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  1. AU="Bianco, Delia Mercedes"
  2. AU="Giobbe, Dario"
  3. AU="Gilkey, George D"
  4. AU="Jacob, Pauline"
  5. AU="van Thiel, Eric R E"
  6. AU=March Dana
  7. AU=Wu Bi
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  1. Article: The Dark Side of the COVID-19 Treatments on

    De Maio, Flavio / Bianco, Delia Mercedes / Delogu, Giovanni

    Mediterranean journal of hematology and infectious diseases

    2022  Volume 14, Issue 1, Page(s) e2022021

    Abstract: Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) at the end of 2019, a number of medications have been used to treat the infection and the related Coronavirus disease - 19 (COVID-19). Some of the administered drugs were ...

    Abstract Since the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) at the end of 2019, a number of medications have been used to treat the infection and the related Coronavirus disease - 19 (COVID-19). Some of the administered drugs were tested or used in practice only on the basis of biological plausibility; a promising strategy was to target the host immune response, with host directed therapies (HDTs), to reduce systemic hyperinflammation and hypercytokinemia responsible for additional tissue damage. We summarize the treatments against SARS-CoV-2 and underline their possible effects on
    Language English
    Publishing date 2022-03-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2022.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Profiling the Urobiota in a Pediatric Population with Neurogenic Bladder Secondary to Spinal Dysraphism.

    De Maio, Flavio / Grotti, Giacomo / Mariani, Francesco / Buonsenso, Danilo / Santarelli, Giulia / Bianco, Delia Mercedes / Posteraro, Brunella / Sanguinetti, Maurizio / Rendeli, Claudia

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development ... ...

    Abstract The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development of urinary tract disorders is now of great interest. Patients with spina bifida (SB) can be born with (or develop over time) neurological deficits due to damaged nerves that originate in the lower part of the spinal cord, including the neurogenic bladder. This condition represents a predisposing factor for urinary tract infections so that the most frequently used approach to treat patients with neurogenic bladder is based on clean intermittent catheterization (CIC). In this study, we analyzed the urobiota composition in a pediatric cohort of patients with SB compared to healthy controls, as well as the urobiota characteristics based on whether patients received CIC or not.
    MeSH term(s) Humans ; Child ; Urinary Bladder, Neurogenic/complications ; Urinary Bladder, Neurogenic/therapy ; Spinal Dysraphism/complications ; Intermittent Urethral Catheterization ; Urinary Tract Infections/complications ; Urinary Tract
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of Everolimus Activity against

    Bianco, Delia Mercedes / De Maio, Flavio / Santarelli, Giulia / Palucci, Ivana / Salustri, Alessandro / Bianchetti, Giada / Maulucci, Giuseppe / Citterio, Franco / Sanguinetti, Maurizio / Tamburrini, Enrica / Sali, Michela / Delogu, Giovanni

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 1

    Abstract: Even though Everolimus has been investigated in a phase II randomized trial as a host-directed therapy (HDT) to treat tuberculosis (TB), an oncological patient treated with Everolimus for a neuroendocrine pancreatic neoplasia developed active TB twice ... ...

    Abstract Even though Everolimus has been investigated in a phase II randomized trial as a host-directed therapy (HDT) to treat tuberculosis (TB), an oncological patient treated with Everolimus for a neuroendocrine pancreatic neoplasia developed active TB twice and a non-tuberculous mycobacterial (NTM) infection in a year and a half time span. To investigate this interesting case, we isolated and genotypically characterized the
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12010171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: First description of the katG gene deletion in a Mycobacterium tuberculosis clinical isolate and its impact on the mycobacterial fitness.

    De Maio, Flavio / Cingolani, Antonella / Bianco, Delia Mercedes / Salustri, Alessandro / Palucci, Ivana / Sanguinetti, Maurizio / Delogu, Giovanni / Sali, Michela

    International journal of medical microbiology : IJMM

    2021  Volume 311, Issue 4, Page(s) 151506

    Abstract: Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the ... ...

    Abstract Isoniazid (INH) is the cornerstone of the anti-tuberculosis regimens and emergence of Mycobacterium tuberculosis (Mtb) resistant strains is a major threat to our ability to control tuberculosis (TB) at global level. Mutations in the gene coding the catalase KatG confer resistance to high level of INH. In this paper, we describe for the first time a complete deletion of the genomic region containing the katG gene in an Mtb clinical strain isolated in Italy in a patient with HIV infection that previously completed INH preventive therapy. We genotypically characterized the Mtb strain and showed that katG deletion confers high-level resistance to INH (MIC > 25.6 μg/mL). The katG deletion did not impact significantly on Mtb fitness as we did not detect enhanced susceptibility to H
    MeSH term(s) Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Bacterial Proteins/genetics ; Drug Resistance, Bacterial/genetics ; Gene Deletion ; HIV Infections ; Humans ; Hydrogen Peroxide ; Italy ; Microbial Sensitivity Tests ; Mutation ; Mycobacterium tuberculosis/genetics
    Chemical Substances Antitubercular Agents ; Bacterial Proteins ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2021-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2006518-8
    ISSN 1618-0607 ; 1438-4221
    ISSN (online) 1618-0607
    ISSN 1438-4221
    DOI 10.1016/j.ijmm.2021.151506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5333: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Comparative Fecal Microbiota Analysis of Infants With Acute Bronchiolitis Caused or Not Caused by Respiratory Syncytial Virus.

    De Maio, Flavio / Buonsenso, Danilo / Bianco, Delia Mercedes / Giaimo, Martina / Fosso, Bruno / Monzo, Francesca Romana / Sali, Michela / Posteraro, Brunella / Valentini, Piero / Sanguinetti, Maurizio

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 815715

    Abstract: Bronchiolitis due to respiratory syncytial virus (RSV) or non-RSV agents is a health-menacing lower respiratory tract (LRT) disease of infants. Whereas RSV causes more severe disease than other viral agents may, genus-dominant fecal microbiota profiles ... ...

    Abstract Bronchiolitis due to respiratory syncytial virus (RSV) or non-RSV agents is a health-menacing lower respiratory tract (LRT) disease of infants. Whereas RSV causes more severe disease than other viral agents may, genus-dominant fecal microbiota profiles have been identified in US hospitalized infants with bronchiolitis. We investigated the fecal microbiota composition of infants admitted to an Italian hospital with acute RSV (25/37 [67.6%]; group I) or non-RSV (12/37 [32.4%]; group II) bronchiolitis, and the relationship of fecal microbiota characteristics with the clinical characteristics of infants. Group I and group II infants differed significantly (24/25 [96.0%] versus 5/12 [41.7%];
    MeSH term(s) Bronchiolitis/complications ; Bronchiolitis/microbiology ; Feces/microbiology ; Humans ; Infant ; Microbiota ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human/genetics
    Language English
    Publishing date 2022-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.815715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Relationship Between Maternal and Neonatal Microbiota in Spontaneous Preterm Birth: A Pilot Study.

    Tirone, Chiara / Paladini, Angela / De Maio, Flavio / Tersigni, Chiara / D'Ippolito, Silvia / Di Simone, Nicoletta / Monzo, Francesca Romana / Santarelli, Giulia / Bianco, Delia Mercedes / Tana, Milena / Lio, Alessandra / Menzella, Nicoletta / Posteraro, Brunella / Sanguinetti, Maurizio / Lanzone, Antonio / Scambia, Giovanni / Vento, Giovanni

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 909962

    Abstract: The newborn's microbiota composition at birth seems to be influenced by maternal microbiota. Maternal vaginal microbiota can be a determining factor of spontaneous Preterm Birth ( ... ...

    Abstract The newborn's microbiota composition at birth seems to be influenced by maternal microbiota. Maternal vaginal microbiota can be a determining factor of spontaneous Preterm Birth (SP
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.909962
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Improved gut microbiota features after the resolution of SARS‑CoV‑2 infection.

    De Maio, Flavio / Ianiro, Gianluca / Coppola, Gaetano / Santopaolo, Francesco / Abbate, Valeria / Bianco, Delia Mercedes / Del Zompo, Fabio / De Matteis, Giuseppe / Leo, Massimo / Nesci, Antonio / Nicoletti, Alberto / Pompili, Maurizio / Cammarota, Giovanni / Posteraro, Brunella / Sanguinetti, Maurizio / Gasbarrini, Antonio / Ponziani, Francesca Romana

    Gut pathogens

    2021  Volume 13, Issue 1, Page(s) 62

    Abstract: Background: The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on ... ...

    Abstract Background: The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has a tropism for the gastrointestinal tract and several studies have shown an alteration of the gut microbiota in hospitalized infected patients. However, long-term data on microbiota changes after recovery are lacking.
    Methods: We enrolled 30 patients hospitalized for SARS‑CoV‑2-related pneumonia. Their gut microbiota was analyzed within 48 h from the admission and compared with (1) that of other patients admitted for suspected bacterial pneumonia (control group) (2) that obtained from the same subject 6 months after nasopharyngeal swab negativization.
    Results: Gut microbiota alpha-diversity increased 6 months after the resolution of SARS-CoV-2 infection. Bacteroidetes relative abundance was higher (≈ 36.8%) in patients with SARS-CoV-2, and declined to 18.7% when SARS-CoV-2 infection resolved (p  =  0.004). Conversely, Firmicutes were prevalent (≈ 75%) in controls and in samples collected after SARS-CoV-2 infection resolution (p  =  0.001). Ruminococcaceae, Lachnospiraceae and Blautia increased after SARS-CoV-2 infection resolution, rebalancing the gut microbiota composition.
    Conclusion: SARS-CoV-2 infection is associated with changes in the gut microbiome, which tend to be reversed in long-term period.
    Language English
    Publishing date 2021-10-16
    Publishing country England
    Document type Letter
    ZDB-ID 2478277-4
    ISSN 1757-4749
    ISSN 1757-4749
    DOI 10.1186/s13099-021-00459-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of gut microbiota in patients with metabolic syndrome candidates for bariatric/metabolic surgery: Preliminary findings of a multi-center prospective study.

    De Maio, Flavio / Boru, Cristian Eugeniu / Avallone, Marcello / Velotti, Nunzio / Bianco, Delia Mercedes / Capoccia, Danila / Greco, Francesco / Guarisco, Gloria / Nogara, Manuela / Sanguinetti, Maurizio / Verrastro, Ornella / Capaldo, Brunella / Musella, Mario / Raffaelli, Marco / Delogu, Giovanni / Silecchia, Gianfranco / Leonetti, Frida

    Diabetes research and clinical practice

    2021  Volume 180, Page(s) 109079

    Abstract: Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic ... ...

    Abstract Introduction: gut microbiota (GM) seems to be involved in the pathophysiology and progression of both metabolic syndrome (MS) and obesity. The aim was to investigate GM's composition in patients with severe obesity, candidates for bariatric/metabolic surgery BMS.
    Materials and methods: Multicentre, prospective, cohort study, enrolling 84 patients with BMI 40-55 kg/m
    Results: No differences were foundregarding anthropometric,nutritional parameters, except for vitamin D.As a whole the alpha and beta diversity examinations showed no statistical differences in GM profile. A total of 5/7 phyla with relative frequencies were identified above 0.1% (Actinobacteria,Bacteroidetes,Firmicutes,Proteobacteria,Verrucomicrobia).FusobacteriaandPatescibacteriarepresented the less abundant. There were no significant differences in the top ten genera.Data onBacteroidetes(inversely related to triglycerides and LDL and directly related to HDL levels) and onFirmicutes(opposite trend) relative abundances suggest no differences among the three conditions.No correlation between the relative abundance of themain phylaand plasmatic glucose levels was observed.
    Conclusions: In a selected cohort of patients with obesity, MS did not affect the preoperative GM's profile. Severe obesity, per se, seems to be an independent condition affecting GM.
    MeSH term(s) Bariatric Surgery ; Cohort Studies ; Gastrointestinal Microbiome ; Humans ; Metabolic Syndrome/epidemiology ; Prospective Studies
    Language English
    Publishing date 2021-09-29
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2021.109079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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