Article ; Online: Therapeutic disruption of RAD52-ssDNA complexation via novel drug-like inhibitors.
NAR cancer
2023 Volume 5, Issue 2, Page(s) zcad018
Abstract: RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal with defects in genome caretakers BRCA1 and BRCA2 (∼25% of breast and ... ...
| Abstract | RAD52 protein is a coveted target for anticancer drug discovery. Similar to poly-ADP-ribose polymerase (PARP) inhibitors, pharmacological inhibition of RAD52 is synthetically lethal with defects in genome caretakers BRCA1 and BRCA2 (∼25% of breast and ovarian cancers). Emerging structure activity relationships for RAD52 are complex, making it challenging to transform previously identified disruptors of the RAD52-ssDNA interaction into drug-like leads using traditional medicinal chemistry approaches. Using pharmacophoric informatics on the RAD52 complexation by epigallocatechin (EGC), and the Enamine |
|---|---|
| Language | English |
| Publishing date | 2023-05-01 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2632-8674 |
| ISSN (online) | 2632-8674 |
| DOI | 10.1093/narcan/zcad018 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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