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Article ; Online: Syphilitic Proctitis.

Cai, Qiya / Bi, Xinling

2023 Volume 389, Issue 5, Page(s) e9

MeSH term(s)	Humans ; Proctitis/diagnosis ; Syphilis/complications ; Syphilis/diagnosis
Language	English
Publishing date	2023-07-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMicm2301469
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Article ; Online: Congenital Lipedematous Alopecia in a 6-Year-Old Asian Boy.

He, Yufei / Wu, Jianhua / Bi, Xinling / Wang, Yulian

Indian journal of dermatology

2024 Volume 68, Issue 6, Page(s) 691–692

Language	English
Publishing date	2024-01-09
Publishing country	India
Document type	Journal Article
ZDB-ID	416069-1
ISSN	1998-3611 ; 0019-5154
ISSN (online)	1998-3611
ISSN	0019-5154
DOI	10.4103/ijd.ijd_975_22
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Article: Secondary Generalized Cutaneous Mucinosis Developed During Etanercept Treatment in a Patient with Psoriasis.

Zhou, Xin / Mubanga, David / Chen, Zhuo / Bi, Xinling

Clinical, cosmetic and investigational dermatology

2022 Volume 15, Page(s) 987–992

Abstract: Cutaneous mucinosis is a rare disease that manifests as an excessive accumulation of mucin in the skin that forms waxy papules or plaques. We report a case of a 44-year-old male psoriatic patient who developed generalized cutaneous mucinosis after 11 ... ...

Abstract	Cutaneous mucinosis is a rare disease that manifests as an excessive accumulation of mucin in the skin that forms waxy papules or plaques. We report a case of a 44-year-old male psoriatic patient who developed generalized cutaneous mucinosis after 11 months of biological treatment. The patient had a history of psoriasis for 20 years and had been treated with narrow-band UVB phototherapy, methotrexate, or acitretin intermittently. He was started on etanercept after he was diagnosed with psoriatic arthritis, and 11 months later, he complained of swelling in his extremities and myxoid cysts on his fingers. Etanercept was then discontinued due to loss of efficacy and widespread skin lesions. However, the lesions subsided spontaneously after 6 months without specific systemic treatment.
Language	English
Publishing date	2022-05-31
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494852-4
ISSN	1178-7015
ISSN	1178-7015
DOI	10.2147/CCID.S368390
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Article ; Online: An Update Review of Biosimilars of Adalimumab in Psoriasis - Bioequivalence and Interchangeability.

Zhou, Xin / Chen, Zhuo / Bi, Xinling

Drug design, development and therapy

2021 Volume 15, Page(s) 2987–2998

Abstract: Biologic drugs have revolutionized the treatment of psoriasis and other rheumatological diseases. In recent years, many biosimilar agents that are highly similar in structure and function to their originator products have been developed, including the ... ...

Abstract	Biologic drugs have revolutionized the treatment of psoriasis and other rheumatological diseases. In recent years, many biosimilar agents that are highly similar in structure and function to their originator products have been developed, including the tumor necrosis factor-alpha antagonist adalimumab. The considerably lower cost of these products has greatly cut the economic burden of the patients and increased the accessibility of biologic therapies worldwide. The US Food and Drug Administration and/or the European Medicines Agency have approved eight biosimilars of adalimumab (ABP 501/BI 695501/SB5/GP2017/FKB327/MSB11022/PF-06410293/CT-P17) for the treatment of psoriasis, and others are under review. Given that these agents showed pharmacokinetic, efficacy, safety, and immunogenicity profiles comparable to those of the originator, adalimumab biosimilars were licensed for all indications approved for reference adalimumab based on extrapolation; however, some of the equivalence studies were only conducted in one or two disease populations. This review discusses the bioequivalence of adalimumab biosimilars as demonstrated by various clinical trials, the extrapolation of indications, guidance and policies of the EU and US on interchangeability (nonmedical switching/automatic substitution) between biosimilars and originators, and the real-life practices of switching from reference adalimumab to the respective biosimilars. Further data from real-world studies and post-marketing analyses are needed better to address the efficacy and safety of the transition strategy.
MeSH term(s)	Adalimumab/administration & dosage ; Adalimumab/adverse effects ; Adalimumab/pharmacokinetics ; Biosimilar Pharmaceuticals/administration & dosage ; Biosimilar Pharmaceuticals/adverse effects ; Biosimilar Pharmaceuticals/pharmacokinetics ; Humans ; Psoriasis/drug therapy ; Therapeutic Equivalency ; Tumor Necrosis Factor Inhibitors/administration & dosage ; Tumor Necrosis Factor Inhibitors/adverse effects ; Tumor Necrosis Factor Inhibitors/pharmacokinetics
Chemical Substances	Biosimilar Pharmaceuticals ; Tumor Necrosis Factor Inhibitors ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2021-07-08
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S317382
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Article ; Online: New insights into inflammatory memory of epidermal stem cells.

Cheng, Dapeng / Zhu, Xiaochen / Yan, Shaochen / Shi, Linli / Liu, Zhi / Zhou, Xin / Bi, Xinling

Frontiers in immunology

2023 Volume 14, Page(s) 1188559

Abstract: Inflammatory memory, as one form of innate immune memory, has a wide range of manifestations, and its occurrence is related to cell epigenetic modification or metabolic transformation. When re-encountering similar stimuli, executing cells with ... ...

Abstract	Inflammatory memory, as one form of innate immune memory, has a wide range of manifestations, and its occurrence is related to cell epigenetic modification or metabolic transformation. When re-encountering similar stimuli, executing cells with inflammatory memory function show enhanced or tolerated inflammatory response. Studies have identified that not only hematopoietic stem cells and fibroblasts have immune memory effects, but also stem cells from various barrier epithelial tissues generate and maintain inflammatory memory. Epidermal stem cells, especially hair follicle stem cells, play an essential role in wound healing, immune-related skin diseases, and skin cancer development. In recent years, it has been found that epidermal stem cells from hair follicle can remember the inflammatory response and implement a more rapid response to subsequent stimuli. This review updates the advances of inflammatory memory and focuses on its mechanisms in epidermal stem cells. We are finally looking forward to further research on inflammatory memory, which will allow for the development of precise strategies to manipulate host responses to infection, injury, and inflammatory skin disease.
MeSH term(s)	Hair Follicle/metabolism ; Wound Healing/physiology ; Skin ; Epidermal Cells ; Stem Cells/metabolism
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1188559
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Article: Inorganic hollow mesoporous spheres-based delivery for antimicrobial agents.

Qiao, Yunping / Han, Yanyang / Guan, Rengui / Liu, Shiliang / Bi, Xinling / Liu, Shanshan / Cui, Wei / Zhang, Tao / He, Tao

Frontiers of materials science

2023 Volume 17, Issue 1, Page(s) 230631

Abstract: Microorganisms coexist with human beings and have formed a complex relationship with us. However, the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents. Currently available antimicrobials, such as silver ions, ... ...

Abstract	Microorganisms coexist with human beings and have formed a complex relationship with us. However, the abnormal spread of pathogens can cause infectious diseases thus demands antibacterial agents. Currently available antimicrobials, such as silver ions, antimicrobial peptides and antibiotics, have diverse concerns in chemical stability, biocompatibility, or triggering drug resistance. The "encapsulate-and-deliver" strategy can protect antimicrobials against decomposing, so to avoid large dose release induced resistance and achieve the controlled release. Considering loading capacity, engineering feasibility, and economic viability, inorganic hollow mesoporous spheres (iHMSs) represent one kind of promising and suitable candidates for real-life antimicrobial applications. Here we reviewed the recent research progress of iHMSs-based antimicrobial delivery. We summarized the synthesis of iHMSs and the drug loading method of various antimicrobials, and discussed the future applications. To prevent and mitigate the spread of an infective disease, multilateral coordination at the national level is required. Moreover, developing effective and practicable antimicrobials is the key to enhancing our capability to eliminate pathogenic microbes. We believe that our conclusion will be beneficial for researches on the antimicrobial delivery in both lab and mass production phases.
Language	English
Publishing date	2023-03-08
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2649481-4
ISSN	2095-0268 ; 2095-025X
ISSN (online)	2095-0268
ISSN	2095-025X
DOI	10.1007/s11706-023-0631-2
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Article: MicroRNA-146a Deficiency Delays Wound Healing in Normal and Diabetic Mice.

Bi, Xinling / Zhou, Li / Liu, Yanfang / Gu, Jun / Mi, Qing-Sheng

Advances in wound care

2021 Volume 11, Issue 1, Page(s) 19–27

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Diabetes Complications/metabolism ; Diabetes Complications/pathology ; Diabetes Complications/therapy ; Diabetes Mellitus, Experimental/genetics ; Inflammation/genetics ; Inflammation/immunology ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Wound Healing/genetics ; Wound Healing/physiology
Chemical Substances	MIRN146 microRNA, rat ; MicroRNAs ; NF-kappa B
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2650541-1
ISSN	2162-1934 ; 2162-1918
ISSN (online)	2162-1934
ISSN	2162-1918
DOI	10.1089/wound.2020.1165
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Article ; Online: FANCI serve as a prognostic biomarker correlated with immune infiltrates in skin cutaneous melanoma.

Cai, Zhenguo / Duan, Yanjuan / Li, Wen / Liu, Zhuohang / Gong, Zijun / Hong, Sheng / He, Xu / Xuanyuan, Xinyang / Chen, Youdong / Bi, Xinling / Wang, Wuqing

Frontiers in immunology

2023 Volume 14, Page(s) 1295831

Abstract: Background: As a member of tumor, Skin cutaneous melanoma (SKCM) poses a serious threat to people's health because of its strong malignancy. Unfortunately, effective treatment methods for SKCM remain lacking. FANCI plays a vital role in the occurrence ... ...

Abstract	Background: As a member of tumor, Skin cutaneous melanoma (SKCM) poses a serious threat to people's health because of its strong malignancy. Unfortunately, effective treatment methods for SKCM remain lacking. FANCI plays a vital role in the occurrence and metastasis of various tumor types. However, its regulatory role in SKCM is unclear. The purpose of this study was to explore the association of FANCI with SKCM. Methods: This study investigated the expression of FANCI in GSE46517, GSE15605, and GSE114445 from the Gene Expression Omnibus database and The Cancer Genome Atlas (TCGA)-SKCM datasets using the package "limma" or "DESeq2" in R environment and also investigated the prognostic significance of FANCI by utilizing the GEPIA database. Additionally, our research made use of real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemical (IHC) staining to verify FANCI expression between SKCM and normal tissues and developed the knockdown of FANCI in A375 and A875 cells to further analyze the function of FANCI. Finally, this study analyzed the correlation of FANCI and tumor-infiltrating immune cells by CIBERSORT, ESTIMATE, and ssGSEA algorithms. Results: The FANCI level was increasing in SKCM tissues from GSE46517, GSE15605, GSE114445, and TCGA-SKCM. However, high FANCI expression correlated with poor overall survival. The RT-qPCR and IHC confirmed the accuracy of bioinformatics. Knocking down FANCI suppresses A375 and A875 cell proliferation, migration, and invasion. FANCI could be involved in the immunological milieu of SKCM by regulating immune responses and infiltrating numerous immune cells, particularly neutrophils, CD8+ T cells, and B cells. Furthermore, patients with SKCM who have a high FANCI expression level are reported to exhibit immunosuppression, whereas those with a low FANCI expression level are more likely to experience positive outcomes from immunotherapy. Conclusions: The increased FANCI expression in SKCM can be a prognostic biomarker. Knockdown FANCI can reduce the occurrence and progression of SKCM. The FANCI expression provides a foundation for predicting the immune status and treatment of SKCM.
MeSH term(s)	Humans ; Melanoma/genetics ; Skin Neoplasms/genetics ; Prognosis ; Biomarkers ; Fanconi Anemia Complementation Group Proteins
Chemical Substances	Biomarkers ; FANCI protein, human ; Fanconi Anemia Complementation Group Proteins
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1295831
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Article ; Online: Lesion area reduction and the amelioration of anxiety and depression states in psoriasis patients: A prospective clinical study.

Yu, Yingyuan / Zhou, Jing / Huang, Dawei / Zhong, Xiaoyuan / Kong, Luyang / Ding, Yangfeng / Bi, Xinling / Deng, Hui / Chen, Jianhua / Gu, Jun / Lu, Jiajing / Shi, Yuling

Journal of affective disorders

2023 Volume 344, Page(s) 335–338

Abstract: Background: Psoriasis patients are more likely to have mental disorders. The relationship between the reduction of involvement area and severity of lesions and the associated improvement in anxiety and depression in psoriasis patients, remains ... ...

Abstract	Background: Psoriasis patients are more likely to have mental disorders. The relationship between the reduction of involvement area and severity of lesions and the associated improvement in anxiety and depression in psoriasis patients, remains inadequately researched. Methods: 200 psoriasis patients were enrolled in this prospective study, and received 12-week narrowband ultraviolet B (NB-UVB) therapy. The Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Physician Global Assessment (PGA) scores were obtained as the objective assessments of disease, each reflecting distinct aspects of the disease. The Hospital Anxiety and Depression Scale (HADS) was used to evaluate the anxiety and depression symptoms. Results: Successful treatment brought an improvement in anxiety and depression levels and rates (all p < 0.05). Statistical analysis revealed no significant improvements in the scores of HADS or rates of symptomatic anxiety and depression in patients who did not achieve a PASI 75 response (all p > 0.05). Reductions in PASI, BSA and PGA were all statistically associated with reductions in HADS (all p < 0.05). BSA 75 response was found to play a more crucial role in the transition of symptomatic psoriatic patients to asymptomatic status (all p < 0.01). Limitations: The study focused on the short-term effects, and further research is needed to investigate the long-term effects. Conclusion: Successful treatment of psoriasis resulted in improvements in anxiety and depression levels and rates. In comparison with the lesion severity, reduction in the lesion involvement area had a greater impact on the anxiety and depression symptoms.
MeSH term(s)	Humans ; Prospective Studies ; Depression/therapy ; Anxiety/therapy ; Anxiety Disorders/complications ; Psoriasis/complications ; Psoriasis/therapy ; Severity of Illness Index ; Treatment Outcome
Language	English
Publishing date	2023-10-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2023.10.018
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Article ; Online: Measurement properties of the patient global assessment numerical rating scale in moderate-to-severe psoriasis.

Yu, Ning / Peng, Chen / Zhou, Jing / Gu, Jun / Xu, Jinhua / Li, Xia / Bi, Xinling / Deng, Hui / Li, Xin / Ding, Yangfeng / Shi, Yuling

The British journal of dermatology

2023 Volume 189, Issue 4, Page(s) 437–446

Abstract: Background: Patient global assessment (PtGA) has been recommended as one of the core domains in psoriasis clinical trials. Among multiple versions of PtGA, the single-question, 11-point PtGA numeric rating scale (NRS) remains to be validated in patients ...

Abstract	Background: Patient global assessment (PtGA) has been recommended as one of the core domains in psoriasis clinical trials. Among multiple versions of PtGA, the single-question, 11-point PtGA numeric rating scale (NRS) remains to be validated in patients with plaque psoriasis. Objectives: To evaluate the psychometric characteristics of an 11-point PtGA NRS for disease severity in patients with moderate-to-severe plaque psoriasis. Methods: Data were analysed from 759 patients with moderate-to-severe psoriasis in the Shanghai Psoriasis Effectiveness Evaluation CoHort (SPEECH), a prospective, multicentre and observational registry assessing the comparative effectiveness and safety of biologics (adalimumab, ustekinumab, secukinumab or ixekizumab), conventional systemic therapies (acitretin or methotrexate) and phototherapy. Results: The test-retest reliability of the PtGA NRS showed good agreement (intraclass correlation coefficient range 0.79-0.83). No floor or ceiling effects of PtGA NRS were observed. The PtGA NRS was significantly correlated with the Psoriasis Area and Severity Index (PASI), static Physician Global Assessment (sPGA), body surface area, Dermatology Quality of Life Index (DLQI) and Hospital Anxiety and Depression Scale. Relatively large correlations of PtGA NRS with PASI and the DLQI 'symptoms and feelings' domain (all correlations ≥ 0.4 except at baseline) supported convergent validity. The presence of psoriatic arthritis or joint symptoms had no significant association with the PtGA NRS. In multivariate regression analyses, the PtGA NRS at baseline was predicted by age, lesion extent, lesion intensity, patients' symptoms and feelings, and impact on work or school. The PtGA NRS displayed known-groups validity with the PASI, sPGA and DLQI score bands. The PtGA NRS was responsive to change in PASI and DLQI after treatment. Anchor- and distribution-based approaches supported -3 as the minimal important difference for PtGA NRS. An absolute PtGA NRS ≤ 2 during follow-up was concordant with the state of minimal disease activity based on a 90% reduction in PASI (PASI 90) or PASI 90 plus a DLQI of 0/1. Sensitivity analysis using subgroup comparison and multiple imputation model yielded consistent conclusions. Conclusions: The PtGA NRS showed good reliability, validity and responsiveness in patients with psoriasis, and was feasible in clinical trials and daily practice.
MeSH term(s)	Humans ; Quality of Life ; Reproducibility of Results ; Prospective Studies ; Severity of Illness Index ; China ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/pathology ; Treatment Outcome
Language	English
Publishing date	2023-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljad188
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