proteins differ in their excitation spectra, response kinetics, and signal amplification cascade. Although most of the studies have reported high fidelity of responses in the retina, only a handful of them have achieved functional vision in the visual cortex. This review is a summary of the visuocortical and behavioral responses after optogenetic treatment of the degenerated retina. This clarifies to what extent improved and meaningful vision can be obtained for therapeutic efficacy and continued clinical progress.
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1236826
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  7. Article ; Online: A data-driven approach to quantify disparities in power outages.

    Bhattacharyya, Arkaprabha / Hastak, Makarand

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7247

    Abstract: This research proposes a data-driven approach to identify possible disparities in a utility's outage management practices. The approach has been illustrated for an Investor-Owned Utility located in the Midwest region in the U.S. Power outage data for ... ...

    Abstract This research proposes a data-driven approach to identify possible disparities in a utility's outage management practices. The approach has been illustrated for an Investor-Owned Utility located in the Midwest region in the U.S. Power outage data for approximately 5 years between March 2017 and January 2022 was collected for 36 ZIP/postal codes located within the utility's service territory. The collected data was used to calculate the total number of outages, customers affected, and the duration of outages during those 5 years for each ZIP code. Next, each variable was normalized with respect to the population density of the ZIP code. After normalizing, a K-means clustering algorithm was implemented that created five clusters out of those 36 ZIP codes. The difference in the outage parameters was found to be statistically significant. This indicated differential experience with power outages in different ZIP codes. Next, three Generalized Linear Models were developed to test if the presence of critical facilities such as hospitals, 911 centers, and fire stations, as socioeconomic and demographic characteristics of the ZIP codes, can explain their differential experience with the power outage. It was found that the annual duration of outages is lower in the ZIP codes where critical facilities are located. On the other hand, ZIP codes with lower median household income have experienced more power outages, i.e., higher outage counts in those 5 years. Lastly, the ZIP codes with a higher percentage of the White population have experienced more severe outages that have affected more customers.
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-34186-9
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  8. Article ; Online: Don't forget that children gamble too.

    Bhattacharyya, Adrija / Freeman, Hannah

    BMJ (Clinical research ed.)

    2023  Volume 381, Page(s) 1003

    MeSH term(s) Humans ; Child ; Gambling
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1003
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  9. Article ; Online: Learning from health justice partnerships.

    Freeman, Hannah / Bhattacharyya, Adrija

    Medical teacher

    2023  Volume 45, Issue 12, Page(s) 1438–1439

    MeSH term(s) Humans ; Delivery of Health Care ; Social Justice
    Language English
    Publishing date 2023-08-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2023.2247148
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2176: Show issues Location:
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  10. Article ; Online: Quantum state complexity meets many-body scars.

    Nandy, Sourav / Mukherjee, Bhaskar / Bhattacharyya, Arpan / Banerjee, Aritra

    Journal of physics. Condensed matter : an Institute of Physics journal

    2024  Volume 36, Issue 15

    Abstract: Scar eigenstates in a many-body system refers to a small subset of non-thermal finite energy density eigenstates embedded into an otherwise thermal spectrum. This novel non-thermal behaviour has been seen in recent experiments simulating a one- ... ...

    Abstract Scar eigenstates in a many-body system refers to a small subset of non-thermal finite energy density eigenstates embedded into an otherwise thermal spectrum. This novel non-thermal behaviour has been seen in recent experiments simulating a one-dimensional PXP model with a kinetically-constrained local Hilbert space realised by a chain of Rydberg atoms. We probe these small sets of special eigenstates starting from particular initial states by computing the spread complexity associated to time evolution of the PXP hamiltonian. Since the scar subspace in this model is embedded only loosely, the scar states form a weakly broken representation of the Lie algebra. We demonstrate why a careful usage of the forward scattering approximation (FSA), instead of any other method, is required to extract the most appropriate set of Lanczos coefficients in this case as the consequence of this approximate symmetry. Only such a method leads to a well defined notion of a closed Krylov subspace and consequently, that of spread complexity. We show this using three separate initial states, namely|Z2⟩,|Z3⟩and the vacuum state, due to the disparate classes of scar states hosted by these sectors. We also discuss systematic methods of remedying the imperfections in the FSA setup stemming from these approximate symmetries.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ad1a7b
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