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Article ; Conference proceedings: How can herbal medicine be well developed under the current regulatory system?

Bian, Zhao-xiang

2023 Volume 89, Issue 14

Event/congress	71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Trinity College Dublin Ireland, 2023-07-02
Language	English
Publishing date	2023-11-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/s-0043-1774123
Database	Thieme publisher's database

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Article ; Online: The double-edged sword effect of indigo naturalis.

Xu, Yiqi / Lin, Chengyuan / Tan, Hor-Yue / Bian, Zhao-Xiang

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 185, Page(s) 114476

Abstract: Indigo naturalis (IN) is a dried powder derived from plants such as Baphicacanthus cusia (Neeks) Bremek., Polygonum tinctorium Ait. and Isatis indigotica Fork. It has a historical application as a dye in ancient India, Egypt, Africa and China. Over time, ...

Abstract	Indigo naturalis (IN) is a dried powder derived from plants such as Baphicacanthus cusia (Neeks) Bremek., Polygonum tinctorium Ait. and Isatis indigotica Fork. It has a historical application as a dye in ancient India, Egypt, Africa and China. Over time, it has been introduced to China and Japan for treatment of various ailments including hemoptysis, epistaxis, chest discomfort, and aphtha. Clinical and pre-clinical studies have widely demonstrated its promising effects on autoimmune diseases like psoriasis and Ulcerative colitis (UC). Despite the documented efficacy of IN in UC patients, concerns have been raised on the development of adverse effects with long term consumption, prompting a closer examination of its safety and tolerability in these contexts. This review aims to comprehensively assess the efficacy of IN in both clinical and pre-clinical settings, with a detailed exploration of the mechanisms of action involved. Additionally, it summarizes the observed potential toxicity of IN in animal and human settings was summarized. This review will deepen our understanding on the beneficial and detrimental effects of IN in UC, providing valuable insights for its future application in patients with this condition.
MeSH term(s)	Animals ; Humans ; Indigo Carmine/therapeutic use ; Colitis, Ulcerative/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Psoriasis/chemically induced ; China
Chemical Substances	Indigo Carmine (D3741U8K7L) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-30
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114476
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Article: Chinese medicine practice and research in Hong Kong, China: Current status and future direction.

Bian, Zhao-Xiang

Chinese journal of integrative medicine

2017 Volume 23, Issue 7, Page(s) 490–493

MeSH term(s)	Hong Kong ; Humans ; Medicine, Chinese Traditional/trends ; Practice Patterns, Physicians'/trends ; Research
Keywords	covid19
Language	English
Publishing date	2017-06-17
Publishing country	China
Document type	Journal Article
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-017-2817-x
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Zs.A 5823: Show issues

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Article ; Online: Traditional Chinese medicine for irritable bowel syndrome

Bian Zhaoxiang

Journal of Translational Medicine, Vol 10, Iss Suppl 2, p A

from classic formula to modern medicine development

2012 Volume 35

Keywords	Medicine ; R
Language	English
Publishing date	2012-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimization of amino acid-based poly(ester urea urethane) nanoparticles for the systemic delivery of gambogic acid for treating triple negative breast cancer.

Ji, Ying / Li, Juan / Xiao, Shilin / Kwan, Hiu Yee / Bian, Zhaoxiang / Chu, Chih-Chang

Biomaterials science

2023 Volume 11, Issue 12, Page(s) 4370–4384

Abstract: Amino acid-based poly(ester urea urethane) (AA-PEUU) is developed from amino acid-based ester urea building blocks interconnected with urethane blocks functionalized with poly(ethylene glycol) (PEG). Each functional block consists of structural design ... ...

Abstract	Amino acid-based poly(ester urea urethane) (AA-PEUU) is developed from amino acid-based ester urea building blocks interconnected with urethane blocks functionalized with poly(ethylene glycol) (PEG). Each functional block consists of structural design features that could impact the properties and performances of AA-PEUU as a nanocarrier for the systemic delivery of gambogic acid (GA). The multifunctional AA-PEUU structure provides broad tunability to enable the optimization of nanocarriers. The study investigates the structure-property relationship by fine-tuning the structure of AA-PEUU, including the amino acid type, hydrocarbons, the ratio of functional building blocks, and PEGylation, to identify the nanoparticle candidate with optimized delivery performances. Compared to free GA, the optimized PEUU nanocarrier improves the intratumoral distribution of GA by more than 9-fold, which significantly enhances the bioavailability and persistence of GA after intravenous administration. In an MDA-MB-231 xenograft mouse model, GA delivered by the optimized AA-PEUU nanocarrier exhibits significant tumor inhibition, apoptosis induction, and the anti-angiogenesis effect. The study demonstrates the potency of engineering AA-PEUU nanocarriers with tailor-designed structures and versatile tunability for the systemic delivery of therapeutics in the treatment of triple negative breast tumor.
MeSH term(s)	Humans ; Mice ; Animals ; Amino Acids ; Urethane ; Triple Negative Breast Neoplasms/drug therapy ; Urea ; Esters ; Nanoparticles/chemistry
Chemical Substances	Amino Acids ; Urethane (3IN71E75Z5) ; gambogic acid (8N585K83U2) ; Urea (8W8T17847W) ; Esters
Language	English
Publishing date	2023-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00128h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One-step enrichment of phenolics from Chaenomeles speciosa (Sweet) Nakai fruit using macroporous resin: Adsorption/desorption characteristics, process optimization and UPLC-QqQ-MS/MS-based quantification.

Hou, Mengyang / Lin, Chengyuan / Ma, Yanhua / Shi, Jingchun / Liu, Jie / Zhu, Lin / Bian, Zhaoxiang

Food chemistry

2023 Volume 439, Page(s) 138085

Abstract: Chaenomeles speciosa (Sweet) Nakai fruit is a good source of phenolics with many health benefits. In this work, the enrichment of C. speciosa fruit total phenolics (CSFTP) using macroporous resins was studied. NKA-Ⅱ resin was selected for enriching CSFTP ...

Abstract	Chaenomeles speciosa (Sweet) Nakai fruit is a good source of phenolics with many health benefits. In this work, the enrichment of C. speciosa fruit total phenolics (CSFTP) using macroporous resins was studied. NKA-Ⅱ resin was selected for enriching CSFTP due to its highest adsorption/desorption quantity. Adsorption characteristics of CSFTP on NKA-Ⅱ resin exhibited a good fit with the Langmuir isotherm model and pseudo-second order kinetics model. This adsorption was spontaneous, exothermic, and entropy-decreasing through a physisorption mechanism. The breakthrough-elution curves were studied to optimize CSFTP enrichment conditions. One-step enrichment increased CSFTP content in the extracts from 26.51 % to 78.63 %, with a recovery of 81.03 %. A UPLC-QqQ-MS/MS method in multiple reaction monitoring (MRM) mode was established and validated for the simultaneous quantification of seven phenolic compounds. This study demonstrates the feasibility of industrial enrichment of CSFTP using NKA-Ⅱ resin and proposes a reliable method for quality control of CSFTP-rich products.
MeSH term(s)	Plant Extracts ; Tandem Mass Spectrometry ; Adsorption ; Fruit ; Chromatography, High Pressure Liquid/methods ; Phenols ; Resins, Plant ; Rosaceae
Chemical Substances	Plant Extracts ; Phenols ; Resins, Plant
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2023.138085
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Article ; Online: Gut microbiota and colorectal cancer metastasis.

Zheng, Zongmei / Hou, Xinxin / Bian, Zhaoxiang / Jia, Wei / Zhao, Ling

Cancer letters

2022 Volume 555, Page(s) 216039

Abstract: Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive ... ...

Abstract	Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis, but the underlying mechanisms remain elusive. This review discusses the molecular mechanisms by which the gut microbiota contribute to a tumor-permissive microenvironment and facilitate malignant transformation and dissemination of tumor cells, thereby mediating CRC metastasis.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Colorectal Neoplasms/pathology ; Tumor Microenvironment
Language	English
Publishing date	2022-12-15
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2022.216039
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Zs.A 1177: Show issues

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Article ; Online: Detecting the skewness of data from the five-number summary and its application in meta-analysis.

Shi, Jiandong / Luo, Dehui / Wan, Xiang / Liu, Yue / Liu, Jiming / Bian, Zhaoxiang / Tong, Tiejun

Statistical methods in medical research

2023 Volume 32, Issue 7, Page(s) 1338–1360

Abstract: For clinical studies with continuous outcomes, when the data are potentially skewed, researchers may choose to report the whole or part of the five-number summary (the sample median, the first and third quartiles, and the minimum and maximum values) ... ...

Abstract	For clinical studies with continuous outcomes, when the data are potentially skewed, researchers may choose to report the whole or part of the five-number summary (the sample median, the first and third quartiles, and the minimum and maximum values) rather than the sample mean and standard deviation. In the recent literature, it is often suggested to transform the five-number summary back to the sample mean and standard deviation, which can be subsequently used in a meta-analysis. However, if a study contains skewed data, this transformation and hence the conclusions from the meta-analysis are unreliable. Therefore, we introduce a novel method for detecting the skewness of data using only the five-number summary and the sample size, and meanwhile, propose a new flow chart to handle the skewed studies in a different manner. We further show by simulations that our skewness tests are able to control the type I error rates and provide good statistical power, followed by a simulated meta-analysis and a real data example that illustrate the usefulness of our new method in meta-analysis and evidence-based medicine.
MeSH term(s)	Sample Size ; Evidence-Based Medicine
Language	English
Publishing date	2023-05-10
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802231172043
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Zs.A 3564: Show issues

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Article ; Online: The Landscape of Gut Microbiota and Its Metabolites: A Key to Understanding the Pathophysiology of Pattern in Chinese Medicine.

Zhang, Zhaozhou / Du, Liqing / Ji, Qiuchen / Liu, Hao / Ren, Zhenxing / Ji, Guang / Bian, Zhao-Xiang / Zhao, Ling

The American journal of Chinese medicine

2024 Volume 52, Issue 1, Page(s) 89–122

Abstract: Liver Stagnation and Spleen Deficiency (LSSD) is a Chinese Medicine (CM) pattern commonly observed in gastrointestinal (GI) diseases, yet its biological nature remains unknown. This limits the global use of CM medications for treating GI diseases. Recent ...

Abstract	Liver Stagnation and Spleen Deficiency (LSSD) is a Chinese Medicine (CM) pattern commonly observed in gastrointestinal (GI) diseases, yet its biological nature remains unknown. This limits the global use of CM medications for treating GI diseases. Recent studies emphasize the role of gut microbiota and their metabolites in the pathogenesis and treatment of LSSD-associated GI diseases. There is increasing evidence supporting that an altered gut microbiome in LSSD patients or animals contributes to GI and extra-intestinal symptoms and affects the effectiveness of CM therapies. The gut microbiota is considered to be an essential component of the biological basis of LSSD. This study aims to provide an overview of existing research findings and gaps for the pathophysiological study of LSSD from the gut microbiota perspective in order to understand the relationship between the CM pattern and disease progression and to optimize CM-based diagnosis, prevention, and therapy.
MeSH term(s)	Animals ; Humans ; Gastrointestinal Diseases ; Gastrointestinal Microbiome ; Medicine, Chinese Traditional
Language	English
Publishing date	2024-02-08
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X24500046
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Article ; Online: Tong-Xie-Yao-Fang strengthens intestinal feedback control of bile acid synthesis to ameliorate irritable bowel syndrome by enhancing bile salt hydrolase-expressing microbiota.

Jia, Fengjing / Du, Liqing / He, Jinchao / Zhang, Zhaozhou / Hou, Xinxin / Dong, Qinjun / Bian, Zhaoxiang / Zhao, Ling

Journal of ethnopharmacology

2024 , Page(s) 118256

Abstract: Ethnopharmacological relevance: A herbal formula Tong-Xie-Yao-Fang (TXYF) is traditionally used to treat irritable bowel syndrome (IBS), modern pharmacological evidence supports that the formula efficacy is associated with altered gut microbiota. Yet, ... ...

Abstract	Ethnopharmacological relevance: A herbal formula Tong-Xie-Yao-Fang (TXYF) is traditionally used to treat irritable bowel syndrome (IBS), modern pharmacological evidence supports that the formula efficacy is associated with altered gut microbiota. Yet, the mechanistic role of gut microbiota in the therapy of TXYF remains unclear. We previously clarified that gut microbiota-dysregulated bile acid (BA) metabolism contribute to the pathogenesis of IBS, deriving a hypothesis that microbiota-BA metabolic axis might be a potential target of TXYF. Aim of the study: We aim to investigate a new gut microbiota-mediated mechanism underlying anti-IBS efficacy of TXYF. Materials and methods: We established an IBS rat model with a combination of stressors, compared the herbal efficacy in models undergone gut bacterial manipulations, also examined BA metabolism-related microbiota, metabolites, genes and proteins by 16S rRNA gene sequencing, targeted metabolomics, qPCR and multiplex immunofluorescence staining. Results: We observed that TXYF attenuated visceral hyperalgesia and diarrhea in IBS rats but not in those underwent gut bacteria depletion. Transferring gut microbiota from TXYF-treated donors also decreased visceral sensitivity and slightly relief diarrhea-like behaviors in IBS recipient rats. Fecal 16S rRNA gene sequencing revealed that TXYF modulated microbial β-diversity and taxonomic structure of IBS rats, with a significant increase in relative abundance of bile salt hydrolase (BSH)-expressing Bacteroidaceae. qPCR and culturing data validated that TXYF had a promotive effect on the growth and BSH activity of Bacteroides species. TXYF-reshaped microbiota upregulated the expression of intestinal Fgf15, a feedback signal to control BA synthesis in the liver. As a result, the BA synthetic and excretory levels in IBS rats were decreased by TXYF, so as that colonic BA membrane receptor Tgr5 sensing and its mediated Calcitonin gene-related peptide (Cgrp)-positive neuronal response were attenuated. Conclusion: This study poses a new microbiota-driven therapeutic action for TXYF, highlighting the potential of developing new anti-IBS strategies from the herbal formula targeting BSH-expressing gut bacteria.
Language	English
Publishing date	2024-04-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118256
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