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Article ; Online: High-Dose Statins in Preventing Microvascular Obstruction: "The Devil Lies in the Details".

Laborante, Renzo / Bianchini, Emiliano / Borovac, Josip A / D'Amario, Domenico

2023 Volume 206, Page(s) 384–387

MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2023-09-24
Publishing country	United States
Document type	Letter
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.08.047
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Ui IV Zs.73: Show issues

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Article ; Online: Intravascular ultrasound-guided 'OrbiTripsy' for a severely calcified neo-atherosclerotic coronary in-stent restenosis.

Restivo, Attilio / Bianchini, Emiliano / Bellamoli, Michele / Buono, Andrea / Bettari, Luca / Stanzione, Alessio / De Ornelas, Benjamin / Maffeo, Diego

Journal of cardiovascular medicine (Hagerstown, Md.)

2023 Volume 24, Issue 12, Page(s) 931–932

MeSH term(s)	Humans ; Coronary Restenosis/diagnostic imaging ; Coronary Restenosis/etiology ; Coronary Restenosis/therapy ; Stents ; Atherosclerosis ; Ultrasonography, Interventional ; Coronary Angiography ; Treatment Outcome ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001572
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Long-Term Outcome of Percutaneously Managed Coronary Pseudoaneurysm Caused by Stent Fracture.

Burzotta, Francesco / Bianchini, Francesco / Di Giusto, Federico / Bianchini, Emiliano / Aurigemma, Cristina / Romagnoli, Enrico / Marano, Riccardo / Trani, Carlo

JACC. Cardiovascular interventions

2023 Volume 17, Issue 2, Page(s) 315–316

MeSH term(s)	Humans ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Treatment Outcome ; Stents/adverse effects ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Artery Disease/complications
Language	English
Publishing date	2023-11-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2023.09.025
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Zs.A 6669: Show issues

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Article ; Online: Statins as preventive therapy for anthracycline cardiotoxicity: a meta-analysis of randomized controlled trials.

D'Amario, Domenico / Laborante, Renzo / Bianchini, Emiliano / Galli, Mattia / Ciliberti, Giuseppe / Mennuni, Marco / Patti, Giuseppe

International journal of cardiology

2023 Volume 391, Page(s) 131219

Abstract: Background: Cardiotoxicity occurs in 5-20% of cancer patients who receive anthracyclines. The aim of this study was to pool all the randomized controlled trials (RCTs) investigating the cardio-protective role of statins in patients treated with ... ...

Abstract	Background: Cardiotoxicity occurs in 5-20% of cancer patients who receive anthracyclines. The aim of this study was to pool all the randomized controlled trials (RCTs) investigating the cardio-protective role of statins in patients treated with anthracyclines. Methods: PubMed and Scopus electronic databases were scanned for eligible studies up to May 3rd, 2023. A total of 5 RCTs with 808 patients were included. Efficacy endpoints were the rate of anthracycline-mediated cardiotoxicity, the incidence of hospitalization for heart failure (HF), left ventricular ejection fraction (LVEF) value after anthracycline treatment, and ∆LVEF calculated as the difference in LVEF before and after anthracycline therapy. Safety endpoints [i.e., the incidence of muscle pain and serious adverse events (SAE)] were also assessed. Results: On pooled analysis, the statin-treated group had a lower incidence of cardiotoxicity compared to the placebo group [risk ratio (RR) 0.52, 95% confidence Interval (CI) 0.33-0.83, P = 0.01; I Conclusions: The current meta-analysis of all RCTs conducted so far shows an overall beneficial effect of statins on the risk of anthracyclines-induced cardiotoxicity and LVEF preservation. No difference was observed in the rate of HF hospitalization. More powered RCTs are needed to fully investigate the impact of statins on prognosis in patients receiving anthracyclines therapy.
MeSH term(s)	Humans ; Anthracyclines/adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Randomized Controlled Trials as Topic ; Antibiotics, Antineoplastic/adverse effects ; Heart Failure/chemically induced ; Heart Failure/prevention & control ; Heart Failure/drug therapy ; Stroke Volume
Chemical Substances	Anthracyclines ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Antibiotics, Antineoplastic
Language	English
Publishing date	2023-07-30
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131219
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Zs.A 1673: Show issues

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Article ; Online: Impact of coronary microvascular dysfunction in heart failure with preserved ejection fraction: a meta-analysis.

D'Amario, Domenico / Laborante, Renzo / Bianchini, Emiliano / Ciliberti, Giuseppe / Paglianiti, Donato Antonio / Galli, Mattia / Restivo, Attilio / Stolfo, Davide / Vergallo, Rocco / Rosano, Giuseppe M C / Crea, Filippo / Lam, Carolyn S P / Lund, Lars H / Metra, Marco / Patti, Giuseppe / Savarese, Gianluigi

ESC heart failure

2024

Abstract: Aims: Several mechanisms have been identified in the aetiopathogenesis of heart failure with preserved ejection fraction (HFpEF). Among these, coronary microvascular dysfunction (CMD) may play a key pathophysiological role. We performed a systematic ... ...

Abstract	Aims: Several mechanisms have been identified in the aetiopathogenesis of heart failure with preserved ejection fraction (HFpEF). Among these, coronary microvascular dysfunction (CMD) may play a key pathophysiological role. We performed a systematic review and meta-analysis to investigate the prevalence, echocardiographic correlates, and prognostic implications of CMD in patients with HFpEF. Methods and results: A systematic search for articles up to 1 May 2023 was performed. The primary aim was to assess the prevalence of CMD. Secondary aims were to compare key echocardiographic parameters (E/e' ratio, left atrial volume index [LAVi], and left ventricular mass index [LVMi]), clinical outcomes [death and hospitalization for heart failure (HF)], and prevalence of atrial fibrillation (AF) between patients with and without CMD. Meta-regressions according to baseline patient characteristics and study features were performed to explore potential heterogeneity sources. We identified 14 observational studies, enrolling 1138 patients with HFpEF. The overall prevalence of CMD was 58%. Compared with patients without CMD, patients with HFpEF and CMD had larger LAVi [mean difference (MD) 3.85 confidence interval (CI) 1.19-6.5, P < 0.01)], higher E/e' ratio (MD 2.76 CI 1.54-3.97; P < 0.01), higher prevalence of AF (odds ratio 1.61 CI 1.04-2.48, P = 0.03) and higher risk of death or hospitalization for HF [hazard ratio 3.19, CI 1.04-9.57, P = 0.04]. Conclusions: CMD is present in little more than half of the patients with HFpEF and is associated with echocardiographic evidence of more severe diastolic dysfunction and a higher prevalence of AF, doubling the risk of death or HF hospitalization.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14626
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Article ; Online: Heart failure management guided by remote multiparameter monitoring: A meta-analysis.

Zito, Andrea / Restivo, Attilio / Ciliberti, Giuseppe / Laborante, Renzo / Princi, Giuseppe / Romiti, Giulio Francesco / Galli, Mattia / Rodolico, Daniele / Bianchini, Emiliano / Cappannoli, Luigi / D'Oria, Marika / Trani, Carlo / Burzotta, Francesco / Cesario, Alfredo / Savarese, Gianluigi / Crea, Filippo / D'Amario, Domenico

International journal of cardiology

2023 Volume 388, Page(s) 131163

Abstract: Background: Several implant-based remote monitoring strategies are currently tested to optimize heart failure (HF) management by anticipating clinical decompensation and preventing hospitalization. Among these solutions, the modern implantable ... ...

Abstract	Background: Several implant-based remote monitoring strategies are currently tested to optimize heart failure (HF) management by anticipating clinical decompensation and preventing hospitalization. Among these solutions, the modern implantable cardioverter-defibrillator and cardiac resynchronization therapy devices have been equipped with sensors allowing continuous monitoring of multiple preclinical markers of worsening HF, including factors of autonomic adaptation, patient activity, and intrathoracic impedance. Objectives: We aimed to assess whether implant-based multiparameter remote monitoring strategy for guided HF management improves clinical outcomes when compared to standard clinical care. Methods: A systematic literature research for randomized controlled trials (RCTs) comparing multiparameter-guided HF management versus standard of care was performed on PubMed, Embase, and CENTRAL databases. Incidence rate ratios (IRRs) and associated 95% confidence intervals (CIs) were calculated using the Poisson regression model with random study effects. The primary outcome was a composite of all-cause death and HF hospitalization events, whereas secondary endpoints included the individual components of the primary outcome. Results: Our meta-analysis included 6 RCTs, amounting to a total of 4869 patients with an average follow-up time of 18 months. Compared with standard clinical management, the multiparameter-guided strategy reduced the risk of the primary composite outcome (IRR 0.83, 95%CI 0.71-0.99), driven by statistically significant effect on both HF hospitalization events (IRR 0.75, 95%CI 0.61-0.93) and all-cause death (IRR 0.80, 95%CI 0.66-0.96). Conclusion: Implant-based multiparameter remote monitoring strategy for guided HF management is associated with significant benefit on clinical outcomes compared to standard clinical care, providing a benefit on both hospitalization events and all-cause death.
MeSH term(s)	Humans ; Heart Failure/therapy ; Heart Failure/drug therapy ; Cardiac Resynchronization Therapy Devices
Language	English
Publishing date	2023-07-08
Publishing country	Netherlands
Document type	Meta-Analysis ; Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131163
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Zs.A 1673: Show issues

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Article ; Online: Impact of thrombus aspiration on left ventricular remodeling and function in patients with ST-segment elevation myocardial infarction: A meta-analysis of randomized controlled trials.

Bianchini, Emiliano / Lombardi, Marco / Buonpane, Angela / Ricchiuto, Alfredo / Maino, Alessandro / Laborante, Renzo / Anastasia, Gianluca / D'Amario, Domenico / Aurigemma, Cristina / Romagnoli, Enrico / Leone, Antonio Maria / D'Ascenzo, Fabrizio / Trani, Carlo / Crea, Filippo / Porto, Italo / Burzotta, Francesco / Vergallo, Rocco

International journal of cardiology

2023 Volume 397, Page(s) 131590

Abstract: Background: Routine thrombus aspiration (TA) does not improve clinical outcomes in patients with ST-segment-elevation myocardial infarction (STEMI), although data from meta-analyses suggest that patients with high thrombus burden may benefit from it. ... ...

Abstract	Background: Routine thrombus aspiration (TA) does not improve clinical outcomes in patients with ST-segment-elevation myocardial infarction (STEMI), although data from meta-analyses suggest that patients with high thrombus burden may benefit from it. The impact of TA on left ventricular (LV) functional recovery and remodeling after STEMI remains controversial. We aimed to pool data from randomized controlled trials (RCTs) on the impact of TA on LV function and remodeling after primary percutaneous coronary intervention (pPCI). Methods: PubMed and CENTRAL databases were scanned for eligible studies. Primary outcome measures were: LV ejection fraction (LVEF), LV end diastolic volume (LVEDV), LV end systolic volume (LVESV) and wall motion score index (WMSI). A primary pre-specified subgroup analysis was performed comparing manual TA with mechanical TA. Results: A total of 28 studies enrolling 4990 patients were included. WMSI was lower in TA group than in control (mean difference [MD] -0.11, 95% confidence interval [CI] -0.19 to -0.03). A greater LVEF (MD 1.91, 95% CI 0.76 to 3) and a smaller LVESV (MD -6.19, 95% CI -8.7 to -3.6) were observed in manual TA group compared to control. Meta regressions including patients with left anterior descending artery (LAD) involvement showed an association between TA use and the reduction of both LVEDV and LVESV (z = -2.13, p = 0.03; z = -3.7, p < 0.01) and the improvement in myocardial salvage index (z = 2.04, p = 0.04). Conclusion: TA is associated with improved LV function. TA technique, total ischemic time and LAD involvement appears to influence TA benefit on post-infarction LV remodeling.
MeSH term(s)	Humans ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/surgery ; ST Elevation Myocardial Infarction/etiology ; Ventricular Remodeling ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Ventricular Function, Left ; Percutaneous Coronary Intervention/adverse effects ; Thrombosis/etiology
Language	English
Publishing date	2023-11-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2023.131590
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Article ; Online: Adenosine as adjunctive therapy in acute coronary syndrome: a meta-analysis of randomized controlled trials.

Laborante, Renzo / Bianchini, Emiliano / Restivo, Attilio / Ciliberti, Giuseppe / Galli, Mattia / Vergallo, Rocco / Rodolico, Daniele / Zito, Andrea / Princi, Giuseppe / Leone, Antonio Maria / Aurigemma, Cristina / Romagnoli, Enrico / Montone, Rocco Antonio / Burzotta, Francesco / Trani, Carlo / Crea, Filippo / D'Amario, Domenico

European heart journal. Cardiovascular pharmacotherapy

2022 Volume 9, Issue 2, Page(s) 173–182

Abstract: Aims: Adenosine has been tested in several randomized controlled trials (RCTs) to minimize the incidence of coronary microvascular obstruction (CMVO). The aim of this study was to pool all the RCTs comparing intracoronary or intravenous adenosine versus ...

Abstract	Aims: Adenosine has been tested in several randomized controlled trials (RCTs) to minimize the incidence of coronary microvascular obstruction (CMVO). The aim of this study was to pool all the RCTs comparing intracoronary or intravenous adenosine versus placebo in patients with acute coronary syndrome (ACS) undergoing myocardial revascularization. Methods and results: PubMed and Scopus electronic databases were scanned for eligible studies up to 5th June 2022. A total of 26 RCTs with 5843 patients were included. Efficacy endpoints were major adverse cardiac events (MACE), all-cause death, non-fatal myocardial infarction, and heart failure. Atrioventricular blocks and ventricular fibrillation/sustained ventricular tachycardia (VF/SVT) were the safety endpoints. Myocardial blush grade, thrombolysis in myocardial infarction (TIMI) flow grade, left ventricular ejection fraction (LVEF), infarct size, and ST-segment resolution were also assessed. Adenosine administration was not associated with any clinical benefit in terms of MACE, all-cause death, non-fatal myocardial infarction, and heart failure. However, adenosine was associated with an increased rate of advanced atrioventricular blocks and of VF/SVT in studies with total mean ischaemic time >3 h, compared to placebo. Remarkably, among patients undergoing percutaneous coronary intervention, adenosine was associated with reduced myocardial blush grade 0-1 and TIMI flow grade 0-2, compared to placebo. Furthermore, adenosine did not show favourable effects on LVEF and infarct size. Conclusion: Adenosine infusion, as adjunctive therapy in ACS, was associated with an increased risk of advanced atrioventricular blocks and increased rates of adenosine-triggered ventricular arrhythmias in patients with long ischaemic time, without providing any clinical benefit compared to placebo.
MeSH term(s)	Humans ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Adenosine/adverse effects ; Atrioventricular Block/chemically induced ; Atrioventricular Block/drug therapy ; Heart Failure/drug therapy ; Myocardial Infarction/drug therapy ; Randomized Controlled Trials as Topic ; Vasodilator Agents/adverse effects
Chemical Substances	Adenosine (K72T3FS567) ; Vasodilator Agents
Language	English
Publishing date	2022-12-07
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvac069
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Article ; Online: Pre-stenting residual thrombotic volume assessed by dual quantitative coronary angiography predicts microvascular obstruction in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

Minerva cardiology and angiology

2023 Volume 71, Issue 4, Page(s) 421–430

Abstract: Background: Microvascular obstruction (MVO) is a frequent occurrence after primary percutaneous coronary intervention (pPCI), and is associated with adverse left ventricular remodeling and worse clinical outcome. Distal embolization of thrombotic ... ...

Abstract	Background: Microvascular obstruction (MVO) is a frequent occurrence after primary percutaneous coronary intervention (pPCI), and is associated with adverse left ventricular remodeling and worse clinical outcome. Distal embolization of thrombotic material is one of the most important underlying mechanisms. The aim of this study was to investigate the relation between the thrombotic volume evaluated by dual quantitative coronary angiography (QCA) prior to stenting and the occurrence of MVO as assessed by cardiac magnetic resonance (CMR). Methods: Forty-eight patients with ST-segment elevation myocardial infarction (STEMI) undergoing pPCI and receiving CMR within 7 days from admission were included. Pre-stenting residual thrombus volume at the site of the culprit lesion was measured by applying automated edge detection and video-assisted densitometry techniques (i.e., dual-QCA), and patients were categorized into tertiles of thrombus volume. The presence of delayed-enhancement MVO, as well as its extent (MVO mass), were assessed by CMR. Results: Pre-stenting dual-QCA thrombus volume was significantly greater in patients with MVO than in those without (5.85 mm Conclusions: Pre-stenting dual-QCA thrombus volume is associated with the presence and extent of MVO detected by CMR in patients with STEMI. This methodology may aid the identification of patients at higher risk of MVO and guide adoption of preventive strategies.
MeSH term(s)	Humans ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/surgery ; Coronary Angiography/methods ; Coronary Circulation ; Thrombosis/etiology ; Percutaneous Coronary Intervention/adverse effects
Language	English
Publishing date	2023-02-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3059238-0
ISSN	2724-5772
ISSN (online)	2724-5772
DOI	10.23736/S2724-5683.22.06156-7
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Article ; Online: Comparison of ultrasound- versus fluoroscopy-guidEd femorAl access In tranS-catheter aortic valve replacement In the Era of contempoRary devices: The EASIER registry.

Bianchini, Emiliano / Morello, Alberto / Bellamoli, Michele / Romagnoli, Enrico / Aurigemma, Cristina / Tagliaferri, Marco / Montonati, Carolina / Dumonteil, Nicolas / Cimmino, Michele / Villa, Emmanuel / Corcione, Nicola / Bettari, Luca / Messina, Antonio / Stanzione, Alessio / Troise, Giovanni / Mor, Donata / Maggi, Antonio / Bellosta, Raffaello / Pegorer, Matteo Alberto /

Zoccai, Giuseppe Biondi / Ielasi, Alfonso / Burzotta, Francesco / Trani, Carlo / Maffeo, Diego / Tchétché, Didier / Buono, Andrea / Giordano, Arturo

Cardiovascular revascularization medicine : including molecular interventions

2023 Volume 62, Page(s) 40–47

Abstract: Background: Vascular complications (VCs) still represent one of the principal concerns of trans-femoral trans-catheter aortic valve replacement (TF-TAVR). New-generation devices can minimize such complications but the arterial access management is left ... ...

Abstract	Background: Vascular complications (VCs) still represent one of the principal concerns of trans-femoral trans-catheter aortic valve replacement (TF-TAVR). New-generation devices can minimize such complications but the arterial access management is left to the operator's choice. This study aims to describe the rate of VCs in a contemporary cohort of patients undergoing TAVR with new-generation devices and to determine whether an ultrasound-guided (USG) vs. a fluoroscopy-guided (FG) femoral access management has an impact on their prevention. Methods: This is a prospective, observational, multicenter study. Consecutive patients undergoing TAVR with new-generation devices were analyzed from January 2022 to October 2022 in five tertiary care centers. Femoral accesses were managed according to the operator's preferences. All the patients underwent a pre-discharge peripheral ultrasound control. VCs and bleedings were the main endpoints of interest. Results: A total of 458 consecutive patients were enrolled (274 in the USG group and 184 in the FG group). VCs occurred in 6.5 % of the patients (5.2 % minor and 1.3 % major). There was no difference between the USG and the FG groups in terms of any VCs (7.3 % vs. 5.4 %; p = 0.4), or any VARC-3 bleedings (6.9 % vs 6 %, p = 0.9). At logistic regression analysis, the two guidance strategies did not result as predictors of VCs (odds Ratio 0.8, 95 % Confidence Interval 0.46-1.4; P = 0.4). Conclusions: In a contemporary cohort of patients undergoing TAVR with new-generation devices, the occurrence of VCs is low and mostly represented by minor VCs. USG and FG modalities did not affect the rate of VCs.
MeSH term(s)	Humans ; Femoral Artery/diagnostic imaging ; Male ; Female ; Prospective Studies ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/instrumentation ; Aged, 80 and over ; Aged ; Registries ; Fluoroscopy ; Ultrasonography, Interventional ; Treatment Outcome ; Catheterization, Peripheral/adverse effects ; Catheterization, Peripheral/instrumentation ; Punctures ; Aortic Valve/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/physiopathology ; Risk Factors ; Radiography, Interventional/adverse effects ; Heart Valve Prosthesis ; Time Factors ; Aortic Valve Stenosis/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Prosthesis Design
Language	English
Publishing date	2023-12-16
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Comparative Study ; Observational Study
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2023.12.007
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