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Article ; Conference proceedings: How can herbal medicine be well developed under the current regulatory system?

Bian, Zhao-xiang

2023 Volume 89, Issue 14

Event/congress	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
Language	English
Publishing date	2023-11-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0043-1774123
Database	Thieme publisher's database

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Article ; Online: The double-edged sword effect of indigo naturalis.

Xu, Yiqi / Lin, Chengyuan / Tan, Hor-Yue / Bian, Zhao-Xiang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 185, Page(s) 114476

Abstract: Indigo naturalis (IN) is a dried powder derived from plants such as Baphicacanthus cusia (Neeks) Bremek., Polygonum tinctorium Ait. and Isatis indigotica Fork. It has a historical application as a dye in ancient India, Egypt, Africa and China. Over time, ...

Abstract	Indigo naturalis (IN) is a dried powder derived from plants such as Baphicacanthus cusia (Neeks) Bremek., Polygonum tinctorium Ait. and Isatis indigotica Fork. It has a historical application as a dye in ancient India, Egypt, Africa and China. Over time, it has been introduced to China and Japan for treatment of various ailments including hemoptysis, epistaxis, chest discomfort, and aphtha. Clinical and pre-clinical studies have widely demonstrated its promising effects on autoimmune diseases like psoriasis and Ulcerative colitis (UC). Despite the documented efficacy of IN in UC patients, concerns have been raised on the development of adverse effects with long term consumption, prompting a closer examination of its safety and tolerability in these contexts. This review aims to comprehensively assess the efficacy of IN in both clinical and pre-clinical settings, with a detailed exploration of the mechanisms of action involved. Additionally, it summarizes the observed potential toxicity of IN in animal and human settings was summarized. This review will deepen our understanding on the beneficial and detrimental effects of IN in UC, providing valuable insights for its future application in patients with this condition.
MeSH term(s)	Animals ; Humans ; Indigo Carmine/therapeutic use ; Colitis, Ulcerative/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Psoriasis/chemically induced ; China
Chemical Substances	Indigo Carmine (D3741U8K7L) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114476
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chinese medicine practice and research in Hong Kong, China: Current status and future direction.

Bian, Zhao-Xiang

Chinese journal of integrative medicine

2017 Volume 23, Issue 7, Page(s) 490–493

MeSH term(s)	Hong Kong ; Humans ; Medicine, Chinese Traditional/trends ; Practice Patterns, Physicians'/trends ; Research
Keywords	covid19
Language	English
Publishing date	2017-06-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-017-2817-x
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Article ; Online: The Landscape of Gut Microbiota and Its Metabolites: A Key to Understanding the Pathophysiology of Pattern in Chinese Medicine.

Zhang, Zhaozhou / Du, Liqing / Ji, Qiuchen / Liu, Hao / Ren, Zhenxing / Ji, Guang / Bian, Zhao-Xiang / Zhao, Ling

The American journal of Chinese medicine

2024 Volume 52, Issue 1, Page(s) 89–122

Abstract: Liver Stagnation and Spleen Deficiency (LSSD) is a Chinese Medicine (CM) pattern commonly observed in gastrointestinal (GI) diseases, yet its biological nature remains unknown. This limits the global use of CM medications for treating GI diseases. Recent ...

Abstract	Liver Stagnation and Spleen Deficiency (LSSD) is a Chinese Medicine (CM) pattern commonly observed in gastrointestinal (GI) diseases, yet its biological nature remains unknown. This limits the global use of CM medications for treating GI diseases. Recent studies emphasize the role of gut microbiota and their metabolites in the pathogenesis and treatment of LSSD-associated GI diseases. There is increasing evidence supporting that an altered gut microbiome in LSSD patients or animals contributes to GI and extra-intestinal symptoms and affects the effectiveness of CM therapies. The gut microbiota is considered to be an essential component of the biological basis of LSSD. This study aims to provide an overview of existing research findings and gaps for the pathophysiological study of LSSD from the gut microbiota perspective in order to understand the relationship between the CM pattern and disease progression and to optimize CM-based diagnosis, prevention, and therapy.
MeSH term(s)	Animals ; Humans ; Gastrointestinal Diseases ; Gastrointestinal Microbiome ; Medicine, Chinese Traditional
Language	English
Publishing date	2024-02-08
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X24500046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Herbal Medicines for Constipation and Phytochemical Comparison of Active Components.

Ma, Qinge / Wang, Chong-Zhi / Sawadogo, Wamtinga R / Bian, Zhao-Xiang / Yuan, Chun-Su

The American journal of Chinese medicine

2022 Volume 50, Issue 3, Page(s) 723–732

Abstract: Constipation is a very common medical condition worldwide, negatively affecting patients' quality of life and healthcare system. Rhubarb, senna leaf, and aloe are three frequently used herbal medications for achieving regular bowel movement. Rhubarb is ... ...

Abstract	Constipation is a very common medical condition worldwide, negatively affecting patients' quality of life and healthcare system. Rhubarb, senna leaf, and aloe are three frequently used herbal medications for achieving regular bowel movement. Rhubarb is also a key ingredient in MaZiRenWan, a Chinese medicine formula used every so often for constipation in oriental countries. We reviewed and summarized the major chemical components from these three botanicals, including dianthrones, anthraquinone glycosides, free anthraquinones, and other polyphenols. The purgative actions of these constituents have been compared. Anthraquinone, especially its dianthrone compounds such as sennoside A and sennoside B, as natural stimulant laxatives, possesses significant effects to promote gastrointestinal motility and relieve functional constipation. Furthermore, the safety, reported side effects, and other benefits of anthraquinone compounds are presented. To date, many anti-constipation natural products are being used but their research is relatively limited, and thus, more investigations in this field are indeed needed.
MeSH term(s)	Anthraquinones/therapeutic use ; Constipation/drug therapy ; Humans ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Plants, Medicinal ; Quality of Life ; Rheum/chemistry ; Sennosides
Chemical Substances	Anthraquinones ; Phytochemicals ; Sennosides
Language	English
Publishing date	2022-03-24
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X2250029X
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Article: A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong, China.

Wei, Dong-Jue / Li, Hui-Juan / Lyu, Zi-Pan / Lyu, Ai-Ping / Bian, Zhao-Xiang / Ld Zhong, Linda

Journal of integrative medicine

2023 Volume 21, Issue 6, Page(s) 550–560

Abstract: Objective: Functional constipation (FC) is a common intestinal disease worldwide. Despite the presence of criteria such as Roman IV, there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine ... ...

Abstract	Objective: Functional constipation (FC) is a common intestinal disease worldwide. Despite the presence of criteria such as Roman IV, there is no standardized diagnosis and treatment algorithm in Hong Kong that combines both Western and Chinese medicine approaches. This study integrates current effective and safe diagnosis and treatment methods for FC and provides a clear and scientific pathway for clinical professionals and patients. Methods: A systematic search of the PubMed, Cochrane Library, and China National Knowledge Infrastructure databases was performed from their inception to June 30th, 2022, collecting the current evidence about the efficacious integrative management for FC. We organized a meeting of professionals in fields relevant to treatment and management of FC to develop a consensus agreement on clinical pathway process. Results: We developed a clinical pathway for the treatment of FC based on the most recent published guidelines and consultation with experts. This pathway includes a hierarchy of recommendations for every step of the clinical process, including clinical intake, diagnostic examination, recommended labs, diagnostic flowchart, and guidance for selection of therapeutic drugs. Conclusion: This pathway establishes clinical standards for the diagnosis and treatment of FC using Chinese medicine and Western medicine; it will help to provide high-quality medical services in Hong Kong for patients with FC. Please cite this article as: Wei DJ, Li HJ, Lyu ZP, Lyu AP, Bian ZX, Zhong LL. A clinical pathway for integrative medicine in the treatment of functional constipation in Hong Kong, China. J Integr Med. 2023; 21(6): 550-560.
MeSH term(s)	Humans ; Hong Kong ; Integrative Medicine ; Critical Pathways ; China ; Constipation/diagnosis ; Constipation/therapy
Language	English
Publishing date	2023-11-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2705612-0
ISSN	2095-4964
ISSN	2095-4964
DOI	10.1016/j.joim.2023.11.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Formative History of Integrative Medicine in Hong Kong.

Yu, Edwin Chau-Leung / Bian, Zhao-Xiang

Chinese journal of integrative medicine

2019 Volume 25, Issue 6, Page(s) 403–408

MeSH term(s)	Evidence-Based Medicine ; History, 21st Century ; Hong Kong ; Humans ; Integrative Medicine/economics ; Integrative Medicine/education ; Integrative Medicine/history ; Research
Language	English
Publishing date	2019-06-25
Publishing country	China
Document type	Historical Article ; Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-019-3160-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Managing Chronic Diarrhea From a Gut Microbiota-Bile Acid Perspective.

Zhao, Ling / Fang, Xiao-Dong / Jia, Wei / Bian, Zhao-Xiang

Clinical and translational gastroenterology

2020 Volume 11, Issue 8, Page(s) e00208

MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Bile Acids and Salts/analysis ; Bile Acids and Salts/antagonists & inhibitors ; Bile Acids and Salts/metabolism ; Chronic Disease/therapy ; Clostridiaceae/metabolism ; Combined Modality Therapy/methods ; Diarrhea/diagnosis ; Diarrhea/metabolism ; Diarrhea/microbiology ; Diarrhea/therapy ; Diet, Fat-Restricted ; Feces/microbiology ; Gastrointestinal Agents/pharmacology ; Gastrointestinal Agents/therapeutic use ; Gastrointestinal Microbiome/physiology ; Humans ; Probiotics/administration & dosage ; Receptors, Cytoplasmic and Nuclear/agonists ; Sequestering Agents/pharmacology ; Sequestering Agents/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Bile Acids and Salts ; Gastrointestinal Agents ; Receptors, Cytoplasmic and Nuclear ; Sequestering Agents ; farnesoid X-activated receptor (0C5V0MRU6P)
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2581516-7
ISSN	2155-384X ; 2155-384X
ISSN (online)	2155-384X
ISSN	2155-384X
DOI	10.14309/ctg.0000000000000208
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives.

Chan, Yau-Tuen / Lu, Yuanjun / Wu, Junyu / Zhang, Cheng / Tan, Hor-Yue / Bian, Zhao-Xiang / Wang, Ning / Feng, Yibin

Theranostics

2022 Volume 12, Issue 7, Page(s) 3329–3344

Abstract: CRISPR-Cas9 is a Nobel Prize-winning robust gene-editing tool developed in the last decade. This technique enables a stable genetic engineering method with high precision on the genomes of all organisms. The latest advances in the technology include a ... ...

Abstract	CRISPR-Cas9 is a Nobel Prize-winning robust gene-editing tool developed in the last decade. This technique enables a stable genetic engineering method with high precision on the genomes of all organisms. The latest advances in the technology include a genome library screening approach, which can detect survival-essential and drug resistance genes via gain or loss of function. The versatile machinery allows genomic screening for gene activation or inhibition, and targets non-coding sequences, such as promoters, miRNAs, and lncRNAs. In this review, we introduce the emerging high-throughput CRISPR-Cas9 library genome screening technology and its working principles to detect survival and drug resistance genes through positive and negative selection. The technology is compared with other existing approaches while focusing on the advantages of its variable applications in anti-cancer drug discovery, including functions and target identification, non-coding RNA information, actions of small molecules, and drug target discoveries. The combination of the CRISPR-Cas9 system with multi-omic platforms represents a dynamic field expected to advance anti-cancer drug discovery and precision medicine in the clinic.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; CRISPR-Cas Systems/genetics ; Gene Editing/methods ; Genetic Engineering ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-04-11
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.71144
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells.

Gong, Rui-Hong / Yang, Da-Jian / Kwan, Hiu-Yee / Lyu, Ai-Ping / Chen, Guo-Qing / Bian, Zhao-Xiang

International journal of medical sciences

2022 Volume 19, Issue 1, Page(s) 175–185

Abstract: Our previous study found that the combination of halofuginone (HF) and artemisinin (ATS) synergistically arrest colorectal cancer (CRC) cells at the G1/G0 phase of the cell cycle; however, it remains unclear whether HF-ATS induces cell death. Here we ... ...

Abstract	Our previous study found that the combination of halofuginone (HF) and artemisinin (ATS) synergistically arrest colorectal cancer (CRC) cells at the G1/G0 phase of the cell cycle; however, it remains unclear whether HF-ATS induces cell death. Here we report that HF-ATS synergistically induced caspase-dependent apoptosis in CRC cells. Specifically, both
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Autophagy/drug effects ; Caspase 8/metabolism ; Caspase 9/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Drug Synergism ; Enzyme Activation ; Humans ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Quinazolinones/pharmacology ; Quinazolinones/therapeutic use ; Receptor Cross-Talk
Chemical Substances	Antineoplastic Agents ; Artemisinins ; Piperidines ; Quinazolinones ; artemisinin (9RMU91N5K2) ; CASP8 protein, human (EC 3.4.22.-) ; CASP9 protein, human (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; halofuginone (L31MM1385E)
Language	English
Publishing date	2022-01-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.66737
Database	MEDical Literature Analysis and Retrieval System OnLINE

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