Article: Circulating choline and phosphocholine measurement by a hydrophilic interaction liquid chromatography-tandem mass spectrometry.
2023 Volume 9, Issue 11, Page(s) e21921
Abstract: Background: Given the growing interest in studying the role of choline and phosphocholine in the development and progression of tumor pathology, in this study we describe the development and validation of a fast and robust method for the simultaneous ... ...
| Abstract | Background: Given the growing interest in studying the role of choline and phosphocholine in the development and progression of tumor pathology, in this study we describe the development and validation of a fast and robust method for the simultaneous analysis of choline and phosphocholine in human plasma. Methods: Choline and phosphocholine quantification in human plasma was obtained using a hydrophilic interaction liquid chromatography-tandem mass spectrometry technique. Assay performance parameters were evaluated using EMA guidelines. Results: Calibration curve ranged from 0.60 to 38.40 μmol/L (R Conclusions: The developed method shows good reliability in quantifying Choline and Phosphocholine in human plasma for clinical purposes. |
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| Language | English |
| Publishing date | 2023-11-02 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2835763-2 |
| ISSN | 2405-8440 |
| ISSN | 2405-8440 |
| DOI | 10.1016/j.heliyon.2023.e21921 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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