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Article ; Online: Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease

Dan Wang / Daojun Xie / Juan Zhang / Biao Cai / Bo Yang / Lei Zhou / Xiaofeng Huang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 19

Abstract: Abstract Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear. Tx-J mice, with an 82% sequence ... ...

Abstract	Abstract Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear. Tx-J mice, with an 82% sequence homology of the ATP7B gene to the human gene, are considered the most suitable model for WD. This study employs deep sequencing to investigate the differences in RNA transcript profiles, both coding and non-coding, as well as the functional characteristics of the regulatory network involved in WD cognitive impairment. The cognitive function of tx-J mice was evaluated using the Water Maze Test (WMT). Long non-coding RNA (lncRNA), circular RNA (circRNA), and messenger RNA (mRNA) profiles were analyzed in the hippocampal tissue of tx-J mice to identify differentially expressed RNAs (DE-RNAs). Subsequently, the DE-RNAs were used to construct protein–protein interaction (PPI) networks, as well as DE-circRNAs and lncRNAs-associated competing endogenous RNA (ceRNA) expression networks, and coding-noncoding co-expression (CNC) networks. To elucidate their biological functions and pathways, the PPI and ceRNA networks were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. A total of 361 differentially expressed mRNAs (DE-mRNAs), comprising 193 up-regulated and 168 down-regulated mRNAs, 2627 differentially expressed long non-coding RNAs (DE-lncRNAs), consisting of 1270 up-regulated and 1357 down-regulated lncRNAs, and 99 differentially expressed circular RNAs (DE-circRNAs), consisting of 68 up-regulated and 31 down-regulated circRNAs, were observed in the tx-J mice group when compared to the control mice group. Gene Ontology (GO) and pathway analyses revealed that DE-mRNAs were enriched in cellular processes, calcium signaling pathways, and mRNA surveillance pathways. In contrast, the DE-circRNAs-associated competing endogenous RNA (ceRNA) network was enriched for covalent chromatin modification, histone modification, and ...
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contour detection improved by context-adaptive surround suppression.

Qiang Sang / Biao Cai / Hao Chen

PLoS ONE, Vol 12, Iss 7, p e

2017 Volume 0181792

Abstract: Recently, many image processing applications have taken advantage of a psychophysical and neurophysiological mechanism, called "surround suppression" to extract object contour from a natural scene. However, these traditional methods often adopt a single ... ...

Abstract	Recently, many image processing applications have taken advantage of a psychophysical and neurophysiological mechanism, called "surround suppression" to extract object contour from a natural scene. However, these traditional methods often adopt a single suppression model and a fixed input parameter called "inhibition level", which needs to be manually specified. To overcome these drawbacks, we propose a novel model, called "context-adaptive surround suppression", which can automatically control the effect of surround suppression according to image local contextual features measured by a surface estimator based on a local linear kernel. Moreover, a dynamic suppression method and its stopping mechanism are introduced to avoid manual intervention. The proposed algorithm is demonstrated and validated by a broad range of experimental results.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Huang-Pu-Tong-Qiao Formula Ameliorates Tau Phosphorylation by Inhibiting the CaM-CaMKIV Pathway

Shu Ye / Biao Cai / Peng Zhou / Guoquan Wang / Huawu Gao / Rupeng Hua / Liangzhen You / Yongchuan Yao / Yan Wang / Guoming Shen

Evidence-Based Complementary and Alternative Medicine, Vol

2020 Volume 2020

Abstract: Alzheimer’s disease (AD) is a complex neurodegenerative disease. It is a chronic, lethal disease in which brain function is severely impaired and neuronal damage is irreversible. Huang-Pu-Tong-Qiao (HPTQ), a formula from traditional Chinese medicine, has ...

Abstract	Alzheimer’s disease (AD) is a complex neurodegenerative disease. It is a chronic, lethal disease in which brain function is severely impaired and neuronal damage is irreversible. Huang-Pu-Tong-Qiao (HPTQ), a formula from traditional Chinese medicine, has been used in the clinical treatment of AD for many years, with remarkable effects. However, the neuroprotective mechanisms of HPTQ in AD have not yet been investigated. In the present study, we used AD models in vivo and in vitro, to investigate both the neuroprotective effect of HPTQ water extracts (HPTQ-W) and the potential mechanisms of this action. For the in vivo study, after HPTQ intervention, the Morris water maze test was used to examine learning and memory in rats. Transmission electron microscopy and immunofluorescence methods were then used to investigate neuronal damage. For the in vitro experiments, rat primary hippocampal neurons were cultured and cell viability was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Additionally, mRNA levels of CaM, CaMKK, CaMKIV, and tau were examined using qRT-PCR, and protein expression of CaM, CaMKK, p-CaMKIV, and p-tau were examined using western blot. In vivo, we revealed that HPTQ significantly improved learning and memory deficits and attenuated neuronal damage in the AD rat model. Furthermore, in vitro results showed that HPTQ significantly increased cell viability in the AD cell model. We also demonstrated that HPTQ significantly decreased the mRNA levels of CaM, CaMKK, CaMKIV, and tau and significantly decreased the protein expressions of CaM, CaMKK, p-CaMKIV, and p-tau. In conclusion, our results indicated that HPTQ improved cognition and ameliorated neuronal damage in AD models and implicated a reduction in tau phosphorylation caused by inhibition of the CaM-CaMKIV pathway as a possible mechanism.
Keywords	Other systems of medicine ; RZ201-999
Subject code	571
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Computing and Routing for Trust in Structured P2P Network

Biao Cai / Zhishu Li

Journal of Networks, Vol 4, Iss 7, Pp 667-

2009 Volume 674

Abstract: Study of trust in P2P network now is focus on how to effectively against various malicious behaviors such as providing fake or misleading feedback about other peers and the management of trust in a P2P environment. But the scotoma of portability that ... ...

Abstract	Study of trust in P2P network now is focus on how to effectively against various malicious behaviors such as providing fake or misleading feedback about other peers and the management of trust in a P2P environment. But the scotoma of portability that trust peer can join (leave) a certain P2P network at anytime and anywhere is seldom discussed. In this paper, a structured topology for trusts management in portable P2P network based on DHT (discrete hash table) is proposed first, in which includes trust management strategies and peer operations on certain DHT circle. After that, a novel trust-computing model for the structured P2P network and the main trust decisions in the structured network are introduced too. Effectiveness and practicality of the proposed trust management have been showed in simulation experiments at the end.
Keywords	P2P network ; trust ; structured topology ; trust computing ; trust location ; trust accumulating ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Subject code	000 ; 650
Language	English
Publishing date	2009-09-01T00:00:00Z
Publisher	ACADEMY PUBLISHER
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Self-organized Public-Key Certificate System in P2P network

Zhen Luo / Zhishu Li / Biao Cai

Journal of Networks, Vol 6, Iss 10, Pp 1437-

2011 Volume 1443

Abstract: P2P network is open, anonymous and dynamical in contrast with conventional network. It’s full of dishonesty, deceit, selfishness. It’s necessary to build a robust security infrastructure system. The one important module of security infrastructure is to ... ...

Abstract	P2P network is open, anonymous and dynamical in contrast with conventional network. It’s full of dishonesty, deceit, selfishness. It’s necessary to build a robust security infrastructure system. The one important module of security infrastructure is to identify the users in transactions. This paper will propose an identification solution based on PKI. In our algorithm, the peer generates their public-private key pairs by themselves, issues certificates, and performs authentication without any centralized services. It can realize the identification, meanwhile keep peers anonymous. Moreover, it can limit the quantity of ID that a user applies for; alleviate the risk of Sybil attack.
Keywords	Peer-to-Peer ; security ; key authentication ; public-key cryptography ; PKI ; DHT ; Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Language	English
Publishing date	2011-10-01T00:00:00Z
Publisher	Academy Publisher
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Astragalus Polysaccharide Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Damage and Mitochondrial Dysfunction

Qing Ma / Yao Xu / Lumin Tang / Xiaoqian Yang / Zhejun Chen / Yuehan Wei / Xinghua Shao / Xiaoguang Shao / Zhixiang Xin / Biao Cai / Qi Wang / Shan Mou

BioMed Research International, Vol

2020 Volume 2020

Abstract: Cisplatin is a widely used chemotherapeutic drug in the treatment of various solid tumors. However, the cisplatin-induced acute kidney injury remains a disturbing complication, which still lacks effective prevention. Cisplatin-induced oxidative damage ... ...

Abstract	Cisplatin is a widely used chemotherapeutic drug in the treatment of various solid tumors. However, the cisplatin-induced acute kidney injury remains a disturbing complication, which still lacks effective prevention. Cisplatin-induced oxidative damage and mitochondrial dysfunction are anticipated to be crucial in the occurrence of kidney injury. Astragalus polysaccharide (APS) has been reported to possess multiple biological activities including anti-inflammatory, antioxidant, and mitochondria protection. In this study, we investigated the potentially protective effect of APS against cisplatin-induced kidney injury both in vivo and in vitro. We found that APS pretreatment attenuated the cisplatin-induced renal dysfunction and histopathological damage in mice; in addition, it also protected the viability of HK-2 cells upon cisplatin exposure. APS attenuated the cisplatin-induced oxidative damage by reducing reactive oxygen species (ROS) generation and recovering the activities of total superoxide dismutase and glutathione peroxidase in mice kidney. In addition, electron microscope analysis indicated that cisplatin induced extensive mitochondrial vacuolization in mice kidney. However, APS administration reversed these mitochondrial morphology changes. In HK-2 cells, APS reduced the cisplatin-induced mitochondrial and intracellular ROS generation. Furthermore, APS protected the normal morphology of mitochondria, blocked the cisplatin-induced mitochondrial permeability transition pore opening, and reduced the cytochrome c leakage. Subsequently, APS reduced the cisplatin-induced apoptosis in mice renal and HK-2 cells. In conclusion, our data suggested that APS pretreatment might prevent cisplatin-induced kidney injury through attenuating oxidative damage, protecting mitochondria, and ameliorating mitochondrial-mediated apoptosis.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway

Shu Ye / Dao-Jun Xie / Peng Zhou / Hua-Wu Gao / Meng-Ting Zhang / Da-Bao Chen / Yun-Peng Qin / Xin Lei / Xin-Quan Li / Juan Liu / Ya-Xun Cheng / Yong-Chuan Yao / Biao Cai / Guo-Ming Shen

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Background. Huang-Pu-Tong-Qiao formula (HPTQ), a traditional Chinese medicine (TCM) formula used to improve cognitive impairment. However, the underlying neuroprotective mechanism of HPTQ treated for diabetic cognitive dysfunction (DCD) remains unclear. ... ...

Abstract	Background. Huang-Pu-Tong-Qiao formula (HPTQ), a traditional Chinese medicine (TCM) formula used to improve cognitive impairment. However, the underlying neuroprotective mechanism of HPTQ treated for diabetic cognitive dysfunction (DCD) remains unclear. The purpose of this study was to investigate the neuroprotective mechanism of HPTQ in DCD mice based on molecular docking. Methods. To investigate the neuroprotective effect of HPTQ in DCD, the Morris water maze (MWM), novel object recognition (NOR) test was used to detect the learning and memory changes of mice; hematoxylin-eosin (HE) staining was used to investigate the damage of hippocampal neurons; the western blot (WB) was used to examine the level of brain-derived neurotrophic factor (BDNF) of hippocampus. To investigate the neuroprotective mechanism of HPTQ in DCD, molecular docking was used to predict the possible target proteins of different active components in HPTQ and then the WB was used to verify the expression of key target proteins in the hippocampus of mice. Results. HPTQ improved the learning and memory ability, hippocampal neuron damage, and the level of BDNF in the hippocampus of the DCD model treated with HFD/STZ for 12 weeks. Besides, the results of molecular docking showed that the main chemical components of HPTQ could be well combined with the targets of Bcl-2-associated X (Bax) and B-cell lymphoma2 (Bcl-2) and caspase-3. The levels of Bax/Bcl-2 protein ratio and caspase-3 increased in the DCD model while the HPTQ inhibited it. In addition, HPTQ restored DCD-induced decline of p-CREB, BDNF, TrkB, and p-Akt in the hippocampus. Conclusions. These data indicated that HPTQ ameliorates the hippocampus apoptosis in diabetic cognitive dysfunction mice by activating CREB/BDNF/TrkB signaling pathway.
Keywords	Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fruit and vegetable consumption and risk of cardiovascular disease: A meta-analysis of prospective cohort studies

Zhan, Jian / Fang-Rong Xu / Long-Biao Cai / Qi-Qiang He / Tao Xie / Yu-Jian Liu

Critical reviews in food science and nutrition. 2017 May 24, v. 57, no. 8

2017

Abstract: A meta-analysis of prospective cohort studies was conducted to examine the relation between fruit and vegetables (FV) consumption and the risk of cardiovascular disease (CVD). We searched PubMed and EMBASE up to June 2014 for relevant studies. Pooled ... ...

Abstract	A meta-analysis of prospective cohort studies was conducted to examine the relation between fruit and vegetables (FV) consumption and the risk of cardiovascular disease (CVD). We searched PubMed and EMBASE up to June 2014 for relevant studies. Pooled relative risks (RRs) were calculated and doseâresponse relationship was assessed. Thirty-eight studies, consisting of 47 independent cohorts, were eligible in this meta-analysis. There were 1,498,909 participants (44,013 CVD events) with a median follow-up of 10.5Â years. The pooled RR (95% confidence interval) of CVD for the highest versus lowest category was 0.83 (0.79â0.86) for FV consumption, 0.84 (0.79â0.88) for fruit consumption, and 0.87 (0.83â0.91) for vegetable consumption, respectively. Doseâresponse analysis showed that those eating 800Â g per day of FV consumption had the lowest risk of CVD. Our results indicate that increased FV intake is inversely associated with the risk of CVD. This meta-analysis provides strong support for the current recommendations to consume a high amount of FV to reduce CVD risk.
Keywords	cardiovascular diseases ; cohort studies ; confidence interval ; dose response ; fruit consumption ; ingestion ; meta-analysis ; risk ; vegetable consumption ; vegetables
Language	English
Dates of publication	2017-0524
Size	p. 1650-1663.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2015.1008980
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: High-energy, high-resolution, fly-scan X-ray phase tomography

Hongchang Wang / Robert C. Atwood / Matthew James Pankhurst / Yogesh Kashyap / Biao Cai / Tunhe Zhou / Peter David Lee / Michael Drakopoulos / Kawal Sawhney

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 11

Abstract: Abstract High energy X-ray phase contrast tomography is tremendously beneficial to the study of thick and dense materials with poor attenuation contrast. Recently, the X-ray speckle-based imaging technique has attracted widespread interest because ... ...

Abstract	Abstract High energy X-ray phase contrast tomography is tremendously beneficial to the study of thick and dense materials with poor attenuation contrast. Recently, the X-ray speckle-based imaging technique has attracted widespread interest because multimodal contrast images can now be retrieved simultaneously using an inexpensive wavefront modulator and a less stringent experimental setup. However, it is time-consuming to perform high resolution phase tomography with the conventional step-scan mode because the accumulated time overhead severely limits the speed of data acquisition for each projection. Although phase information can be extracted from a single speckle image, the spatial resolution is deteriorated due to the use of a large correlation window to track the speckle displacement. Here we report a fast data acquisition strategy utilising a fly-scan mode for near field X-ray speckle-based phase tomography. Compared to the existing step-scan scheme, the data acquisition time can be significantly reduced by more than one order of magnitude without compromising spatial resolution. Furthermore, we have extended the proposed speckle-based fly-scan phase tomography into the previously challenging high X-ray energy region (120 keV). This development opens up opportunities for a wide range of applications where exposure time and radiation dose are critical.
Keywords	Medicine ; R ; Science ; Q
Subject code	530
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Study on the correlation between the concentration of plasma lipoprotein-associated phospholipase A2 and coronary heart disease

Jin-Ming Cen / Jie Cheng / Qing-Yuan Xiong / Bai-Qiang Mei / Wei-Biao Cai / Xi-Li Yang

Chronic Diseases and Translational Medicine, Vol 1, Iss 2, Pp 105-

2015 Volume 109

Abstract: Objective: This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. Methods: ... ...

Abstract	Objective: This study explores the correlation between plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) and coronary heart disease (CHD) by comparing the level of plasma Lp-PLA2 in the plasma of patients with different types of CHD. Methods: Blood samples were collected from 56 patients diagnosed with CHD by the Department of Cardiology of the First People's Hospital of Foshan and 34 healthy subjects from February 2013 to January 2014. We measured the concentration of plasma Lp-PLA2 and determined the levels of total cholesterol (Tch), triglyceride (TG), apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), lipoprotein a (Lp(a)), glucose (Glu), and high-sensitivity C-reactive protein (hs-CRP). The concentration of plasma Lp-PLA2 in the healthy control group and each subgroup of CHD patients were compared and analyzed for correlations of plasma Lp-PLA2 between the patients in different CHD subgroups and several laboratory indicators. Results: The concentration of plasma Lp-PLA2 in each subgroup of CHD was significantly higher than in the control group (P < 0.05). The concentration of Lp-PLA2 in the unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were significantly higher than in the stable angina pectoris (SAP) group (P < 0.05), and the concentration of plasma Lp-PLA2 in the AMI group was significantly higher than in the UAP group (P < 0.05). The concentration of plasma Lp-PLA2 in the CHD group merely showed a positive correlation (r = 0.493, P < 0.05) with the hs-CRP group, but the levels of Tch, TG, Apo-A1, Apo-B, HDL-c, LDL-c, Lp(a) and Glu did not. Conclusions: The concentration of plasma Lp-PLA2 in patients with CHD was higher than that in the control group. The concentration of plasma Lp-PLA2 in the subgroups of CHD patients varied greatly from each other. The inflammatory response of atherosclerosis might be resulted from the synergy of plasma Lp-PLA2 and hs-CRP. ...
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2015-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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