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Article ; Online: Most appropriate surgical approach in children with Wilms tumour, risk of kidney disease, and related considerations.

Spreafico, Filippo / Biasoni, Davide / Montini, Giovanni

2023 Volume 39, Issue 4, Page(s) 1019–1022

MeSH term(s)	Child ; Humans ; Wilms Tumor/surgery ; Wilms Tumor/pathology ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology
Language	English
Publishing date	2023-11-07
Publishing country	Germany
Document type	Editorial
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-023-06213-4
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Article ; Online: Superior rectal artery preservation to reduce anastomotic leak rates in familial adenomatous polyposis patients treated with total colectomy and ileorectal anastomosis.

Rausa, E / Colletti, G / Ciniselli, C M / Signoroni, S / Duroni, V / Cavalcoli, F / Magarotto, A / Ricci, M T / Brignola, C / Biasoni, D / Verderio, P / Vitellaro, M

Techniques in coloproctology

2023 Volume 27, Issue 12, Page(s) 1327–1334

Abstract: Background: Total colectomy with ileorectal anastomosis (TC/IRA) is one of the prophylactic surgical options in patients with familial adenomatous polyposis (FAP). This study investigated the effectiveness of superior rectal artery (SRA) preservation ... ...

Abstract	Background: Total colectomy with ileorectal anastomosis (TC/IRA) is one of the prophylactic surgical options in patients with familial adenomatous polyposis (FAP). This study investigated the effectiveness of superior rectal artery (SRA) preservation during TC/IRA in reducing anastomotic leakage (AL). Methods: This retrospective study was based on prospectively collected data (01/2000 - 12/2022) at the National Cancer Institute, Milan, Italy. FAP patients undergoing TC/IRA were enrolled. A 1:1 propensity score matching (PSM) was performed. Associations between SRA preservation and complications were investigated using univariate and multivariate analysis. Results: The study population included 211 patients undergoing TC/IRA (Sex: 106 Male, 105 Female; Age: median 30 yrs, IQR: 20-48 yrs), 82 with SRA preservation (SRA group) and 129 without SRA preservation (controls). After PSM, 75 patients were considered for each group. SRA preservation was associated with fewer complications (OR 0.331, 95% CI 0.116; 0.942) in univariate logistic regression analysis. AL events were significantly fewer in the SRA group than in the control group (0 vs 12, p = 0.028). The SRA group had fewer overall surgical complication and pelvic sepsis rates (p = 0.020 and p = 0.028, respectively). Median operative time was significantly longer in the SRA group (340 min vs 240 min, p<0.001), and median hospital stay was significantly shorter (6 vs 7 days, p=0.017). Twenty-seven patients in the SRA group experienced intraoperative anastomotic bleeding, which was controlled endoscopically. Superimposable results were obtained analyzing the whole patient cohort. Conclusions: SRA preservation can be considered an advantage in this patient population, despite adding a further technical step during surgery and thereby prolonging the operative time. Intraoperative endoscopic checking of possible anastomotic bleeding sites is recommended.
MeSH term(s)	Humans ; Male ; Female ; Young Adult ; Adult ; Middle Aged ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Anastomotic Leak/surgery ; Retrospective Studies ; Ileum/surgery ; Rectum/surgery ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Adenomatous Polyposis Coli/surgery ; Colectomy/adverse effects ; Colectomy/methods ; Arteries/surgery
Language	English
Publishing date	2023-09-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2083309-X
ISSN	1128-045X ; 1123-6337
ISSN (online)	1128-045X
ISSN	1123-6337
DOI	10.1007/s10151-023-02858-3
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Zs.A 5842: Show issues

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Article ; Online: Nutritional management of chylous leakage following surgery for high-risk neuroblastoma in a toddler: a case report.

Casirati, Amanda / Mulazzani, Giulia / Luksch, Roberto / Morosi, Carlo / Biasoni, Davide / Della Valle, Serena

European journal of clinical nutrition

2021 Volume 76, Issue 4, Page(s) 626–628

MeSH term(s)	Child, Preschool ; Humans ; Neuroblastoma/complications ; Neuroblastoma/surgery ; Postoperative Complications/etiology
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	639358-5
ISSN	1476-5640 ; 0954-3007
ISSN (online)	1476-5640
ISSN	0954-3007
DOI	10.1038/s41430-021-00988-1
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Zs.A 1045: Show issues

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Article ; Online: Surveillance or Dynamic Sentinel Lymph-Node Biopsy in Low-Risk Clinically N0 Penile Squamous Cell Carcinoma: Single-Institution Real World Data.

Nazzani, Sebastiano / Catanzaro, Mario / Bruniera, Martina / Torelli, Tullio / Macchi, Alberto / Stagni, Silvia / Tesone, Antonio / Silvani, Carlo / Ceccato, Tommaso / Bernasconi, Valentina / Lanocita, Rodolfo / Cascella, Tommaso / Claps, Melanie / Giannatempo, Patrizia / Zimatore, Matteo / Cattaneo, Laura / Biasoni, Davide / Montanari, Emanuele / Nicolai, Nicola

Clinical genitourinary cancer

2024 Volume 22, Issue 2, Page(s) 544–548

Abstract: Introduction: Surveillance is the standard management in low-risk cN0 penile squamous cell carcinoma (peSCC) patients. However, no previous analysis focused on early and long-term outcomes of these patients. We report on main oncological outcomes of a ... ...

Abstract	Introduction: Surveillance is the standard management in low-risk cN0 penile squamous cell carcinoma (peSCC) patients. However, no previous analysis focused on early and long-term outcomes of these patients. We report on main oncological outcomes of a large series of low-risk cN0 peSCC patients. Patients and methods: Between 1980 and 2017 included, 93 evaluable consecutive low-risk (ie, pT1a G1 cN0M0) peSCC patients underwent primary tumor surgery and either observation (74) or dynamic sentinel node biopsy (DSNB) (19) following a clinical diagnosis of T1 in 66 (71%), T2 in 15 (16.1%) and Tx in 12 (12.9%) patients, respectively. The statistical significance of differences in medians and proportions was tested with the Kruskal-Wallis and chi-square tests. Kaplan-Meier plots illustrated 5-year inguinal relapse (IR)-free survival rates. Results: Median age was 60 years (IQR: 50-69 years). Median follow-up was 92 months (IQR 54-133 months). Surveillance was more frequently adopted in clinical (c)T1 than in cT2 tumors (79.7% vs. 36.8%). None of 19 patients who had DSNB had nodal metastasis. Overall, 7 (7.5%) out of 93 pT1aG1cN0 peSCC patients had IR after a median interval of 9 months. Of note, 1 patient only relapsed after 12 months of surveillance. After stratification according to IR, relapses occurred more frequently in younger patients (59 vs. 64 years, P < .001). The 5-year IR-free survival rates for the entire cohort was 92% (95% Confidence interval [CI] 87-98%). Conclusions: Observation is a safe and effective management for low-risk peSCC patients. Younger patients may be offered a mini-invasive staging as an alternative.
MeSH term(s)	Male ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Sentinel Lymph Node Biopsy ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Neoplasm Staging
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2225121-2
ISSN	1938-0682 ; 1558-7673
ISSN (online)	1938-0682
ISSN	1558-7673
DOI	10.1016/j.clgc.2024.01.009
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Zs.A 6168: Show issues

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Article: Implications of an Underlying Beckwith-Wiedemann Syndrome for Wilms Tumor Treatment Strategies.

Quarello, Paola / Carli, Diana / Biasoni, Davide / Gerocarni Nappo, Simona / Morosi, Carlo / Cotti, Roberta / Garelli, Emanuela / Zucchetti, Giulia / Spadea, Manuela / Tirtei, Elisa / Spreafico, Filippo / Fagioli, Franca

Cancers

2023 Volume 15, Issue 4

Abstract: Beckwith-Wiedemann Syndrome (BWS) is a pediatric overgrowth disorder involving a predisposition to embryonal tumors. Most of the tumors associated with BWS occur in the first 8-10 years of life, and the most common is Wilms tumor (WT). BWS clinical ... ...

Abstract	Beckwith-Wiedemann Syndrome (BWS) is a pediatric overgrowth disorder involving a predisposition to embryonal tumors. Most of the tumors associated with BWS occur in the first 8-10 years of life, and the most common is Wilms tumor (WT). BWS clinical heterogeneity includes subtle overgrowth features or even silent phenotypes, and WT may be the presenting symptom of BWS. WT in BWS individuals exhibit distinct characteristics from those of sporadic WT, and the management of these patients needs a peculiar approach. The most important feature is a higher risk of developing bilateral disease at some time in the course of the illness (synchronous bilateral disease at diagnosis or metachronous recurrence after initial presentation with unilateral disease). Accordingly, neoadjuvant chemotherapy is the recommended approach also for BWS patients with unilateral WT to facilitate nephron-sparing surgical approaches. This review emphasizes the importance of early BWS recognition, particularly if a WT has already occurred, as this will result in an urgent consideration of first-line cancer therapy.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041292
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Article ; Online: Should we reduce routine surveillance imaging in pediatric germ cell tumors?

Terenziani, Monica / Barretta, Francesco / Gattuso, Giovanna / Bisogno, Gianni / Conte, Massimo / Crocoli, Alessandro / De Pasquale, Maria Debora / Biasoni, Davide / Spreafico, Filippo / D'Angelo, Paolo

Pediatric blood & cancer

2023 Volume 70, Issue 3, Page(s) e30200

Abstract: This paper retrospectively investigated the site and the detection method of relapses in children and adolescents with malignant germ cell tumors enrolled in the TCGM-AIEOP-2004 Study and subsequently developed a relapse, in order to evaluate a possible ... ...

Abstract	This paper retrospectively investigated the site and the detection method of relapses in children and adolescents with malignant germ cell tumors enrolled in the TCGM-AIEOP-2004 Study and subsequently developed a relapse, in order to evaluate a possible reduction in radiological exposure during follow-up. Including all malignant cases, serum tumor markers identified a relapse in more than 70% and, according to the selection criteria published by Children Oncology Group in 2018, in more than 90% of cases. These results confirm the importance of serum tumor markers as a relapse detection method, with possible reduction of radiology exams in specific subgroups.
MeSH term(s)	Child ; Adolescent ; Humans ; Male ; Retrospective Studies ; Neoplasm Recurrence, Local/diagnosis ; Diagnostic Imaging ; Neoplasms, Germ Cell and Embryonal/diagnostic imaging ; Biomarkers, Tumor ; Testicular Neoplasms
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30200
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Article ; Online: Technical advances in the surgical management of Wilms tumors in children.

Romao, Rodrigo L P / van der Steeg, Alida F W / Malek, Marcus / Irtan, Sabine / Gow, Kenneth / Ghandour, Khalil / Biasoni, David / Davidoff, Andrew / Pachl, Max

Pediatric blood & cancer

2023 Volume 70 Suppl 2, Page(s) e30267

Abstract: Surgery is one of the cornerstones of Wilms tumor treatment. In this article, we present technical advancements that are finding their way into the armamentarium of pediatric cancer surgeons. We discuss the current approaches, challenges, opportunities, ... ...

Abstract	Surgery is one of the cornerstones of Wilms tumor treatment. In this article, we present technical advancements that are finding their way into the armamentarium of pediatric cancer surgeons. We discuss the current approaches, challenges, opportunities, and future directions of minimally invasive surgery (laparoscopic and robotics), image-guided surgery, and fluorescence-guided surgery. Furthermore, we discuss the use of intraoperative ultrasonography, as well as the use of new techniques to improve the quality of lymph node sampling.
MeSH term(s)	Child ; Humans ; Wilms Tumor/surgery ; Minimally Invasive Surgical Procedures/methods ; Laparoscopy/methods ; Forecasting ; Kidney Neoplasms/pathology
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30267
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Article ; Online: "When You Hear Hoofbeats, Think of Horses, Not Zebras:" A Case of Bladder Endometriosis in Menopause.

Solima, Eugenio / Pino, Ida / Scagnelli, Giuseppe / Biasoni, Davide / Vignali, Michele

Journal of minimally invasive gynecology

2018 Volume 26, Issue 5, Page(s) 796–797

Language	English
Publishing date	2018-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2018.11.012
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Article ; Online: Gardner-associated fibroma of the neck: role of a multidisciplinary evaluation for familial adenomatous polyposis diagnosis.

Signoroni, Stefano / Piozzi, Guglielmo Niccolò / Collini, Paola / Cocco, Ivana Maria Francesca / Biasoni, Davide / Chiaravalli, Stefano / Ricci, Maria Teresa / Vitellaro, Marco

Tumori

2021 Volume 107, Issue 6, Page(s) NP73–NP76

Abstract: Introduction: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant disorder characterized by the development of multiple adenomas in the colon and rectum with a lifetime risk of 80%-100% to develop colorectal cancer if undetected or ... ...

Abstract	Introduction: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant disorder characterized by the development of multiple adenomas in the colon and rectum with a lifetime risk of 80%-100% to develop colorectal cancer if undetected or untreated. Gardner-associated fibroma (GAF) is a rare, benign soft tissue lesion with uncertain pathogenesis. GAF is generally associated with FAP in its clinical variant, called Gardner syndrome (GS). Case description: A 16-year-old boy with no comorbidities and no significant medical history was referred to the Unit of Hereditary Digestive Tract Tumours, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, for genetic counselling after surgical removal of a right anterior cervical paramedian fibroma. The histopathology on the specimen led to the diagnosis of GAF. He had no family history for colorectal cancer or gastrointestinal polyposis and denied any gastrointestinal symptoms. Physical examination showed a small frontal osteoma and colonoscopy showed the presence of multiple small sessile polyps (>100 polyps, diameter <5 mm) diffusely present on the large bowel. Genetic testing revealed a pathogenic germline variant in the Conclusions: GAF may represent a sentinel sign of FAP, preceding gastrointestinal symptoms and endoscopic findings. A careful multidisciplinary approach is determinant for correct and early diagnosis of FAP.
MeSH term(s)	Adenomatous Polyposis Coli/diagnosis ; Adenomatous Polyposis Coli/genetics ; Adolescent ; Colonoscopy ; Diagnosis, Differential ; Fibroma/diagnosis ; Fibroma/genetics ; Gardner Syndrome/diagnosis ; Gardner Syndrome/genetics ; Genetic Testing ; Germ-Line Mutation ; Humans ; Male
Language	English
Publishing date	2021-04-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/03008916211009316
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Article ; Online: Bilateral inguinal lymph-node dissection vs. unilateral inguinal lymph-node dissection and dynamic sentinel node biopsy in clinical N1 squamous cell carcinoma of the penis.

Nazzani, Sebastiano / Catanzaro, Mario / Biasoni, Davide / Maccauro, Marco / Stagni, Silvia / Torelli, Tullio / Macchi, Alberto / Bernasconi, Valentina / Taverna, Alessandra / Sessa, Dario / Lorenzoni, Alice / Piva, Luigi / Lanocita, Rodolfo / Cascella, Tommaso / Cattaneo, Laura / Montanari, Emanuele / Salvioni, Roberto / Nicolai, Nicola

Urologic oncology

2023 Volume 41, Issue 4, Page(s) 210.e1–210.e8

Abstract: Introduction: To evaluate the role of unilateral inguinal lymph-node dissection (ILND) plus contralateral dynamic sentinel node biopsy (DSNB) vs. bilateral ILND in clinical N1 (cN1) penile squamous cell carcinoma (peSCC) patients.: Material and ... ...

Abstract	Introduction: To evaluate the role of unilateral inguinal lymph-node dissection (ILND) plus contralateral dynamic sentinel node biopsy (DSNB) vs. bilateral ILND in clinical N1 (cN1) penile squamous cell carcinoma (peSCC) patients. Material and methods: Within our institutional database (1980-2020, included), we identified 61 consecutive cT1-4 cN1 cM0 patients with histological confirmed peSCC who underwent either unilateral ILND plus DSNB (26) or bilateral ILND (35). Results: Median age was 54 years (Interquartile range [IQR]: 48-60 years). Median follow-up was 68 months (IQR 21-105 months). Most patients had pT1 (23 %) or pT2 (54.1%), as well as G2 (47.5%) or G3 (23%) tumors, while lymphovascular invasion (LVI) was present in 67.1% of cases. Considering a cN1 and a cN0 groin, overall 57 out of 61 patients (93.5%) had nodal disease in the cN1 groin. Conversely, only 14 out of 61 patients (22.9%) had nodal disease in the cN0 groin. 5-year IR-free survival was 91% (Confidence interval [CI] 80%-100%) for bilateral ILND group and 88% (CI 73%-100%) for the ipsilateral ILND plus DSNB group (P-value 0.8). Conversely, 5-year CSS was 76% (CI 62%-92%) for bilateral ILND group and 78% (CI 63%-97%) for the ipsilateral ILND plus contralateral DSNB group (P-value 0.9). Conclusions: In patients with cN1 peSCC the risk of occult contralateral nodal disease is comparable to cN0 high risk peSCC and the gold standard, namely bilateral ILND, may be replaced by unilateral ILND and contralateral DSNB without affecting positive node detection, IRRs and CSS.
MeSH term(s)	Male ; Humans ; Middle Aged ; Sentinel Lymph Node Biopsy ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Penis/pathology ; Penile Neoplasms/surgery ; Penile Neoplasms/pathology ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Neoplasm Staging
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2023.02.001
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