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  1. Article: Brain Calcifications Secondary to Idiopathic Hyperthyroidism and Hypoparathyroidism.

    Sayeed, Bushra Zafar / Sayeed, Faiza Zafar / Nashit, Muhammad / Bhatty, Shaheen

    Ochsner journal

    2024  Volume 24, Issue 1, Page(s) 53–57

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Case Reports
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0004
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  2. Article: Asymptomatic Dandy Walker Malformation In An Elderly Male With Acute Haemorrhagic Stroke - A Case Report.

    Minhaj, Areeba / Minhaj, Marium / Farooqui, Muhammad Osama / Naseeb, Muhammad Wahdan / Saad, Hafiz Muhammad / Bhatty, Shaheen

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 7, Page(s) 1536–1538

    Abstract: Dandy-Walker Malformation (DWM) is a rare congenital anomaly of the posterior cranial fossa. Features of DWM include hypoplasia of the cerebellar vermis, enlargement of the posterior fossa, and cystic dilatation of the fourth ventricle. MRI is the ... ...

    Abstract Dandy-Walker Malformation (DWM) is a rare congenital anomaly of the posterior cranial fossa. Features of DWM include hypoplasia of the cerebellar vermis, enlargement of the posterior fossa, and cystic dilatation of the fourth ventricle. MRI is the modality to confirm the diagnosis. Treatment is usually symptomatic and required when signs of hydrocephalus develop. Rare cases of asymptomatic DWM diagnosed incidentally are reported in literature. We report a case of DWM in a 60-year-old male who presented with haemorrhagic stroke and was later found to have DWM on brain imaging.
    MeSH term(s) Male ; Humans ; Aged ; Middle Aged ; Female ; Pregnancy ; Dandy-Walker Syndrome/complications ; Dandy-Walker Syndrome/diagnostic imaging ; Hemorrhagic Stroke ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/etiology ; Brain ; Prenatal Diagnosis/methods ; Magnetic Resonance Imaging/methods ; Stroke/diagnostic imaging ; Stroke/etiology
    Language English
    Publishing date 2023-05-22
    Publishing country Pakistan
    Document type Case Reports
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.7379
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  3. Article: A Rare Presentation of Brucellosis as Myocarditis.

    Bhatty, Shaheen / Kumar, Pawan / Javed, Bareera / Zafar, Amara

    Cureus

    2020  Volume 12, Issue 11, Page(s) e11345

    Abstract: Brucellosis is commonly transmitted by consumption of unpasteurized dairy products and most commonly presents as fever, arthralgia, fatigue, hepatosplenomegaly, and peripheral arthritis. Our patient presented with a history of three months of high-grade ... ...

    Abstract Brucellosis is commonly transmitted by consumption of unpasteurized dairy products and most commonly presents as fever, arthralgia, fatigue, hepatosplenomegaly, and peripheral arthritis. Our patient presented with a history of three months of high-grade fever, undocumented significant weight loss, jaundice, and hepatosplenomegaly. On the seventh day of admission, he developed sudden onset of shortness of breath, and his jugular venous pressure was raised with fine crackles at the lung bases bilaterally and pedal edema up to the ankles bilaterally. Electrocardiography was done, which showed T wave inversions in 1 and augmented Vector Left (aVL). Troponin I was raised at that time, and echocardiography revealed an ejection fraction of 40%. A diagnosis of myocarditis secondary to brucellosis was made.
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.11345
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  4. Article: Electrocardiographic Abnormalities in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

    Kumar, Wikram / Shaikh, Wajid / Kp, Sandeep / Bhatty, Shaheen / Hassan, Sadaf

    Cureus

    2021  Volume 13, Issue 12, Page(s) e20820

    Abstract: Objective: The objective of this article was to determine the frequency of different electrocardiographic (ECG) abnormalities in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).: Design: This is a cross-sectional ... ...

    Abstract Objective: The objective of this article was to determine the frequency of different electrocardiographic (ECG) abnormalities in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).
    Design: This is a cross-sectional study.
    Place and duration: The study was conducted at the medicine department at Civil Hospital Karachi, Pakistan, between November 2018 and May 2019.
    Method:  Both female and male participants aged 18-60 years with acute exacerbation of COPD (as per the operational definition) for more than three days who did not receive any treatment for exacerbation were included in the study. Twelve-lead ECG was recorded (Schiller AG, Baar, Switzerland) for 10 minutes after the supine rest, with a 50 mm/s of paper speed, 10 mm/mV of gain, and filter default settings.
    Results:  In total, 140 participants (male: n = 124 [88.6%] and female: n = 16 [11.4%]) were included the research. The mean age of the participants was 40.43 ± 11.51 years. In terms of severity, 46 (32.95) patients presented with mild, 46 (32.9%) with moderate, and 48 (34.4%) with severe exacerbation. Moreover, 33 (23.65%) participants had ECG abnormalities, i.e., 13 (9.3%) patients presented with right atrial enlargement, and eight (5.7%) with right ventricular hypertrophy. Patients with a longer smoking duration (years) were likely to present with ECG abnormalities.
    Conclusion:  Patients with COPD who had severe acute exacerbation and a long smoking duration have a high prevalence of ECG abnormalities. Hence, ECG may be a valuable tool for detecting ischemic abnormalities among patients with COPD, independent of previously known heart disease, in clinical settings.
    Language English
    Publishing date 2021-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.20820
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  5. Article: A Case Report of Behcet's Disease With Thromboses in the Superior Vena Cava and External Iliac Vein.

    Sayeed, Faiza Zafar / Nashit, Muhammad / Bhatty, Shaheen / Sayeed, Bushra Z / Asad, Fariha

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24064

    Abstract: Behcet's disease (BD), also known as Behcet's syndrome, is a rare, chronic, autoimmune disorder of unknown origin. Its manifestations are thought to be caused by vasculitis, resulting in damage to blood vessels of all sizes throughout the body. We report ...

    Abstract Behcet's disease (BD), also known as Behcet's syndrome, is a rare, chronic, autoimmune disorder of unknown origin. Its manifestations are thought to be caused by vasculitis, resulting in damage to blood vessels of all sizes throughout the body. We report a 25-year-old Pakistani male who is sexually active and presents with a one-year history of shortness of breath, cough, exertional dyspnea, and neck and facial swelling. On examination, he had severe anemia, mouth ulcers, distended neck and chest veins, prominent abdominal veins, and a scrotal ulcer. After going through mandatory investigations to evaluate the presenting signs and symptoms, thromboses were found in the major veins, including the superior vena cava (SVC) and external iliac vein, as well as a positive pathergy test. Accordingly, a diagnosis of Behcet's disease with cardiomyopathy and venous thrombosis was made. He was treated with anticoagulants, steroids, and azathioprine for six months and subsequently went into remission.
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24064
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  6. Article ; Online: Unusual Initial Presentation Of Primary Antiphospholipid Syndrome As Postpartum Symmetrical Peripheral Gangrene.

    Khan, Marium Marufia / Shahid, Sana / Zafar, Amara / Khan, Nudrat Naz / Bhatty, Shaheen

    Journal of Ayub Medical College, Abbottabad : JAMC

    2022  Volume 34, Issue 1, Page(s) 200–202

    Abstract: Background: Antiphospholipid syndrome (APS) is an acquired prothrombic state with recurring thromboembolic and obstetric complications in the presence of antiphospholipid antibodies. Isolated skin manifestation especially symmetrical peripheral gangrene ...

    Abstract Background: Antiphospholipid syndrome (APS) is an acquired prothrombic state with recurring thromboembolic and obstetric complications in the presence of antiphospholipid antibodies. Isolated skin manifestation especially symmetrical peripheral gangrene (SPG) in postpartum phase is reported rarely. To highlight this unusual presentation of APS with SPG we present a case of young female who developed SPG on her third postpartum day. Postpartum period runs a high risk of sepsis but development of such extensive and rapid ischemic changes in APS is seen uncommonly.
    MeSH term(s) Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Female ; Gangrene/complications ; Humans ; Postpartum Period ; Pregnancy ; Sepsis/complications
    Language English
    Publishing date 2022-04-07
    Publishing country Pakistan
    Document type Case Reports
    ZDB-ID 2192473-9
    ISSN 1819-2718 ; 1025-9589
    ISSN (online) 1819-2718
    ISSN 1025-9589
    DOI 10.55519/JAMC-01-8695
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  7. Article ; Online: Termination of seizures in the paediatric age group, best benzodiazepine and route of administration: A network meta-analysis.

    Hasan, Syed Umar / Pervez, Alina / Bhatty, Shaheen / Shamim, Shifa / Naeem, Aaima / Naseeb, Muhammad Wahdan

    The European journal of neuroscience

    2022  Volume 56, Issue 3, Page(s) 4234–4245

    Abstract: This network meta-analysis aims to compare various benzodiazepines and their route of administration using the data published exclusively in randomized controlled trials (RCTs). Two thousand two hundred sixty-three children presenting with an episode of ... ...

    Abstract This network meta-analysis aims to compare various benzodiazepines and their route of administration using the data published exclusively in randomized controlled trials (RCTs). Two thousand two hundred sixty-three children presenting with an episode of seizure to ER or to a paramedic where they were administered a benzodiazepine as the first-line treatment were included. All the outcomes were measured for their mean with 95% CI and rank probability. The primary outcome was the number of successful seizure cessation. Secondary outcomes were the time interval between drug administration and seizure cessation, the time interval between patient arrival and seizure cessation and the number of episodes of seizure recurrence after drug administration. For the number of successful cessations, intramuscular midazolam showed the highest mean and best rank probability with a value of .881 (.065) and 57.9%, respectively. For the time of cessation, both intravenous lorazepam (IVL) and intravenous diazepam showed a mean of 3.30 (1.30) with IVL having the highest rank probability of 32%. For total time for cessation, intranasal midazolam showed the best mean and rank probability with a value of 4.3 (1.1) and 55%, respectively. Buccal midazolam showed the lowest mean with a value of .106 (.084) for rate of recurrence. Although there was no significant difference between the treatments, but based on the rank probability, IVL shows more promising results for patients who already have an established intravenous line, and for patients presenting in the ER without an intravenous line, the first line of treatment should be INM as it shows the highest rank probability in total time with second-highest successful cessation rate.
    MeSH term(s) Anticonvulsants/therapeutic use ; Benzodiazepines/therapeutic use ; Child ; Diazepam/therapeutic use ; Humans ; Lorazepam ; Midazolam/therapeutic use ; Network Meta-Analysis ; Seizures/drug therapy ; Status Epilepticus
    Chemical Substances Anticonvulsants ; Benzodiazepines (12794-10-4) ; Lorazepam (O26FZP769L) ; Diazepam (Q3JTX2Q7TU) ; Midazolam (R60L0SM5BC)
    Language English
    Publishing date 2022-06-17
    Publishing country France
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 645180-9
    ISSN 1460-9568 ; 0953-816X
    ISSN (online) 1460-9568
    ISSN 0953-816X
    DOI 10.1111/ejn.15732
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    Zs.A 2548: Show issues Location:
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  8. Article: Crimean-Congo Haemorrhagic Fever: Breaking the chain of transmission.

    Shaikh, Muhammad Ateeb / Safder, Sahar / Bhatty, Shaheen Ayoob

    JPMA. The Journal of the Pakistan Medical Association

    2015  Volume 65, Issue 5, Page(s) 576

    MeSH term(s) Abattoirs ; Animal Husbandry ; Animals ; Animals, Domestic ; Communicable Disease Control/methods ; Health Education ; Hemorrhagic Fever, Crimean/epidemiology ; Hemorrhagic Fever, Crimean/prevention & control ; Hemorrhagic Fever, Crimean/transmission ; Humans ; Pakistan/epidemiology
    Language English
    Publishing date 2015-05
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
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  9. Article ; Online: GeneXpert in stool: Diagnostic yield in Intestinal Tuberculosis.

    Talib, Abu / Bhatty, Shaheen / Mehmood, Khalid / Naim, Huda / Haider, Iftikhar / Lal, Hari / Ali, Gohar / Nashit, Muhammad

    Journal of clinical tuberculosis and other mycobacterial diseases

    2019  Volume 17, Page(s) 100131

    Abstract: Background: Diagnosing intestinal (Luminal) tuberculosis is challenging due to limited yield of diagnostic modalities like CT scan, colonoscopy with blind ileal biopsies. GeneXpert MTB/RIF (Xpert) assays for diagnosing tuberculosis have been performed ... ...

    Abstract Background: Diagnosing intestinal (Luminal) tuberculosis is challenging due to limited yield of diagnostic modalities like CT scan, colonoscopy with blind ileal biopsies. GeneXpert MTB/RIF (Xpert) assays for diagnosing tuberculosis have been performed in the body secretions with excellent results. Its yield in stool is tested in this study.
    Objective: The study aims to evaluate the yield of GeneXpert assay in stool of suspected cases of intestinal tuberculosis.
    Methods: Hundred patients with suspected intestinal tuberculosis underwent routine biochemical tests, radiological investigations, colonoscopy with caecal and blind ileal biopsies for histopathology. Fresh stool samples were collected, processed for DNA extraction, tested using 2:1 ratio of GeneXpert reagent to sample to give positive or negative results for Mycobacterium tuberculosis and Rifampicin resistance.
    Results: Out of hundred participants, 52% were female. Mean age was 28.21 ± 12.13. CT scan and colonoscopy findings suggestive of TB were present in 47% and 43% participants respectively. GeneXpert in stool was positive in 20% cases. Considering mucosal biopsy with histopathology of intestinal specimens as diagnostic of abdominal Tuberculosis, sensitivity and specificity of GeneXpert was 39.1% and 85.7% respectively.
    Conclusion: Stool GeneXpert assay offers an alternative approach to detect intestinal tuberculosis rapidly with good diagnostic accuracy. Although it cannot replace the AFB culture and histopathology but contribute for early diagnosis and management.
    Language English
    Publishing date 2019-11-05
    Publishing country England
    Document type Journal Article
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2019.100131
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  10. Article ; Online: Neuromyelitis Optica (NMO) with Abdominal Tuberculosis (TB).

    Bhatty, Shaheen A / Lal, Hari / Talib, Abu / Mahmood, Khalid / Naqvi, Iftekhar / Zaidi, Syeda Shaheera

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2015  Volume 25 Suppl 2, Page(s) S102–4

    Abstract: Neuromyelitis Optica (NMO), previously regarded as a form of multiple sclerosis, is defined by Gault and Devic, as a retrobulbar neuritis or papillitis accompanied by acute myelitis and occasionally other neurological symptom or signs not restricted to ... ...

    Abstract Neuromyelitis Optica (NMO), previously regarded as a form of multiple sclerosis, is defined by Gault and Devic, as a retrobulbar neuritis or papillitis accompanied by acute myelitis and occasionally other neurological symptom or signs not restricted to the spinal cord or optic nerves. With the diagnosis of specific antibodies, probable role of humoral immunity supports its pathogenesis. Only a few cases of NMO have been reported in association with pulmonary tuberculosis (TB). Here we report a case of young girl with acute onset paraplegia diagnosed to have NMO, who later on during hospital stay developed ascites which cultured positive for Mycobacterium tuberculosis. This association of abdominal TB with NMO is under-reported in literature.
    MeSH term(s) Antitubercular Agents/therapeutic use ; Evoked Potentials, Visual ; Female ; Humans ; Magnetic Resonance Imaging ; Methylprednisolone/therapeutic use ; Mycobacterium tuberculosis/isolation & purification ; Neuromyelitis Optica/diagnosis ; Neuromyelitis Optica/drug therapy ; Neuromyelitis Optica/etiology ; Paraplegia/etiology ; Spinal Cord/pathology ; Treatment Outcome ; Tuberculosis/complications ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Young Adult
    Chemical Substances Antitubercular Agents ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2015-10
    Publishing country Pakistan
    Document type Case Reports ; Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.2015/JCPSP.S102S104
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