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Article ; Online: Fatigue, Weight Loss, and Acute Chest Pain in a 15-year-old Boy.

Parr, Madeline F E / Clouser, Katharine N / Tozzi, Meghan / Bhavsar, Sejal M

2023 Volume 44, Issue 12, Page(s) 716–719

MeSH term(s)	Male ; Humans ; Adolescent ; Chest Pain/etiology ; Fatigue/etiology ; Weight Loss
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2022-005552
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Article ; Online: Enterobacter cloacae Complex

Pallitto, Candace R / Feuerstein, Jessica L / Baer, Aryeh Z / Bishara, Joanne D / Bhavsar, Sejal M

Clinical pediatrics

2023 Volume 62, Issue 10, Page(s) 1150–1154

MeSH term(s)	Infant, Newborn ; Humans ; Enterobacter cloacae ; Meningitis ; Enterobacteriaceae Infections/diagnosis ; Enterobacteriaceae Infections/drug therapy
Language	English
Publishing date	2023-03-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231155391
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Article ; Online: Cardiac Complications Associated with COVID-19, MIS-C, and mRNA COVID-19 Vaccination.

Chin, Stephanie E / Bhavsar, Sejal M / Corson, Andrew / Ghersin, Zelda J / Kim, Hannah S

Pediatric cardiology

2022 Volume 43, Issue 3, Page(s) 483–488

Abstract: The COVID-19 vaccine is now approved for individuals greater than 5 years of age, but vaccination rates remain lower than expected in the pediatric age group. Misinformation and widespread reporting of vaccine-related myocarditis are contributing to ... ...

Abstract	The COVID-19 vaccine is now approved for individuals greater than 5 years of age, but vaccination rates remain lower than expected in the pediatric age group. Misinformation and widespread reporting of vaccine-related myocarditis are contributing to vaccine hesitancy. When compared to severe cardiac complications that are associated with COVID-19, vaccine-related myocarditis has a milder presentation, is easily treated, and has a good prognosis. Acute COVID-19 has been associated with higher rates of myocarditis and myocardial injury. Multisystem inflammatory syndrome in children occurs weeks after initial infection with SARS-CoV-2 and can be associated with severe cardiovascular complications and death. Cardiac complications associated with acute COVID-19 and MIS-C are more severe and occur more frequently than myocarditis after mRNA COVID-19 vaccination. Furthermore, some of the academic and social disruptions caused by the pandemic expect to be eased by widespread vaccination. For all these reasons, COVID-19 vaccination is strongly recommended for all eligible age groups.
MeSH term(s)	COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Child ; Humans ; RNA, Messenger ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome ; Vaccination/adverse effects
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	800857-7
ISSN	1432-1971 ; 0172-0643
ISSN (online)	1432-1971
ISSN	0172-0643
DOI	10.1007/s00246-022-02851-x
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Article ; Online: Hospital and ICU Admission Risk Associated With Comorbidities Among Children With COVID-19 Ancestral Strains.

Ungar, Stephanie P / Solomon, Sadie / Stachel, Anna / Shust, Gail F / Clouser, Katharine N / Bhavsar, Sejal M / Lighter, Jennifer

Clinical pediatrics

2023 Volume 62, Issue 9, Page(s) 1048–1058

Abstract: A large proportion of children have been affected by COVID-19; we evaluated the association between comorbidities and hospitalization/ICU (intensive care unit) admission among 4097 children under age 21 years with symptomatic COVID-19 (not just ... ...

Abstract	A large proportion of children have been affected by COVID-19; we evaluated the association between comorbidities and hospitalization/ICU (intensive care unit) admission among 4097 children under age 21 years with symptomatic COVID-19 (not just polymerase chain reaction [PCR]-positive or multisystem inflammatory syndrome in children associated with COVID-19 [MIS-C]) from 2 large health systems from March 2020 to September 2021. Significant comorbidities and demographic factors identified by univariable analysis were included in a multivariable logistic regression compared with children ages 6 to 11 without comorbidities. In all, 475 children (11.6%) were hospitalized, of whom 25.5% required ICU admission. Children under 1 year had high hospitalization risk, but low risk of ICU admission. Presence of at least 1 comorbidity was associated with hospitalization and ICU admission (odds ratio [OR] > 4). Asthma, obesity, chronic kidney disease, sickle cell disease, bone marrow transplantation, and neurologic disorders were associated with hospitalization (adjusted odds ratio [AOR] > 2). Malignancy, intellectual disability, and prematurity were associated with ICU admission (AOR > 4). Comorbidities are significantly associated with hospitalization/ICU admission among children with COVID-19.
MeSH term(s)	Humans ; Child ; Young Adult ; Adult ; COVID-19/epidemiology ; SARS-CoV-2 ; Risk Factors ; Hospitalization ; Comorbidity ; Intensive Care Units ; Hospitals ; Retrospective Studies
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228221150605
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Article ; Online: Characteristics and Presentations of Hospitalized Children Due to 3 Predominate COVID-19 Variants Within a Health Care Network.

Bhavsar, Sejal M / Clouser, Katharine N / Connolly, Hailey / Gadhavi, Jasmine / Kaur, Ranbir / Lozy, Tara / Naganathan, Srividya / Pierre, Margarette / Riollano Cruz, Mariawy / Shah, Pooja / Siu, Anita / Swenson, Carly / Ballance, Cathleen

Clinical pediatrics

2023 Volume 63, Issue 1, Page(s) 66–72

Abstract: Objective of this article is to describe differences in the demographic and clinical characteristics, severity of illness, and outcomes in pediatric patients with different SARS-CoV-2 variants. We conducted a retrospective study of pediatric patients ... ...

Abstract	Objective of this article is to describe differences in the demographic and clinical characteristics, severity of illness, and outcomes in pediatric patients with different SARS-CoV-2 variants. We conducted a retrospective study of pediatric patients admitted with COVID-19 during the 3 large waves of infection within a health network in New Jersey. We included demographic characteristics, clinical features, and outcomes and compared the data with respect to the different variants. Of 351 total patients included in this study, 74 were admitted during wave 1, 94 during wave 2, and 181 during wave 3. The median age of patients decreased from wave 1 (11.5 years) to wave 3 (3 years) (
MeSH term(s)	Adult ; Humans ; Child ; Infant ; Child, Hospitalized ; SARS-CoV-2 ; COVID-19/epidemiology ; COVID-19/therapy ; Retrospective Studies ; Delivery of Health Care
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231207314
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Article: COVID-19 Infection Associated With Encephalitis in an Adolescent.

Bhavsar, Sejal M / Agarwal, Saranga / Lewis, Rachel / Ganta, Avani / Roshchina, Yelena S / Clouser, Katharine N / Baer, Aryeh Z / Gliksman, Felicia / Piwoz, Julia A

Neurology. Clinical practice

2021 Volume 11, Issue 2, Page(s) e189–e192

Language	English
Publishing date	2021-03-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000000911
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Article ; Online: COVID-19 in Pediatrics: Characteristics of Hospitalized Children in New Jersey.

Bhavsar, Sejal M / Clouser, Katharine N / Gadhavi, Jasmine / Anene, Okechukwu / Kaur, Ranbir / Lewis, Rachel / Naganathan, Srividya / Michalak, Zuzanna / Chen, Clara Q / Shah, Pooja / Siu, Anita / Ballance, Cathleen

Hospital pediatrics

2020 Volume 11, Issue 1, Page(s) 79–87

Abstract: Objectives: Understanding the risk factors, predictors, and clinical presentation of coronavirus disease 2019 (COVID-19) in pediatric patients with severe disease.: Methods: We conducted a retrospective chart review of pediatric patients admitted ... ...

Abstract	Objectives: Understanding the risk factors, predictors, and clinical presentation of coronavirus disease 2019 (COVID-19) in pediatric patients with severe disease. Methods: We conducted a retrospective chart review of pediatric patients admitted between March 1, 2020, and May 31, 2020, to a large health network in New Jersey with positive test results for severe acute respiratory syndrome coronavirus 2 on reverse transcriptase polymerase chain reaction, rapid testing, or serum immunoglobulin G testing; we included demographic characteristics, clinical features, and outcomes. Results: A total of 81 patients ≤21 years old were admitted with positive test results for severe acute respiratory syndrome coronavirus 2 on reverse transcriptase polymerase chain reaction and/or serum immunoglobulin testing. Sixty-seven patients (82.7%) were admitted for management of acute COVID-19 infection, whereas 14 (17.3%) were admitted for management of multisystem inflammatory syndrome in children (MIS-C). Of the 81 hospitalized patients, 28 (34.6%) required intensive care. A majority of patients (42 [51.9%]) admitted for both acute COVID-19 infection and MIS-C were Hispanic. Underlying chronic health conditions were not present in most patients. Obesity (mean BMI of 41.1) was noted in the patients with MIS-C requiring ICU care, although not statistically significant. Absolute lymphopenia and elevated levels of inflammatory markers were statistically significant in the patients with MIS-C treated in the ICU. Conclusions: This study adds to the growing literature of potential risk factors for severe disease in pediatric patients due to COVID-19 infection and MIS-C. Patients of Hispanic ethnicity represented the majority of patients with both acute COVID-19 infection and MIS-C, despite only representing 10% to 20% of the population our hospitals serve. Infants and patients with chronic health conditions were not at increased risk for severe disease. Absolute lymphopenia and elevated levels of inflammatory markers were associated with more severe disease.
Language	English
Publishing date	2020-12-29
Publishing country	United States
Document type	Journal Article
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2020-001719
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Article ; Online: Short-Term Outcomes After Multisystem Inflammatory Syndrome in Children Treatment.

Clouser, Katharine N / Gadhavi, Jasmine / Bhavsar, Sejal M / Lewis, Rachel / Ballance, Cathleen / Michalak, Zuzanna / Baer, Aryeh / Kriegel, Marni / Pall, Harpreet / Piwoz, Julia / Slavin, Kevin / Siegel, Mark E / Tozzi, Meghan E / Tozzi, Robert / Walker, David M / Lapidus, Sivia / Aschner, Judy

Journal of the Pediatric Infectious Diseases Society

2020 Volume 10, Issue 1, Page(s) 52–56

Abstract: This is a retrospective chart review of 20 patients treated with a consensus-driven treatment algorithm in multisystem inflammatory syndrome in children patients across a wide clinical spectrum. Their treatments and clinical status are described as well ... ...

Abstract	This is a retrospective chart review of 20 patients treated with a consensus-driven treatment algorithm in multisystem inflammatory syndrome in children patients across a wide clinical spectrum. Their treatments and clinical status are described as well as their favorable return to functional baseline by 30 days post presentation.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Algorithms ; COVID-19/diagnostic imaging ; COVID-19/drug therapy ; COVID-19/therapy ; Child ; Child, Preschool ; Clinical Protocols ; Echocardiography ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Male ; Retrospective Studies ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/diagnostic imaging ; Systemic Inflammatory Response Syndrome/drug therapy ; Systemic Inflammatory Response Syndrome/therapy ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Immunoglobulins, Intravenous
Language	English
Publishing date	2020-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2668791-4
ISSN	2048-7207 ; 2048-7193
ISSN (online)	2048-7207
ISSN	2048-7193
DOI	10.1093/jpids/piaa151
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Article ; Online: COVID-19 infection associated with encephalitis in an adolescent

Bhavsar, Sejal M. / Agarwal, Saranga / Lewis, Rachel / Ganta, Avani / Roshchina, Yelena S. / Clouser, Katharine N. / Baer, Aryeh Z. / Gliksman, Felicia / Piwoz, Julia A.

Neurology: Clinical Practice

2020 , Page(s) 10.1212/CPJ.0000000000000911

Abstract: Abstract Although adults with coronavirus disease 2019 (COVID-19) who require admission to the hospital have often required critical care, infants and children with COVID-19 have generally demonstrated milder disease severity, fewer complications, and ... ...

Abstract	Abstract Although adults with coronavirus disease 2019 (COVID-19) who require admission to the hospital have often required critical care, infants and children with COVID-19 have generally demonstrated milder disease severity, fewer complications, and overall a much lower case fatality rate (1-2). Neurologic manifestations have been reported with COVID-19 in adult patients including acute cerebrovascular disease, ischemic and hemorrhagic strokes, skeletal muscle injury and rare cases of encephalopathy (3-5). We report here an adolescent patient with acute encephalitis associated with COVID-19.
Keywords	Clinical Neurology ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/cpj.0000000000000911
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth.

Fernandes, Danielle M / Oliveira, Carlos R / Guerguis, Sandra / Eisenberg, Ruth / Choi, Jaeun / Kim, Mimi / Abdelhemid, Ashraf / Agha, Rabia / Agarwal, Saranga / Aschner, Judy L / Avner, Jeffrey R / Ballance, Cathleen / Bock, Joshua / Bhavsar, Sejal M / Campbell, Melissa / Clouser, Katharine N / Gesner, Matthew / Goldman, David L / Hammerschlag, Margaret R /

Hymes, Saul / Howard, Ashley / Jung, Hee-Jin / Kohlhoff, Stephan / Kojaoghlanian, Tsoline / Lewis, Rachel / Nachman, Sharon / Naganathan, Srividya / Paintsil, Elijah / Pall, Harpreet / Sy, Sharlene / Wadowski, Stephen / Zirinsky, Elissa / Cabana, Michael D / Herold, Betsy C

The Journal of pediatrics

2020 Volume 230, Page(s) 23–31.e10

Abstract: Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.: Study design: We conducted a ... ...

Abstract	Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity. Study design: We conducted a multicenter, retrospective, and prospective study of pediatric patients hospitalized with acute SARS-CoV-2 infections and multisystem inflammatory syndrome in children (MIS-C) at 8 sites in New York, New Jersey, and Connecticut. Results: We identified 281 hospitalized patients with SARS-CoV-2 infections and divided them into 3 groups based on clinical features. Overall, 143 (51%) had respiratory disease, 69 (25%) had MIS-C, and 69 (25%) had other manifestations including gastrointestinal illness or fever. Patients with MIS-C were more likely to identify as non-Hispanic black compared with patients with respiratory disease (35% vs 18%, P = .02). Seven patients (2%) died and 114 (41%) were admitted to the intensive care unit. In multivariable analyses, obesity (OR 3.39, 95% CI 1.26-9.10, P = .02) and hypoxia on admission (OR 4.01; 95% CI 1.14-14.15; P = .03) were predictive of severe respiratory disease. Lower absolute lymphocyte count (OR 8.33 per unit decrease in 10 Conclusions: We identified variables at the time of hospitalization that may help predict the development of severe SARS-CoV-2 disease manifestations in children and youth. These variables may have implications for future prognostic tools that inform hospital admission and clinical management.
MeSH term(s)	Adolescent ; Biomarkers/analysis ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/epidemiology ; Child ; Child, Preschool ; Connecticut/epidemiology ; Female ; Hospitalization ; Humans ; Hypoxia/epidemiology ; Infant ; Intensive Care Units ; Lymphocyte Count ; Male ; Multivariate Analysis ; New Jersey/epidemiology ; New York/epidemiology ; Pediatric Obesity/epidemiology ; Procalcitonin/blood ; Prospective Studies ; Retrospective Studies ; Severity of Illness Index ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/epidemiology ; Troponin/blood ; Young Adult
Chemical Substances	Biomarkers ; Procalcitonin ; Troponin ; C-Reactive Protein (9007-41-4)
Keywords	covid19
Language	English
Publishing date	2020-11-14
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2020.11.016
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