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  1. Article ; Online: Treatment of pancreatic cancer in 2022.

    Casolino, Raffaella / Biankin, Andrew V

    Cambridge prisms. Precision medicine

    2023  Volume 1, Page(s) e14

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed at an advanced, incurable, stage and has an extremely poor prognosis. Systemic chemotherapy represents the standard treatment either in the pre-operative, adjuvant and palliative setting, which ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed at an advanced, incurable, stage and has an extremely poor prognosis. Systemic chemotherapy represents the standard treatment either in the pre-operative, adjuvant and palliative setting, which is associated with only modest improvement in survival. More recently, advances in cancer genomic sequencing have unravelled the molecular heterogeneity of PDAC and identified small patient subgroups harbouring unique actionable aberrations in
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2752-6143
    ISSN (online) 2752-6143
    DOI 10.1017/pcm.2023.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 provides an opportunity to transform cancer research.

    Casolino, Raffaella / Biankin, Andrew V

    Cancer cell

    2021  Volume 39, Issue 9, Page(s) 1169–1170

    MeSH term(s) Biomedical Research/economics ; Biomedical Research/organization & administration ; COVID-19 ; Clinical Trials as Topic ; Humans ; Neoplasms ; Translational Medical Research/economics ; Translational Medical Research/organization & administration
    Language English
    Publishing date 2021-07-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2021.07.018
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  3. Article ; Online: Impact of COVID-19 on Pancreatic Cancer Research and the Path Forward.

    Casolino, Raffaella / Biankin, Andrew V

    Gastroenterology

    2021  Volume 161, Issue 6, Page(s) 1758–1763

    MeSH term(s) Biomedical Research/trends ; COVID-19 ; Humans ; Pancreatic Neoplasms ; SARS-CoV-2
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.06.080
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  4. Article ; Online: Data sharing in cancer research: perceived risks and the consequences of not sharing.

    Topham, James T / Lawlor, Rita T / Lemaire, Diana / Casolino, Raffaella / Biankin, Andrew V

    The Lancet. Oncology

    2024  Volume 25, Issue 3, Page(s) 275–276

    MeSH term(s) Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Research ; Information Dissemination
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00021-4
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  5. Article ; Online: The road to precision oncology.

    Biankin, Andrew V

    Nature genetics

    2017  Volume 49, Issue 3, Page(s) 320–321

    Abstract: The ultimate goal of precision medicine is to use population-based molecular, clinical and other data to make individually tailored clinical decisions for patients, although the path to achieving this goal is not entirely clear. A new study shows how ... ...

    Abstract The ultimate goal of precision medicine is to use population-based molecular, clinical and other data to make individually tailored clinical decisions for patients, although the path to achieving this goal is not entirely clear. A new study shows how knowledge banks of patient data can be used to make individual treatment decisions in acute myeloid leukemia.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Clinical Decision-Making/methods ; Databases, Factual/statistics & numerical data ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Medical Oncology/trends ; Precision Medicine/trends ; Remission Induction ; Survival Analysis
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2017-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.3796
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  6. Article: Germline BRCA testing in pancreatic cancer: improving awareness, timing, turnaround, and uptake.

    Golan, Talia / Casolino, Raffaella / Biankin, Andrew V / Hammel, Pascal / Whitaker, Kristen D / Hall, Michael J / Riegert-Johnson, Douglas L

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231189127

    Abstract: Prognosis is generally poor for patients with pancreatic ductal adenocarcinoma. However, patients with ... ...

    Abstract Prognosis is generally poor for patients with pancreatic ductal adenocarcinoma. However, patients with germline
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231189127
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  7. Article ; Online: ICGC ARGO precision medicine: genomic profiling-informed prediction of immunotherapy response in two patients with metastatic head and neck squamous cell carcinoma.

    Nocini, Riccardo / Tondulli, Luca / D'Ambrosio, Consuelo / Luchini, Claudio / Biankin, Andrew V / Casolino, Raffaella / Scarpa, Aldo / Milella, Michele / Lawlor, Rita T

    The Lancet. Oncology

    2023  Volume 24, Issue 8, Page(s) 851–853

    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/therapy ; Precision Medicine ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Immunotherapy ; Genomics
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00241-3
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  8. Article ; Online: Interpreting and integrating genomic tests results in clinical cancer care: Overview and practical guidance.

    Casolino, Raffaella / Beer, Philip A / Chakravarty, Debyani / Davis, Melissa B / Malapelle, Umberto / Mazzarella, Luca / Normanno, Nicola / Pauli, Chantal / Subbiah, Vivek / Turnbull, Clare / Westphalen, C Benedikt / Biankin, Andrew V

    CA: a cancer journal for clinicians

    2024  

    Abstract: The last decade has seen rapid progress in the use of genomic tests, including gene panels, whole-exome sequencing, and whole-genome sequencing, in research and clinical cancer care. These advances have created expansive opportunities to characterize the ...

    Abstract The last decade has seen rapid progress in the use of genomic tests, including gene panels, whole-exome sequencing, and whole-genome sequencing, in research and clinical cancer care. These advances have created expansive opportunities to characterize the molecular attributes of cancer, revealing a subset of cancer-associated aberrations called driver mutations. The identification of these driver mutations can unearth vulnerabilities of cancer cells to targeted therapeutics, which has led to the development and approval of novel diagnostics and personalized interventions in various malignancies. The applications of this modern approach, often referred to as precision oncology or precision cancer medicine, are already becoming a staple in cancer care and will expand exponentially over the coming years. Although genomic tests can lead to better outcomes by informing cancer risk, prognosis, and therapeutic selection, they remain underutilized in routine cancer care. A contributing factor is a lack of understanding of their clinical utility and the difficulty of results interpretation by the broad oncology community. Practical guidelines on how to interpret and integrate genomic information in the clinical setting, addressed to clinicians without expertise in cancer genomics, are currently limited. Building upon the genomic foundations of cancer and the concept of precision oncology, the authors have developed practical guidance to aid the interpretation of genomic test results that help inform clinical decision making for patients with cancer. They also discuss the challenges that prevent the wider implementation of precision oncology.
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603553-x
    ISSN 1542-4863 ; 0007-9235
    ISSN (online) 1542-4863
    ISSN 0007-9235
    DOI 10.3322/caac.21825
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  9. Article ; Online: Disruption of the pro-oncogenic c-RAF-PDE8A complex represents a differentiated approach to treating KRAS-c-RAF dependent PDAC.

    Cooke, Sean F / Wright, Thomas A / Sin, Yuan Yan / Ling, Jiayue / Kyurkchieva, Elka / Phanthaphol, Nattaporn / Mcskimming, Thomas / Herbert, Katharine / Rebus, Selma / Biankin, Andrew V / Chang, David K / Baillie, George S / Blair, Connor M

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8998

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is considered the third leading cause of cancer mortality in the western world, offering advanced stage patients with few viable treatment options. Consequently, there remains an urgent unmet need to develop novel ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered the third leading cause of cancer mortality in the western world, offering advanced stage patients with few viable treatment options. Consequently, there remains an urgent unmet need to develop novel therapeutic strategies that can effectively inhibit pro-oncogenic molecular targets underpinning PDACs pathogenesis and progression. One such target is c-RAF, a downstream effector of RAS that is considered essential for the oncogenic growth and survival of mutant RAS-driven cancers (including KRAS
    MeSH term(s) Humans ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Signal Transduction ; Cell Proliferation ; Cell Line, Tumor ; 3',5'-Cyclic-AMP Phosphodiesterases/metabolism
    Chemical Substances Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; KRAS protein, human ; PDE8A protein, human (EC 3.1.4.17) ; 3',5'-Cyclic-AMP Phosphodiesterases (EC 3.1.4.17)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59451-3
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  10. Article ; Online: Defining the clinical genomic landscape for real-world precision oncology.

    Beer, Philip A / Cooke, Susanna L / Chang, David K / Biankin, Andrew V

    Genomics

    2020  Volume 112, Issue 6, Page(s) 5324–5330

    Abstract: Through the delivery of large international projects including ICGC and TCGA, knowledge of cancer genomics is reaching saturation point. Enabling this to improve patient outcomes now requires embedding comprehensive genomic profiling into routine ... ...

    Abstract Through the delivery of large international projects including ICGC and TCGA, knowledge of cancer genomics is reaching saturation point. Enabling this to improve patient outcomes now requires embedding comprehensive genomic profiling into routine oncology practice. Towards this goal, this study defined the biologically and clinically relevant genomic features of adult cancer through detailed curation and analysis of large genomic datasets, accumulated literature and biomarker-driven therapeutics in clinic and development. The characteristics and prevalence of these features were then interrogated in 2348 whole genome sequences, covering 21 solid tumour types, generated by the PCAWG project. This analysis highlights the predominant contribution of copy number alterations and identifies a critical role for disruptive structural variants in the inactivation of clinically important tumour suppressor genes, including PTEN and RB1, which are not currently captured by diagnostic assays. This study defines a set of essential genomic features for the characterisation of common adult cancers.
    MeSH term(s) Adult ; Genes, Neoplasm ; Genetic Variation ; Genomics ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Whole Genome Sequencing
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 356334-0
    ISSN 1089-8646 ; 0888-7543
    ISSN (online) 1089-8646
    ISSN 0888-7543
    DOI 10.1016/j.ygeno.2020.10.032
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