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  1. Article: Unraveling the miRnome of Nicotiana rustica (Aztec tobacco) - A Genomewide computational assessment

    Bhavsar, Mansi / Mangukia, Naman / Patel, Saumya / Rawal, Rakesh / Mankad, Archana

    Plant gene. 2022 Aug. 22,

    2022  

    Abstract: MicroRNAs (miRNAs) are endogenous small non-coding RNAs, known as chief regulators for cellular growth and development in plants. Nicotiana rustica (N. rustica), also known as Aztec tobacco is the second most widely used lucrative crop for tobacco ... ...

    Abstract MicroRNAs (miRNAs) are endogenous small non-coding RNAs, known as chief regulators for cellular growth and development in plants. Nicotiana rustica (N. rustica), also known as Aztec tobacco is the second most widely used lucrative crop for tobacco production across the globe. Since the miRNAs of Nicotiana rustica have never been reported, we employed a genome-wide computational approach which resulted in 101 potential candidates of miRNAs, belonging to 73 families, followed by stringent filtration criteria. Statistical analysis confirmed the occurrence of uracil as the dominant initial biased nucleotide base at 5 prime ends of mature miRNAs that may lead to a significant role in miRNA biogenesis and or miRNA mediated gene regulation. Due to unavailability of target sequences, the RNAseq data of N. rustica leaf, flower, stem, and root were retrieved, assembled de novo and concatenated into a clustered customized transcript dataset. The study validates miR160, miR393, miR397, miR403 & miR529 miRNAs and confirmed their targets through experimentally proven literature evidence. These miRNAs can modulate the biological role in transcription regulation, defense response, transporter activity, hormonal signaling and different protein kinase activities. Collectively, this study reports putative miRNAs and their role in Aztec tobacco development and stress response.
    Keywords Nicotiana rustica ; biogenesis ; cell growth ; data collection ; filtration ; flowers ; genes ; growth and development ; leaves ; microRNA ; protein kinases ; statistical analysis ; stress response ; tobacco ; transcription (genetics) ; uracil
    Language English
    Dates of publication 2022-0822
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ISSN 2352-4073
    DOI 10.1016/j.plgene.2022.100378
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Small RNA sequencing and identification of papaya (Carica papaya L.) miRNAs with potential cross-kingdom human gene targets

    Jha, Neha / Mangukia, Naman / Gadhavi, Harshida / Patel, Maulik / Bhavsar, Mansi / Rawal, Rakesh / Patel, Saumya

    Molecular genetics and genomics. 2022 July, v. 297, no. 4

    2022  

    Abstract: Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host cells to regulate certain host cellular functions. How nutrient-rich plants regulate host cellular ... ...

    Abstract Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host cells to regulate certain host cellular functions. How nutrient-rich plants regulate host cellular functions, which in turn alleviate physiological and disease conditions in the host remains to be explored in detail. This computational study explores the potential targets, putative role, and functional implications of miRNAs derived from Carica papaya L., one of the most cultivated tropical crops in the world and a rich source of phytochemicals and enzymes, in human diet. Using the next-generation sequencing, -Illumina HiSeq2500, ~ 30 million small RNA sequence reads were generated from C. papaya young leaves, resulting in the identification of a total of 1798 known and 49 novel miRNAs. Selected novel C. papaya miRNAs were predicted to regulate certain human targets, and subsequent annotation of gene functions indicated a probable role in various biological processes and pathways, such as MAPK, WNT, and GPCR signaling pathways, and platelet activation. These presumptive target gene in humans were predominantly linked to various diseases, including cancer, diabetes, mental illness, and platelet disorder. The computational finding of this study provides insights into how C. papaya-derived miRNAs may regulate certain conditions of human disease and provide a new perspective on human health. However, the therapeutic potential of C. papaya miRNA can be further explored through experimental studies.
    Keywords Carica papaya ; behavior disorders ; diabetes ; genes ; genomics ; human diseases ; human health ; human nutrition ; humans ; microRNA ; nucleotide sequences ; phytochemicals ; platelet activation ; therapeutics
    Language English
    Dates of publication 2022-07
    Size p. 981-997.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 2044817-X
    ISSN 1617-4615
    ISSN 1617-4615
    DOI 10.1007/s00438-022-01904-3
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Small RNA sequencing and identification of papaya (Carica papaya L.) miRNAs with potential cross-kingdom human gene targets.

    Jha, Neha / Mangukia, Naman / Gadhavi, Harshida / Patel, Maulik / Bhavsar, Mansi / Rawal, Rakesh / Patel, Saumya

    Molecular genetics and genomics : MGG

    2022  Volume 297, Issue 4, Page(s) 981–997

    Abstract: Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host cells to regulate certain host cellular functions. How nutrient-rich plants regulate host cellular ... ...

    Abstract Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom species relationships by transferring into non-plant host cells to regulate certain host cellular functions. How nutrient-rich plants regulate host cellular functions, which in turn alleviate physiological and disease conditions in the host remains to be explored in detail. This computational study explores the potential targets, putative role, and functional implications of miRNAs derived from Carica papaya L., one of the most cultivated tropical crops in the world and a rich source of phytochemicals and enzymes, in human diet. Using the next-generation sequencing, -Illumina HiSeq2500, ~ 30 million small RNA sequence reads were generated from C. papaya young leaves, resulting in the identification of a total of 1798 known and 49 novel miRNAs. Selected novel C. papaya miRNAs were predicted to regulate certain human targets, and subsequent annotation of gene functions indicated a probable role in various biological processes and pathways, such as MAPK, WNT, and GPCR signaling pathways, and platelet activation. These presumptive target gene in humans were predominantly linked to various diseases, including cancer, diabetes, mental illness, and platelet disorder. The computational finding of this study provides insights into how C. papaya-derived miRNAs may regulate certain conditions of human disease and provide a new perspective on human health. However, the therapeutic potential of C. papaya miRNA can be further explored through experimental studies.
    MeSH term(s) Base Sequence ; Carica/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Plant Leaves/genetics ; Sequence Analysis, RNA
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2044817-X
    ISSN 1617-4623 ; 1617-4615
    ISSN (online) 1617-4623
    ISSN 1617-4615
    DOI 10.1007/s00438-022-01904-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: EGFR Mutation

    Joshi, Jigna / Raval, Apexa / Desai, Urja / Upadhyay, Vinal / Bhavsar, Mansi / Shah, Kanisha / Rawal, Rakesh / Panchal, Harsha / Shah, Franky

    Indian journal of clinical biochemistry : IJCB

    2019  Volume 36, Issue 1, Page(s) 51–58

    Abstract: In the era of the targeted therapy identification ... ...

    Abstract In the era of the targeted therapy identification of
    Language English
    Publishing date 2019-12-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 1033583-3
    ISSN 0974-0422 ; 0970-1915
    ISSN (online) 0974-0422
    ISSN 0970-1915
    DOI 10.1007/s12291-019-00864-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2949: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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