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  1. Article ; Online: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study.

    Arns, Beatriz / Agani, Crepin Aziz Jose Oluwafoumi / Sesin, Guilhermo Prates / Horvath, Jaqueline Driemeyer C / Fogazzi, Débora Vacaro / Romeiro Silva, Fernanda Kelly / Costa, Lauren Sezera / Pereira, Adriano Jose / Nassar Junior, Antônio Paulo / Cavalcanti, Bruno Tomazini / Dietrich, Camila / Veiga, Viviane Cordeiro / Catarino, Daniela G M / Cheno, Maysa Yukari / Biasi, Alexandre / Ferronatto, Bianca Ramos / Bassetti, Bil Randerson / Fernandes, Caio Cesar Ferreira / Deutschendorf, Caroline /
    Grion, Cintia Magalhães Carvalho / Vidal, Claudia Fernanda de Lacerda / de Oliveira, Cláudio Dornas / Caser, Eliana Bernadete / Boschi, Emerson / Silva, Everton Macêdo / Pizzol, Felipe Dal / Urbano, Hugo Correa de Andrade / Silva, Iany / Maia, Israel Silva / Rego, Leila Rezegue de Moraes / Oliveira, Luana Pontes / Tavares, Maria Brandão / Dracoulakis, Marianna Deway Andrade / Bainy, Marina Peres / Golin, Nicole Alberti / Tomba, Pablo Oscar / Kurtz, Pedro Martins Pereira / Foernges, Rafael Botelho / Prestes, Rejane Martins / de Melo, Rodrigo Morel Vieira / Da Silva, Rodrigo Reghini / Toledo, Tatiana Gozzi Pancev / Lima, Valéria Paes / Fernandes, Vanildes de Fátima / Lovato, Wilson José / Zavascki, Alexandre Prehn

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e79

    Abstract: Objective: Data are scarce regarding hospital infection control committees and compliance with infection prevention and control (IPC) recommendations in Brazil, a country of continental dimensions. We assessed the main characteristics of infection ... ...

    Abstract Objective: Data are scarce regarding hospital infection control committees and compliance with infection prevention and control (IPC) recommendations in Brazil, a country of continental dimensions. We assessed the main characteristics of infection control committees (ICCs) on healthcare-associated infections (HAIs) in Brazilian hospitals.
    Methods: This cross-sectional study was conducted in ICCs of public and private hospitals distributed across all Brazilian regions. Data were collected directly from the ICC staff by completing an online questionnaire and during on-site visits through face-to-face interviews.
    Results: In total, 53 Brazilian hospitals were evaluated from October 2019 to December 2020. All hospitals had implemented the IPC core components in their programs. All centers had protocols for the prevention and control of ventilator-associated pneumonia as well as bloodstream, surgical site, and catheter-associated urinary tract infections. Most hospitals (80%) had no budget specifically allocated to the IPC program; 34% of the laundry staff had received specific IPC training; and only 7.5% of hospitals reported occupational infections in healthcare workers.
    Conclusions: In this sample, most ICCs complied with the minimum requirements for IPC programs. The main limitation regarding ICCs was the lack of financial support. The findings of this survey support the development of strategic plans to improve IPCs in Brazilian hospitals.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Erratum: Evaluation of the characteristics of infection prevention and control programs and infection control committees in Brazilian hospitals: A countrywide cross-sectional study - CORRIGENDUM.

    Arns, Beatriz / Agani, Crepin Aziz Jose Oluwafoumi / Sesin, Guilhermo Prates / Horvath, Jaqueline Driemeyer C / Fogazzi, Débora Vacaro / Romeiro Silva, Fernanda Kelly / Costa, Lauren Sezera / Pereira, Adriano Jose / Nassar Junior, Antônio Paulo / Cavalcanti, Bruno Tomazini / Dietrich, Camila / Veiga, Viviane Cordeiro / Catarino, Daniela G M / Cheno, Maysa Yukari / Biasi, Alexandre / Ferronatto, Bianca Ramos / Bassetti, Bil Randerson / Fernandes, Caio Cesar Ferreira / Deutschendorf, Caroline /
    Grion, Cintia Magalhães Carvalho / Vidal, Claudia Fernanda de Lacerda / de Oliveira, Cláudio Dornas / Caser, Eliana Bernadete / Boschi, Emerson / Silva, Everton Macêdo / Pizzol, Felipe Dal / Urbano, Hugo Correa de Andrade / Silva, Iany / Maia, Israel Silva / Rego, Leila Rezegue de Moraes / Oliveira, Luana Pontes / Tavares, Maria Brandão / Dracoulakis, Marianna Deway Andrade / Bainy, Marina Peres / Golin, Nicole Alberti / Tomba, Pablo Oscar / Kurtz, Pedro Martins Pereira / Foernges, Rafael Botelho / Prestes, Rejane Martins / de Melo, Rodrigo Morel Vieira / Da Silva, Rodrigo Reghini / Toledo, Tatiana Gozzi Pancev / Lima, Valéria Paes / Fernandes, Vanildes de Fátima / Lovato, Wilson José / Zavascki, Alexandre Prehn

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Volume 3, Issue 1, Page(s) e102

    Abstract: This corrects the article DOI: 10.1017/ash.2023.136.]. ...

    Abstract [This corrects the article DOI: 10.1017/ash.2023.136.].
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Published Erratum
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Open-Label Clinical Trial of Hypothalamic Deep Brain Stimulation for Human Morbid Obesity: BLESS Study Protocol.

    De Salles, Antonio A F / Barbosa, Daniel A N / Fernandes, Fernando / Abucham, Julio / Nazato, Debora M / Oliveira, Juliana D / Cury, Abrão / Biasi, Alexandre / Rossi, Ronaldo / Lasagno, Camila / Bueno, Priscila T / Santos, Renato H N / Damiani, Lucas P / Gorgulho, Alessandra A

    Neurosurgery

    2018  Volume 83, Issue 4, Page(s) 800–809

    Abstract: Background: Human morbid obesity is increasing worldwide in an alarming way. The hypothalamus is known to mediate its mechanisms. Deep brain stimulation (DBS) of the ventromedial hypothalamus (VMH) may be an alternative to treat patients refractory to ... ...

    Abstract Background: Human morbid obesity is increasing worldwide in an alarming way. The hypothalamus is known to mediate its mechanisms. Deep brain stimulation (DBS) of the ventromedial hypothalamus (VMH) may be an alternative to treat patients refractory to standard medical and surgical therapies.
    Objective: To assess the safety, identify possible side effects, and to optimize stimulation parameters of continuous VMH-DBS. Additionally, this study aims to determine if continuous VMH-DBS will lead to weight loss by causing changes in body composition, basal metabolism, or food intake control.
    Methods: The BLESS study is a feasibility study, single-center open-label trial. Six patients (body mass index > 40) will undergo low-frequency VMH-DBS. Data concerning timing, duration, frequency, severity, causal relationships, and associated electrical stimulation patterns regarding side effects or weight changes will be recorded.
    Expected outcomes: We expect to demonstrate the safety, identify possible side effects, and to optimize electrophysiological parameters related to VMH-DBS. No clinical or behavioral adverse changes are expected. Weight loss ≥ 3% of the basal weight after 3 mo of electrical stimulation will be considered adequate. Changes in body composition and increase in basal metabolism are expected. The amount of food intake is likely to remain unchanged.
    Discussion: The design of this study protocol is to define the safety of the procedure, the surgical parameters important for target localization, and additionally the safety of long-term stimulation of the VMH in morbidly obese patients. Novel neurosurgical approaches to treat metabolic and autonomic diseases can be developed based on the data made available by this investigation.
    MeSH term(s) Adult ; Body Mass Index ; Deep Brain Stimulation/methods ; Feasibility Studies ; Female ; Humans ; Male ; Obesity, Morbid/physiopathology ; Obesity, Morbid/therapy ; Ventromedial Hypothalamic Nucleus/physiology
    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Clinical Trial, Phase I ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incremental cost-effectiveness of percutaneous versus surgical closure of atrial septal defects in children under a public health system perspective in Brazil.

    Costa, Rodrigo / Pedra, Carlos A C / Ribeiro, Marcelo / Pedra, Simone / Ferreira-Da-Silva, André Luis / Polanczyk, Carisi / Berwanger, Otávio / Biasi, Alexandre / Ribeiro, Rodrigo

    Expert review of cardiovascular therapy

    2014  Volume 12, Issue 11, Page(s) 1369–1378

    Abstract: Introduction: Cost-effectiveness (CE) studies of percutaneous (PC) versus surgical (SC) atrial septal defect closure are lacking.: Methods: A systematic literature review in children and a CE analysis based on a model of long-term outcomes were ... ...

    Abstract Introduction: Cost-effectiveness (CE) studies of percutaneous (PC) versus surgical (SC) atrial septal defect closure are lacking.
    Methods: A systematic literature review in children and a CE analysis based on a model of long-term outcomes were performed. Direct costs of PC and SC were US$8700 (defined arbitrarily) and US$5700 (actually paid), respectively. Three-times the Brazilian GDI (US$28,700) per year of life saved (with a discount rate of 5%) was used as a limit for willingness-to-pay.
    Discussion: PC had a high (US$104,500) incremental CE ratio despite lower complication rates, shorter hospital stay and better (nonsignificant) adjusted life expectancy. PC would be cost-effective if it cost US$6400 or SC had an 8% loss of utility or its indirect costs were US$2250. Costs of PC should be reduced to be cost-effective in the Brazilian public health system. Indirect costs and impact on quality of life should be further assessed.
    MeSH term(s) Brazil ; Child ; Cost-Benefit Analysis ; Heart Septal Defects, Atrial/drug therapy ; Heart Septal Defects, Atrial/economics ; Heart Septal Defects, Atrial/surgery ; Humans ; Public Health ; Quality of Life ; Quality-Adjusted Life Years ; Treatment Outcome
    Language English
    Publishing date 2014-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2192343-7
    ISSN 1744-8344 ; 1477-9072
    ISSN (online) 1744-8344
    ISSN 1477-9072
    DOI 10.1586/14779072.2014.967216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: DONORS (Donation Network to Optimise Organ Recovery Study): Study protocol to evaluate the implementation of an evidence-based checklist for brain-dead potential organ donor management in intensive care units, a cluster randomised trial.

    Westphal, Glauco Adrieno / Robinson, Caroline Cabral / Biasi, Alexandre / Machado, Flávia Ribeiro / Rosa, Regis Goulart / Teixeira, Cassiano / de Andrade, Joel / Franke, Cristiano Augusto / Azevedo, Luciano Cesar Pontes / Bozza, Fernando / Guterres, Cátia Moreira / da Silva, Daiana Barbosa / Sganzerla, Daniel / do Prado, Débora Zechmeister / Madalena, Itiana Cardoso / Rohden, Adriane Isabel / da Silva, Sabrina Souza / Giordani, Natalia Elis / Andrighetto, Luiza Vitelo /
    Benck, Patrícia Spessatto / Roman, Fernando Roberto / de Melo, Maria de Fátima Rodrigues Buarque / Pereira, Thattyane Borba / Grion, Cintia Magalhães Carvalho / Diniz, Pedro Carvalho / Oliveira, João Fernando Picollo / Mecatti, Giovana Colozza / Alves, Flávio André Cardona / Moraes, Rafael Barberena / Nobre, Vandack / Hammes, Luciano Serpa / Meade, Maureen O / Nothen, Rosana Reis / Falavigna, Maicon

    BMJ open

    2019  Volume 9, Issue 6, Page(s) e028570

    Abstract: Introduction: There is an increasing demand for multi-organ donors for organ transplantation programmes. This study protocol describes the Donation Network to Optimise Organ Recovery Study, a planned cluster randomised controlled trial that aims to ... ...

    Abstract Introduction: There is an increasing demand for multi-organ donors for organ transplantation programmes. This study protocol describes the Donation Network to Optimise Organ Recovery Study, a planned cluster randomised controlled trial that aims to evaluate the effectiveness of the implementation of an evidence-based, goal-directed checklist for brain-dead potential organ donor management in intensive care units (ICUs) in reducing the loss of potential donors due to cardiac arrest.
    Methods and analysis: The study will include ICUs of at least 60 Brazilian sites with an average of ≥10 annual notifications of valid potential organ donors. Hospitals will be randomly assigned (with a 1:1 allocation ratio) to the intervention group, which will involve the implementation of an evidence-based, goal-directed checklist for potential organ donor maintenance, or the control group, which will maintain the usual care practices of the ICU. Team members from all participating ICUs will receive training on how to conduct family interviews for organ donation. The primary outcome will be loss of potential donors due to cardiac arrest. Secondary outcomes will include the number of actual organ donors and the number of organs recovered per actual donor.
    Ethics and dissemination: The institutional review board (IRB) of the coordinating centre and of each participating site individually approved the study. We requested a waiver of informed consent for the IRB of each site. Study results will be disseminated to the general medical community through publications in peer-reviewed medical journals.
    Trial registration number: NCT03179020; Pre-results.
    MeSH term(s) Brain Death/diagnosis ; Brazil ; Checklist/methods ; Evidence-Based Medicine/methods ; Humans ; Intensive Care Units/organization & administration ; Outcome Assessment, Health Care/methods ; Tissue and Organ Procurement/methods ; Tissue and Organ Procurement/organization & administration
    Language English
    Publishing date 2019-06-25
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2018-028570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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