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  1. Article: Relative apparent diffusion coefficient: a promising tool to differentiate metastatic from benign lymph nodes in animal models.

    Xing, Wei / Sheng, Jing / Chen, Jie / Tian, Jian-Ming / Bi, Heng-Liang

    Chinese medical journal

    2011  Volume 124, Issue 18, Page(s) 2907–2910

    Abstract: Background: Diffusion-weighted imaging has been widely used to differentiate the character of lymphadenopathy. But there are significant differences between prior studies. The aim of the study was to compare the benefit of apparent diffusion coefficient ...

    Abstract Background: Diffusion-weighted imaging has been widely used to differentiate the character of lymphadenopathy. But there are significant differences between prior studies. The aim of the study was to compare the benefit of apparent diffusion coefficient (ADC) and rADC in the differentiation of metastatic and benign lymph nodes in a rabbit model.
    Methods: Two observers independently measured ADCs in quadriceps of every rabbit on diffusion-weighted images with different sizes of regions of interest (ROI). The appropriate ROI for rADC was determined using the interobserver coefficient. rADC was calculated by ADC(lesion)/ADC(reference site). Receiver operating characteristics (ROC) analysis was performed to compare the diagnostic value of the ADC values and rADC values in differentiating metastatic from benign lymph nodes.
    Results: When the ROIs included five pixels, the ICC was 0.816, indicating a good interobserver agreement. The differences of ADC and rADC values between metastatic and benign lymph nodes were both statistically significant. The area under the ROC curve was greater for the rADC than for the ADC. With the rADC criteria of 0.640, the sensitivity and specificity for differentiating metastatic from benign lymph nodes were 93% and 90%, respectively.
    Conclusion: As a reference site, muscles reveal a good repeatability using a small ROI and the rADC may improve diagnostic accuracy for detecting metastatic nodes in animal models.
    MeSH term(s) Animals ; Diffusion Magnetic Resonance Imaging/methods ; Lymph Nodes/pathology ; Lymphatic Metastasis/diagnosis ; Rabbits ; Sensitivity and Specificity
    Language English
    Publishing date 2011-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monitoring early response of lymph node metastases to radiotherapy in animal models: diffusion-weighted imaging vs. morphological MR imaging.

    Chen, Jie / Sheng, Jing / Xing, Wei / Aoun, Hussein / Chen, Ming / Bi, Heng-Liang / Tian, Jian-Ming / Dai, Yong-Ming

    Acta radiologica (Stockholm, Sweden : 1987)

    2011  Volume 52, Issue 9, Page(s) 989–994

    Abstract: Background: Diffusion-weighted imaging (DWI) offers a non-invasive technique that can reveal microscopic details about the architecture of both normal and anomalous tissues. Some studies have confirmed DWI can detect the early changes of tumors that ... ...

    Abstract Background: Diffusion-weighted imaging (DWI) offers a non-invasive technique that can reveal microscopic details about the architecture of both normal and anomalous tissues. Some studies have confirmed DWI can detect the early changes of tumors that have originated from various organs, even after treatment.
    Purpose: To compare the usefulness of apparent diffusion coefficient (ADC) and morphologic magnetic resonance (MR) imaging for monitoring the therapeutic response of metastatic disease in lymph nodes to radiotherapy.
    Material and methods: Twenty-six rabbits (metastatic, n = 17; non-metastatic, n = 9) were divided into group A (metastatic, n = 10), group B (metastatic, n = 7) and group C (non-metastatic, n = 9). Groups A and C underwent irradiation, whereas group B was set as a reference. Standard MR imaging and DWI were performed before and 1, 3, and 7 days after radiotherapy for all rabbits. The lymph node volumes and ADCs were measured and evaluated with repeated measures ANOVA. The difference between group A and B was analyzed using Student's t-test.
    Results: In all rabbits, a total of 35 lymph nodes were found, including 16 nodes in group A, 10 in group B and nine in group C. In group A, 3 and 7 days after therapy ADCs were significantly higher than pre-treatment and 1 day after therapy (P < 0.05). For groups A and B, a significant difference of ADCs was present 7 days after therapy. A significant difference of variation of ADCs among the three groups was also present (P < 0.001).
    Conclusion: DWI is superior to morphological MRI in monitoring early radiation response in animal models.
    MeSH term(s) Animals ; Diffusion Magnetic Resonance Imaging ; Lymphatic Metastasis/diagnosis ; Lymphatic Metastasis/pathology ; Lymphatic Metastasis/radiotherapy ; Magnetic Resonance Imaging ; Monitoring, Physiologic ; Rabbits
    Language English
    Publishing date 2011-11-01
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 105-3
    ISSN 1600-0455 ; 0284-1851 ; 0349-652X
    ISSN (online) 1600-0455
    ISSN 0284-1851 ; 0349-652X
    DOI 10.1258/ar.2011.110254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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