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  1. Article ; Online: Peri-Operative Brain MRI in Children Undergoing Congenital Heart Surgery: Is it Time for Routine Imaging?

    Bhutta, Adnan T

    Journal of the American College of Cardiology

    2018  Volume 71, Issue 18, Page(s) 1997–1998

    MeSH term(s) Brain ; Brain Injuries ; Child ; Heart Defects, Congenital ; Humans ; Infant, Newborn ; Magnetic Resonance Imaging ; Neuroimaging
    Language English
    Publishing date 2018-05-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2018.03.455
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 196: Show issues

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  2. Article: Expanding current guidelines for management of COVID-19 focusing on low- and middle-income countries.

    Fonseca, Yudy / Urbina, Evangelina / Bhutta, Adnan

    Journal of public health in Africa

    2022  Volume 13, Issue 3, Page(s) 1465

    Abstract: Within a short time, Coronavirus disease 2019 (COVID-19) has evolved into a pandemic spreading at a speed and scale that has been able to overwhelm even the most advanced health care systems quickly. Multiple guidelines published by organizations such as ...

    Abstract Within a short time, Coronavirus disease 2019 (COVID-19) has evolved into a pandemic spreading at a speed and scale that has been able to overwhelm even the most advanced health care systems quickly. Multiple guidelines published by organizations such as the WHO and US' CDC address the response to COVID-19 at the international, national, and local levels. Although these guidelines are meant to be globally accessible, implementing them is a challenge given the variability in the health care systems worldwide between low- and middleincome countries (LMIC) and high-income countries and even amongst different regions within each LMIC. We have chosen to evaluate the current guidelines focusing on LMIC and expand on the guidelines as necessary.
    Language English
    Publishing date 2022-10-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2574977-8
    ISSN 2038-9930 ; 2038-9922
    ISSN (online) 2038-9930
    ISSN 2038-9922
    DOI 10.4081/jphia.2022.1465
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  3. Article ; Online: Reduction in paediatric intensive care admissions during COVID-19 lockdown in Maryland, USA.

    Graciano, Ana Lia / Bhutta, Adnan T / Custer, Jason W

    BMJ paediatrics open

    2020  Volume 4, Issue 1, Page(s) e000876

    Abstract: As a public health measure during the COVID-19 pandemic, governments around the world instituted a variety of interventions to 'flatten the curve'. The government of Maryland instituted similar measures. We observed a striking decline in paediatric ... ...

    Abstract As a public health measure during the COVID-19 pandemic, governments around the world instituted a variety of interventions to 'flatten the curve'. The government of Maryland instituted similar measures. We observed a striking decline in paediatric intensive care unit (PICU) admissions during that period, mostly due to a decease in respiratory infections. We believe this decline is multifactorial: less person-to-person contact, better air quality and perhaps 'fear' of going to a hospital during the pandemic. We report an analysis of our PICU admissions during the lockdown period and compared them with the same time period during the four previous years.
    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article
    ISSN 2399-9772
    ISSN (online) 2399-9772
    DOI 10.1136/bmjpo-2020-000876
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  4. Article: Bedside Rounds in Intensive Care Units during the COVID-19 Pandemic and Beyond.

    Custer, Jason W / Simone, Shari / Bhutta, Adnan T

    Journal of pediatric intensive care

    2020  Volume 10, Issue 3, Page(s) 210–215

    Abstract: A survey-based pilot study was performed to examine the feasibility of videoconferencing to facilitate multidisciplinary rounds following the initiation of strict isolation and social distancing policies in a pediatric intensive care unit (PICU). The use ...

    Abstract A survey-based pilot study was performed to examine the feasibility of videoconferencing to facilitate multidisciplinary rounds following the initiation of strict isolation and social distancing policies in a pediatric intensive care unit (PICU). The use of a mobile workstation was implemented as the central hub for rounding at the bedside by the attending physicians, while other members of the multidisciplinary and multispecialty team joined rounds from other locations with maintaining appropriate social distance. Fifty-eight staff members who participated in videoconferencing rounds completed the postimplementation survey. Eighty-eight per cent of staff agreed that the use of videoconferencing to facilitate rounds was an effective strategy to maintain social distancing between team members during the pandemic. Sixty-four percent of staff agreed that the use of videoconferencing improved participation of the PICU team and consultants by increasing access to rounds. Over 50% of staff agreed that the use of videoconferencing improved the efficiency of rounds and team productivity. Only 4% of staff responded that videoconferencing increased the duration of rounds and 37% responded that it decreased resident and team education. Fifty-five percent of staff agreed that videoconferencing was used to promote parental participation during this pandemic month. Videoconferencing was found to be a feasible solution to safely conduct multidisciplinary rounds while maintaining social distancing, and participants found it effective without interfering with normal workflow. Incorporating videoconferencing into traditional rounding practices may be advantageous following the pandemic to improve team and family access to rounds and workflow efficiency and rounding structure.
    Language English
    Publishing date 2020-09-11
    Publishing country Germany
    Document type Journal Article
    ISSN 2146-4618
    ISSN 2146-4618
    DOI 10.1055/s-0040-1716578
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  5. Article ; Online: Post-operative course of pulmonary artery pressure after complete atrioventricular canal defect repair.

    Pierre Louis, Marie Emeline / Bhutta, Adnan / Holloway, Adrian / Gaskin, Peter

    Cardiology in the young

    2021  Volume 32, Issue 3, Page(s) 398–404

    Abstract: Complete atrioventricular canal defect is a CHD associated with intra-cardiac shunting of blood, which can lead to irreversible changes in pulmonary vascular resistance and pulmonary artery hypertension if unrepaired. Patients with Trisomy 21 are at risk ...

    Abstract Complete atrioventricular canal defect is a CHD associated with intra-cardiac shunting of blood, which can lead to irreversible changes in pulmonary vascular resistance and pulmonary artery hypertension if unrepaired. Patients with Trisomy 21 are at risk for early development of pulmonary artery hypertension if left uncorrected.1,2.
    Objectives: The purpose of this study is to describe the evolution of pulmonary artery hypertension after repair of complete atrioventricular canal defect and to determine the time to normalisation of pulmonary artery pressure in both patients with and without Trisomy 21.
    Methods: This is a single centre, retrospective analysis of patients with complete atrioventricular canal defect admitted for surgical repair at the University of Maryland Medical Center from 2005 to 2015. T-test or Mann-Whitney test and Chi-Square or Fisher's exact tests were used to compare the two groups (patients with Trisomy 21 and those without). Repeated measures of analysis of variance and serial measurement analysis were performed.
    Results: Twenty-nine patients meeting the inclusion criteria underwent repair of complete atrioventricular defects during the study period. The right ventricular pressure estimate remained elevated over time and did not show a significant difference between the two groups. Right ventricular to systolic blood pressure ratios for all patients remained > 0.5 over the time periods assessed.
    Conclusions: Our study suggests that in patients with complete atrioventricular canal defects, the right ventricular pressure remains elevated and does not normalise on echocardiograms performed up to one year after surgery, suggesting a sustained elevation in pulmonary vascular resistance.
    MeSH term(s) Down Syndrome/complications ; Heart Septal Defects/complications ; Heart Septal Defects/surgery ; Humans ; Hypertension/complications ; Infant ; Pulmonary Artery/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951121002201
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    Zs.A 4050: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Application of Nonhuman Primate Models in the Studies of Pediatric Anesthesia Neurotoxicity.

    Wang, Cheng / Liu, Shuliang / Liu, Fang / Bhutta, Adnan / Patterson, Tucker A / Slikker, William

    Anesthesia and analgesia

    2022  Volume 134, Issue 6, Page(s) 1203–1214

    Abstract: Numerous animal models have been used to study developmental neurotoxicity associated with short-term or prolonged exposure of common general anesthetics at clinically relevant concentrations. Pediatric anesthesia models using the nonhuman primate (NHP) ... ...

    Abstract Numerous animal models have been used to study developmental neurotoxicity associated with short-term or prolonged exposure of common general anesthetics at clinically relevant concentrations. Pediatric anesthesia models using the nonhuman primate (NHP) may more accurately reflect the human condition because of their phylogenetic similarity to humans with regard to reproduction, development, neuroanatomy, and cognition. Although they are not as widely used as other animal models, the contribution of NHP models in the study of anesthetic-induced developmental neurotoxicity has been essential. In this review, we discuss how neonatal NHP animals have been used for modeling pediatric anesthetic exposure; how NHPs have addressed key data gaps and application of the NHP model for the studies of general anesthetic-induced developmental neurotoxicity. The appropriate application and evaluation of the NHP model in the study of general anesthetic-induced developmental neurotoxicity have played a key role in enhancing the understanding and awareness of the potential neurotoxicity associated with pediatric general anesthetics.
    MeSH term(s) Anesthesia/adverse effects ; Anesthetics/toxicity ; Anesthetics, General/toxicity ; Animals ; Animals, Newborn ; Child ; Humans ; Neurotoxicity Syndromes/etiology ; Phylogeny ; Primates
    Chemical Substances Anesthetics ; Anesthetics, General
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.78: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 149: Show issues

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  7. Article ; Online: Remote Didactic Education Effectively Increases Cardiac Critical Care Nursing Staff Knowledge in Low-Resource Settings.

    Kliot, Tamara / Holloway, Adrian / Spillman, Katherine / Moss, Julianne / Davis, Natalie Louise / Ayalew, Abebech / Bhutta, Adnan / Ejigu, Yayehyirad Mekonnen

    World journal for pediatric & congenital heart surgery

    2023  Volume 15, Issue 1, Page(s) 74–80

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Child ; Humans ; Critical Care Nursing ; Curriculum ; Heart Defects, Congenital/surgery ; Clinical Competence ; Critical Care
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2550261-X
    ISSN 2150-136X ; 2150-1351
    ISSN (online) 2150-136X
    ISSN 2150-1351
    DOI 10.1177/21501351231186419
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  8. Article ; Online: Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain.

    Wang, Cheng / Bhutta, Adnan / Zhang, Xuan / Liu, Fang / Liu, Shuliang / Latham, Leah E / Talpos, John C / Patterson, Tucker A / Slikker, William

    Experimental biology and medicine (Maywood, N.J.)

    2023  Volume 248, Issue 7, Page(s) 624–632

    Abstract: With advances in pediatric and obstetric surgery, pediatric patients are subject to complex procedures under general anesthesia. The effects of anesthetic exposure on the developing brain may be confounded by several factors including pre-existing ... ...

    Abstract With advances in pediatric and obstetric surgery, pediatric patients are subject to complex procedures under general anesthesia. The effects of anesthetic exposure on the developing brain may be confounded by several factors including pre-existing disorders and surgery-induced stress. Ketamine, a noncompetitive
    MeSH term(s) Animals ; Anesthetics/pharmacology ; Animals, Newborn ; Brain/metabolism ; Ketamine/pharmacology ; Primates
    Chemical Substances Anesthetics ; Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-05-19
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial, Veterinary ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.1177/15353702231168144
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    Ua VI Zs.111: Show issues Location:
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  9. Article: Outcomes of Pediatric Patients With Sepsis Related to

    Foster, Cortney / Bagdure, Dayanand / Custer, Jason / Holloway, Adrian / Rycus, Peter / Day, Jenni / Bhutta, Adnan

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 706638

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-10-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.706638
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  10. Article ; Online: Understanding the Role of Pharmacometrics-Based Clinical Decision Support Systems in Pediatric Patient Management: A Case Study Using Lyv Software.

    Jarugula, Praneeth / Scott, Sarah / Ivaturi, Vijay / Noack, Andreas / Moffett, Brady S / Bhutta, Adnan / Gobburu, Jogarao V S

    Journal of clinical pharmacology

    2022  Volume 61 Suppl 1, Page(s) S125–S132

    Abstract: Pharmacometrics could play a key role in shifting pediatric pharmacotherapy from dosing for an average patient to individualizing dosing. Clinicians can have these quantitative tools at their disposal without requiring significant training through the ... ...

    Abstract Pharmacometrics could play a key role in shifting pediatric pharmacotherapy from dosing for an average patient to individualizing dosing. Clinicians can have these quantitative tools at their disposal without requiring significant training through the development of clinical decision support systems with easy-to-use interfaces that have a back-end analysis engine or pharmacometric model that uses extensive electronic health record data to predict an individualized dose for each patient. There has been increased development of these clinical decision support systems recently, and for these tools to make the proper breakthrough into clinical practice, it is of utmost importance to perform rigorous testing to ensure adequate predictive performance. In this article, we walk through the components of a decision support tool and the testing required to determine its robustness using an example of a decision support tool we developed for vancomycin dosing in pediatrics.
    MeSH term(s) Adolescent ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/blood ; Anti-Bacterial Agents/pharmacokinetics ; Child ; Child, Preschool ; Decision Support Techniques ; Delivery of Health Care/methods ; Electronic Health Records ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Models, Biological ; Pediatrics/methods ; Pharmacokinetics ; Software ; Vancomycin/administration & dosage ; Vancomycin/blood ; Vancomycin/pharmacokinetics
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 188980-1
    ISSN 1552-4604 ; 0091-2700 ; 0021-9754
    ISSN (online) 1552-4604
    ISSN 0091-2700 ; 0021-9754
    DOI 10.1002/jcph.1892
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    Uf I Zs.176: Show issues Location:
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